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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Glypican 6

GPC6, glypican 6
The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and they have been implicated in the control of cell growth and cell division. The glypican encoded by this gene is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. [provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: GPC3, GPC5, glypican-1, glypican-4, CAN
Papers on GPC6
Whole-genome association analysis of treatment response in obsessive-compulsive disorder.
New
Shugart et al., Bethesda, United States. In Mol Psychiatry, Feb 2016
The other 35 variations with signals of potential significance (P<10(-4)) involve multiple genes expressed in the brain, including GRIN2B, PCDH10 and GPC6.
Cell surface heparan sulfate proteoglycans as novel markers of human neural stem cell fate determination.
New
Haupt et al., Brisbane, Australia. In Stem Cell Res, Jan 2016
Furthermore, neuronal differentiation of the cells upregulated SDC4, GPC1, GPC2, GPC3 and GPC6 expression with increased GPC4 expression observed under astrocyte culture conditions.
Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk.
New
Phelan et al., Tampa, United States. In Genet Epidemiol, Dec 2015
In the larger dataset, GPC6/GPC5 rs17702471 was associated with the endometrioid subtype among Caucasians (odds ratio (OR) = 1.16, 95% CI = 1.07-1.25,
Genome-wide Association Study of Autism Spectrum Disorder in the East Asian Populations.
New
Gau et al., Tokyo, Japan. In Autism Res, Sep 2015
In the discovery stage, significant associations were suggested for 14 loci, including 5 known ASD candidate genes: GPC6, JARID2, YTHDC2, CNTN4, and CSMD1.
T-Brain-1--A Potential Master Regulator in Autism Spectrum Disorders.
New
Hsueh et al., Taipei, Taiwan. In Autism Res, Aug 2015
A further five of the 24 genes (Cd44, Cdh8, Cntn6, Gpc6, and Ntng1) encode membrane proteins that regulate cell adhesion and axonal outgrowth.
Diagnostic and prognostic significance of glypican 5 and glypican 6 gene expression levels in gastric adenocarcinoma.
New
Tukun et al., Ankara, Turkey. In Mol Clin Oncol, May 2015
In this study, we aimed to investigate the diagnostic and prognostic significance of the expression levels of the glypican 5 and glypican 6 genes (GPC5 and GPC6, respectively) in gastric cancer.
Whole genome microarray analysis in non-small cell lung cancer.
New
Toncheva et al., Sofia, Bulgaria. In Biotechnol Biotechnol Equip, Feb 2015
GPC6 (13q32.1).
Overexpression of GPC6 and TMEM132D in Early Stage Ovarian Cancer Correlates with CD8+ T-Lymphocyte Infiltration and Increased Patient Survival.
Sandaltzopoulos et al., Alexandroúpolis, Greece. In Biomed Res Int, 2014
In the present study, we validated by qPCR the expression of two genes encoding the transmembrane proteins GPC6 and TMEM132D in a cohort of early stage ovarian cancer patients.
The transmembrane heparan sulphate proteoglycan syndecan-4 is involved in establishment of the lamellar structure of the annulus fibrosus of the intervertebral disc.
Hayes et al., Cardiff, United Kingdom. In Eur Cell Mater, 2014
In this study, we investigate the role of two cell surface heparan sulphate proteoglycans (HSPGs), glypican-6 and syndecan-4, in the matrix assembly process in the developmental rat intervertebral disc.
A novel (paternally inherited) duplication 13q31.3q32.3 in a 12-year-old patient with facial dysmorphism and developmental delay.
Balasubramanian et al., Sheffield, United Kingdom. In Mol Syndromol, 2014
This region contains 24 OMIM genes, including the glypicans GPC5 and GPC6, and the ZIC2 gene.
The role of glypicans in Hedgehog signaling.
Review
Capurro et al., Canada. In Matrix Biol, 2014
Six glypicans have been found in the mammalian genome (GPC1 to GPC6).
Boning up on glypicans--opportunities for new insights into bone biology.
Review
Powell et al., Adelaide, Australia. In Cell Biochem Funct, 2013
Analyses of gene knockout models and the human conditions of Simpson-Golabi-Behmel syndrome and omodysplasia, which arise from mutations in glypican 3 (GPC3) and GPC6, respectively, highlight both subtle and striking effects of glypicans on bone growth.
Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors.
Impact
GeneRIF
Barres et al., Stanford, United States. In Nature, 2012
data identify glypicans as a family of novel astrocyte-derived molecules that are necessary and sufficient to promote glutamate receptor clustering and receptivity and to induce the formation of postsynaptically functioning CNS synapses
NFAT promotes carcinoma invasive migration through glypican-6.
GeneRIF
Toker et al., Boston, United States. In Biochem J, 2011
GPC6 promotes invasive migration by inhibition of canonical beta-catenin and Wnt signalling, and up-regulation of non-canonical Wnt5A signalling leading to the activation of JNK and p38 MAPK.
Allelic imbalance at 13q31 is associated with reduced GPC6 in Chinese with sporadic retinoblastoma.
GeneRIF
Choy et al., Hong Kong, Hong Kong. In Br J Ophthalmol, 2010
a reduction in GPC6 mRNA in retinoblastoma is associated with the non-random allelic loss at 13q31 that could contribute to RB development.
Mutations in the heparan-sulfate proteoglycan glypican 6 (GPC6) impair endochondral ossification and cause recessive omodysplasia.
GeneRIF
Bonafé et al., Lausanne, Switzerland. In Am J Hum Genet, 2009
Mutations in the heparan-sulfate proteoglycan glypican 6 impair endochondral ossification and cause recessive omodysplasia
Glypicans.
Review
Rast et al., Toronto, Canada. In Genome Biol, 2007
There are six family members in mammals (GPC1 to GPC6).
Glypicans in growth control and cancer.
Review
Filmus, Toronto, Canada. In Glycobiology, 2001
To date, six family members of this family have been identified in mammals (GPC1 to GPC6) and two in Drosophila.
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