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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

G protein-coupled receptor 21

GPR21
Top mentioned proteins: GPCR, GPR52, GPR3, GPR20, GPR22
Papers on GPR21
Constitutive Activity among Orphan Class-A G Protein Coupled Receptors.
Aronstam et al., Rolla, United States. In Plos One, 2014
Five patterns of activity were noted: 1) inhibition under both baseline and forskolin stimulated expression (GPR15, GPR17, GPR18, GPR20, GPR25, GPR27, GPR31, GPR32, GPR45, GPR57, GPR68, GPR83, GPR84, GPR132, GPR150, GPR176); 2) no effect on baseline expression, but inhibition of forskolin stimulated expression (GPR4, GPR26, GPR61, GPR62, GPR78, GPR101, GPR119); 3) elevation of baseline signaling coupled with inhibition of forskolin stimulated expression (GPR6, GPR12); 4) elevation of baseline signaling without inhibition of forskolin stimulated expression (GPR3, GPR21, GPR52, GPR65); and 5) no effect on expression (GPR1, GPR19, GPR22, GPR34, GPR35, GPR39, GPR63, GPR82, GPR85, GPR87).
Sequence-structure based phylogeny of GPCR Class A Rhodopsin receptors.
Jamil et al., India. In Mol Phylogenet Evol, 2014
Our study was able to identify potential ligand association for Class A Orphans and putative/unclassified Class A receptors with no cognate ligand information: GPR21 and GPR52 with fatty acids; GPR75 with Neuropeptide Y; GPR82, GPR18, GPR141 with N-arachidonylglycine; GPR176 with Free fatty acids, GPR10 with Tachykinin & Neuropeptide Y; GPR85 with ATP, ADP & UDP glucose; GPR151 with Galanin; GPR153 and GPR162 with Adrenalin, Noradrenalin; GPR146, GPR139, GPR142 with Neuromedin, Ghrelin, Neuromedin U-25 & Thyrotropin-releasing hormone; GPR171 with ATP, ADP & UDP Glucose; GPR88, GPR135, GPR161, GPR101with 11-cis-retinal; GPR83 with Tackykinin; GPR148 with Prostanoids, GPR109b, GPR81, GPR31with ATP & UTP and GPR150 with GnRH I & GnRHII.
G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice.
GeneRIF
Olefsky et al., Los Angeles, United States. In J Clin Invest, 2012
GPR21 has a critical function in coordinating macrophage proinflammatory activity in the context of obesity-induced insulin resistance
G-protein-coupled receptor GPR21 knockout mice display improved glucose tolerance and increased insulin response.
GeneRIF
Baribault et al., San Francisco, United States. In Biochem Biophys Res Commun, 2012
these findings suggest that GPR21 may play an important role in regulating body weight and glucose metabolism.
Identification of signal transduction pathways used by orphan g protein-coupled receptors.
McAllister et al., Harlow, United Kingdom. In Assay Drug Dev Technol, 2003
The likely signaling pathways of the GPR3, GPR12, GPR19, GPR21, and HG55 oGPCRs are shown, and a high throughput assay for GPR26 receptors developed.
Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain.
O'Dowd et al., Toronto, Canada. In Brain Res Mol Brain Res, 1999
GPR52 gene localized to chromosome 1q24 shares the highest identity with GPR21 (71%), histamine H2 (27%) and 5-HT4 (26%) human receptors.
Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes.
George et al., Toronto, Canada. In Gene, 1997
This resulted in the isolation of genes GPR21, GPR22 and GPR23.
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