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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

G protein-coupled receptor, family C, group 5, member B

GPRC5B, RAIG-2
The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, GPRC5A, GPCR, orphan G-protein-coupled receptor, fibrillin-1
Papers on GPRC5B
Genetic variation at the CELF1 (CUGBP, elav-like family member 1 gene) locus is genome-wide associated with Alzheimer's disease and obesity.
GIANT Consortium et al., Essen, Germany. In Am J Med Genet B Neuropsychiatr Genet, 2014
Additionally, among the SNPs used for confirmation in both studies the AD risk allele of rs1858973, with an AD association just below genome-wide significance (pAD  = 7.20 × 10(-07)), was also associated with obesity (SNP at IQCK/GPRC5B; pBMI  = 5.21 × 10(-06) ; pcorr  = 3.24 × 10(-04)).
Identification of a radiation sensitivity gene expression profile in primary fibroblasts derived from patients who developed radiotherapy-induced fibrosis.
Sprung et al., Australia. In Radiother Oncol, 2014
RESULTS: A set of genes (FBN2, FST, GPRC5B, NOTCH3, PLCB1, DPT, DDIT4L and SGCG) were identified as potential predictors for radiation-induced fibrosis.
G protein-coupled receptor, family C, group 5 (GPRC5B) downregulation in spinal cord neurons is involved in neuropathic pain.
Jeong et al., Pusan, South Korea. In Korean J Anesthesiol, 2014
BACKGROUND: G protein-coupled receptor, family C, group 5 (GPRC5B), a retinoic acid-inducible orphan G-protein-coupled receptor (GPCR), is a member of the group C metabotropic glutamate receptor family proteins presumably related in non-canonical Wnt signaling.
Intercellular transfer of GPRC5B via exosomes drives HGF-mediated outward growth.
Mostov et al., San Francisco, United States. In Curr Biol, 2014
We report that GPRC5B, an orphan G protein coupled receptor, is in exosomes produced by HGF-treated cysts and released into the cyst lumen.
The emerging roles of GPRC5A in diseases.
Review
Rigoutsos et al., Philadelphia, United States. In Oncoscience, 2013
The 'Retinoic Acid-Inducible G-protein-coupled receptors' or RAIG are a group comprising the four orphan receptors GPRC5A, GPRC5B, GPRC5C and GPRC5D.
GPRC5B a putative glutamate-receptor candidate is negative modulator of insulin secretion.
Salehi et al., In Biochem Biophys Res Commun, 2013
GPRC5B is an orphan receptor belonging to the group C family of G protein-coupled receptors (GPCRs).
The G protein-coupled receptor GPRC5B contributes to neurogenesis in the developing mouse neocortex.
Sanada et al., Tokyo, Japan. In Development, 2013
Here we show that GPRC5B, which encodes an orphan G protein-coupled receptor, is present in the ventricular surface of cortical progenitors in the mouse developing neocortex and is required for their neuronal differentiation.
GPRC5B a putative glutamate-receptor candidate is negative modulator of insulin secretion.
Salehi et al., Lund, Sweden. In Biochem Biophys Res Commun, 2013
GPRC5B is an orphan receptor belonging to the group C family of G protein-coupled receptors (GPCRs).
Common obesity risk alleles in childhood attention-deficit/hyperactivity disorder.
Psychiatric GWAS Consortium: ADHD Subgroup et al., Essen, Germany. In Am J Med Genet B Neuropsychiatr Genet, 2013
In the meta-analysis data we found rs6497416 in the intronic region of the GPRC5B gene (G protein-coupled receptor, family C, group 5, member B; P = 7.2 × 10(-4) ; Pcorr  = 0.02) as a risk allele for ADHD.
G protein-linked signaling pathways in bipolar and major depressive disorders.
Vawter et al., Irvine, United States. In Front Genet, 2012
Two orphan GPCRs, GPRC5B and GPR37, showed significantly decreased expression levels in MDD, and significantly increased expression levels in BPD.
GPRC5B activates obesity-associated inflammatory signaling in adipocytes.
Hirabayashi et al., Wako, Japan. In Sci Signal, 2012
A genome-wide association study identified a strong correlation between body mass index and the presence of a 21-kb copy number variation upstream of the human GPRC5B gene; however, the functional role of GPRC5B in obesity remains unknown.
Comparative characterization of GPRC5B and GPRC5CLacZ knockin mice; behavioral abnormalities in GPRC5B-deficient mice.
GeneRIF
Hirabayashi et al., Wako, Japan. In Biochem Biophys Res Commun, 2011
GPRC5B has important roles for animal behavior controlled by the central nervous system.
Molecular evolution of a chordate specific family of G protein-coupled receptors.
Neuhaus et al., Bochum, Germany. In Bmc Evol Biol, 2010
Additional duplications of GPRC5B and GPRC5C sequences occurred in teleost fishes.
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
Impact
Loos et al., Cambridge, United States. In Nat Genet, 2010
We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10⁻⁸), one of which includes a copy number variant near GPRC5B.
A flanking gene problem leads to the discovery of a Gprc5b splice variant predominantly expressed in C57Bl/6J mouse brain and in maturing neurons.
GeneRIF
Hu et al., Seattle, United States. In Plos One, 2009
Gprc5b-v2 may play a role during brain maturation and in matured brain, possibly through the regulation of neuronal morphology and protein-protein interaction
Changes in expression and localization of GPRC5B and RARalpha in the placenta and yolk sac during middle to late gestation in mice.
GeneRIF
Manabe et al., Tsukuba, Japan. In J Reprod Dev, 2007
GPRC5B is involved in retinoic acid -dependent morphogenesis/angiogenesis and regulation of extracellular matrix synthesis in the murine placenta and yolk sac.
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