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Rho GTPase activating protein 26

Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: Rhodopsin, GAP, HAD, RhoA, OUT
Papers on GRAF
Endocytic membrane turnover at the leading edge is driven by a transient interaction between Cdc42 and GRAF1.
Lundmark et al., Umeå, Sweden. In J Cell Sci, Dec 2015
Here, we describe how a direct interaction between the Rho GTPase Cdc42 and the GTPase-activating protein (GAP) GRAF1 (also known as ARHGAP26), facilitates rapid cell surface turnover at the leading edge.
CD151-α3β1 integrin complexes are prognostic markers of glioblastoma and cooperate with EGFR to drive tumor cell motility and invasion.
Yang et al., Boston, United States. In Oncotarget, Nov 2015
Also, knockdown- or pharmacological agent-based attenuation of EGFR, FAK or Graf (ARHGAP26)/small GTPase-mediated pathways markedly mitigated the aggressiveness of glioblastoma cells.
Psychotic syndrome associated with anti-Ca/ARHGAP26 and voltage-gated potassium channel antibodies.
Wandinger et al., Heidelberg, Germany. In J Neuroimmunol, Oct 2015
BACKGROUND: Antibodies to the Rho GTPase-activating protein 26 (ARHGAP26, GRAF1) (also termed anti-Ca) were first described in patients with cerebellar ataxia.
Isobaric Tags for Relative and Absolute Quantitation-Based Proteomic Analysis of Patent and Constricted Ductus Arteriosus Tissues Confirms the Systemic Regulation of Ductus Arteriosus Closure.
Zhang et al., Shanghai, China. In J Cardiovasc Pharmacol, Aug 2015
Of 132 proteins, voltage-gated sodium channel 1.3 (SCN3A), myosin 1d (Myo1d), Rho GTPase activating protein 26 (ARHGAP26), and retinitis pigmentosa 1 (RP1) were selected for validation by Western blot and quantitative real-time polymerase chain reaction analyses.
Recurrent Fusion Genes in Gastric Cancer: CLDN18-ARHGAP26 Induces Loss of Epithelial Integrity.
Hillmer et al., Singapore, Singapore. In Cell Rep, Aug 2015
In three out of 100 GC cases, we found recurrent fusions between CLDN18, a tight junction gene, and ARHGAP26, a gene encoding a RHOA inhibitor.
Follow-up to genome-wide linkage and admixture mapping studies implicates components of the extracellular matrix in susceptibility to and size of uterine fibroids.
Wiener et al., Birmingham, United States. In Fertil Steril, Feb 2015
Furthermore, the cell-matrix Rho GTPase-encoding ARHGAP26 gene, and MAN1C1, a gene encoding a Golgi mannosidase involved in the maturation of procollagens, emerged as new candidate uterine leiomyoma genes affecting both risk and tumor size.
Severity of Mitral Valve Degeneration Is Associated with Chromosome 15 Loci in Whippet Dogs.
Stepien et al., Davis, United States. In Plos One, 2014
Positional candidate genes were identified within the primary and secondary loci including follistatin-related protein 5 precursor (FSTL5) and Rho GTPase-activating protein 26 (ARHGAP26).
'Medusa head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 2: Anti-PKC-gamma, anti-GluR-delta2, anti-Ca/ARHGAP26 and anti-VGCC.
Wildemann et al., Heidelberg, Germany. In J Neuroinflammation, 2014
Serological testing for anti-neural autoantibodies is important in patients presenting with idiopathic cerebellar ataxia, since these autoantibodies may indicate cancer, determine treatment and predict prognosis.
High expression of GTPase regulator associated with the focal adhesion kinase (GRAF) is a favorable prognostic factor in acute myeloid leukemia.
Ghazy et al., Al Manşūrah, Egypt. In Blood Cells Mol Dis, 2014
BACKGROUND: GRAF is a recognized tumor suppressor gene that was found inactivated in AML.
GRAF1a is a brain-specific protein that promotes lipid droplet clustering and growth, and is enriched at lipid droplet junctions.
McMahon et al., Cambridge, United Kingdom. In J Cell Sci, 2014
We found that GRAF1a, the longest GRAF1 isoform (GRAF1 is also known as ARHGAP26), was enriched in the brains of neonates.
Seroprevalence of autoantibodies against brain antigens in health and disease.
Ehrenreich et al., Göttingen, Germany. In Ann Neurol, 2014
Appreciable frequency was noted for AB against amphiphysin (2.0%), ARHGAP26 (1.3%), CASPR2 (0.9%), MOG (0.8%), GAD65 (0.5%), Ma2 (0.5%), Yo (0.4%), and Ma1 (0.4%), with titers and Ig class distribution similar among groups.
Anti-Ca/anti-ARHGAP26 antibodies associated with cerebellar atrophy and cognitive decline.
Jarius et al., Berlin, Germany. In J Neuroimmunol, 2014
Recently, we identified a novel Purkinje cell-specific autoantibody (termed anti-Ca) targeting rhoGTPase-activating-protein-26 (ARHGAP26) in a patient with cerebellar ataxia.
Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia.
Komorowski et al., Heidelberg, Germany. In J Neuroinflammation, 2013
The antibody bound to PC somata, dendrites, and axons, resulting in a binding pattern similar to that reported for anti-Ca/anti-ARHGAP26, but did not react with recombinant ARHGAP26.
ADAR1 regulates ARHGAP26 gene expression through RNA editing by disrupting miR-30b-3p and miR-573 binding.
Wang et al., In Rna, 2013
Rho GTPase activating protein 26 (ARHGAP26) is a negative regulator of the Rho family that converts the small G proteins RhoA and Cdc42 to their inactive GDP-bound forms.
Identifying differentially expressed genes and small molecule drugs for prostate cancer by a bioinformatics strategy.
Guo et al., Chengdu, China. In Asian Pac J Cancer Prev, 2012
Furthermore, the transcription factor, SP1, and its target genes ARHGAP26 and USF1 were identified.
The endocytic protein GRAF1 is directed to cell-matrix adhesion sites and regulates cell spreading.
Lundmark et al., Cambridge, United Kingdom. In Mol Biol Cell, 2011
proposed that GRAF1 remodels membrane microdomains at adhesion sites into endocytic carriers, facilitating membrane turnover during cell morphological changes
Skeletal muscle differentiation and fusion are regulated by the BAR-containing Rho-GTPase-activating protein (Rho-GAP), GRAF1.
Taylor et al., In J Biol Chem, 2011
a GTPase-activating protein that regulates muscle maturation and to highlight the functional importance of BAR domains in myotube formation
Abnormal methylation of GRAF promoter Chinese patients with acute myeloid leukemia.
Wang et al., Zhenjiang, China. In Leuk Res, 2011
Findings suggest that the hypermethylation of GRAF promoter might be one of early events in the development of AML.
Decreased expression of GRAF1/OPHN-1-L in the X-linked alpha thalassemia mental retardation syndrome.
Condorelli et al., Catania, Italy. In Bmc Med Genomics, 2009
The analysis of the expression pattern of the GRAF1/OPHN-1-L gene in human tissues and organs revealed the predominant brain expression of a novel splicing isoform.
GTPase regulator associated with the focal adhesion kinase (GRAF) transcript was down-regulated in patients with myeloid malignancies.
Li et al., Zhenjiang, China. In J Exp Clin Cancer Res, 2009
Decreased level of GRAF transcript is associated with acute myeloid leukemia, myelodysplastic syndrome and chronic myeloid leukemia.
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