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G protein-coupled receptor 61

GPR61, BALGR, G-protein-coupled receptor 61, biogenic amine receptor-like G protein-coupled receptor
This gene belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. The protein encoded by this gene is most closely related to biogenic amine receptors. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on GPR61
The N-terminal domain of GPR61, an orphan G-protein-coupled receptor, is essential for its constitutive activity.
Takeda et al., Japan. In J Neurosci Res, 2009
We conclude that the N-terminal domain of GPR61 is required for maintaining its constitutive activity and functions as a tethered intramolecular ligand.
A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors.
Poyner et al., Birmingham, United Kingdom. In Mol Pharmacol, 2005
Modeling rationalizes the effects of transmembrane proline mutants previously reported for another family of GPCR.
Cloning of a novel biogenic amine receptor-like G protein-coupled receptor expressed in human brain.
Koppel et al., KoŇ°ice, Slovakia. In Biochim Biophys Acta, 2001
maps to chromosome 1, is widely expressed, with expression highest in the brain areas associated with cognition, learning, and memory.
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