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G protein-coupled receptor 61

GPR61, BALGR, G-protein-coupled receptor 61, biogenic amine receptor-like G protein-coupled receptor
This gene belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. The protein encoded by this gene is most closely related to biogenic amine receptors. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, fibrillin-1, GPR63, type 2 G protein-coupled receptor, PSP24
Papers on GPR61
Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.
New
Bone Mineral Density in Childhood Study BMDCS et al., Copenhagen, Denmark. In Hum Mol Genet, Feb 2016
In total, 15 loci reached genome-wide significance (P-value < 5 × 10(-8)) in the joint discovery and replication analysis, of which 12 are previously identified loci in or close to ADCY3, GNPDA2, TMEM18, SEC16B, FAIM2, FTO, TFAP2B, TNNI3K, MC4R, GPR61, LMX1B and OLFM4 associated with adult body mass index or childhood obesity.
Constitutive Activity among Orphan Class-A G Protein Coupled Receptors.
Aronstam et al., Rolla, United States. In Plos One, 2014
Five patterns of activity were noted: 1) inhibition under both baseline and forskolin stimulated expression (GPR15, GPR17, GPR18, GPR20, GPR25, GPR27, GPR31, GPR32, GPR45, GPR57, GPR68, GPR83, GPR84, GPR132, GPR150, GPR176); 2) no effect on baseline expression, but inhibition of forskolin stimulated expression (GPR4, GPR26, GPR61, GPR62, GPR78, GPR101, GPR119); 3) elevation of baseline signaling coupled with inhibition of forskolin stimulated expression (GPR6, GPR12); 4) elevation of baseline signaling without inhibition of forskolin stimulated expression (GPR3, GPR21, GPR52, GPR65); and 5) no effect on expression (GPR1, GPR19, GPR22, GPR34, GPR35, GPR39, GPR63, GPR82, GPR85, GPR87).
An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins.
Spector et al., Shenzhen, China. In Nat Commun, 2013
We also detect signals specific to T2D-discordant twins in the GPR61 and PRKCB genes.
Characterization of metabolic phenotypes of mice lacking GPR61, an orphan G-protein coupled receptor.
Ohta et al., Tsukuba, Japan. In Life Sci, 2011
AIMS: GPR61 is an orphan G protein-coupled receptor whose function remains unknown.
DNA hypermethylation accompanied by transcriptional repression in follicular lymphoma.
Caldwell et al., Columbia, United States. In Genes Chromosomes Cancer, 2009
Combined Bisulfite Restriction Analysis (COBRA) also established DNA methylation for the previously identified PRC2 targets DCC, DES, GAD2, AQP5, GPR61, GRIA4, GJD2, and AMPH in FL but not in BFH.
The N-terminal domain of GPR61, an orphan G-protein-coupled receptor, is essential for its constitutive activity.
GeneRIF
Takeda et al., Japan. In J Neurosci Res, 2009
We conclude that the N-terminal domain of GPR61 is required for maintaining its constitutive activity and functions as a tethered intramolecular ligand.
A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors.
GeneRIF
Poyner et al., Birmingham, United Kingdom. In Mol Pharmacol, 2005
Modeling rationalizes the effects of transmembrane proline mutants previously reported for another family of GPCR.
Cloning of a novel biogenic amine receptor-like G protein-coupled receptor expressed in human brain.
GeneRIF
Koppel et al., Košice, Slovakia. In Biochim Biophys Acta, 2001
maps to chromosome 1, is widely expressed, with expression highest in the brain areas associated with cognition, learning, and memory.
Identification of four novel human G protein-coupled receptors expressed in the brain.
O'Dowd et al., Toronto, Canada. In Brain Res Mol Brain Res, 2001
We report the discovery and tissue distributions of four novel human genes, GPR61, GPR62, GPR63 and GPR77, all of which encode G protein-coupled receptors (GPCRs).
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