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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

G protein-coupled receptor, family C, group 5, member A

GPRC5A, RAI3, RAIG1
This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, GPRC5B, CAN, V1a, SET
Papers on GPRC5A
Epithelial neoplasia coincides with exacerbated injury and fibrotic response in the lungs of Gprc5a-knockout mice following silica exposure.
New
Han et al., Shanghai, China. In Oncotarget, Dec 2015
Previously, we showed that, Gprc5a-/- mice are susceptible to both lung tumorigenesis and endotoxin-induced acute lung injury.
GPRC5A overexpression predicted advanced biological behaviors and poor prognosis in patients with gastric cancer.
New
Jia et al., Tianjin, China. In Tumour Biol, Aug 2015
UNASSIGNED: G protein-coupled receptor, family C, group 5, member A (GPRC5A) had received attentions for its role in carcinogenesis and prognostic values in several types of cancer.
Lung Tumor Suppressor GPRC5A Binds EGFR and Restrains Its Effector Signaling.
New
Deng et al., Shanghai, China. In Cancer Res, Jun 2015
GPRC5A is a G-protein-coupled receptor expressed in lung tissue but repressed in most human lung cancers.
Gprc5a-deficiency confers susceptibility to endotoxin-induced acute lung injury via NF-κB pathway.
Deng et al., Shanghai, China. In Cell Cycle, 2014
G protein coupled receptor family C group 5 member A (GPRC5A), a retinoic acid target gene, is predominately expressed in the bronchioalveolar epithelium of lung.
Temporal Dissection of Rate Limiting Transcriptional Events Using Pol II ChIP and RNA Analysis of Adrenergic Stress Gene Activation.
Michelotti et al., Durham, United States. In Plos One, 2014
Arrival of Pol II at the 3' cleavage site usually correlated with increased polyadenylated mRNA; however, for Nfil3 and probably Gprc5a expression was delayed and accompanied by apparent pre-mRNA degradation.
MicroRNA-31 negatively regulates peripherally derived regulatory T-cell generation by repressing retinoic acid-inducible protein 3.
Wang et al., Shanghai, China. In Nat Commun, 2014
Unexpectedly, we identify Gprc5a as a direct target of miR-31.
MiR-103a-3p targets the 5' UTR of GPRC5A in pancreatic cells.
Rigoutsos et al., Philadelphia, United States. In Rna, 2014
Here we describe and characterize two miR-103a-3p target sites in the 5' UTR of GPRC5A, a gene that acts as a tumor suppressor in some cancer contexts and as an ongocene in other cancer contexts.
Discovery of colorectal cancer biomarker candidates by membrane proteomic analysis and subsequent verification using selected reaction monitoring (SRM) and tissue microarray (TMA) analysis.
Tomonaga et al., Ōsaka, Japan. In Mol Cell Proteomics, 2014
Significant differences were observed in the expression of 44 of these proteins, including ITGA5, GPRC5A, PDGFRB, and TFRC, which have already been shown to be overexpressed in colorectal cancer, as well as proteins with unknown function, such as C8orf55.
High prevalence of GPRC5A germline mutations in BRCA1-mutant breast cancer patients.
Imyanitov et al., Saint Petersburg, Russia. In Int J Cancer, 2014
Arg61fs] in an orphan G protein-coupled receptor GPRC5A.
EGFR phosphorylates and inhibits lung tumor suppressor GPRC5A in lung cancer.
Deng et al., Shanghai, China. In Mol Cancer, 2013
BACKGROUND: GPRC5A is a retinoic acid inducible gene that is preferentially expressed in lung tissue.
The emerging roles of GPRC5A in diseases.
Review
Rigoutsos et al., Philadelphia, United States. In Oncoscience, 2013
The 'Retinoic Acid-Inducible G-protein-coupled receptors' or RAIG are a group comprising the four orphan receptors GPRC5A, GPRC5B, GPRC5C and GPRC5D.
Establishment and characterization of 7 novel hepatocellular carcinoma cell lines from patient-derived tumor xenografts.
Qin et al., Shanghai, China. In Plos One, 2013
mRNA level of retinoic acid induced protein 3 (RAI3) was decreased in all cell lines.
Genome-wide association study for wool production traits in a Chinese Merino sheep population.
Wang et al., Harbin, China. In Plos One, 2013
About 43% of the significant SNP markers were located within known or predicted genes, including YWHAZ, KRTCAP3, TSPEAR, PIK3R4, KIF16B, PTPN3, GPRC5A, DDX47, TCF9, TPTE2, EPHA5 and NBEA genes.
Repression of G protein-coupled receptor family C group 5 member A is associated with pathologic differentiation grade of oral squamous cell carcinoma.
Deng et al., Shanghai, China. In J Oral Pathol Med, 2013
BACKGROUND: G protein-coupled receptor family C group 5 member A (GPRC5A), a member of G protein-coupled receptor family, has been shown to function as a tumor suppressor in lung tissue.
Gprc5a deletion enhances the transformed phenotype in normal and malignant lung epithelial cells by eliciting persistent Stat3 signaling induced by autocrine leukemia inhibitory factor.
GeneRIF
Lotan et al., Houston, United States. In Cancer Res, 2010
Gprc5a deletion enhances the transformed phenotype in normal and malignant lung epithelial cells by eliciting persistent Stat3 signaling induced by autocrine leukemia inhibitory factor.
A Gprc5a tumor suppressor loss of expression signature is conserved, prevalent, and associated with survival in human lung adenocarcinomas.
GeneRIF
Lotan et al., Houston, United States. In Neoplasia, 2010
Loss of GPRC5A is associated with lung adenocarcinomas.
Knockout of the tumor suppressor gene Gprc5a in mice leads to NF-kappaB activation in airway epithelium and promotes lung inflammation and tumorigenesis.
GeneRIF
Lotan et al., Houston, United States. In Cancer Prev Res (phila), 2010
Gprc5a loss enhances NF-kappaB activation in lung epithelial cells
Mechanisms underlying the induction of the putative human tumor suppressor GPRC5A by retinoic acid.
GeneRIF
Lotan et al., Houston, United States. In Cancer Biol Ther, 2009
Mechanisms underlying the induction of the putative human tumor suppressor GPRC5A are reported.
Production and characterisation of monoclonal antibodies against RAI3 and its expression in human breast cancer.
GeneRIF
Klockenbring et al., Aachen, Germany. In Bmc Cancer, 2008
analysis of RAI3 expression in normal and cancerous human breast tissue at both the mRNA and protein levels
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