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GPD1 Gpd1p

GPD1, Gdc-1, TDH1, Gpd1p
This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012] (from NCBI)
Papers on GPD1
Transient infantile hypertriglyceridemia, fatty liver, and hepatic fibrosis caused by mutated GPD1, encoding glycerol-3-phosphate dehydrogenase 1.
Shamir et al., Petah Tikva, Israel. In Am J Hum Genet, 2012
Mutation analysis revealed a homozygous splicing mutation, c.361-1G>C, which resulted in an aberrantly spliced mRNA in the ten affected individuals.
The influence of obstructive sleep apnea on the expression of glycerol-3-phosphate dehydrogenase 1 gene.
Tufik et al., São Paulo, Brazil. In Exp Biol Med (maywood), 2010
The expression levels of the GPD1 gene did not differ between patients with OSA and their matched controls. The results were not affected by the clinical and biochemical measurements, the sleep parameters or the severity of nocturnal hypoxemia.
Decreased levels of metabolic enzymes in pancreatic islets of patients with type 2 diabetes.
Ostenson et al., Madison, United States. In Diabetologia, 2009
The activities of glycerol phosphate dehydrogenase were decreased by 73% in pancreatic islets of patients with type 2 diabetes.
[Colorectal cancer 2D-proteomics: identification of altered protein expression].
Beresten' et al., In Mol Biol (mosk), 2009
the discovery overexpression of GPD1 and RRBP1 proteins and lack of expression for HNRNPH1 and SERPINB6 proteins which are new candidate biomarkers of colon cancer.
Glycolytic enzyme GAPDH promotes peroxide stress signaling through multistep phosphorelay to a MAPK cascade.
Shiozaki et al., Davis, United States. In Mol Cell, 2008
Data show that the glyceraldehyde-3-phosphate dehydrogenase Tdh1 physically associates with the Mcs4 response regulator and stress-responsive MAP kinase kinase kinases.
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