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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Oxoglutarate

GPR80, GPR99, P2Y15, OXGR1
human homolog binds adenosine and AMP; induces Ca2+ mobilization and cyclic AMP production [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Envelope Protein, P2Y, ACID, CAN, Nrf2
Papers on GPR80
Expression and localization of GPR91 and GPR99 in murine organs.
New
Paddenberg et al., Gießen, Germany. In Cell Tissue Res, Dec 2015
In 2004, GPR91 and GPR99 were identified as receptors for the citric acid cycle intermediates, succinate and α-ketoglutarate, respectively.
N-linked glycosylation protects gammaretroviruses against deamination by APOBEC3 proteins.
New
Langlois et al., Ottawa, Canada. In J Virol, Feb 2015
Glycosylated Gag, also called glycosylated Pr80 Gag (gPr80), is a gammaretrovirus genome-encoded protein that inhibits the antiretroviral activity of mouse A3 (mA3).
Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7.
Review
Rovati et al., Stockholm, Sweden. In Br J Pharmacol, 2014
Furthermore, a cross-talk between the CysLT and P2Y receptor systems has been described, and also the presence of novel receptors for cysteinyl-LTs, such as GPR17 and GPR99.
Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor.
Boyce et al., Boston, United States. In J Immunol, 2014
They signal through three specific receptors (type 1 cys-LT receptor [CysLT1R], CysLT2R, and GPR99) with overlapping ligand preferences.
α-Ketoglutarate regulates acid-base balance through an intrarenal paracrine mechanism.
Firsov et al., Lausanne, Switzerland. In J Clin Invest, 2013
Here we show that the resulting changes in the luminal concentrations of αKG are sensed by the αKG receptor OXGR1 expressed in the type B and non-A-non-B intercalated cells of the connecting tubule (CNT) and the cortical collecting duct (CCD).
Mitochondrial TCA cycle intermediates regulate body fluid and acid-base balance.
Peti-Peterdi, Los Angeles, United States. In J Clin Invest, 2013
In this issue of the JCI, Tokonami et al. report on the function of an exciting new paracrine mediator, the mitochondrial the citric acid(TCA) cycle intermediate α-ketoglutarate (αKG), which via its OXGR1 receptor plays an unexpected, nontraditional role in the adaptive regulation of renal HCO(3⁻) secretion and salt reabsorption.
Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand.
Austen et al., Boston, United States. In J Biol Chem, 2013
GPR99, previously described as an oxoglutarate receptor (Oxgr1), showed both a functional and a binding response to LTE4 in these transfectants.
Phenylbutyric acid suppresses protein accumulation-mediated ER stress in retrovirus-infected astrocytes and delays onset of paralysis in infected mice.
Wong et al., United States. In Neurochem Int, 2010
We have previously reported that accumulation of the precursor envelope protein gPr80(env) of ts1, a mutant of Moloney murine leukemia virus (MoMuLV), in the endoplasmic reticulum (ER) of infected astrocytes, results in ER stress, oxidative stress and cell death, subsequently leading to ts1-mediated neurodegeneration in infected mice.
The cellular protein La functions in enhancement of virus release through lipid rafts facilitated by murine leukemia virus glycosylated Gag.
Fan et al., Irvine, United States. In Mbio, 2010
Murine leukemia viruses (MuLVs) encode two forms of Gag polyprotein: the precursor for the viral core proteins (Pr65(gag) for Moloney MuLV [M-MuLV]) and a longer glycosylated form (glyco-gag, or gPr80(gag)).
Aberrant DNA methylation profile and frequent methylation of KLK10 and OXGR1 genes in hepatocellular carcinoma.
GeneRIF
Chang et al., Taipei, Taiwan. In Genes Chromosomes Cancer, 2009
Down-Regulation of OXGR1 through DNA Methylation is associated with hepatocellular carcinoma.
The drug monosodium luminol (GVT) preserves crypt-villus epithelial organization and allows survival of intestinal T cells in mice infected with the ts1 retrovirus.
Wong et al., United States. In Immunol Lett, 2009
Apoptosis of ts1-infected T-lineage cells, in the thymus, peripheral lymphoid system and intestines is caused by accumulation of the ts1 mutant viral envelope preprotein gPr80(env), which is inefficiently cleaved into the mature viral proteins gp70 and PrP15E.
The drug monosodium luminol (GVT) preserves thymic epithelial cell cytoarchitecture and allows thymocyte survival in mice infected with the T cell-tropic, cytopathic retrovirus ts1.
Wong et al., United States. In Immunol Lett, 2009
We have shown previously that the death of ts1-infected cells is not caused by viral replication per se, but by oxidative stress and apoptosis following their accumulation the ts1 viral envelope precursor protein, gPr80(env).
GPR80/99, proposed to be the P2Y(15) receptor activated by adenosine and AMP, is not a P2Y receptor.
Nicholas et al., Chapel Hill, United States. In Purinergic Signal, 2004
The orphan receptor GPR80 (also called GPR99) was recently reported to be the P2Y(15) receptor activated by AMP and adenosine and coupled to increases in cyclic AMP accumulation and intracellular Ca(2+) mobilization (Inbe et al.
The fate of P2Y-related orphan receptors: GPR80/99 and GPR91 are receptors of dicarboxylic acids.
Boeynaems et al., Brussels, Belgium. In Purinergic Signal, 2004
Several orphan G protein-coupled receptors are structurally close to the family of P2Y nucleotide receptors: GPR80/99 and GPR91 are close to P2Y(1/2/4/6/11) receptors, whereas GPR87, H963 and GPR34 are close to P2Y(12/13/14).
Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors.
Impact
Ling et al., San Francisco, United States. In Nature, 2004
We also report that GPR99 (ref.
Identification and characterization of a cell-surface receptor, P2Y15, for AMP and adenosine.
GeneRIF
Encinas et al., Kyoto, Japan. In J Biol Chem, 2004
P2Y15 is a cell surface receptor for AMP and adenosine
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