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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Urotensin 2 receptor

GPR14, urotensin II receptor
G protein-coupled receptor isolated from retinal and taste cells [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: urotensin-II, URP, CAN, ACID, endothelin-1
Papers on GPR14
Expression levels of urotensin II are associated with endoplasmic reticulum stress in patients with severe preeclampsia.
Zhang et al., Beijing, China. In J Hum Hypertens, Feb 2016
Expression levels of UII, UII receptor (GPR14) and the markers of ERS in placenta specimens of patients were performed.
Use of Diverse Chemometric and Validation Methods to Accurately Predict Human Urotensin-II Receptor Antagonist Activity.
Paliwal et al., Tonk, India. In Curr Comput Aided Drug Des, Dec 2015
Despite being identified as the most potent receptor related to vasoconstriction, human urotensin-II receptor (hUT) has not been fully explored as a target for the treatment of cardiovascular diseases.
Urotensin II receptor on preoperative biopsy is associated with upstaging and upgrading in prostate cancer.
Ferro et al., Milano, Italy. In Future Oncol, Nov 2015
AIM: A higher Gleason score was associated with a lower tumor urotensin II receptor (UTII-R) expression in prostate cancer patients.
Using exome sequencing to identify the cause of myocardial hypertrophy in a Chinese family.
Chen et al., Shanghai, China. In Mol Med Report, Sep 2015
A stop‑gain mutation in urotensin II receptor (UTS2R) (p.S241X), which is associated with congestive heart failure, was identified in the proband and in one other affected family member.
Attenuation of renovascular hypertension by cyclooxygenase-2 inhibitor partly through ANP release.
Kim et al., Chŏnju, South Korea. In Peptides, Jul 2015
Chronic treatment with nimesulide or NS-398 (5 mg/kg/day) for 3 weeks lowered high blood pressure and cardiac hypertrophy with decreased expression levels of cardiac hypertrophy markers [atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP)], Ang type 1 receptor, urotensin II, and urotensin II receptor in 2K1C rats.
De Novo Conception of Small Molecule Modulators Based on Endogenous Peptide Ligands: Pyrrolodiazepin-2-one γ-Turn Mimics That Differentially Modulate Urotensin II Receptor-Mediated Vasoconstriction ex Vivo.
Lubell et al., Montréal, Canada. In J Med Chem, Jul 2015
Pyrrolodiazepinone R-4a represents, to the best of our knowledge, a first-in-class small molecule that exerts a probe-dependent effect on hUII and URP biological activities and proves that UT modulators of the urotensin II receptor (UT) can be rationally designed.
Urotensin II Protects Cardiomyocytes from Apoptosis Induced by Oxidative Stress through the CSE/H2S Pathway.
Zou et al., Shanghai, China. In Int J Mol Sci, 2014
SiRNA targeted to the urotensin II receptor (UT) greatly inhibited these effects.
Biochemical and pharmacological characterization of nuclear urotensin-II binding sites in rat heart.
Chatenet et al., Québec, Canada. In Br J Pharmacol, 2012
we report a specific nuclear/perinuclear expression of the U-II receptor in the rat heart, which upon activation by U-II or URP results in different modulatory effects on transcription
Presence of urotensin-II receptors at the cell nucleus: specific tissue distribution and hypoxia-induced modulation.
Fournier et al., Québec, Canada. In Int J Biochem Cell Biol, 2012
presence of functional nuclear UT in various rat and monkey tissues as well as in human cell lines
Down-regulation of GABA(A) receptor via promiscuity with the vasoactive peptide urotensin II receptor. Potential involvement in astrocyte plasticity.
Castel et al., Mont-Saint-Aignan, France. In Plos One, 2011
Data show that vasoactive peptide urotensin II receptor and GABA(A)R are co-expressed in cerebellar glial cells from rat brain slices, in human native astrocytes and in glioma cell line.
EGFR trans-activation by urotensin II receptor is mediated by β-arrestin recruitment and confers cardioprotection in pressure overload-induced cardiac hypertrophy.
Chiariello et al., Napoli, Italy. In Basic Res Cardiol, 2011
a new urotensin II receptor signalling pathway which is mediated by EGFR trans-activation, dependent by beta-arrestin 1/2, promoting cell survival and cardioprotection.
A rat brain atlas of urotensin-II receptor expression and a review of central urotensin-II effects.
Lambert et al., Leicester, United Kingdom. In Naunyn Schmiedebergs Arch Pharmacol, 2010
In rat brain, areas of high, medium, and low expression of urotein II receptor include the arcuate, paraventricular, and pedunculopontine tegmental nuclei, respectively
Role of urotensin II in health and disease.
Giaid et al., Montréal, Canada. In Am J Physiol Regul Integr Comp Physiol, 2010
UII binds to a class of G protein-coupled receptor known as GPR14 or the urotensin receptor (UT).
Behavioral actions of urotensin-II.
Costentin et al., Rouen, France. In Peptides, 2008
Urotensin-II (U-II) and urotensin-II-related peptide (URP) have been identified as the endogenous ligands of the orphan G-protein-coupled receptor GPR14 now renamed UT.
Biological properties and functional determinants of the urotensin II receptor.
Leduc et al., Sherbrooke, Canada. In Peptides, 2008
The urotensin II receptor (UT) is a member of the G protein-coupled receptor (GPCR) family and binds the cyclic undecapeptide urotensin II (U-II) as well as the octapeptide urotensin II-related peptide (URP).
Nonpeptide Urotensin-II receptor agonists and antagonists: review and structure-activity relationships.
Rault et al., Caen, France. In Peptides, 2008
Its receptor is a member of the class A of G-protein-coupled receptors, called GPR14.
[Expression of Urotensin II and its receptor on right ventricle in rats of pulmonary hypertension].
Wu et al., Wenzhou, China. In Zhongguo Ying Yong Sheng Li Xue Za Zhi, 2006
The expression of U II and Uts2R in right ventricle arteries and right ventricle myocytes increases significantly during the formation of pulmonary hypertension and right ventricle hypertrophy in rats chronically exposed to hypoxia-hypercapnia.
Congestive heart failure and expression of myocardial urotensin II.
Giaid et al., King of Prussia, United States. In Lancet, 2002
Our aim was to ascertain degree of expression of urotensin II and its receptor GPR14 (now known as UT receptor) in the myocardium of patients with congestive heart failure (CHF).
Role of urotensin II in patients on dialysis.
Murakami et al., In Lancet, 2001
Messenger RNA encoding theurotensin II precursor and the urotensin II receptor precursor were expressed in various human tissues.
Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14.
Douglas et al., King of Prussia, United States. In Nature, 1999
Here we describe the identification of an orphan human G-protein-coupled receptor homologous to rat GPR14 and expressed predominantly in cardiovascular tissue, which functions as a U-II receptor.
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