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G protein-coupled receptor 87

GPR87, G protein-coupled receptor 87, GPR95
This gene encodes a G protein-coupled receptor and is located in a cluster of G protein-couple receptor genes on chromosome 3. The encoded protein has been shown to be overexpressed in lung squamous cell carcinoma (PMID:18057535) and regulated by p53 (PMID:19602589). [provided by RefSeq, Nov 2011] (from NCBI)
Top mentioned proteins: ACID, P2Y, CAN, V1a, p53
Papers on GPR87
Constitutive Activity among Orphan Class-A G Protein Coupled Receptors.
Aronstam et al., Rolla, United States. In Plos One, 2014
Five patterns of activity were noted: 1) inhibition under both baseline and forskolin stimulated expression (GPR15, GPR17, GPR18, GPR20, GPR25, GPR27, GPR31, GPR32, GPR45, GPR57, GPR68, GPR83, GPR84, GPR132, GPR150, GPR176); 2) no effect on baseline expression, but inhibition of forskolin stimulated expression (GPR4, GPR26, GPR61, GPR62, GPR78, GPR101, GPR119); 3) elevation of baseline signaling coupled with inhibition of forskolin stimulated expression (GPR6, GPR12); 4) elevation of baseline signaling without inhibition of forskolin stimulated expression (GPR3, GPR21, GPR52, GPR65); and 5) no effect on expression (GPR1, GPR19, GPR22, GPR34, GPR35, GPR39, GPR63, GPR82, GPR85, GPR87).
G Protein-Coupled Receptor 87 (GPR87) Promotes Cell Proliferation in Human Bladder Cancer Cells.
Kakehi et al., Japan. In Int J Mol Sci, 2014
G protein-coupled receptor 87 (GPR87) is a newly deorphanized member of the cell surface molecule G protein-coupled receptor family.
Overexpression of G protein-coupled receptor 87 correlates with poorer tumor differentiation and higher tumor proliferation in non-small-cell lung cancer.
Yokomise et al., Japan. In Mol Clin Oncol, 2014
G protein-coupled receptor 87 (GPR87) is a newly deorphanized member of the transmembrane G protein-coupled receptor family.
GPR87 mediates lysophosphatidic acid-induced colony dispersal in A431 cells.
Review
Fujita et al., Kusatsu, Japan. In Eur J Pharmacol, 2013
We have previously reported that an orphan G protein-coupled receptor GPR87 was activated by lysophosphatidic acid (LPA) and that it induced an increase in the intracellular Ca(2+) levels in the CHO cells genetically engineered to express GPR87-Gα16 fusion protein.
Computational analysis of the 3-D structure of human GPR87 protein: implications for structure-based drug design.
Khattri et al., Lucknow, India. In Asian Pac J Cancer Prev, 2012
The G-protein coupled receptor 87 (GPR87) is a recently discovered orphan GPCR which means that the search of their endogenous ligands has been a novel challenge.
Expression and role of GPR87 in urothelial carcinoma of the bladder.
Kakehi et al., Japan. In Int J Mol Sci, 2012
The orphan GPR87 has recently been matched with its ligand LPA, which is a lipid mediator with multiple physiological functions, including cancer cell proliferation.
G protein-coupled receptor 87 (GPR87) promotes the growth and metastasis of CD133⁺ cancer stem-like cells in hepatocellular carcinoma.
Li et al., Shanghai, China. In Plos One, 2012
Gene expression analysis of the CD133(+) and CD133(-) cells of the HCC line SMMC-7721 revealed that G protein-coupled receptor 87 (GPR87) is highly expressed in CD133(+) HCC cells.
Systematic identification and characterization of novel human skin-associated genes encoding membrane and secreted proteins.
Zlotnik et al., Düsseldorf, Germany. In Plos One, 2012
Four of these are expressed specifically by epidermal keratinocytes; two that encode G-protein-coupled receptors (GPR87 and GPR115), and two that encode secreted proteins (WFDC5 and SERPINB7).
G Protein-Coupled Receptor 87: a Promising Opportunity for Cancer Drug Discovery.
Chen et al., Davis, United States. In Mol Cell Pharmacol, 2010
GPR87, a cell surface GPR related to the LPA receptor family, is overexpressed in diverse carcinomas and plays an essential role in tumor cell survival.
Utilization of the Tango beta-arrestin recruitment technology for cell-based EDG receptor assay development and interrogation.
Hanson et al., Madison, United States. In J Biomol Screen, 2009
The authors describe the use of this technique to build cell-based receptor-specific assays for all 8 members of the EDG receptor family as well as the related LPA receptors GPR23, GPR92, and GPR87.
The G protein-coupled receptor 87 is necessary for p53-dependent cell survival in response to genotoxic stress.
GeneRIF
Chen et al., Davis, United States. In Cancer Res, 2009
GPR87 knockdown sensitized cancer cells to DNA damage-induced growth suppression via enhanced p53 stabilization and activation.
Serum proteomic approach for the identification of serum biomarkers contributed by oral squamous cell carcinoma and host tissue microenvironment.
Alaoui-Jamali et al., Montréal, Canada. In J Proteome Res, 2009
Differentially expressed proteins of human origin included the epidermal growth factor receptor (EGFR), cytokeratins, G-protein coupled receptor 87, Rab11 GTPase, PDZ-domain containing proteins, and PEST-containing nuclear proteins.
Novel implications for lysophospholipids, lysophosphatidic acid and sphingosine 1-phosphate, as drug targets in cancer.
Review
Peyruchaud, Lyon, France. In Anticancer Agents Med Chem, 2009
During the past decade, studies revealed that LPA and S1P interact with a large series of G-protein-coupled receptors, at least seven for LPA (LPA1-5, GPR-87, P2Y5) and five for S1P (S1P1-5).
Two pathways for lysophosphatidic acid production.
Review
Okudaira et al., Sendai, Japan. In Biochim Biophys Acta, 2008
So far, five GPCRs, designated LPA1-5, and, more recently, two additional GPCRs, GPR87 and P2Y5, have been identified as receptors for LPA.
hGPR87 contributes to viability of human tumor cells.
GeneRIF
Sommergruber et al., Vienna, Austria. In Int J Cancer, 2008
Human GPR87 mRNA transcript was preferentially overexpressed in squamous cell carcinomas. Up-regulation of both, transcript and protein, was detected in samples of SCC of the lung, cervix, skin and head and neck (pharynx, larynx and epiglottis).
GPR87 is an overexpressed G-protein coupled receptor in squamous cell carcinoma of the lung.
GeneRIF
Reubi et al., Bern, Switzerland. In Dis Markers, 2007
G-protein coupled receptor(GPR87) stands out as a candidate for further target validation due to its marked overexpression and correlation on a mutation-based level to squamous cell carcinoma
LPA and its analogs-attractive tools for elucidation of LPA biology and drug development.
Review
Aoki et al., Sendai, Japan. In Curr Med Chem, 2007
So far, seven GPCRs (LPA(1-5) and recently reported GPR87/LPA(6) and P2Y5/LPA(7)) and a nuclear hormone receptor, PPARgamma, have been identified.
The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor.
GeneRIF
Fujita et al., Kusatsu, Japan. In Biochem Biophys Res Commun, 2007
Results suggest that the GPR87 is a LPA receptor which evolved from a common ancestor of P2Y receptors.
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