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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Oxoeicosanoid

GPCR, TG1019
Top mentioned proteins: CAN, V1a, ACID, Rhodopsin, IRBP
Papers on GPCR
A 4-midable Connection: CCR7 Tetramers Link GPCR to Src Kinase Signaling.
New
Impact
Werth et al., Hannover, Germany. In Immunity, Feb 2016
UNASSIGNED: Chemokine receptors are known to signal through heterotrimeric G proteins.
S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-α autoamplification.
New
Rosen et al., Tokyo, Japan. In Proc Natl Acad Sci U S A, Feb 2016
These data illustrate a lipid G-protein coupled receptor (GPCR)-IFNAR1 regulatory loop that balances effective and detrimental immune responses and elevated endogenous S1PR1 signaling.
Modular activation of Rho1 by GPCR signalling imparts polarized myosin II activation during morphogenesis.
New
Impact
Lecuit et al., Marseille, France. In Nat Cell Biol, Feb 2016
We identify a ubiquitously expressed GPCR called Smog required for cell intercalation and apical constriction.
Biased agonism: An emerging paradigm in GPCR drug discovery.
Review
New
Bohn et al., Indianapolis, United States. In Bioorg Med Chem Lett, Feb 2016
This pinnacle observation has changed a previously held notion of the linear spectrum of GPCR efficacy and uncovered a new paradigm in GPCR research and drug discovery that relies on multidimensionality of GPCR signaling.
Feedback Regulation of G Protein-Coupled Receptor Signaling by GRKs and Arrestins.
Review
New
Daaka et al., Durham, United States. In Semin Cell Dev Biol, Feb 2016
UNASSIGNED: GPCR are ubiquitous in mammalian cells and present intricate mechanisms for cellular signaling and communication.
Design of Next-Generation G Protein-Coupled Receptor Drugs: Linking Novel Pharmacology and In Vivo Animal Models.
New
Impact
Tobin et al., Leicester, United Kingdom. In Annu Rev Pharmacol Toxicol, Feb 2016
Here, we present optimism that this may change in the future by reviewing the substantial progress made in the understanding of GPCR molecular pharmacology that has generated an extensive toolbox of ligand types that include orthosteric, allosteric, and bitopic ligands, many of which show signaling bias.
G Protein-Coupled Receptor Heteromers.
New
Impact
Devi et al., France. In Annu Rev Pharmacol Toxicol, Feb 2016
We conclude that advances in approaches to study receptor complex functionality in heterologous systems, coupled with techniques that enable specific examination of native receptor heteromers in vivo, are likely to establish GPCR heteromers as novel therapeutic targets.
Epidermal Growth Factor Receptor Transactivation: Mechanisms, Pathophysiology, and Potential Therapies in the Cardiovascular System.
New
Impact
Eguchi et al., Australia. In Annu Rev Pharmacol Toxicol, Feb 2016
The capacity of G protein-coupled receptor (GPCR) agonists, such as angiotensin II (AngII), to promote EGFR signaling is called transactivation and is well described, yet delineating the molecular processes and functional relevance of this crosstalk has been challenging.
Role of ocular albinism type 1 (OA1) GPCR in Asian gypsy moth development and transcriptional expression of heat-shock protein genes.
New
Cao et al., Harbin, China. In Pestic Biochem Physiol, Jan 2016
The ocular albinism type 1 gene, named OA1, is a coding pigment cell-specific G protein-coupled receptor exclusively localized in intracellular organelles.
The Pharmacology and Function of Short Chain Fatty Acid Receptors.
Review
New
Moss et al., Glasgow, United Kingdom. In Mol Pharmacol, Jan 2016
UNASSIGNED: Despite some block-buster G protein-coupled receptor (GPCR) drugs only a small fraction (~15%) of the more than 390 non-odorant GPCRs have been successfully targeted by the pharmaceutical industry.
The atypical antipsychotic, olanzapine, potentiates ghrelin-induced receptor signaling: An in vitro study with cells expressing cloned human growth hormone secretagogue receptor.
New
Uezono et al., Tokyo, Japan. In Neuropeptides, Jan 2016
UNASSIGNED: The growth hormone secretagogue receptor (GHS-R) belongs to Gαq-coupled G protein-coupled receptor (GPCR) that mediates growth hormone release, food intake, appetite, glucose metabolism and body composition.
Regulation of N-Formyl Peptide Receptor Signaling and Trafficking by Arrestin-Src Kinase Interaction.
New
Prossnitz et al., Albuquerque, United States. In Plos One, Dec 2015
It was later revealed that arrestins also mediate GPCR internalization and recruit a number of signaling proteins including, but not limited to, Src family kinases, ERK1/2, and JNK3.
Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension.
New
Nishida et al., Okazaki, Japan. In Sci Signal, Dec 2015
In our investigation of how Ang II signals are converted by the AT1R from physiological to pathological outputs, we found that the purinergic P2Y6 receptor (P2Y6R), an inflammation-inducible G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor (GPCR), promoted Ang II-induced hypertension in mice.
Transactivation of Epidermal Growth Factor Receptor by G Protein-Coupled Receptors: Recent Progress, Challenges and Future Research.
Review
Wang, Edmonton, Canada. In Int J Mol Sci, 2014
Since the first report of EGFR transactivation by GPCR, significant progress has been made including the elucidation of the mechanisms underlying the transactivation.
Function and Regulation of Heterotrimeric G Proteins during Chemotaxis.
Review
Kortholt et al., Groningen, Netherlands. In Int J Mol Sci, 2014
In this review, we will discuss the different levels of regulation in GPCR signaling and the downstream pathways that are essential for proper chemotaxis.
Expression of 5-oxoETE receptor in prostate cancer cells: critical role in survival.
GeneRIF
Ghosh et al., Detroit, United States. In Biochem Biophys Res Commun, 2006
5-oxoER is critical for prostate cancer cell survival.
Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils.
GeneRIF
Finan et al., Burgess Hill, United Kingdom. In Mol Pharmacol, 2003
identification and cloning of a novel GPCR, R527; 5-oxo-ETE was identified as the ligand for R527; very high level of mRNA expression in eosinophils with high expression also detected in neutrophils and lung macrophages
Identification of a novel human eicosanoid receptor coupled to G(i/o).
GeneRIF
Ohnuki et al., Toda, Japan. In J Biol Chem, 2002
Identification of a novel human receptor coupled to G(i/o).
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