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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Free fatty acid receptor 1

GPR40, FFAR1, free fatty acid receptor 1, free fatty acid receptor
This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. [provided by RefSeq, Apr 2009] (from NCBI)
Top mentioned proteins: ACID, Insulin, GPR120, V1a, Glucagon
Papers on GPR40
G protein-coupled receptors: signalling and regulation by lipid agonists for improved glucose homoeostasis.
New
McKillop et al., Coleraine, United Kingdom. In Acta Diabetol, Feb 2016
GPR40 and GPR120 are activated by long-chain fatty acids (>C12) with both receptors coupling to the Gαq subunit that activates the Ca(2+)-dependent pathway.
GPR40, a free fatty acid receptor, differentially impacts osteoblast behavior depending on differentiation stage and environment.
New
Wittrant et al., Clermont-Ferrand, France. In Mol Cell Biochem, Jan 2016
GPR40 is a free fatty acid receptor that has been recently shown to impact bone remodeling.
New Insights into the High-Density Lipoprotein Dilemma.
Review
New
Gotto et al., Houston, United States. In Trends Endocrinol Metab, Jan 2016
We propose here that the cardioprotective effects of alcohol are mediated by the interaction of its terminal metabolite, acetate, with the adipocyte free fatty acid receptor 2 (FFAR2), which elicits a profound antilipolytic effect that may increase insulin sensitivity without necessarily raising plasma HDL-C concentration.
Design, synthesis, and biological evaluation of novel thiazolidinediones as PPARγ/FFAR1 dual agonists.
New
Helal et al., Ismailia, Egypt. In Eur J Med Chem, Jan 2016
Another emerging target for the design of antidiabetic agents is the free fatty acid receptor 1 (FFAR1), previously known as GPR40.
Alpha-cell dysfunctions and molecular alterations in male insulinopenic diabetic mice are not completely corrected by insulin.
New
Gosmain et al., Genève, Switzerland. In Endocrinology, Jan 2016
Pten, insulin receptor, NeuroD1, GPR40 and Sumo1 genes, which were abnormally regulated in diabetic mice.
L-Rhamnose as a source of colonic propionate inhibits insulin secretion but does not influence measures of appetite or food intake.
New
Robertson et al., Guildford, United Kingdom. In Appetite, Jan 2016
UNASSIGNED: Activation of free fatty acid receptor (FFAR)2 and FFAR3 via colonic short-chain fatty acids, particularly propionate, are postulated to explain observed inverse associations between dietary fiber intake and body weight.
Dietary Lipids Inform the Gut and Brain about Meal Arrival via CD36-Mediated Signal Transduction.
Review
New
Abumrad et al., Saint Louis, United States. In J Nutr, Oct 2015
Components of dietary fat that are recognized by these receptors are the long-chain fatty acids that act as ligands for 2 G protein-coupled receptors, GPR40 and GPR120, and the fatty acid (FA) translocase/CD36.
Intestinal nutrient sensing and blood glucose control.
Review
New
Daniel et al., Freising, Germany. In Curr Opin Clin Nutr Metab Care, Jul 2015
This still holds true for GPR40 and GPR120 as sensors for medium/long-chain fatty acids and GPR41 and GPR43 for microbiota-derived short-chain fatty acids.
The role of polyunsaturated fatty acids and GPR40 receptor in brain.
Review
New
He et al., Nanjing, China. In Neuropharmacology, Jun 2015
G-protein-coupled receptor 40 (GPR40), also called free fatty acid receptor 1 (FFA1), is ubiquitously expressed in various regions of the human brain including the olfactory bulb, midbrain, medulla oblongata, hippocampus, hypothalamus, cerebral cortex, cerebellum and in the spinal cord.
Dietary Fatty Acids and Their Potential for Controlling Metabolic Diseases Through Activation of FFA4/GPR120.
Review
Christiansen et al., Odense, Denmark. In Annu Rev Nutr, 2014
The free fatty acid receptor 4 (FFA4, previously GPR120) is linked to the regulation of body weight, inflammation, and insulin resistance and represents a potential target for the treatment of metabolic disorders, including type 2 diabetes and obesity.
High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875.
Impact
Okada et al., San Diego, United States. In Nature, 2014
Human GPR40 receptor (hGPR40), also known as free fatty-acid receptor 1 (FFAR1), is a G-protein-coupled receptor that binds long-chain free fatty acids to enhance glucose-dependent insulin secretion.
A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice.
Impact
Olefsky et al., San Diego, United States. In Nat Med, 2014
Gpr40 is another lipid-sensing G protein-coupled receptor, and it has been difficult to identify compounds with a high degree of selectivity for Gpr120 over Gpr40 (ref.
Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis.
Impact
Marsland et al., Lausanne, Switzerland. In Nat Med, 2014
The effects of propionate on allergic inflammation were dependent on G protein-coupled receptor 41 (GPR41, also called free fatty acid receptor 3 or FFAR3), but not GPR43 (also called free fatty acid receptor 2 or FFAR2).
Pax6 is a key component of regulated glucagon secretion.
GeneRIF
Philippe et al., Genève, Switzerland. In Endocrinology, 2012
Results indicate that Pax6 acts on the regulation of glucagon secretion at least through the transcriptional control of GCK, GPR40, and GIPR.
Thiazolidinediones induce osteocyte apoptosis by a G protein-coupled receptor 40-dependent mechanism.
GeneRIF
Mabilleau et al., Oxford, United Kingdom. In J Biol Chem, 2012
Data indicate that thiazolidinediones (TZDs) rapidly activated Erk1/2 and p38 through G protein-coupled receptor 40 (GPR40), a receptor expressed on the surface of osteocytes.
GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins.
GeneRIF
Walker et al., Israel. In J Biol Chem, 2012
GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins
TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial.
Impact
Leifke et al., Ann Arbor, United States. In Lancet, 2012
BACKGROUND: Activation of free fatty acid receptor 1 (FFAR1; also known as G-protein-coupled receptor 40) by fatty acids stimulated glucose-dependent β-cell insulin secretion in preclinical models.
The effects of TAK-875, a selective G protein-coupled receptor 40/free fatty acid 1 agonist, on insulin and glucagon secretion in isolated rat and human islets.
GeneRIF
Rorsman et al., Ōsaka, Japan. In J Pharmacol Exp Ther, 2012
GPR40/FFA1 influences both insulin and glucagon secretion in rat islets, but only insulin secretion in human islets.
Involvement of the long-chain fatty acid receptor GPR40 as a novel pain regulatory system.
GeneRIF
Tokuyama et al., Kōbe, Japan. In Brain Res, 2012
Antinociception via beta-endorphin release is mediated through GPR40 signaling in the supraspinal area and provides valuable information on a novel therapeutic approach for pain control.
The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse.
Impact
GeneRIF
Edlund et al., Umeå, Sweden. In Cell Metab, 2005
GPR40 plays an important role in the chain of events linking obesity and type 2 diabetes.
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