GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Aug 2016.
G-protein coupled receptor 88
GPR88, Strg, G protein-coupled receptor 88
orphan G-protein coupled receptor [RGD, Feb 2006] (from
NCBI)
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Top mentioned proteins:
GPCR, ACID, GPR52, PCCA, Rdl
Papers on
GPR88
Loss of glutamic acid decarboxylase (Gad67) in striatal neurons expressing the Drdr1a dopamine receptor prevents L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned mice.
New
Boston, United States. In Neuroscience, Oct 2015
In light of evidence that the dopamine Drd1a receptor is densely expressed in striatal direct pathway striatal neurons while the orphan G-protein-coupled receptor Gpr88 is densely expressed in striatal direct and indirect pathway striatal neurons, we used a cre-lox strategy to produce two lines of mice that were Gad1 (Gad1 is the gene encoding for Gad67)-deficient in neurons expressing the Drd1a or the Gpr88 receptor.
Local inactivation of Gpr88 in the nucleus accumbens attenuates behavioral deficits elicited by the neonatal administration of phencyclidine in rats.
New
Paris, France. In Mol Psychiatry, Aug 2015
Gpr88, an orphan G-protein-coupled receptor, is highly and almost exclusively expressed in the medium spiny projection neurons of the striatum, and may thus participate in the control of motor functions and cognitive processing that are impaired in neuropsychiatric disorders such as Parkinson's disease or schizophrenia (SZ).
Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning, and Low Anxiety Reversed by Delta Opioid Antagonist.
New
Illkirch-Graffenstaden, France. In Biol Psychiatry, Jul 2015
BACKGROUND: GPR88 is an orphan G protein coupled receptor highly enriched in the striatum, and previous studies have focused on GPR88 function in striatal physiology.
Design, synthesis, and evaluation of phenylglycinols and phenyl amines as agonists of GPR88.
New
Wallingford, United States. In Bioorg Med Chem Lett, May 2015
Small molecule modulators of GPR88 activity (agonists, antagonists, or modulators) are of interest as potential agents for the treatment of a variety of psychiatric disorders including schizophrenia.
The discovery of potent agonists for GPR88, an orphan GPCR, for the potential treatment of CNS disorders.
New
Princeton, United States. In Bioorg Med Chem Lett, May 2015
Modulating GPR88 activity is suggested to have therapeutic utility in the treatment of CNS disorders, such as schizophrenia.
Biomarkers of hippocampal gene expression in a mouse restraint chronic stress model.
Italy. In Pharmacogenomics, 2014
CONCLUSION: Our study indicated that Gpr88, Ttr, Gh and Tac1 mRNAs were modulated in mice exposed to chronic restraint stress.
Novel Therapeutic GPCRs for Psychiatric Disorders.
Review
Tokyo, Japan. In Int J Mol Sci, 2014
Recently, anatomical and comprehensive transcriptome analysis of the non-odorant GPCR superfamily revealed that the orphan GPCRs GPR88, GPR6, and GPR52, as well as dopamine D1 and D2 receptors and the adenosine A2a receptor, are the most highly enriched in the rodent striatum.
Loss of glutamic acid decarboxylase (Gad67) in Gpr88-expressing neurons induces learning and social behavior deficits in mice.
Boston, United States. In Neuroscience, 2014
We assessed motor function, spatial learning, social behavior, olfactory and object recognition preferences in mice lacking the GABA-synthesizing enzyme glutamic acid decarboxylase, Gad67, in neurons expressing the protein Gpr88, an orphan G-protein-coupled receptor primarily expressed in the striatum.
Synthesis, pharmacological characterization, and structure-activity relationship studies of small molecular agonists for the orphan GPR88 receptor.
United States. In Acs Chem Neurosci, 2014
GPR88 is an orphan G-protein-coupled receptor (GPCR) enriched in the striatum.
Sequence-structure based phylogeny of GPCR Class A Rhodopsin receptors.
India. In Mol Phylogenet Evol, 2014
Our study was able to identify potential ligand association for Class A Orphans and putative/unclassified Class A receptors with no cognate ligand information: GPR21 and GPR52 with fatty acids; GPR75 with Neuropeptide Y; GPR82, GPR18, GPR141 with N-arachidonylglycine; GPR176 with Free fatty acids, GPR10 with Tachykinin & Neuropeptide Y; GPR85 with ATP, ADP & UDP glucose; GPR151 with Galanin; GPR153 and GPR162 with Adrenalin, Noradrenalin; GPR146, GPR139, GPR142 with Neuromedin, Ghrelin, Neuromedin U-25 & Thyrotropin-releasing hormone; GPR171 with ATP, ADP & UDP Glucose; GPR88, GPR135, GPR161, GPR101with 11-cis-retinal; GPR83 with Tackykinin; GPR148 with Prostanoids, GPR109b, GPR81, GPR31with ATP & UTP and GPR150 with GnRH I & GnRHII.
Association study in three different populations between the GPR88 gene and major psychoses.
Cagliari, Italy. In Mol Genet Genomic Med, 2014
GPR88, coding for a G protein-coupled orphan receptor that is highly represented in the striatum, is a strong functional candidate gene for neuropsychiatric disorders and is located at 1p22-p21, a chromosomal region that we have previously linked to bipolar disorder (BD) in the Sardinian population.
Striatum-specific expression of Cre recombinase using the Gpr88 promoter in mice.
Wako, Japan. In Transgenic Res, 2013
We generated a transgenic (Tg) mouse line expressing Cre recombinase under the control of the Gpr88 promoter within a bacterial artificial chromosome clone.
Anatomical transcriptome of G protein-coupled receptors leads to the identification of a novel therapeutic candidate GPR52 for psychiatric disorders.
Fujisawa, Japan. In Plos One, 2013
Among them, GPR6, GPR52, and GPR88, known as orphan GPCRs, were shown to co-localize either with a D2 receptor alone or with both D1 and D2 receptors in neurons of the basal ganglia.
The GPR88 receptor agonist 2-PCCA does not alter the behavioral effects of methamphetamine in rats.
Buffalo, United States. In Eur J Pharmacol, 2013
GPR88 is a novel orphan G protein-coupled receptor that is primarily located at the striatum.
GPR88 reveals a discrete function of primary cilia as selective insulators of GPCR cross-talk.
San Francisco, United States. In Plos One, 2012
We identified a distinct signaling effect of primary cilia through investigating GPR88, an orphan GPCR that is co-expressed with the D1R in brain, and which we show here is targeted to cilia similarly to the D1R.
The orphan GPCR, GPR88, modulates function of the striatal dopamine system: a possible therapeutic target for psychiatric disorders?
GeneRIF
Princeton, United States. In Mol Cell Neurosci, 2009
The modulatory role of Gpr88 in striatal dopamine function suggests it may be a new target for treatments for psychiatric disorders.
Striatal GPR88 expression is confined to the whole projection neuron population and is regulated by dopaminergic and glutamatergic afferents.
GeneRIF
Paris, France. In Eur J Neurosci, 2009
GPR88 is confined to striatal medium spiny neurons and indicate that L-DOPA-mediated behavioural effects in hemiparkinsonian rats may involve normalization of striatal GPR88 levels
