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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

G protein-coupled receptor 12

GPR12, R334
orphan G-protein coupled receptor expressed in brain [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: GPR3, ACID, V1a, Cystic Fibrosis Transmembrane Conductance Regulator, CAN
Papers on GPR12
Identification of Ten Additional Susceptibility Loci for Ulcerative Colitis Through Immunochip Analysis in Koreans.
New
Song et al., Seoul, South Korea. In Inflamm Bowel Dis, Jan 2016
RESULTS: We confirmed the associations of 10 known UC risk loci in Koreans: rs76418789 in IL23R (combined P = 1.25 × 10), rs4728142 in IRF5 (combined P = 3.17 × 10), rs1830610 near JAK2 (combined P = 2.28 × 10), rs1555791 near TNFRSF14 (combined P = 1.62 × 10), rs880790 between IL10-IL19 (combined P = 3.73 × 10), rs10185424 between IL1R2-IL1R1 (combined P = 1.54 × 10), rs6478108 in TNFSF15 (combined P = 9.28 × 10), rs861857 between UBE2L3-YDJC (combined P = 3.05 × 10), rs1801274 in FCGR2A (discovery P = 1.54 × 10), and rs17085007 between GPR12-USP12 (discovery P = 3.64 × 10).
Constitutive Activity among Orphan Class-A G Protein Coupled Receptors.
Aronstam et al., Rolla, United States. In Plos One, 2014
Five patterns of activity were noted: 1) inhibition under both baseline and forskolin stimulated expression (GPR15, GPR17, GPR18, GPR20, GPR25, GPR27, GPR31, GPR32, GPR45, GPR57, GPR68, GPR83, GPR84, GPR132, GPR150, GPR176); 2) no effect on baseline expression, but inhibition of forskolin stimulated expression (GPR4, GPR26, GPR61, GPR62, GPR78, GPR101, GPR119); 3) elevation of baseline signaling coupled with inhibition of forskolin stimulated expression (GPR6, GPR12); 4) elevation of baseline signaling without inhibition of forskolin stimulated expression (GPR3, GPR21, GPR52, GPR65); and 5) no effect on expression (GPR1, GPR19, GPR22, GPR34, GPR35, GPR39, GPR63, GPR82, GPR85, GPR87).
Developmental expression of GPR3 in rodent cerebellar granule neurons is associated with cell survival and protects neurons from various apoptotic stimuli.
Sakai et al., Hiroshima, Japan. In Neurobiol Dis, 2014
G-protein coupled receptor 3 (GPR3), GPR6, and GPR12 belong to a family of constitutively active Gs-coupled receptors that activate 3'-5'-cyclic adenosine monophosphate (cAMP) and are highly expressed in the brain.
Network of hydrogen bonds near the oxygen-evolving Mn(4)CaO(5) cluster of photosystem II probed with FTIR difference spectroscopy.
Debus et al., Riverside, United States. In Biochemistry, 2014
We conclude that D1-R334 participates in the same dominant proton-egress pathway that was identified in our previous study.
Lipid regulation of BK channel function.
Review
Bukiya et al., Memphis, United States. In Front Physiol, 2013
Subunit domains or amino acids that participate in lipid action have been identified in a few cases: hslo1 Y318, cerebral artery smooth muscle (cbv1) R334,K335,K336, cbv1 seven cytosolic CRAC domains, slo1 STREX and β1 T169,L172,L173 for docosahexaenoic acid, PIP2, cholesterol, sulfatides, and cholane steroids, respectively.
Structural dynamic analysis of apo and ATP-bound IRAK4 kinase.
Choi et al., Suwŏn, South Korea. In Sci Rep, 2013
The MD results strongly suggested that lobe uncoupling occurs in apo unphosphorylated IRAK4 kinase via the disruption of the R334/T345 and R310/T345 interaction.
Molecular control of oocyte meiotic arrest and resumption.
Review
Zhang et al., Beijing, China. In Reprod Fertil Dev, 2012
The maintenance of meiotic arrest requires high levels of cAMP, resulting from G-protein-coupled receptor (GPR) 3 and/or GPR12 activation of adenylyl cyclase within the oocyte.
Involvement of GPR12 in the regulation of cell proliferation and survival.
GeneRIF
Hu et al., Shanghai, China. In Mol Cell Biochem, 2012
GPR12 may play a role in cell proliferation and survival
Hormonal control of mammalian oocyte meiosis at diplotene stage.
Review
Xia et al., Beijing, China. In Cell Mol Life Sci, 2012
This cAMP is generated through the activity of the Gs G-protein by the G-protein-coupled receptor, GPR3 and GPR12, and adenylyl cyclases (ADCY) endogenous to the oocyte.
Involvement of GPR12 in the induction of neurite outgrowth in PC12 cells.
GeneRIF
Hu et al., Shanghai, China. In Brain Res Bull, 2012
These findings indicate that GPR12 may play a role in neurite outgrowth during PC12 cell differentiation.
Metabolic parameters and emotionality are little affected in G-protein coupled receptor 12 (Gpr12) mutant mice.
Huang et al., Sydney, Australia. In Plos One, 2011
GPR12 is of major interest given its putative role in metabolic function and its unique brain distribution, which suggests a role in emotionality and affect.
Regulation of the activity of the dual-function DnaA protein in Caulobacter crescentus.
Collier et al., Lausanne, Switzerland. In Plos One, 2010
The R357 residue in the AAA+ domain of the C. crescentus DnaA protein is equivalent to the R334 residue of the E. coli DnaA protein, which is required for the Regulatory Inactivation of DnaA (RIDA).
G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice.
GeneRIF
Bohlooly-Y et al., Göteborg, Sweden. In Biochem Biophys Res Commun, 2006
GPCR12 is considered important for the energy balance since GPCR12 KO mice develop obesity and have lower energy expenditure.
The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes.
GeneRIF
Conti et al., Stanford, United States. In Dev Biol, 2005
the cAMP levels required for maintaining meiotic arrest in mouse and rat oocytes are dependent on the expression of Gpr3 and/or Gpr12
Vascular sphingosine-1-phosphate S1P1 and S1P3 receptors.
Review
Salomone et al., United States. In Drug News Perspect, 2004
The sphingolipid sphingosine-1-phosphate (S1P) acts on five subtypes of G-protein- coupled receptors, termed S1P(1) (formerly endothelial differentiation gene-1 [Edg-1]), S1P(2) (Edg-5), S1P(3) (Edg-3), S1P(4) (Edg-6) and S1P(5) (Edg-8), and possibly several other "orphan" receptors, such as GPR3, GPR6 and GPR12.
CFTR: what's it like inside the pore?
Review
Dawson et al., Portland, United States. In J Exp Zool A Comp Exp Biol, 2003
A residue in transmembrane segment 6 (TM6) (R334) appears to reside in the outer vestibule of the CFTR pore where it creates a positive electrostatic potential that enhances anion conduction.
Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells.
GeneRIF
Kostenis et al., Frankfurt am Main, Germany. In Cell Physiol Biochem, 2002
control of gene expression in vascular endothelial cells in the presence of fluid shear stress and classifies it as a sphingosine 1-phosphate receptor
Mutations in CFTR associated with mild-disease-form Cl- channels with altered pore properties.
Impact
Welsh et al., Iowa City, United States. In Nature, 1993
These results explain the quantitative decrease in macroscopic Cl- current, and suggest that R117, R334 and R347 contribute to the pore of the CFTR Cl- channel.
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