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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Pyroglutamylated RFamide peptide receptor

GPR103, AQ27
orphan G protein-coupled receptor; has a role in regulating adrenal function [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Neuropeptide, ACID, V1a, HAD, neuropeptide FF
Papers on GPR103
Effects of systematic N-terminus deletions and benzoylations of endogenous RF-amide peptides on NPFF1R, NPFF2R, GPR10, GPR54 and GPR103.
New
Bihel et al., Illkirch-Graffenstaden, France. In Peptides, Sep 2015
Mammalian RF-amide peptides including RF-amide-related peptides-1 and -3, neuropeptides AF and FF, Prolactin releasing peptides, Kisspeptins and RFa peptides are currently considered endogenous peptides for the GPCRs NPFF1R, NPFF2R, GPR10, GPR54 and GPR103, respectively.
Effects of direct QRFP-26 administration into the medial hypothalamic area on food intake in rats.
New
Lénárd et al., Pécs, Hungary. In Brain Res Bull, Sep 2015
QRFPs have been suggested as the endogenous ligands of the previously orphan GPR103 receptors.
Hypothalamic Neuropeptide 26RFa Acts as an Incretin to Regulate Glucose Homeostasis.
New
Chartrel et al., Caen, France. In Diabetes, Aug 2015
In addition, we found that 26RFa and its receptor GPR103 are present in human pancreatic β-cells as well as in the gut.
Genome wide identification of new genes and pathways in patients with both autoimmune thyroiditis and type 1 diabetes.
New
SEARCH for Diabetes in Youth Study et al., New York City, United States. In J Autoimmun, Jun 2015
Outside the HLA region, variants in GPR103, a gene not suggested by previous studies of APS3v, T1D, or AITD, showed genome-wide significance (p < 5 × 10(-8)).
Characterization of peptide QRFP (26RFa) and its receptor from amphioxus, Branchiostoma floridae.
Larhammar et al., Uppsala, Sweden. In Gen Comp Endocrinol, 2015
In mammals, a longer version of the peptide, 43 amino acids, was identified and found to bind to the orphan G protein-coupled receptor GPR103.
Orexin receptors exert a neuroprotective effect in Alzheimer's disease (AD) via heterodimerization with GPR103.
Karteris et al., Coventry, United Kingdom. In Sci Rep, 2014
The exact expression and signalling characteristics and physiological actions of QRFP and its receptor GPR103 are poorly understood.
Molecular basis of agonist docking in a human GPR103 homology model by site-directed mutagenesis and structure-activity relationship studies.
Leprince et al., France. In Br J Pharmacol, 2014
BACKGROUND AND PURPOSE: The neuropeptide 26RFa and its cognate receptor GPR103 are involved in the control of food intake and bone mineralization.
GPR103 antagonists demonstrating anorexigenic activity in vivo: design and development of pyrrolo[2,3-c]pyridines that mimic the C-terminal Arg-Phe motif of QRFP26.
Svensson Henriksson et al., Mölndal, Sweden. In J Med Chem, 2014
GPR103, a G-protein coupled receptor, has been reported to have orexigenic properties through activation by the endogenous neuropeptide ligands QRFP26 and QRFP43.
Molecular evolution of GPCRs: 26Rfa/GPR103.
Review
Tsutsui et al., Mont-Saint-Aignan, France. In J Mol Endocrinol, 2014
It has been shown to exert orexigenic activity in mammals and to be a ligand for the previously identified orphan G protein-coupled receptor, GPR103 (QRFPR).
New Hits as Antagonists of GPR103 Identified by HTS.
Nilsson et al., Mölndal, Sweden. In Acs Med Chem Lett, 2014
Preclinical data indicate that GPR103 receptor and its endogenous neuropeptides QRFP26 and QRFP43 are involved in appetite regulation.
Five novel variants of GPR103 and their expression in different tissues of goose (Anser cygnoides).
Zhang et al., China. In Comp Biochem Physiol B Biochem Mol Biol, 2014
GPR103 plays an important role in various tissues, while little information is available about the alternative splicing (AS) of its mRNA.
Unexpected multiplicity of QRFP receptors in early vertebrate evolution.
Bergqvist et al., Uppsala, Sweden. In Front Neurosci, 2013
Recently, we reported that a QRFP peptide is present in amphioxus, Branchiostoma floridae, and we also identified a QRFP receptor (QRFPR) that mediates a functional response to sub-nanomolar concentrations of the amphioxus peptide as well as short and long human QRFP (Xu et al., submitted).
Identification, localization and function of a novel neuropeptide, 26RFa, and its cognate receptor, GPR103, in the avian hypothalamus.
Review
Tsutsui et al., Hiroshima, Japan. In Gen Comp Endocrinol, 2013
Since the discovery of the 26-amino acid RFamide peptide (termed 26RFa) from the frog brain, 26RFa has been shown to exert orexigenic activity in mammals and to be a ligand of the previously identified orphan G protein-coupled receptor GPR103.
The RFamide neuropeptide 26RFa and its role in the control of neuroendocrine functions.
Review
Llorens-Cortes et al., Mont-Saint-Aignan, France. In Front Neuroendocrinol, 2011
26RFa is the cognate ligand of the orphan G protein-coupled receptor GPR103 that is also present from fish to human.
Molecular evolution and functional characterization of the orexigenic peptide 26RFa and its receptor in vertebrates.
Review
Tsutsui et al., Hiroshima, Japan. In Cell Tissue Res, 2011
Since the discovery of the 26-amino acid RFamide peptide (termed 26RFa) from the frog brain, 26RFa has been shown to exert orexigenic activity in mammals and to be a ligand of the previously identified orphan G-protein-coupled receptor GPR103.
GPR103b functions in the peripheral regulation of adipogenesis.
GeneRIF
Ong et al., Montréal, Canada. In Mol Endocrinol, 2010
Results suggest that GPR103b and QRFP work in an autocrine/paracrine manner to regulate adipogenesis.
Distribution of 26RFa binding sites and GPR103 mRNA in the central nervous system of the rat.
GeneRIF
Chartrel et al., Mont-Saint-Aignan, France. In J Comp Neurol, 2007
the expression of GPR103 mRNA was more discrete, notably in the midbrain, the pons, and the medulla oblongata.
Effect of central administration of QRFP(26) peptide on energy balance and characterization of a second QRFP receptor in rat.
GeneRIF
Bagnol et al., Cincinnati, United States. In Brain Res, 2006
We found an additional receptor with high homology for GPR103 in rat. This receptor increases inositol triphosphate production in transfected cells in presence of QRFP(26) and its mRNA was particularly enriched in the brain.(GPR103 protein, rat)
A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice.
GeneRIF
Sakai et al., Tokyo, Japan. In Proc Natl Acad Sci U S A, 2006
QRFP and GPR103A/B may regulate diverse neuroendocrine and behavioral functions and implicate this neuropeptide system in metabolic syndrome
The G-protein-coupled receptor GPR103 regulates bone formation.
GeneRIF
Tian et al., San Francisco, United States. In Mol Cell Biol, 2006
Osteopenia in GPR103-/- mice may be mediated directly by the loss of GPR103 expression in bone.
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