PKCs in thrombus formation.
Montréal, Canada. In Pathol Biol (paris), Dec 2015
In addition, PKCβ by interacting with its receptor RACK1 has been implicated in the primary phases of signaling via the αIIbβ3 and finally PKCɛ appears to be involved in platelet function downstream GPVI.
Genetics of Venous Thrombosis: update in 2015.
Marseille, France. In Thromb Haemost, Dec 2015
To date, 17 genes have been robustly demonstrated to harbour genetic variations associated with VT risk: ABO, F2, F5, F9, F11, FGG, GP6, KNG1, PROC, PROCR, PROS1, SERPINC1, SLC44A2, STXBP5, THBD, TSPAN15 and VWF.
The platelet Fc receptor, FcγRIIa.
Melbourne, Australia. In Immunol Rev, Nov 2015
Finally, we present some new data investigating whether levels of the extracellular ligand-binding region of platelet glycoprotein VI which is rapidly shed upon engagement of platelet FcγRIIa by autoantibodies, can report on the presence of pathological anti-heparin/platelet factor 4 immune complexes and thus identify patients with pathological autoantibodies who are at the greatest risk of developing life-threatening thrombosis in the setting of heparin-induced thrombocytopenia.
Focusing on plasma glycoprotein VI.
Melbourne, Australia. In Thromb Haemost, 2012
analysis of platelet GPVI, a unique platelet-specific receptor with uses in diagnosis and/or disease prevention [review]
Gene variants associated with deep vein thrombosis.
Leiden, Netherlands. In Jama, 2008
false discovery rate < or =.10): rs13146272 in CYP4V2 (risk allele frequency, 0.64), rs2227589 in SERPINC1 (risk allele frequency, 0.10), and rs1613662 in GP6 (risk allele frequency, 0.84).