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Phosphatidylinositol glycan anchor biosynthesis, class C

This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI) lipid anchor biosynthesis. The GPI lipid anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. The encoded protein is one subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. Two alternatively spliced transcripts that encode the same protein have been found for this gene. A pseudogene on chromosome 11 has also been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: STEP, PIG-H, ACID, DSCR5, OUT
Papers on GPI2
GPI Anchor Modification Machinery Deficiency is Responsible for the Formation of Pro-PrP in BxPC-3 and Increases Cancer Cell Motility.
Li et al., China. In J Biol Chem, Jan 2016
We also identified 6 missense mutations in DPM2, PIG-C, PIG-N and PIG-P alongside 8 silent mutations.
Saccharomyces cerevisiae Gpi2, an accessory subunit of the enzyme catalyzing the first step of glycosylphosphatidylinositol (GPI) anchor biosynthesis, selectively complements some of the functions of its homolog in Candida albicans.
Komath et al., New Delhi, India. In Glycoconj J, 2014
GPI2 encodes for one of the six accessory subunits of the GPI-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the first step of GPI biosynthesis in S. cerevisiae and C. albicans.
First step of glycosylphosphatidylinositol (GPI) biosynthesis cross-talks with ergosterol biosynthesis and Ras signaling in Candida albicans.
Komath et al., New Delhi, India. In J Biol Chem, 2014
Using mutational analysis, we show that the accessory subunits, GPI2 and GPI19, of GPI-GnT exhibit opposite effects on ergosterol biosynthesis and Ras signaling (which determines hyphal morphogenesis).
Gpi19, the Saccharomyces cerevisiae homologue of mammalian PIG-P, is a subunit of the initial enzyme for glycosylphosphatidylinositol anchor biosynthesis.
Levin et al., Baltimore, United States. In Eukaryot Cell, 2005
The human enzyme has six known subunits, at least four of which, GPI1, PIG-A, PIG-C, and PIG-H, have functional homologs in the budding yeast Saccharomyces cerevisiae.
Genes for glycosylphosphatidylinositol toxin biosynthesis in Plasmodium falciparum.
Schofield et al., Melbourne, Australia. In Infect Immun, 2002
Moreover, we show preliminary evidence for the PIG-L and PIG-C genes.
The GPI1 homologue from Plasmodium falciparum complements a Saccharomyces cerevisiae GPI1 anchoring mutant.
Schwarz et al., Marburg an der Lahn, Germany. In Mol Biochem Parasitol, 2002
This chemically simple step is genetically complex because three or four genes are required in both yeast (GPI1, GPI2 and GPI3) and mammals (GPI1, PIG A, PIG H and PIG C), respectively.
The human GPI1 gene is required for efficient glycosylphosphatidylinositol biosynthesis.
Schubert et al., Hannover, Germany. In Gene, 2001
Six human genes encode subunits of this enzyme, namely PIG-A, PIG-C, PIG-H, PIG-P, GPI1, and DPM2.
Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2.
Kinoshita et al., Suita, Japan. In Embo J, 2000
Biosynthesis of GPI is initiated by GPI-N-acetylglucosaminyltransferase (GPI-GnT), which transfers N-acetylglucosamine from UDP- N-acetylglucosamine to phosphatidylinositol. GPI-GnT is a uniquely complex glycosyltransferase, consisting of at least four proteins, PIG-A, PIG-H, PIG-C and GPI1.
Characterisation of the enzymatic complex for the first step in glycosylphosphatidylinositol biosynthesis.
Schmidt et al., Hannover, Germany. In Int J Biochem Cell Biol, 2000
The mammalian N-acetylglucosaminyl transferase for the first step in glycosylphosphatidylinositol biosynthesis has been shown to consist of at least four components: PIG-A, PIG-C, PIG-H and GPI1.
GPI1 stabilizes an enzyme essential in the first step of glycosylphosphatidylinositol biosynthesis.
Kinoshita et al., Ōsaka, Japan. In J Biol Chem, 1999
In mammalian cells, this reaction is mediated by a complex of PIG-A, PIG-H, PIG-C, and GPI1.
Cloning of two putative Giardia lamblia glucosamine 6-phosphate isomerase genes only one of which is transcriptionally activated during encystment.
Jarroll et al., Cleveland, United States. In J Eukaryot Microbiol, 1998
Two genes, gpi1 and gpi2, encoding putative glucosamine 6-phosphate isomerases were identified but one, gpi1 was expressed.
Human and mouse Gpi1p homologues restore glycosylphosphatidylinositol membrane anchor biosynthesis in yeast mutants.
Schmidt et al., Hannover, Germany. In Biochem J, 1998
The products of three mammalian genes, PIG-A, PIG-C and PIG-H, have previously been shown to be involved in the putative enzymic complex.
The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1.
Kinoshita et al., Ōsaka, Japan. In Embo J, 1998
Mammalian PIG-A and PIG-C are homologous to yeast GPI3 and GPI2, respectively; however, mammalian PIG-H is not homologous to yeast GPI1.
Gpi1, a Saccharomyces cerevisiae protein that participates in the first step in glycosylphosphatidylinositol anchor synthesis.
Orlean et al., Urbana, United States. In J Biol Chem, 1996
Homozygous gpi1/gpi1, gpi1::URA3/gpi1::URA3, gpi2/gpi2, and gpi3/gpi3 diploids undergo meiosis, but are defective in ascospore wall maturation for they fail to give the fluorescence due to the dityrosine-containing layer in the ascospore wall.
Endothelium-derived constricting factor(s): the last novelty--endothelin.
Wennmalm et al., Warsaw, Poland. In Clin Physiol, 1990
Under certain conditions endothelial cells have been shown to produce powerful vasodilators, like endothelium-derived relaxing factor (EDRF) and prostacyclin (GPI2), and vasoconstrictors like endothelium-derived constricting factor (EDCF) and endothelin (ET) (Griffith et al., 1988; Vanhoutte & Katusic, 1988).
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