GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Aug 2016.
G protein-coupled receptor 55
GPR55
Members of the G protein-coupled receptor (GPR) family, such as GPR55, play important roles in signal transduction from the external environment to the inside of the cell (Sawzdargo et al., 1999 [PubMed 9931487]).[supplied by OMIM, Apr 2008] (from
NCBI)
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Top mentioned proteins:
CB1, V1a, CAN, ACID, TRPV1
Papers on
GPR55
Identification of Novel GPR55 Modulators Using Cell-Impedance-Based Label-Free Technology.
New
In J Med Chem, Feb 2016
UNASSIGNED: The orphan G protein-coupled receptor GPR55 has been proposed as a novel receptor of the endocannabinoid system.
The emerging role of the cannabinoid receptor family in peripheral and neuro-immune interactions.
New
Dublin, Ireland. In Curr Drug Targets, Feb 2016
However, putative, novel lipid-sensing CB receptors have recently been identified, including the orphan GPR55 and GPR18 receptors that are regulated by cannabinoid-like molecules and interact with CB system.
The endocannabinoid system in the human granulosa cell line KGN.
New
Halle, Germany. In Mol Cell Endocrinol, Feb 2016
CB1, CB2, DAGL, FAAH, GPR55, MAGL, NAPE-PLD and TRPV1 were expressed without FSH-dependent effects.
G protein-coupled receptors: signalling and regulation by lipid agonists for improved glucose homoeostasis.
New
Coleraine, United Kingdom. In Acta Diabetol, Feb 2016
In addition, GPR43 also couples to the Gαq subunit augmenting intracellular Ca(2+) and activating phospholipase C. GPR55 is specific for cannabinoid endogenous agonists (endocannabinoids) and non-cannabinoid fatty acids, which couples to Gα12/13 and Gαq proteins, leading to enhancing intracellular Ca(2+), extracellular signal-regulated kinase 1/2 (ERK) phosphorylation and Rho kinase.
Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists.
New
Kuopio, Finland. In Eur J Med Chem, Feb 2016
To date, many known G protein-coupled receptor 55 (GPR55) ligands are those identified among the cannabinoids.
GPR55 - a putative "type 3" cannabinoid receptor in inflammation.
New
In J Basic Clin Physiol Pharmacol, Jan 2016
UNASSIGNED: G protein-coupled receptor 55 (GPR55) shares numerous cannabinoid ligands with CB1 and CB2 receptors despite low homology with those classical cannabinoid receptors.
Lysophosphatidylinositol Signalling and Metabolic Diseases.
Review
New
Kuantan, Malaysia. In Metabolites, Dec 2015
In this review, we will focus on the physiological and pathophysiological roles of the lysophospholipid mediator lysophosphatidylinositol (LPI) and its receptor G-protein coupled receptor 55 (GPR55) in metabolic diseases.
Characterization of calcium signals provoked by lysophosphatidylinositol in human microvascular endothelial cells.
New
Cambridge, United Kingdom. In Physiol Res, Dec 2015
UNASSIGNED: The lipid molecule, lysophosphatidylinositol (LPI), is hypothesized to form part of a novel lipid signaling system that involves the G protein-coupled receptor GPR55 and distinct intracellular signaling cascades in endothelial cells.
Role of the lysophosphatidylinositol/GPR55 axis in cancer.
Review
New
Perth, Australia. In Adv Biol Regul, Nov 2015
It is well-established that the G protein-coupled receptor 55 (GPR55) is the specific receptor for LPI.
Role of GPR55 during Axon Growth and Target Innervation(1,2,3).
New
Montréal, Canada. In Eneuro, Sep 2015
In this study, we demonstrate that the G-protein-coupled receptor 55 (GPR55) is expressed in the retina during development, and regulates growth cone (GC) morphology and axon growth.
NEURONAL DEVELOPMENT. Glycerophospholipid regulation of modality-specific sensory axon guidance in the spinal cord.
New
Impact
Wako, Japan. In Science, Sep 2015
Library screening identified the G protein-coupled receptor GPR55 as a high-affinity receptor for LysoPtdGlc, and GPR55 deletion or LysoPtdGlc loss of function in vivo caused the misallocation of nociceptive axons into proprioceptive zones.
The role of cannabinoids in regulation of nausea and vomiting, and visceral pain.
Review
New
Philadelphia, United States. In Curr Gastroenterol Rep, Feb 2015
Several cannabinoid receptors, which include the cannabinoid receptor 1 (CB1), CB2, and possibly GPR55, have been identified throughout the GI tract.
The therapeutic potential of orphan GPCRs, GPR35 and GPR55.
Review
Greensboro, United States. In Front Pharmacol, 2014
Here, we focus on the therapeutic potential of two recently deorphanized GPCRs: GPR35/CXCR8 and GPR55.
Lysophosphatidylcholine and lysophosphatidylinosiol--novel promissing signaling molecules and their possible therapeutic activity.
Review
In Acta Pol Pharm, 2014
Their recently revealed activities as novel ligands of orphan G protein-coupled receptors (i.e., GPR55 and GPR119) involved in modulation of tumor physiology and insulin secretion seem to be one of the most interesting aspects of these compounds.
The GPCR-associated sorting protein 1 regulates ligand-induced down-regulation of GPR55.
GeneRIF
Graz, Austria. In Br J Pharmacol, 2012
GASP-1 is a key regulator of the trafficking and, by extension, functional expression of GPR55
The L-α-lysophosphatidylinositol/GPR55 system and its potential role in human obesity.
GeneRIF
Girona, Spain. In Diabetes, 2012
alpha-lysophosphatidylinositol(LPI)/GPR55 system is positively associated with obesity in humans.
A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans.
GeneRIF
Málaga, Spain. In J Endocrinol, 2011
Data show that activation of GPR55 in pancreatic islets with the agonist O-1602 increased glucose-stimulated insulin secretion (GSIS), but this effect was blunted in islets from Gpr55 KO mice.
New blood brothers: the GPR55 and CB2 partnership.
Review
GeneRIF
Dundee, United Kingdom. In Cell Res, 2011
New blood brothers: the GPR55 and CB2 partnership
A novel CB receptor GPR55 and its ligands are involved in regulation of gut movement in rodents.
GeneRIF
Shanghai, China. In Neurogastroenterol Motil, 2011
Data show that G protein-coupled receptor 55 exists throughout the intestines of rats, and that O-1602 or CBD selectively normalized motility disturbances due to inflammation.
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂.
Review
Impact
Aberdeen, United Kingdom. In Pharmacol Rev, 2010
This review summarizes current data indicating the extent to which cannabinoid receptor ligands undergo orthosteric or allosteric interactions with non-CB(1), non-CB(2) established GPCRs, deorphanized receptors such as GPR55, ligand-gated ion channels, transient receptor potential (TRP) channels, and other ion channels or peroxisome proliferator-activated nuclear receptors.
