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Free fatty acid receptor 2

GPR43, FFAR2
This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for short chain free fatty acids and may be involved in the inflammatory response and in regulating lipid plasma levels. [provided by RefSeq, Apr 2009] (from NCBI)
Top mentioned proteins: ACID, CAN, GPR40, V1a, Insulin
Papers on GPR43
G protein-coupled receptors: signalling and regulation by lipid agonists for improved glucose homoeostasis.
New
McKillop et al., Coleraine, United Kingdom. In Acta Diabetol, Feb 2016
GPR41 and GPR43 are stimulated by short-chain fatty acids (C2-C5), and activation results in binding to Gαi that inhibits the adenylyl cyclase pathway attenuating cAMP production.
New Insights into the High-Density Lipoprotein Dilemma.
Review
New
Gotto et al., Houston, United States. In Trends Endocrinol Metab, Jan 2016
We propose here that the cardioprotective effects of alcohol are mediated by the interaction of its terminal metabolite, acetate, with the adipocyte free fatty acid receptor 2 (FFAR2), which elicits a profound antilipolytic effect that may increase insulin sensitivity without necessarily raising plasma HDL-C concentration.
The Pharmacology and Function of Short Chain Fatty Acid Receptors.
Review
New
Moss et al., Glasgow, United Kingdom. In Mol Pharmacol, Jan 2016
These receptors, FFA2 (GPR43) and FFA3 (GPR41), are each predominantly activated by the short chain fatty acids acetate, propionate and butyrate, ligands that originate largely as fermentation by-products of anaerobic bacteria in the gut.
Beneficial metabolic effects of selected probiotics on diet-induced obesity and insulin resistance in mice are associated with improvement of dysbiotic gut microbiota.
New
Grangette et al., Lille, France. In Environ Microbiol, Jan 2016
At the gut level, the mixture modified the uptake of fatty acids and restored the expression level of the short chain fatty acid receptors GPR43.
Selective novel inverse agonists for human GPR43 augment GLP-1 secretion.
New
Kim et al., Ch'ŏngju, South Korea. In Eur J Pharmacol, Jan 2016
UNASSIGNED: GPR43/Free Fatty Acid Receptor 2 (FFAR2) is known to be activated by short-chain fatty acids and be coupled to Gi and Gq family of heterotrimeric G proteins.
Western diet induces a shift in microbiota composition enhancing susceptibility to Adherent-Invasive E. coli infection and intestinal inflammation.
New
Barnich et al., Clermont-Ferrand, France. In Sci Rep, Dec 2015
The expression of GPR43, a SCFA receptor was reduced in mice treated with a HF/HS diet and reduced in CD patients compared with controls.
Expression of metabolic sensing receptors in adipose tissues of periparturient dairy cows with differing extent of negative energy balance.
New
Mielenz et al., Bonn, Germany. In Animal, Dec 2015
The FFAR1 and FFAR2 mRNA abundance in RPAT was higher at day -21 compared to day 1.
GPR43 - A Prototypic Metabolite Sensor Linking Metabolic and Inflammatory Diseases.
Review
New
Macia et al., Australia. In Trends Endocrinol Metab, Oct 2015
G protein-coupled receptor 43 (GPR43), a key receptor for SCFAs, is expressed on cell types important for immunity and metabolism.
Intestinal nutrient sensing and blood glucose control.
Review
New
Daniel et al., Freising, Germany. In Curr Opin Clin Nutr Metab Care, Jul 2015
This still holds true for GPR40 and GPR120 as sensors for medium/long-chain fatty acids and GPR41 and GPR43 for microbiota-derived short-chain fatty acids.
Dietary gut microbial metabolites, short-chain fatty acids, and host metabolic regulation.
Review
New
Kimura et al., Fuchū, Japan. In Nutrients, Apr 2015
Short-chain fatty acids (SCFAs) such as acetate, butyrate, and propionate, which are produced by gut microbial fermentation of dietary fiber, are recognized as essential host energy sources and act as signal transduction molecules via G-protein coupled receptors (FFAR2, FFAR3, OLFR78, GPR109A) and as epigenetic regulators of gene expression by the inhibition of histone deacetylase (HDAC).
Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes.
New
Impact
Offermanns et al., Bad Nauheim, Germany. In Nat Med, Feb 2015
Here we demonstrate that the short-chain fatty acid receptors FFA2 (encoded by FFAR2) and FFA3 (encoded by FFAR3) are expressed in mouse and human pancreatic beta cells and mediate an inhibition of insulin secretion by coupling to Gi-type G proteins.
Free fatty acid receptors: structural models and elucidation of ligand binding interactions.
Poerio et al., Belfast, United Kingdom. In Bmc Struct Biol, 2014
BACKGROUND: The free fatty acid receptors (FFAs), including FFA1 (orphan name: GPR40), FFA2 (GPR43) and FFA3 (GPR41) are G protein-coupled receptors (GPCRs) involved in energy and metabolic homeostasis.
Diet, metabolites, and "western-lifestyle" inflammatory diseases.
Review
Impact
Mackay et al., Australia. In Immunity, 2014
Dietary-related metabolites engage "metabolite-sensing" G-protein-coupled receptors, such as GPR43, GPR41, GPR109A, GPR120, and GPR35.
Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis.
Impact
Marsland et al., Lausanne, Switzerland. In Nat Med, 2014
The effects of propionate on allergic inflammation were dependent on G protein-coupled receptor 41 (GPR41, also called free fatty acid receptor 3 or FFAR3), but not GPR43 (also called free fatty acid receptor 2 or FFAR2).
Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice.
GeneRIF
Delzenne et al., Brussels, Belgium. In J Nutr Biochem, 2011
Inulin-type fructans, paradoxically counteract GPR43 overexpression induced in the adipose tissue by an high fat diet.
Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3.
GeneRIF
Ulven et al., Bonn, Germany. In J Biol Chem, 2011
Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3.
Mutational analysis of G-protein coupled receptor--FFA2.
GeneRIF
Li et al., San Francisco, United States. In Biochem Biophys Res Commun, 2011
They report the results of mutagenesis studies on the receptor, and the identification of previous unknown residues that may affect receptor activation as well as residues important for allosteric interactions on FFA2.
SCFAs induce mouse neutrophil chemotaxis through the GPR43 receptor.
GeneRIF
Curi et al., São Paulo, Brazil. In Plos One, 2010
results identify GPR43 as a bona fide chemotactic receptor for neutrophils in vitro and start to define important elements in its signal transduction pathways
Diet-induced obesity up-regulates the abundance of GPR43 and GPR120 in a tissue specific manner.
GeneRIF
McAinch et al., Melbourne, Australia. In Cell Physiol Biochem, 2010
up-regulation of GPR43 and GPR120 in response to a high fat diet, is tissue specific
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43.
Impact
GeneRIF
Mackay et al., Australia. In Nature, 2009
GPR43 binding of short-chain fatty acids potentially provides a molecular link between diet, gastrointestinal bacterial metabolism, and immune and inflammatory responses
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