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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Omega-3 fatty acid receptor 1

This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: ACID, GPR40, Insulin, Glucagon, E4
Papers on GPR120
Topical Docosahexaenoic Acid (DHA) Accelerates Skin Wound Healing in Rats and Activates GPR120.
Araújo et al., Campinas, Brazil. In Biol Res Nurs, Feb 2016
PURPOSE: We evaluated whether G-protein-coupled receptor 120 (GPR120), a recently identified receptor for docosahexaenoic acid (DHA) with anti-inflammatory activity, is expressed in the skin and responds to topical DHA.
G protein-coupled receptors: signalling and regulation by lipid agonists for improved glucose homoeostasis.
McKillop et al., Coleraine, United Kingdom. In Acta Diabetol, Feb 2016
GPR40 and GPR120 are activated by long-chain fatty acids (>C12) with both receptors coupling to the Gαq subunit that activates the Ca(2+)-dependent pathway.
Comprehensive Profiling of GPCR Expression in Ghrelin-producing Cells.
Nakao et al., Ōsaka, Japan. In Endocrinology, Jan 2016
Expression levels of GPCRs previously suggested to regulate ghrelin secretion including adrenergic β1 receptor, GPR81, oxytocin receptor, GPR120, and somatostatin receptor 2 were high in MGN3-1 cells.
Discovery of novel FFA4 (GPR120) receptor agonists with β-arrestin2-biased characteristics.
Du et al., Jinan, China. In Future Med Chem, Dec 2015
BACKGROUND: Free fatty acid 4 (FFA4) (GPR120) receptor functions as a receptor for unsaturated long-chain free fatty acids by regulating the secretion of glucagon-like peptide-1 and suppressing the inflammatory process, in which these two distinct biological functions are modulated by two signaling pathways, Gq and β-arrestin2, respectively.
Docosahexaenoic Acid and Its Role in G-Protein-Coupled Receptor 120 Activation in Children Affected by Nonalcoholic Fatty Liver Disease.
Nobili et al., In Endocr Dev, Dec 2015
In fact, DHA may activate GPR120 expression in macrophages causing anti-inflammatory effects, and insulin-sensitizing and antidiabetic effects in vivo.
Dietary Lipids Inform the Gut and Brain about Meal Arrival via CD36-Mediated Signal Transduction.
Abumrad et al., Saint Louis, United States. In J Nutr, Oct 2015
Components of dietary fat that are recognized by these receptors are the long-chain fatty acids that act as ligands for 2 G protein-coupled receptors, GPR40 and GPR120, and the fatty acid (FA) translocase/CD36.
FFA4 receptor (GPR120): A hot target for the development of anti-diabetic therapies.
Sun et al., Jinan, China. In Eur J Pharmacol, Oct 2015
Free Fatty Acid 4 receptor (FFA4 receptor or GPR120), a rhodopsin-like G protein coupled receptor (GPCR) subfamily member, is a receptor that senses specific fatty acids such as ω-3 fatty acid in fish oil or the endogenous signaling lipid, PHASA.
Biological characteristics and agonists of GPR120 (FFAR4) receptor: the present status of research.
Du et al., Jinan, China. In Future Med Chem, 2014
GPR120 receptor functions as a receptor for ω-3 fatty acid, involving regulating the secretion of gastrointestinal peptide hormone, adipogenesis, adipogenic differentiation and anti-inflammatory process and the like in the aspect of biological functions.
Dietary Fatty Acids and Their Potential for Controlling Metabolic Diseases Through Activation of FFA4/GPR120.
Christiansen et al., Odense, Denmark. In Annu Rev Nutr, 2014
The free fatty acid receptor 4 (FFA4, previously GPR120) is linked to the regulation of body weight, inflammation, and insulin resistance and represents a potential target for the treatment of metabolic disorders, including type 2 diabetes and obesity.
Omega-3 Polyunsaturated Fatty Acids Intake to Regulate Helicobacter pylori-Associated Gastric Diseases as Nonantimicrobial Dietary Approach.
Hahm et al., South Korea. In Biomed Res Int, 2014
Recent studies dealing with EPA and DHA have sparked highest interests because detailed molecular mechanisms had been documented with the identification of its receptor, G protein coupled receptor, and GPR120.
Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects.
Kahn et al., Boston, United States. In Cell, 2014
In adipocytes, PAHSAs signal through GPR120 to enhance insulin-stimulated glucose uptake.
[Br]eaking FAt.
Tschöp et al., München, Germany. In Cell, 2014
In this issue, Yore et al. report a group of branched fatty acid esters of hydroxy fatty acids that regulate insulin secretion and glucose uptake through the activation of GPR120.
A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice.
Olefsky et al., San Diego, United States. In Nat Med, 2014
We reported that Gpr120 is the functional receptor for these fatty acids and that ω-3-FAs produce robust anti-inflammatory, insulin-sensitizing effects, both in vivo and in vitro, in a Gpr120-dependent manner.
Diet, metabolites, and "western-lifestyle" inflammatory diseases.
Mackay et al., Australia. In Immunity, 2014
Dietary-related metabolites engage "metabolite-sensing" G-protein-coupled receptors, such as GPR43, GPR41, GPR109A, GPR120, and GPR35.
Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation.
Zhou et al., Hefei, China. In Immunity, 2013
In addition, G protein-coupled receptor 120 (GPR120) and GPR40 and their downstream scaffold protein β-arrestin-2 were shown to be involved in inflammasome inhibition induced by ω-3 FAs.
Differential signaling by splice variants of the human free fatty acid receptor GPR120.
Holliday et al., Nottingham, United Kingdom. In Mol Pharmacol, 2012
agonist-stimulated GPR120S and GPR120L receptors both recruited beta-arrestin2 and underwent robust internalization.
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human.
Froguel et al., Kyoto, Japan. In Nature, 2012
GPR120 expression in adipose tissue is significantly higher in obese individuals than in lean controls; GPR120 exon sequencing in obese subjects reveals a deleterious non-synonymous mutation (p.R270H) that inhibits GPR120 signalling activity
G protein-coupled receptors in human fat taste perception.
Behrens et al., Potsdam, Germany. In Chem Senses, 2012
GPR120 may participate in human gustatory fatty acid perception.
The lipid-sensor candidates CD36 and GPR120 are differentially regulated by dietary lipids in mouse taste buds: impact on spontaneous fat preference.
Besnard et al., Dijon, France. In Plos One, 2010
In contrast to GPR120, CD36 appears to be a food-sensitive lipid sensor in the gustatory circumvallate papillae
Diet-induced obesity up-regulates the abundance of GPR43 and GPR120 in a tissue specific manner.
McAinch et al., Melbourne, Australia. In Cell Physiol Biochem, 2010
up-regulation of GPR43 and GPR120 in response to a high fat diet, is tissue specific
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