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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

G protein-coupled receptor 18

GPR18
Top mentioned proteins: CB1, GPR55, V1a, GPCR, ACID
Papers on GPR18
The emerging role of the cannabinoid receptor family in peripheral and neuro-immune interactions.
New
Campbell et al., Dublin, Ireland. In Curr Drug Targets, Feb 2016
However, putative, novel lipid-sensing CB receptors have recently been identified, including the orphan GPR55 and GPR18 receptors that are regulated by cannabinoid-like molecules and interact with CB system.
G protein coupled receptor 18: A potential role for endocannabinoid signaling in metabolic dysfunction.
Review
New
McAinch et al., Melbourne, Australia. In Mol Nutr Food Res, Jan 2016
Interestingly, the newly deorphanized GPCR (GPR18), which is considered to be a putative cannabinoid receptor, is proposed to have an immunological function.
GPR18 Inhibiting Amauromine and the Novel Triterpene Glycoside Auxarthonoside from the Sponge-Derived Fungus Auxarthron reticulatum.
New
König et al., Bonn, Germany. In Planta Med, Aug 2015
Amauromine (1), which inhibited cannabinoid CB1 receptors (Ki 0.178 µM) also showed antagonistic activity at the cannabinoid-like orphan receptor GPR18 (IC50 3.74 µM).
Identification of resolvin D2 receptor mediating resolution of infections and organ protection.
New
Serhan et al., Boston, United States. In J Exp Med, Aug 2015
Here, using an unbiased G protein-coupled receptor-β-arrestin-based screening and functional sensing systems, we identified a receptor for RvD2, namely GPR18, that is expressed on human leukocytes, including polymorphonuclear neutrophils (PMN), monocytes, and macrophages (MΦ).
Constitutive Activity among Orphan Class-A G Protein Coupled Receptors.
Aronstam et al., Rolla, United States. In Plos One, 2014
Five patterns of activity were noted: 1) inhibition under both baseline and forskolin stimulated expression (GPR15, GPR17, GPR18, GPR20, GPR25, GPR27, GPR31, GPR32, GPR45, GPR57, GPR68, GPR83, GPR84, GPR132, GPR150, GPR176); 2) no effect on baseline expression, but inhibition of forskolin stimulated expression (GPR4, GPR26, GPR61, GPR62, GPR78, GPR101, GPR119); 3) elevation of baseline signaling coupled with inhibition of forskolin stimulated expression (GPR6, GPR12); 4) elevation of baseline signaling without inhibition of forskolin stimulated expression (GPR3, GPR21, GPR52, GPR65); and 5) no effect on expression (GPR1, GPR19, GPR22, GPR34, GPR35, GPR39, GPR63, GPR82, GPR85, GPR87).
Novel Markers to Delineate Murine M1 and M2 Macrophages.
Guerau-de-Arellano et al., Columbus, United States. In Plos One, 2014
We validated by real-time PCR an M1-exclusive pattern of expression for CD38, G-protein coupled receptor 18 (Gpr18) and Formyl peptide receptor 2 (Fpr2) whereas Early growth response protein 2 (Egr2) and c-Myc were M2-exclusive.
GPR18 Controls Reconstitution of Mouse Small Intestine Intraepithelial Lymphocytes following Bone Marrow Transplantation.
Bhattacharya et al., Saint Louis, United States. In Plos One, 2014
Here, we demonstrate that GPR18 regulates the reconstitution of intraepithelial lymphocytes (IELs) of the small intestine following bone marrow transplantation.
Anandamide, Acting via CB2 Receptors, Alleviates LPS-Induced Neuroinflammation in Rat Primary Microglial Cultures.
Starowicz et al., Kraków, Poland. In Neural Plast, 2014
Anandamide as an immune modulator in the central nervous system acts via not only cannabinoid receptors (CB1 and CB2) but also other targets (e.g., GPR18/GPR55).
Primary Macrophage Chemotaxis Induced by Cannabinoid Receptor 2 Agonists Occurs Independently of the CB2 Receptor.
Greaves et al., Oxford, United Kingdom. In Sci Rep, 2014
The obvious candidate receptors GPR18 and GPR55 could not mediate JWH133 or HU308-induced cytoskeletal rearrangement or JWH133-induced β-arrestin recruitment in cells transfected with either receptor, demonstrating that neither are the unidentified GPCR.
GPR18 is required for a normal CD8αα intestinal intraepithelial lymphocyte compartment.
Cyster et al., San Francisco, United States. In J Exp Med, 2014
Here we demonstrate that G protein-coupled receptor 18 (GPR18) is abundantly expressed in CD8αα IELs and that mice lacking this orphan receptor have reduced numbers of γδT IELs.
Neuronal nitric oxide synthase-dependent elevation in adiponectin in the rostral ventrolateral medulla underlies g protein-coupled receptor 18-mediated hypotension in conscious rats.
Abdel-Rahman et al., Greenville, United States. In J Pharmacol Exp Ther, 2014
Direct activation of the endocannabinoid receptor G protein-coupled receptor 18 (GPR18) in the rostral ventrolateral medulla (RVLM) of conscious rats by abnormal cannabidiol (Abn CBD; trans-4-[3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol) elevates local nitric oxide (NO) and adiponectin (ADN) levels and reduces oxidative stress and blood pressure (BP).
GPR18 in microglia: implications for the CNS and endocannabinoid system signalling.
Review
McHugh, Bloomington, United States. In Br J Pharmacol, 2012
A review of what is presently known about the G protein coupled receptor GPR18 in terms of its expression and distribution, pharmacology and potential implications for central nervous system and endocannabinoid system signalling.
The atypical cannabinoid O-1602: targets, actions, and the central nervous system.
Review
Ashton, Dunedin, New Zealand. In Cent Nerv Syst Agents Med Chem, 2012
The GPR18 receptor has been identified with the Abn-CBD receptor, and therefore the evidence that O-1602 also acts at GPR18 is also reviewed.
Quantitative expression profiling of G-protein-coupled receptors (GPCRs) in metastatic melanoma: the constitutively active orphan GPCR GPR18 as novel drug target.
GeneRIF
Osanto et al., Leiden, Netherlands. In Pigment Cell Melanoma Res, 2011
GPR18, the most abundantly overexpressed orphan G-protein-coupled receptor in all melanoma metastases, is constitutively active and inhibits apoptosis, indicating an important role for GPR18 in tumor cell survival.
EBI2, GPR18 and GPR17--three structurally related, but biologically distinct 7TM receptors.
Review
GeneRIF
Rosenkilde et al., Copenhagen, Denmark. In Curr Top Med Chem, 2010
REVIEW: functional properties and in vivo biology
Orphan endogenous lipids and orphan GPCRs: a good match.
Review
McHugh et al., Bloomington, United States. In Prostaglandins Other Lipid Mediat, 2009
Here, we give a brief history of these orphan lipids and highlight the activity of N-arachidonoyl glycine, and farnesyl pyrophosphate at the orphan receptors GPR18 and GPR92, respectively, as well as summarizing the biological and pharmacological data for the recently identified N-palmitoyl glycine that suggests activity at a novel GPCR.
Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18.
GeneRIF
Yasukawa et al., Japan. In Biochem Biophys Res Commun, 2006
N-arachidonylglycine is a natural ligand for GPR18
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