Platelet activation at the onset of human endotoxemia is undetectable in vivo.
Vienna, Austria. In Platelets, Feb 2016
Blood was drawn before, 10, 30 and 60 min after LPS challenge and platelet activation analyzed by flow cytometry (GPIIb/IIIa activation, surface CD62P and CD40L, intraplatelet reactive oxygen formation and platelet-leukocyte aggregates) and ELISA (sCD40L, sCD62P and CXCL4).
HoxA3 is an apical regulator of haemogenic endothelium.
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Minneapolis, United States. In Nat Cell Biol, 2011
We show here that HoxA3, a gene uniquely expressed in the embryonic but not yolk sac vasculature, restrains haematopoietic differentiation of the earliest endothelial progenitors, and induces reversion of the earliest haematopoietic progenitors into CD41-negative endothelial cells.