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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

G protein-coupled receptor 139

GPR139, GPRg1, PgR-3
Top mentioned proteins: GPCR, 15-Oxoprostaglandin 13-Reductase, Rhodopsin, GPR153, SAR
Papers on GPR139
GPR139, an Orphan Receptor Highly Enriched in the Habenula and Septum, Is Activated by the Essential Amino Acids L-Tryptophan and L-Phenylalanine.
Lovenberg et al., San Diego, United States. In Mol Pharmacol, Nov 2015
GPR139 is an orphan G-protein-coupled receptor expressed in the central nervous system.
Identification and SAR of Glycine Benzamides as Potent Agonists for the GPR139 Receptor.
Carruthers et al., San Diego, United States. In Acs Med Chem Lett, Oct 2015
A focused high throughput screening for GPR139 was completed for a select 100K compounds, and new agonist leads were identified.
High-throughput screening of antagonists for the orphan G-protein coupled receptor GPR139.
Wang et al., Shanghai, China. In Acta Pharmacol Sin, Jul 2015
AIM: To discover antagonists of the orphan G-protein coupled receptor GPR139 through high-throughput screening of a collection of diverse small molecules.
Computer-aided discovery of aromatic l-α-amino acids as agonists of the orphan G protein-coupled receptor GPR139.
Gloriam et al., Copenhagen, Denmark. In J Chem Inf Model, 2014
GPR139 is an orphan G protein-coupled receptor expressed mainly in the central nervous system.
Sequence-structure based phylogeny of GPCR Class A Rhodopsin receptors.
Jamil et al., India. In Mol Phylogenet Evol, 2014
Our study was able to identify potential ligand association for Class A Orphans and putative/unclassified Class A receptors with no cognate ligand information: GPR21 and GPR52 with fatty acids; GPR75 with Neuropeptide Y; GPR82, GPR18, GPR141 with N-arachidonylglycine; GPR176 with Free fatty acids, GPR10 with Tachykinin & Neuropeptide Y; GPR85 with ATP, ADP & UDP glucose; GPR151 with Galanin; GPR153 and GPR162 with Adrenalin, Noradrenalin; GPR146, GPR139, GPR142 with Neuromedin, Ghrelin, Neuromedin U-25 & Thyrotropin-releasing hormone; GPR171 with ATP, ADP & UDP Glucose; GPR88, GPR135, GPR161, GPR101with 11-cis-retinal; GPR83 with Tackykinin; GPR148 with Prostanoids, GPR109b, GPR81, GPR31with ATP & UTP and GPR150 with GnRH I & GnRHII.
Copy number variation distribution in six monozygotic twin pairs discordant for schizophrenia.
Singh et al., London, Canada. In Twin Res Hum Genet, 2014
It included PYY (twin pairs 1 and 5), EPHA3 (twin pair 3), KIAA1211L (twin pair 4), and GPR139 (twin pair 5).
Genome-wide association study of inattention and hyperactivity-impulsivity measured as quantitative traits.
Medland et al., Armidale, Australia. In Twin Res Hum Genet, 2013
Neither the GWAS nor subsequent meta-analyses yielded genome-wide significant results; the strongest effect was observed at rs2110267 (4.62 × 10-7) for symptoms of hyperactivity-impulsivity. The strongest effect in the gene-based test was for GPR139 on symptoms of inattention (6.40 × 10-5).
Discovery and SAR of a Series of Agonists at Orphan G Protein-Coupled Receptor 139.
Smith et al., Shanghai, China. In Acs Med Chem Lett, 2011
GPR139 is an orphan G-protein coupled receptor (GPCR) which is primarily expressed in the central nervous system (CNS).
Identification of surrogate agonists and antagonists for orphan G-protein-coupled receptor GPR139.
Liu et al., The Woodlands, United States. In J Biomol Screen, 2009
GPR139 is an orphan G-protein-coupled receptor (GPCR) that is expressed nearly exclusively in the central nervous system and may play a role in the control of locomotor activity.
Differentiated expression of estrogen receptors (ER) and progesterone receptors (PgR) in ductal breast cancers.
Dziegiel et al., Wrocław, Poland. In Folia Histochem Cytobiol, 2008
From every tumour three samples were taken for immunohistochemical studies: the lateral one from the side of axilla (ER-1; PgR-1); the median one (ER-2; PgR-2) and the medial one from the side of sternum (ER-3; PgR-3).
Characterisation and differential expression of two very closely related G-protein-coupled receptors, GPR139 and GPR142, in mouse tissue and during mouse development.
Schaller et al., Hamburg, Germany. In Neuropharmacology, 2006
By searching the human and mouse genomic databases we found two G-protein-coupled receptors, GPR139 and GPR142, with characteristic motifs of the rhodopsin family of receptors.
Molecular cloning and characterization of a novel Gq-coupled orphan receptor GPRg1 exclusively expressed in the central nervous system.
Shigeyoshi et al., Ōsaka, Japan. In Biochem Biophys Res Commun, 2005
Molecular cloning of GPRg1, a Gq-coupled orphan receptor that is expressed in the brain.
Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship.
Fredriksson et al., Uppsala, Sweden. In Biochim Biophys Acta, 2005
Four of the receptors, GPR139, GPR146, GPR153 and GPR162, have one other orphan GPCRs as close relative while GPR148 lacks close relatives.
Novel human G-protein-coupled receptors.
O'Dowd et al., Toronto, Canada. In Biochem Biophys Res Commun, 2003
GPR138 and GPR139 share identities with an odorant-like gene derived from human erythroid cells.
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