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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Granulysin

Granulysin, Lag-2, NKG5, GNLY
The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: FATE, CAN, Glucagon, E4, Perforin
Papers on Granulysin
Tilt Aftereffect due to Adaptation to Natural Images.
New
Sagi et al., In J Vis, Oct 2015
TAE was strongest immediately after image exposure (lag1: 1.44º, ~1.5 sec), minimal on the following trial (lag2: 0.46º, ~3 sec), converging to an intermediate value (0.98º) on later trials.
The Use of Transcriptional Profiling to Improve Personalized Diagnosis and Management of Cutaneous T-cell Lymphoma (CTCL).
New
Kupper et al., Montréal, Canada. In Clin Cancer Res, Jul 2015
Moreover, we determined that 17 genes (CCL18, CCL26, FYB, T3JAM, MMP12, LEF1, LCK, ITK, GNLY, IL2RA, IL26, IL22, CCR4, GTSF1, SYCP1, STAT5A, and TOX) are able to both identify patients who are at risk of progression and also distinguish mycosis fungoides/Sézary syndrome from benign mimickers.
The molecular landscape of antibody-mediated kidney transplant rejection: evidence for NK involvement through CD16a Fc receptors.
New
Halloran et al., Edmonton, Canada. In Am J Transplant, May 2015
cytotoxicity molecules granulysin (GNLY) and FGFBP2.
Differential distributed lag patterns of source-specific particulate matter on respiratory emergency hospitalizations.
New
Qiu et al., Hong Kong, Hong Kong. In Environ Sci Technol, Apr 2015
increase in respiratory hospitalizations at cumulative lag2-5; significant associations of aged sea salt (1.2%; 95% CI: 0.63, 1.78) and soil/road dust (0.42%; 95% CI: 0.03, 0.82) were at lag0-1.
Transmissible cytotoxicity of multiple myeloma cells by cord blood-derived NK cells is mediated by vesicle trafficking.
Shah et al., Houston, United States. In Cell Death Differ, 2015
NK kill target cells by the vesicular delivery of cytolytic molecules such as Granzyme-B and Granulysin activating different cell death pathways, which can be Caspase-3 dependent or Caspase-3 independent.
A High Yield and Cost-efficient Expression System of Human Granzymes in Mammalian Cells.
Walch et al., Fribourg, Switzerland. In J Vis Exp, 2014
Death of the host cells and intracellular pathogens is triggered by the granule serine proteases, granzymes (Gzms), delivered into the host cell cytosol by the pore forming protein perforin (PFN) and into bacterial pathogens by the prokaryotic membrane disrupting protein granulysin (GNLY).
Analyzing Multiple Multivariate Time Series Data Using Multilevel Dynamic Factor Models.
Zhang et al., United States. In Multivariate Behav Res, 2014
To illustrate the uses of MDFMs, we applied lag0, lag1, and lag2 MDFMs to empirical data on affect collected from 205 dating couples who had at least 50 consecutive days of observations.
Association of GNLY genetic polymorphisms with chronic liver disease in a Korean population.
GeneRIF
Kwack et al., South Korea. In Dna Cell Biol, 2012
GNLY polymorphism genotypes and diplotypes were associated with the chronicity of HBV
15 kDa granulysin causes differentiation of monocytes to dendritic cells but lacks cytotoxic activity.
GeneRIF
Krensky et al., Bethesda, United States. In J Immunol, 2012
recombinant 15 kDa granulysin is not cytolytic but is a potent inducer of monocytic differentiation to dendritic cells
Control of Plasmodium falciparum erythrocytic cycle: γδ T cells target the red blood cell-invasive merozoites.
GeneRIF
Behr et al., Bordeaux, France. In Blood, 2012
Findings suggest that Vgamma9Vdelta2 T cell-mediated production of granulysin as an underestimated immune effector in malaria.
NKp46+ cells express granulysin in multiple cutaneous adverse drug reactions.
GeneRIF
Yawalkar et al., Bern, Switzerland. In Allergy, 2011
Granulysin is expressed at different levels in multiple cutaneous adverse drug reactions both by NKp46(+) cells and by CD8(+) T cells.
Notch signaling and Notch signaling modifiers.
Review
Wang, Ann Arbor, United States. In Int J Biochem Cell Biol, 2011
The DSL (Delta, Serrate, LAG-2 family) proteins have long been considered canonical activators of the core Notch pathway.
Granulysin-expressing CD4+ T cells as candidate immune marker for tuberculosis during childhood and adolescence.
GeneRIF
Kaufmann et al., Berlin, Germany. In Plos One, 2010
Proliferating memory T cells (CFSE(low)CD4(+)CD45RO(+)) were identified as main source of granulysin and these cells expressed both central and effector memory phenotype
Control of cardiogenesis by the notch pathway.
Review
Pedrazzini, Lausanne, Switzerland. In Trends Cardiovasc Med, 2007
Notch signaling mediates local cell-cell communication via interaction of the Notch receptors with a membrane-bound ligand of the Delta-Serrate-LAG-2 family.
Hairless: the ignored antagonist of the Notch signalling pathway.
Review
Maier, Stuttgart, Germany. In Hereditas, 2006
Together with mastermind and CSL (CBF-1, Suppressor of Hairless, lag-2) DNA-binding proteins, Notch forms a complex that mediates transcriptional activation of the respective target genes.
Vulval development.
Review
Sternberg, Pasadena, United States. In Wormbook, 2004
The anchor cell also patterns nearby uterine cells, via the DSL ligand LAG-2 and LIN-12, to generate the four uv1 cells that form the tight connection with the vulva.
Antimicrobial peptides in mammalian and insect host defence.
Review
Ganz et al., Los Angeles, United States. In Curr Opin Immunol, 1999
Granulysin, a peptide stored in the cytoplasmic granules of human natural killer cells and cytolytic T cells, was shown to kill Mycobacterium tuberculosis.
The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1.
Impact
Torok-Storb et al., Seattle, United States. In Immunity, 1998
A peptide corresponding to the Delta/Serrate/LAG-2 domain of hJagged1 and supernatants from COS cells expressing a soluble form of the extracellular portion of hJagged1 were able to mimic this effect.
Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision.
Impact
Greenwald et al., New York City, United States. In Cell, 1995
This interaction is mediated by the receptor LIN-12 and its apparent ligand LAG-2.
Sequence of C. elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila.
Impact
Thomas et al., Seattle, United States. In Nature, 1994
The phenotype of this double mutant is called Lag, and recessive mutations in either of the genes lag-1 or lag-2 can also result in the Lag phenotype, indicating that these two genes may participate in the same cell interactions that require lin-12 or glp-1.
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