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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

G protein-coupled receptor 35

GPR35, G-protein-coupled receptor 35
Top mentioned proteins: ACID, IRBP, CAN, GPR55, fibrillin-1
Papers on GPR35
The emerging pharmacology and function of GPR35 in the nervous system.
Milligan et al., Glasgow, United Kingdom. In Neuropharmacology, Aug 2015
UNASSIGNED: G protein-coupled receptor 35 (GPR35) is an orphan G protein-coupled receptor (GPCR) that can be activated by kynurenic acid at high micromolar concentrations.
Functional G-protein-coupled receptor 35 is expressed by neurons in the CA1 field of the hippocampus.
Albuquerque et al., Baltimore, United States. In Biochem Pharmacol, Mar 2015
The G-protein-coupled receptor 35 (GPR35) was de-orphanized after the discovery that kynurenic acid (KYNA), an endogenous tryptophan metabolite, acts as an agonist of this receptor.
Presence and content of kynurenic acid in animal feed.
Paluszkiewicz et al., Lublin, Poland. In J Anim Physiol Anim Nutr (berl), Feb 2015
Furthermore, it was documented that KYNA is an agonist of G-protein coupled GPR35 receptors which are mainly present in the gastrointestinal tract.
Cutting edge: GPR35/CXCR8 is the receptor of the mucosal chemokine CXCL17.
Zlotnik et al., Amsterdam, Netherlands. In J Immunol, 2015
In this article, we show that GPR35 is the receptor of CXCL17.
Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans.
Song et al., Seoul, South Korea. In Inflamm Bowel Dis, 2015
RESULTS: We confirmed 6 previously reported loci in Caucasian: GPR35 at 2q37 (rs3749172; P = 5.30 × 10, odds ratio [OR] = 1.45),
Constitutive Activity among Orphan Class-A G Protein Coupled Receptors.
Aronstam et al., Rolla, United States. In Plos One, 2014
Five patterns of activity were noted: 1) inhibition under both baseline and forskolin stimulated expression (GPR15, GPR17, GPR18, GPR20, GPR25, GPR27, GPR31, GPR32, GPR45, GPR57, GPR68, GPR83, GPR84, GPR132, GPR150, GPR176); 2) no effect on baseline expression, but inhibition of forskolin stimulated expression (GPR4, GPR26, GPR61, GPR62, GPR78, GPR101, GPR119); 3) elevation of baseline signaling coupled with inhibition of forskolin stimulated expression (GPR6, GPR12); 4) elevation of baseline signaling without inhibition of forskolin stimulated expression (GPR3, GPR21, GPR52, GPR65); and 5) no effect on expression (GPR1, GPR19, GPR22, GPR34, GPR35, GPR39, GPR63, GPR82, GPR85, GPR87).
GeneChip expression profiling reveals the alterations of energy metabolism related genes in osteocytes under large gradient high magnetic fields.
Qian et al., Xi'an, China. In Plos One, 2014
12 energy metabolism related genes (PFKL, AK4, ALDOC, COX7A1, STC1, ADM, CA9, CA12, P4HA1, APLN, GPR35 and GPR84) were further confirmed by real-time PCR.
The therapeutic potential of orphan GPCRs, GPR35 and GPR55.
Reggio et al., Greensboro, United States. In Front Pharmacol, 2014
Here, we focus on the therapeutic potential of two recently deorphanized GPCRs: GPR35/CXCR8 and GPR55.
G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease.
Milligan et al., Glasgow, United Kingdom. In Front Pharmacol, 2014
G protein-coupled receptor 35 (GPR35) is an orphan receptor, discovered in 1998, that has garnered interest as a potential therapeutic target through its association with a range of diseases.
On the toxicity of kynurenic acid in vivo and in vitro.
Siwicki et al., Lublin, Poland. In Pharmacol Rep, 2014
Moreover, it is an agonist of G-protein receptor GPR35.
Diet, metabolites, and "western-lifestyle" inflammatory diseases.
Mackay et al., Australia. In Immunity, 2014
Dietary-related metabolites engage "metabolite-sensing" G-protein-coupled receptors, such as GPR43, GPR41, GPR109A, GPR120, and GPR35.
Effect of oral administration of kynurenic acid on the activity of the peripheral blood leukocytes in mice.
Turski et al., Olsztyn, Poland. In Cent Eur J Immunol, 2013
Kynurenic acid (KYNA), an endogenous tryptophan metabolite, is a selective ligand of the GPR35 receptor, expressed mainly on the immune cells.
G protein-coupled receptor mutations and human genetic disease.
Cole et al., Toronto, Canada. In Methods Mol Biol, 2013
De-orphanization projects have identified novel disease-associated receptors, such as NPSR1 and GPR35.
The in vitro effect of kynurenic acid on the rainbow trout (Oncorhynchus mykiss) leukocyte and splenocyte activity.
Kaczorek et al., In Pol J Vet Sci, 2013
Kynurenic acid (KYNA), an endogenous neuroprotectant formed along the kynurenine pathway of tryptophan degradation, is a selective ligand of the GPR35 receptor, which can be found on the surface of various populations of human immune cells.
Synthesis and Agonistic Activity at the GPR35 of 5,6-Dihydroxyindole-2-carboxylic Acid Analogues.
Fang et al., New York City, United States. In Acs Med Chem Lett, 2012
5,6-Dihydroxyindole-2-carboxylic acid (DHICA), an intermediate of melanin synthesis and an eumelanin building block, was recently discovered to be a GPR35 agonist with moderate potency.
Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13.
Milligan et al., Glasgow, United Kingdom. In Biochem J, 2011
screening assays used to identification of small MW agonists; some compounds are species-specific agonists; agonists/ligands include zaprinast, cromolyn & dicumarol
Expression of functional GPR35 in human iNKT cells.
Lombardi et al., Novara, Italy. In Biochem Biophys Res Commun, 2010
human iNKT cells express GPR35 functionally active in reducing IL-4 release.
GPR35 is a novel lysophosphatidic acid receptor.
Sugiura et al., Sagamihara, Japan. In Biochem Biophys Res Commun, 2010
These results strongly suggest that 2-acyl lysophosphatidic acid is an endogenous ligand for GPR35.
GPR35 is a functional receptor in rat dorsal root ganglion neurons.
Ichikawa et al., Taketoyo, Japan. In Biochem Biophys Res Commun, 2008
We propose that GPR35 modulates nociception and that continued study of this receptor will provide additional insight into the role of kynurenic acid in pain perception.
Inhibition of N-type calcium channels by activation of GPR35, an orphan receptor, heterologously expressed in rat sympathetic neurons.
Ikeda et al., Bethesda, United States. In J Pharmacol Exp Ther, 2008
The results of the study demonstrate the coupling of GPR35 to endogenous G proteins that modulate neuronal Ca2+ channel and thereby provide evidence for a potential role of GPR35 in regulating neuronal excitability and synaptic transmission
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