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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

GPR1 Gpr1p

GPR1, Gpr1p
G-protein-coupled orphan receptor [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CD4, ACID, CAN, GPR15, V1a
Papers on GPR1
CMKLR1 and GPR1 mediate chemerin signaling through the RhoA/ROCK pathway.
Sinal et al., Halifax, Canada. In Mol Cell Endocrinol, Jan 2016
Chemerin is also the only known ligand for a second receptor, G protein-coupled receptor-1 (GPR1), whose signaling and function remains unknown.
Chemerin is a novel regulator of lactogenesis in bovine mammary epithelial cells.
Roh et al., Sendai, Japan. In Biochem Biophys Res Commun, Nov 2015
G protein-coupled receptor 1 (GPR1), another receptor of chemerin, was undetectable in MAC-T cells.
Constitutive Activity among Orphan Class-A G Protein Coupled Receptors.
Aronstam et al., Rolla, United States. In Plos One, 2014
Five patterns of activity were noted: 1) inhibition under both baseline and forskolin stimulated expression (GPR15, GPR17, GPR18, GPR20, GPR25, GPR27, GPR31, GPR32, GPR45, GPR57, GPR68, GPR83, GPR84, GPR132, GPR150, GPR176); 2) no effect on baseline expression, but inhibition of forskolin stimulated expression (GPR4, GPR26, GPR61, GPR62, GPR78, GPR101, GPR119); 3) elevation of baseline signaling coupled with inhibition of forskolin stimulated expression (GPR6, GPR12); 4) elevation of baseline signaling without inhibition of forskolin stimulated expression (GPR3, GPR21, GPR52, GPR65); and 5) no effect on expression (GPR1, GPR19, GPR22, GPR34, GPR35, GPR39, GPR63, GPR82, GPR85, GPR87).
The expression and regulation of chemerin in the epidermis.
Cichy et al., Kraków, Poland. In Plos One, 2014
Chemerin is a protein ligand for the G protein-coupled receptor CMKLR1 and also binds to two atypical heptahelical receptors, CCRL2 and GPR1.
Genetic variation in imprinted genes is associated with risk of late-onset Alzheimer's disease.
Kamboh et al., Lahore, Pakistan. In J Alzheimers Dis, 2014
Gene-based analyses revealed four significant associations in the WT1, ZC3H12C, DLGAP2, and GPR1 genes at p < 0.05.
Expression of adiponectin, chemerin and visfatin in plasma and different tissues during a laying season in turkeys.
Dupont et al., France. In Reprod Biol Endocrinol, 2014
Visf receptor is still unknown whereas ADP and Chem mainly act through AdipoR1, AdipoR2 and CMKLR1 and GPR1 receptors, respectively.
Pheromone responsiveness is regulated by components of the Gpr1p-mediated glucose sensing pathway in Saccharomyces cerevisiae.
Wright et al., United States. In Yeast, 2014
We then determined the impact of GPR1 deletion on the mating pathway and observed that, in all end points studied, the mating pathway response to pheromone is reduced in the absence of Gpr1p.
Gpr1 is an active chemerin receptor influencing glucose homeostasis in obese mice.
Sinal et al., Halifax, Canada. In J Endocrinol, 2014
A second chemerin receptor, G protein-coupled receptor 1 (GPR1) in mammals, binds chemerin with an affinity similar to CMKLR1; however, the function of GPR1 in mammals is essentially unknown.
CHEMERIN (RARRES2) decreases in vitro granulosa cell steroidogenesis and blocks oocyte meiotic progression in bovine species.
Dupont et al., Tours, France. In Biol Reprod, 2014
Here we studied the expression of CHEMERIN and its three receptors (CMKLR1, GPR1, and CCRL2) in the bovine ovary and investigated the in vitro effects of this hormone on granulosa cell steroidogenesis and oocyte maturation.
The yeast Sks1p kinase signaling network regulates pseudohyphal growth and glucose response.
Kumar et al., Ann Arbor, United States. In Plos Genet, 2014
Epistasis studies place SKS1 downstream of the G-protein coupled receptor GPR1 and the G-protein RAS2 but upstream of or at the level of cAMP-dependent PKA.
Chemerin and its receptors in leukocyte trafficking, inflammation and metabolism.
Parmentier et al., Brussels, Belgium. In Cytokine Growth Factor Rev, 2011
Recently, two other receptors for chemerin were described, GPR1 and CCRL2, but their functional relevance is largely unknown.
Short communication: identification of the conformational requirement for the specificities of coreceptors for human and simian immunodeficiency viruses.
Hoshino et al., Maebashi, Japan. In Aids Res Hum Retroviruses, 2010
identified homologous amino acid sequences in amino-terminal regions between CCR5 and GPR1/ sequences are important for G protein-coupled receptors to make the conformation critical for the interaction with the Env protein of HIV-1.
G-protein-coupled receptor Gpr1 and G-protein Gpa2 of cAMP-dependent signaling pathway are involved in glucose-induced pexophagy in the yeast Saccharomyces cerevisiae.
Sibirny et al., L'viv, Ukraine. In Cell Biol Int, 2008
proteins Gpr1 and Gpa2 are involved in glucose sensing and signal transduction during pexophagy process in yeast
The synthetic peptide derived from the NH2-terminal extracellular region of an orphan G protein-coupled receptor, GPR1, preferentially inhibits infection of X4 HIV-1.
Hoshino et al., Maebashi, Japan. In J Biol Chem, 2005
Data report that a synthetic peptide derived from the NH2-terminal extracellular region of an orphan GPCR, GPR1, inhibited infection of not only an HIV-1 variant that uses GPR1 as a co-receptor, but also X4, R5, and R5X4 viruses.
Glucose modulation of cell size in yeast.
Alberghina et al., Milano, Italy. In Biochem Soc Trans, 2005
Since inactivation of extracellular glucose sensing through deletion of either the GPR1 or the GPA2 gene causes a marked, but partial, reduction in the ability to modulate cell size and protein content at Start, it is proposed that both extracellular and intracellular glucose signalling is required for properly setting the cell sizer in glucose media.
Senescence-associated genes in normal human oral keratinocytes.
Park et al., Los Angeles, United States. In Exp Cell Res, 2003
GPR1 is a senescence-associated gene in normal human oral keratinocytes.
Sensors of extracellular nutrients in Saccharomyces cerevisiae.
Ljungdahl et al., Stockholm, Sweden. In Curr Genet, 2001
Additionally, the G protein-coupled receptor Gpr1p has been shown to exhibit properties consistent with it being a sensor.
Co-receptor use by HIV and inhibition of HIV infection by chemokine receptor ligands.
Clapham et al., London, United Kingdom. In Immunol Rev, 2000
These included derivatives of a CCR5 ligand, RANTES, with modified N-termini as well as Kaposi's sarcoma-associated herpesvirus-encoded chemokines that bind a wide range of co-receptors, including CCR5, CXCR4, CCR3 and CCR8, as well as the orphan 7TM receptors GPR1 and STRL33.
Characterization of a new set of mutants deficient in fermentation-induced loss of stress resistance for use in frozen dough applications.
Thevelein et al., Leuven, Belgium. In Int J Food Microbiol, 2000
GPR1 encodes a member of the G-protein coupled receptor family which acts as a putative glucose receptor for activation of the Ras-cAMP pathway.
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