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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

G protein-coupled receptor 34

G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM, Apr 2006] (from NCBI)
Top mentioned proteins: GPCR, ACID, P2Y, POLYMERASE, MAST
Papers on GPR34
Structure-activity relationships of lysophosphatidylserine analogs as agonists of G-protein-coupled receptors GPR34, P2Y10, and GPR174.
Ohwada et al., Tokyo, Japan. In J Med Chem, Jun 2015
Recent ligand screening of orphan G-protein-coupled receptors (GPCRs) identified two LysoPS-specific human GPCRs, namely, P2Y10 (LPS2) and GPR174 (LPS3), which, together with previously reported GPR34 (LPS1), comprise a LysoPS receptor family.
Lysophosphatidylserine analogues differentially activate three LysoPS receptors.
Aoki et al., Sendai, Japan. In J Biochem, Mar 2015
Recently, three G protein-coupled receptors (LPS1/GPR34, LPS2/P2Y10 and LPS3/GPR174) were found to react specifically with LysoPS, raising the possibility that LysoPS serves as a lipid mediator that exerts its role through these receptors.
G-protein coupled receptor 34 knockdown impairs the proliferation and migration of HGC-27 gastric cancer cells in vitro.
Yu et al., Beijing, China. In Chin Med J (engl), Mar 2015
BACKGROUND: Overexpression of G-protein coupled receptor 34 (GPR34) affects the progression and prognosis of human gastric adenocarcinoma, however, the role of GPR34 in gastric cancer development and progression has not been well-determined.
Altered microglial phagocytosis in GPR34-deficient mice.
Schulz et al., Leipzig, Germany. In Glia, Feb 2015
GPR34 is a Gi/o protein-coupled receptor (GPCR) of the nucleotide receptor P2Y12 -like group.
Constitutive Activity among Orphan Class-A G Protein Coupled Receptors.
Aronstam et al., Rolla, United States. In Plos One, 2014
Five patterns of activity were noted: 1) inhibition under both baseline and forskolin stimulated expression (GPR15, GPR17, GPR18, GPR20, GPR25, GPR27, GPR31, GPR32, GPR45, GPR57, GPR68, GPR83, GPR84, GPR132, GPR150, GPR176); 2) no effect on baseline expression, but inhibition of forskolin stimulated expression (GPR4, GPR26, GPR61, GPR62, GPR78, GPR101, GPR119); 3) elevation of baseline signaling coupled with inhibition of forskolin stimulated expression (GPR6, GPR12); 4) elevation of baseline signaling without inhibition of forskolin stimulated expression (GPR3, GPR21, GPR52, GPR65); and 5) no effect on expression (GPR1, GPR19, GPR22, GPR34, GPR35, GPR39, GPR63, GPR82, GPR85, GPR87).
Lysophosphatidylserine stimulates chemotactic migration of colorectal cancer cells through GPR34 and PI3K/Akt pathway.
Watanabe et al., Tokyo, Japan. In Anticancer Res, 2014
RESULTS: Among the three lysoPS receptors, GPR34 was highly expressed on all cell lines.
Novel lysophosphoplipid receptors: their structure and function.
Aoki et al., Saitama, Japan. In J Lipid Res, 2014
Recently, a GPCR was found for LPI (GPR55) and three GPCRs (GPR34/LPS1, P2Y10/LPS2, and GPR174/LPS3) were found for LysoPS.
Upregulation of GPR34 expression affects the progression and prognosis of human gastric adenocarcinoma by PI3K/PDK1/AKT pathway.
Wang et al., Beijing, China. In Histol Histopathol, 2013
PURPOSE: G-protein coupled receptor 34 (GPR34), which belongs to the G-protein coupled receptors superfamily, is reportedly expressed highly in the spread of several solid tumors.
GPR34 as a lysophosphatidylserine receptor.
Aoki et al., Sendai, Japan. In J Biochem, 2013
GPR34, a P2Y receptor family member, was identified as a candidate lysophosphatidylserine (LysoPS) receptor in 2006.
t(X;14)(p11;q32) in MALT lymphoma involving GPR34 reveals a role for GPR34 in tumor cell growth.
Novak et al., Rochester, United States. In Blood, 2012
that deregulates expression of an poorly characterized orphan G-protein-coupled receptor, GPR34.
LGR4 and LGR6 are differentially expressed and of putative tumor biological significance in gastric carcinoma.
Röcken et al., Kiel, Germany. In Virchows Arch, 2012
We investigated the differential expression and putative tumor biological significance of five G-protein-coupled receptors (GPCRs) in GC, i.e., LGR4, LGR6, GPR34, GPR160, and GPR171.
The ligand specificity of the G-protein-coupled receptor GPR34.
Schöneberg et al., Leipzig, Germany. In Biochem J, 2012
Lyso-PS (lyso-phosphatidylserine) has been shown to activate the G(i/o)-protein-coupled receptor GPR34.
GPR34 is a receptor for lysophosphatidylserine with a fatty acid at the sn-2 position.
Aoki et al., Sendai, Japan. In J Biochem, 2012
GPR34 is a G protein-coupled receptor belonging to the P2Y family.
t(X;14)(p11.4;q32.33) is recurrent in marginal zone lymphoma and up-regulates GPR34.
Wlodarska et al., Leuven, Belgium. In Haematologica, 2012
Fluorescence in situ hybridization and molecular studies showed that t(X;14), which is mediated by immunoglobulin heavy chain locus, targets the GPR34 gene at Xp11.4.
Mining human genome for novel purinergic P2Y receptors: a sequence analysis and molecular modeling approach.
Pathak et al., New Delhi, India. In J Recept Signal Transduct Res, 2011
We applied this knowledge to human genome GPCR sequences found by sensitive sequence search techniques and identified two orphan receptors, namely GPR34 and GP171 that have all the necessary conserved features of P2Y receptors.
Genomic and supragenomic structure of the nucleotide-like G-protein-coupled receptor GPR34.
Schulz et al., Leipzig, Germany. In Genomics, 2006
data show that multiple translation initiation starts and alternative splicing contribute to the supragenomic diversification of GPR34
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