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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

G protein-coupled receptor 124

GPR124, TEM5, tumor endothelial marker 5
Top mentioned proteins: GPR125, miR, GPCR, vascular endothelial growth factor, TUBE
Papers on GPR124
Searching for candidate genes in familial BRCAX mutation carriers with prostate cancer.
New
Thorne et al., Melbourne, Australia. In Urol Oncol, Dec 2015
In addition, 3 truncating variants, CYP3A43, DOK3, and PLEKHH3, demonstrated complete segregation and 3 truncation mutations, HEATR5B, GPR124, and HKR1, demonstrated partial segregation with PC.
Susceptibility loci for sporadic brain arteriovenous malformation; a replication study and meta-analysis.
New
Klijn et al., Utrecht, Netherlands. In J Neurol Neurosurg Psychiatry, Sep 2015
RESULTS: In our case-control study we found no significant association with brain AVM (BAVM) for previously discovered SNPs near ANGPTL4, IL-1β, GPR124, VEGFA and MMP-3.
GPR124 functions as a WNT7-specific coactivator of canonical β-catenin signaling.
New
St Croix et al., Frederick, United States. In Cell Rep, Feb 2015
G protein-coupled receptor 124 (GPR124) is an orphan receptor in the adhesion family of GPCRs, and previous global or endothelial-specific disruption of Gpr124 in mice led to defective CNS angiogenesis and blood-brain barriergenesis.
International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.
Review
Impact
Schiöth et al., Amsterdam, Netherlands. In Pharmacol Rev, 2014
The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98).
G-protein coupled receptor 124 (GPR124) in endothelial cells regulates vascular endothelial growth factor (VEGF)-induced tumor angiogenesis.
Liu et al., Houston, United States. In Curr Mol Med, 2014
G protein-coupled receptor 124 (GPR124; also called tumor endothelial marker 5, TEM5) is highly expressed in tumor vasculature.
miR-138-5p reverses gefitinib resistance in non-small cell lung cancer cells via negatively regulating G protein-coupled receptor 124.
Fu et al., Wuhan, China. In Biochem Biophys Res Commun, 2014
Bioinformatics analysis and luciferase reporter assay showed that G protein-coupled receptor124 (GPR124) was a direct target of miR-138-5p.
Novel insights into the development and maintenance of the blood-brain barrier.
Review
Liebner et al., Bern, Switzerland. In Cell Tissue Res, 2014
In this review, we summarize the currently known cellular and molecular mechanisms mediating brain angiogenesis and introduce more recently discovered CNS-specific pathways (Wnt/β-catenin, Norrin/Frizzled4 and hedgehog) and molecules (GPR124) that are crucial in BBB differentiation and maturation.
Integrative pathway dissection of molecular mechanisms of moxLDL-induced vascular smooth muscle phenotype transformation.
Minta et al., Toronto, Canada. In Bmc Cardiovasc Disord, 2012
Also, several "nexus" genes in complex networks, including components of the multi-subunit enzyme complex involved in the terminal stages of cholesterol synthesis, microRNAs (miR-203, miR-511, miR-590-3p, miR-346*/miR- 1207-5p/miR-4763-3p), GPCR proteins (GPR1, GPR64, GPRC5A, GPR171, GPR176, GPR32, GPR25, GPR124) and signal transduction pathways, were found to be regulated.
G Protein-Coupled Receptor 124 (GPR124) Gene Polymorphisms and Risk of Brain Arteriovenous Malformation.
Kim et al., San Francisco, United States. In Transl Stroke Res, 2012
G protein-coupled receptor 124 (GPR124) mediates embryonic CNS angiogenesis; thus we investigated the association of single nucleotide polymorphisms (SNPs) and haplotypes in GPR124 with risk of BAVM.
Thrombin-induced shedding of tumour endothelial marker 5 and exposure of its RGD motif are regulated by cell-surface protein disulfide-isomerase.
GeneRIF
Essler et al., München, Germany. In Biochem J, 2012
Thrombin-induced shedding of tumour endothelial marker 5 and exposure of its RGD motif are regulated by cell-surface protein disulfide-isomerase.
GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.
GeneRIF
St Croix et al., Frederick, United States. In Proc Natl Acad Sci U S A, 2011
GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.
Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor.
GeneRIF
Gale et al., United States. In Proc Natl Acad Sci U S A, 2011
TGF-beta stimulates Gpr124 expression which is required for angiogenic sprouting into neural tissues.
News from the brain: the GPR124 orphan receptor directs brain-specific angiogenesis.
Nyqvist et al., Milano, Italy. In Sci Transl Med, 2010
Now Kuhnert et al. reveal that the orphan heterotrimeric GTP-binding protein-coupled receptor GPR124/TEM5 acts as an organ-specific regulator of brain angiogenesis, required for normal endothelial cell sprouting, migration, and expression of the BBB marker Glut-1 in the forebrain and neural tube.
Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124.
Impact
GeneRIF
Kuo et al., Stanford, United States. In Science, 2010
study shows that complete null or endothelial-specific GPR124 deletion resulted in embryonic lethality from CNS-specific angiogenesis arrest in forebrain and neural tube; results demonstrate CNS-specific angiogenesis regulation by an endothelial receptor
High-resolution analysis of genomic alteration on chromosome arm 8p in urothelial carcinoma.
Knowles et al., Leeds, United Kingdom. In Genes Chromosomes Cancer, 2010
Amplification was seen in some samples and shown in the cell line JMSU1 to correlate with overexpression of ZNF703, ERLIN2, PROSC, GPR124, and BRF2.
Tumor endothelial marker 5 expression in endothelial cells during capillary morphogenesis is induced by the small GTPase Rac and mediates contact inhibition of cell proliferation.
GeneRIF
Essler et al., München, Germany. In Exp Cell Res, 2010
TEM5 expression during capillary morphogenesis is induced by the small GTPase Rac and mediates contact inhibition of proliferation in endothelial cells.
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