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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

G protein-coupled receptor 133

GPR133
The adhesion G-protein-coupled receptors (GPCRs), including GPR133, are membrane-bound proteins with long N termini containing multiple domains. GPCRs, or GPRs, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins (summary by Bjarnadottir et al., 2004 [PubMed 15203201]).[supplied by OMIM, Nov 2010] (from NCBI)
Top mentioned proteins: GPCR, SET, EMR3, EMR2, GPR116
Papers on GPR133
A tethered agonist within the ectodomain activates the adhesion G protein-coupled receptors GPR126 and GPR133.
Schöneberg et al., Leipzig, Germany. In Cell Rep, 2015
Here, we show that a short peptide sequence (termed the Stachel sequence) within the ectodomain of two aGPCRs (GPR126 and GPR133) functions as a tethered agonist.
Differential DNA Methylation in Relation to Age and Health Risks of Obesity.
Martínez et al., Pamplona, Spain. In Int J Mol Sci, 2014
Moreover, statistically significant associations between BMI or mRNA levels and two HRO-related CpG sites located in GPR133 and ITGB5 are reported.
International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.
Review
Impact
Schiöth et al., Amsterdam, Netherlands. In Pharmacol Rev, 2014
The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98).
Genetic analysis of 16 NMR-lipoprotein fractions in humans, the GOLDN study.
Arnett et al., Saint Louis, United States. In Lipids, 2013
STXBP6 (14q12), APOB (2p24-p23), GPR133 (12q24.33),
Gene-based copy number variation study reveals a microdeletion at 12q24 that influences height in the Korean population.
Kim et al., South Korea. In Genomics, 2013
approximately 171.6 kb downstream of GPR133, significantly correlated with height; this finding was validated using quantitative PCR.
Identification of novel genes selectively expressed in the follicle-associated epithelium from the meta-analysis of transcriptomics data from multiple mouse cell and tissue populations.
Mabbott et al., Edinburgh, United Kingdom. In Dna Res, 2012
Some of these novel candidate genes were expressed highly by the FAE and M cells (Calcb, Ces3b, Clca2 and Gjb2), and others only by the FAE (Ascl2, Cftr, Fgf15, Gpr133, Kcna1, Kcnj15, Mycl1, Pgap1 and Rps6kl).
Parallel selection mapping using artificially selected mice reveals body weight control loci.
Tautz et al., Germany. In Curr Biol, 2012
We present evidence supporting two G protein-coupled receptors GPR133 and Prlhr as positional candidates controlling body weight.
Exome sequencing and subsequent association studies identify five amino acid-altering variants influencing human height.
Lee et al., Seoul, South Korea. In Hum Genet, 2012
We performed association analysis in 740 cohort individuals and identified 11 nsSNPs in 10 loci (DIS3L2, ZBTB38, FAM154A, PTCH1, TSSC4, KIF18A, GPR133, ACAN, FAM59A, and NINL) associated with adult height (P < 0.05), including five novel loci.
Cell adhesion receptor GPR133 couples to Gs protein.
GeneRIF
Schöneberg et al., Leipzig, Germany. In J Biol Chem, 2012
Cell adhesion receptor GPR133 couples to Gs protein
Genetic variation in GPR133 is associated with height: genome wide association study in the self-contained population of Sorbs.
Stumvoll et al., Leipzig, Germany. In Hum Mol Genet, 2010
In the meta-analysis on those 455 SNPs, only two variants in GPR133 (rs1569019 and rs1976930; in LD with each other) retained a P-value at or below 10(-6) and were associated with height in the three cohorts individually.
A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project.
GeneRIF
EUROSPAN Consortium et al., München, Germany. In Circ Cardiovasc Genet, 2009
A role for GPR133 protein in affecting the length of the electrocardiographic RR interval and heart rate.
Kit K641E oncogene up-regulates Sprouty homolog 4 and trophoblast glycoprotein in interstitial cells of Cajal in a murine model of gastrointestinal stromal tumours.
Vanderwinden et al., Brussels, Belgium. In J Cell Mol Med, 2009
Gja1/Cx43, Gpc6, Gpr133, Pacrg, Pde3a, Prkar2b, Prkcq/Pkce, Rasd2, Spry4 and Tpbg/5T4 were found to be up-regulated.
The Secretin GPCRs descended from the family of Adhesion GPCRs.
Schiöth et al., Uppsala, Sweden. In Mol Biol Evol, 2009
Phylogenetic analysis found Adhesion group V (that contains GPR133 and GPR144) to be the closest relative to the Secretin family in the Adhesion family.
Identification of novel splice variants of Adhesion G protein-coupled receptors.
Schiöth et al., Uppsala, Sweden. In Gene, 2007
Novel functional splice variants were found for: CD97, CELR3, EMR2, EMR3, GPR56, GPR110, GPR112-GPR114, GPR116, GPR123-GPR126, GPR133, HE6, and LEC1-LEC3.
The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.
Schiöth et al., Uppsala, Sweden. In Genomics, 2004
Here, 2 new human adhesion-GPCRs, termed GPR133 and GPR144, have been found by searches done in the human genome databases.
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