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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

G protein-coupled receptor 39

GPR39, G protein-coupled receptor 39
Top mentioned proteins: ghrelin, ACID, V1a, Insulin, CAN
Papers using GPR39 antibodies
Correlations between RNA and protein expression profiles in 23 human cell lines
Schwartz Thue W. et al., In International Journal of Endocrinology, 2008
... To verify doxycycline- (DOX-) induced GPR39 expression, 3 tetGPR39/RIP-rtTA transgenic mice and 6 WT littermates ...
Papers on GPR39
β-Arrestin scaffolds and signaling elements essential for the obestatin/GPR39 system that determine the myogenic program in human myoblast cells.
Camiña et al., Santiago de Compostela, Spain. In Cell Mol Life Sci, Feb 2016
Obestatin/GPR39 signaling stimulates skeletal muscle repair by inducing the expansion of satellite stem cells as well as myofiber hypertrophy.
The role of the obestatin/GPR39 system in human gastric adenocarcinomas.
Pazos et al., Santiago de Compostela, Spain. In Oncotarget, Jan 2016
UNASSIGNED: Obestatin, a 23-amino acid peptide encoded by the ghrelin gene, and the GPR39 receptor were reported to be involved in the control of mitogenesis of gastric cancer cell lines; however, the relationship between the obestatin/GPR39 system and gastric cancer progression remains unknown.
The zinc binding receptor GPR39 interacts with 5-HT1A and GalR1 to form dynamic heteroreceptor complexes with signaling diversity.
Garriga et al., Terrassa, Spain. In Biochim Biophys Acta, Dec 2015
GPR39 is a class A G protein-coupled receptor involved in zinc binding and glucose homeostasis regulation, among other physiological processes.
Up-regulation of the GPR39 Zn2+-sensing receptor and CREB/BDNF/TrkB pathway after chronic but not acute antidepressant treatment in the frontal cortex of zinc-deficient mice.
Nowak et al., Kraków, Poland. In Pharmacol Rep, Dec 2015
BACKGROUND: The GPR39-Zn(2+)-sensing receptor seems to be involved in the pathophysiology of depression.
Regulation of neuronal pH by the metabotropic Zn(2+) -sensing Gq-coupled receptor, mZnR/GPR39.
Hershfinkel et al., Beersheba, Israel. In J Neurochem, Dec 2015
Synaptically released Zn(2+) acts as a neurotransmitter, in part, by activating the postsynaptic metabotropic Zn(2+) -sensing Gq protein-coupled receptor (mZnR/GPR39).
GPR39 activates proliferation and differentiation of porcine intramuscular preadipocytes through targeting the PI3K/AKT cell signaling pathway.
Chen et al., Shaoguan, China. In J Recept Signal Transduct Res, Dec 2015
In this study, the effects and mechanisms of GPR39 on cell proliferation and differentiation were investigated in cultured porcine intramuscular preadipocytes.
Zinc, future mono/adjunctive therapy for depression: Mechanisms of antidepressant action.
Nowak, Kraków, Poland. In Pharmacol Rep, Jun 2015
The mechanisms involving NMDA and AMPA glutamate, 5-HT1A serotonin and the GPR39 zinc-sensing receptor and intracellular pathways will be discussed.
GPR39 Zn(2+)-sensing receptor: a new target in antidepressant development?
Nowak et al., Kraków, Poland. In J Affect Disord, Apr 2015
Recent reports indicate that the GPR39 Zn(2+)-sensing receptor is an important target for zinc "transmission" (its activation modulates/induces diverse biochemical pathways involved in neuroprotection).
Novel Zn2+ Modulated GPR39 Receptor Agonists Do Not Drive Acute Insulin Secretion in Rodents.
Turnbull et al., Mölndal, Sweden. In Plos One, 2014
The GPR39 receptor is expressed in metabolic tissues including pancreatic β-cells and has been proposed as a T2D target.
