Ageing is associated with molecular signatures of inflammation and type 2 diabetes in rat pancreatic islets.
Cambridge, United Kingdom. In Diabetologia, Jan 2016
Age-associated transcriptional differences negatively correlated with promoter DNA methylation at several loci related to inflammation, glucose homeostasis, cell proliferation and cell-matrix interactions (Il33, Cxcl9, Gpr119, Fbp2, Col3a1, Dpt, Spp1).
Toxicokinetics and toxicity of atorvastatin in dogs.
United States. In Toxicol Appl Pharmacol, Dec 2015
We recently had a clinical development program evaluating a combination of atorvastatin with a GPR119 agonist as a treatment for dyslipidemia, where toxicological evaluations in dogs were completed.
Classical endocannabinoid-like compounds and their regulation by nutrients.
Copenhagen, Denmark. In Biofactors, 2014
A chronic high-fat diet will decrease intestinal levels of these anorectic N-acylethanolamines and this may contribute to the hyperphagic effect of high-fat diet; 2-monoacylglycerols mediate endocrine responses in the small intestine; probably trough activation of GPR119 on enteroendocrine cells, and diet-derived 2-monoacylglycerols, for example, 2-oleoylglycerol and 2-palmitoylglycerol might be important for intestinal fat sensing.
Current therapies and emerging drugs in the pipeline for type 2 diabetes.
Reno, United States. In Am Health Drug Benefits, 2011
This article focuses on several new classes, including the sodium-glucose cotransporter-2 inhibitors (which are furthest along in development); 11beta-hydroxysteroid dehydrogenase (some of which are now in phase 2 trials); glycogen phosphorylase inhibitors; glucokinase activators; G protein-coupled receptor 119 agonists; protein tyrosine phosphatase 1B inhibitors; and glucagon-receptor antagonists.