New Insights into the High-Density Lipoprotein Dilemma.
Houston, United States. In Trends Endocrinol Metab, Jan 2016
We propose here that the cardioprotective effects of alcohol are mediated by the interaction of its terminal metabolite, acetate, with the adipocyte free fatty acid receptor 2 (FFAR2), which elicits a profound antilipolytic effect that may increase insulin sensitivity without necessarily raising plasma HDL-C concentration.
The Pharmacology and Function of Short Chain Fatty Acid Receptors.
Glasgow, United Kingdom. In Mol Pharmacol, Jan 2016
These receptors, FFA2 (GPR43) and FFA3 (GPR41), are each predominantly activated by the short chain fatty acids acetate, propionate and butyrate, ligands that originate largely as fermentation by-products of anaerobic bacteria in the gut.
Intestinal nutrient sensing and blood glucose control.
Freising, Germany. In Curr Opin Clin Nutr Metab Care, Jul 2015
This still holds true for GPR40 and GPR120 as sensors for medium/long-chain fatty acids and GPR41 and GPR43 for microbiota-derived short-chain fatty acids.
Dietary gut microbial metabolites, short-chain fatty acids, and host metabolic regulation.
Fuchū, Japan. In Nutrients, Apr 2015
Short-chain fatty acids (SCFAs) such as acetate, butyrate, and propionate, which are produced by gut microbial fermentation of dietary fiber, are recognized as essential host energy sources and act as signal transduction molecules via G-protein coupled receptors (FFAR2, FFAR3, OLFR78, GPR109A) and as epigenetic regulators of gene expression by the inhibition of histone deacetylase (HDAC).
Mutational analysis of G-protein coupled receptor--FFA2.
San Francisco, United States. In Biochem Biophys Res Commun, 2011
They report the results of mutagenesis studies on the receptor, and the identification of previous unknown residues that may affect receptor activation as well as residues important for allosteric interactions on FFA2.