Biased agonism: An emerging paradigm in GPCR drug discovery.
Indianapolis, United States. In Bioorg Med Chem Lett, Feb 2016
This pinnacle observation has changed a previously held notion of the linear spectrum of GPCR efficacy and uncovered a new paradigm in GPCR research and drug discovery that relies on multidimensionality of GPCR signaling.
G Protein-Coupled Receptor Heteromers.
France. In Annu Rev Pharmacol Toxicol, Feb 2016
We conclude that advances in approaches to study receptor complex functionality in heterologous systems, coupled with techniques that enable specific examination of native receptor heteromers in vivo, are likely to establish GPCR heteromers as novel therapeutic targets.