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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Relaxin/insulin-like family peptide receptor 3

G protein-coupled receptor of the family of rhodopsin-type GPCRs [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: LGR7, Insulin, Neuropeptide, CAN, V1a
Papers on GPCR135
Role of relaxin-3/RXFP3 system in stress-induced binge-like eating in female rats.
Timofeeva et al., Québec, Canada. In Neuropharmacology, Mar 2016
The neuropeptide relaxin-3 (RLN3) and its native receptor RXFP3 are implicated in stress and appetitive behaviors.
Increased alcohol consumption in relaxin-3 deficient male mice.
Tanaka et al., Kyoto, Japan. In Neurosci Lett, Jan 2016
In addition, recently relaxin-3 and its receptor, RXFP3, were shown to regulate alcohol intake using an RXFP3 antagonist and RXFP3 gene knockout mice.
Altered relaxin family receptors RXFP1 and RXFP3 in the neocortex of depressed Alzheimer's disease patients.
Lai et al., Singapore, Singapore. In Psychopharmacology (berl), Dec 2015
RATIONALE: The G-protein-coupled relaxin family receptors RXFP1 and RXFP3 are widely expressed in the cortex and are involved in stress responses and memory and emotional processing.
Relaxin-3 receptor (Rxfp3) gene deletion reduces operant sucrose- but not alcohol-responding in mice.
Lawrence et al., Melbourne, Australia. In Genes Brain Behav, Nov 2015
We have shown previously that brain relaxin-3 mRNA levels positively correlate with sucrose and alcohol intake, and that central antagonism of relaxin-3 receptors (RXFP3) attenuates alcohol self-administration and alcohol-seeking in rats, but food-seeking behaviour and palatable food consumption in mice.
Anxiogenic drug administration and elevated plus-maze exposure in rats activate populations of relaxin-3 neurons in the nucleus incertus and serotonergic neurons in the dorsal raphe nucleus.
Hale et al., Australia. In Neuroscience, Oct 2015
Relaxin-3 is the native neuropeptide ligand for the Gi/o-protein-coupled receptor, RXFP3, and is primarily expressed in the nucleus incertus (NI), a tegmental region immediately caudal to the DR.
Involvement of central relaxin-3 signalling in sodium (salt) appetite.
Lawrence et al., Melbourne, Australia. In Exp Physiol, Sep 2015
Here, we tested the contribution made by relaxin family peptide 3 receptor (RXFP3), the cognate G-protein-coupled receptor for the neuropeptide relaxin-3.
The pre-vertebrate origins of neurogenic placodes.
Levine et al., Berkeley, United States. In Nature, Sep 2015
The Ciona PPE is shown to produce ciliated neurons that express genes for gonadotropin-releasing hormone (GnRH), a G-protein-coupled receptor for relaxin-3 (RXFP3) and a functional cyclic nucleotide-gated channel (CNGA), which suggests dual chemosensory and neurosecretory activities.
Orthosteric, Allosteric and Biased Signalling at the Relaxin-3 Receptor RXFP3.
Summers et al., Melbourne, Australia. In Neurochem Res, Sep 2015
The peptide acts on its cognate receptor RXFP3 to induce coupling to inhibitory G proteins to inhibit adenylyl cyclase and activate MAP-kinases such as ERK1/2, p38MAPK and JNK.
The relaxin family peptide receptors and their ligands: new developments and paradigms in the evolution from jawless fish to mammals.
Good et al., Winnipeg, Canada. In Gen Comp Endocrinol, 2015
Most placental mammals harbour genes for four receptors, namely rxfp1, rxfp2, rxfp3 and rxfp4.
International Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family peptide receptors 1-4, the receptors for relaxin family peptides.
Summers et al., Berlin, Germany. In Pharmacol Rev, 2014
Relaxin-3 is primarily a neuropeptide, and its cognate receptor RXFP3 is a target for the treatment of depression, anxiety, and autism.
[Relaxin-3 and relaxin family peptide receptors--from structure to functions of a newly discovered mammalian brain system].
Błasiak et al., In Postepy Hig Med Dosw (online), 2013
The endogenous relaxin-3 receptor (RXFP3) was identified and the anatomy of the yet uncharacterized mammalian brain system was described, with nucleus incertus as the main center of relaxin-3 expression.
Relaxin-3/RXFP3 networks: an emerging target for the treatment of depression and other neuropsychiatric diseases?
Gundlach et al., Melbourne, Australia. In Front Pharmacol, 2013
Relaxin-3 is a newly discovered neuropeptide that binds, and activates the G-protein coupled receptor, RXFP3.
Relaxin family peptides and their receptors.
Summers et al., Australia. In Physiol Rev, 2013
Relaxin-3 and INSL5 are the cognate ligands for RXFP3 and RXFP4 that are closely related to small peptide receptors that when activated inhibit cAMP production and activate MAP kinases.
Relaxin-3/RXFP3 Signaling and Neuroendocrine Function - A Perspective on Extrinsic Hypothalamic Control.
Gundlach et al., Melbourne, Australia. In Front Endocrinol (lausanne), 2012
Extensive anatomical data in rodents and non-human primate, and recent regulatory and functional data, suggest relaxin-3 signaling via its cognate GPCR, RXFP3, has a broad range of effects on neuroendocrine function associated with stress responses, feeding and metabolism, motivation and reward, and possibly sexual behavior and reproduction.
In vitro pharmacological characterization of RXFP3 allosterism: an example of probe dependency.
Bonaventure et al., San Diego, United States. In Plos One, 2011
demonstrate the existence of an allosteric site for modulation of RXFP3
Distribution of relaxin-3 and RXFP3 within arousal, stress, affective, and cognitive circuits of mouse brain.
Gundlach et al., Melbourne, Australia. In J Comp Neurol, 2010
Data provide evidence for the conserved nature of RLN3/RXFP3 systems in mammalian brain and the ability of RLN3/RXFP3 signaling to modulate "behavioral state" and an array of circuits involved in arousal, stress, affect, and cognition.
H2 relaxin is a biased ligand relative to H3 relaxin at the relaxin family peptide receptor 3 (RXFP3).
Summers et al., Australia. In Mol Pharmacol, 2010
H3 relaxin potently activates all signaling pathways coupled to RXFP3, whereas H2 relaxin is an AP-1-biased ligand relative to H3 relaxin.
Promoter hypermethylation of CIDEA, HAAO and RXFP3 associated with microsatellite instability in endometrial carcinomas.
Huang et al., Columbus, United States. In Gynecol Oncol, 2010
Methylation status of CIDEA, HAAO and RXFP3 had significant association with microsatellite instability in endometrial tumors.
The structural and functional role of the B-chain C-terminal arginine in the relaxin-3 peptide antagonist, R3(BDelta23-27)R/I5.
Wade et al., Melbourne, Australia. In Chem Biol Drug Des, 2009
Results decribe the structural and functional aspects of the interaction between relaxin-3 and its receptor, RXFP3.
International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides.
Summers et al., Melbourne, Australia. In Pharmacol Rev, 2006
In this review it is suggested that the receptors for relaxin (LGR7) and those for the related peptides insulin-like peptide 3 (LGR8), relaxin-3 (GPCR135), and insulin-like peptide 5 (LGPCR142) be named the relaxin family peptide receptors 1 through 4 (RXFP1-4).
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