Constitutive Activity among Orphan Class-A G Protein Coupled Receptors.
Aronstam et al., Rolla, United States. In Plos One, 2014
Five patterns of activity were noted: 1) inhibition under both baseline and forskolin stimulated expression (GPR15, GPR17, GPR18, GPR20, GPR25, GPR27, GPR31, GPR32, GPR45, GPR57, GPR68, GPR83, GPR84, GPR132, GPR150, GPR176); 2) no effect on baseline expression, but inhibition of forskolin stimulated expression (GPR4, GPR26, GPR61, GPR62, GPR78, GPR101, GPR119); 3) elevation of baseline signaling coupled with inhibition of forskolin stimulated expression (GPR6, GPR12); 4) elevation of baseline signaling without inhibition of forskolin stimulated expression (GPR3, GPR21, GPR52, GPR65); and 5) no effect on expression (GPR1, GPR19, GPR22, GPR34, GPR35, GPR39, GPR63, GPR82, GPR85, GPR87).
Obestatin and cardiovascular health.
Li et al., Tai'an, China. In Peptides, 2014
Obestatin, encoded by the same gene as ghrelin, was first described as a physiological opponent of ghrelin through an interaction with the orphan receptor GPR39.
Obestatin: is it really doing something?
Granata et al., Torino, Italy. In Front Horm Res, 2013
Initially, obestatin was reported to activate the G-protein-coupled receptor GPR39 and to reduce food intake and gastric emptying.
Obestatin: a new metabolic player in the pancreas and white adipose tissue.
Granata et al., Torino, Italy. In Iubmb Life, 2013
Initially, obestatin was reported to exert opposite effects to those of ghrelin on food intake and body weight gain, through interaction with GPR39; however, these findings are still strongly debated and obestatin biological role remains largely unknown.
SNARE-dependent upregulation of potassium chloride co-transporter 2 activity after metabotropic zinc receptor activation in rat cortical neurons in vitro.
Aizenman et al., Pittsburgh, United States. In Neuroscience, 2012
These results suggest that SNARE proteins are necessary for the increased activity of KCC2 after Zn(2+) stimulation of mZnR/GPR39.
Zinc sensing receptor signaling, mediated by GPR39, reduces butyrate-induced cell death in HT29 colonocytes via upregulation of clusterin.
Hershfinkel et al., Beersheba, Israel. In Plos One, 2011
GPR39 activation increased the expression of the anti-apoptotic protein clusterin in butyrate-treated cells. GPR39 mediates Zn2+-dependent cell growth.
Deficiency of the GPR39 receptor is associated with obesity and altered adipocyte metabolism.
Holst et al., Copenhagen, Denmark. In Faseb J, 2011
GPR39 deficiency is associated with increased fat accumulation on a high-fat diet, conceivably due to decreased energy expenditure and adipocyte lipolytic activity.
GPR39, a receptor of the ghrelin receptor family, plays a role in the regulation of glucose homeostasis in a mouse model of early onset diet-induced obesity.
Depoortere et al., Leuven, Belgium. In J Neuroendocrinol, 2011
GPR39 plays a role in the pathogenesis of obesity-related type 2 diabetes by affecting the regulation of glucose homeostasis.
Overexpression of GPR39 contributes to malignant development of human esophageal squamous cell carcinoma.
Guan et al., Guangzhou, China. In Bmc Cancer, 2010
GPR39 plays an important tumorigenic role in the development and progression of esophageal squamous cell carcinoma.
Comment on "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake".
Llorens-Cortes et al., Mont-Saint-Aignan, France. In Science, 2007
Zhang et al. (Research Articles, 11 November 2005, p. 996) reported that obestatin, a peptide derived from the ghrelin precursor, activated the orphan G protein-coupled receptor GPR39.
Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake.
Hsueh et al., Stanford, United States. In Science, 2005
Obestatin bound to the orphan G protein-coupled receptor GPR39.
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