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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Glypican 5

GPC5, glypican-5
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, GPC6, GPC3, ACID, CAN
Papers using GPC5 antibodies
Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly
Supplier
Filmus Jorge et al., In The Journal of Cell Biology, 2005
... The full-length human GPC5 DNA was obtained from OriGene Technologies and cloned into ...
Papers on GPC5
A targeted functional RNA interference screen uncovers glypican 5 as an entry factor for hepatitis B and D viruses.
New
Baumert et al., Strasbourg, France. In Hepatology, Jan 2016
Using a targeted RNA interference entry screen, we identified glypican 5 as a common host cell entry factor for hepatitis B and delta viruses.
Prognostic significance of GPC5 expression in patients with prostate cancer.
New
Zhang et al., Tianjin, China. In Tumour Biol, Jan 2016
UNASSIGNED: The objective of this study was to evaluate the protein level of glypican-5 (GPC5) and its relationship with clinicopathologic significance in prostate cancer.
Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk.
New
Phelan et al., Tampa, United States. In Genet Epidemiol, Dec 2015
In the larger dataset, GPC6/GPC5 rs17702471 was associated with the endometrioid subtype among Caucasians (odds ratio (OR) = 1.16, 95% CI = 1.07-1.25,
Glypican-5 Increases Susceptibility to Nephrotic Damage in Diabetic Kidney.
New
Noiri et al., Tokyo, Japan. In Am J Pathol, Jul 2015
We recently identified the gene for glypican-5 (GPC5), a cell-surface heparan sulfate proteoglycan, as conferring susceptibility for acquired nephrotic syndrome and additionally identified an association through a genome-wide association study between a variant in GPC5 and DN of type 2 diabetes mellitus.
Diagnostic and prognostic significance of glypican 5 and glypican 6 gene expression levels in gastric adenocarcinoma.
New
Tukun et al., Ankara, Turkey. In Mol Clin Oncol, May 2015
In this study, we aimed to investigate the diagnostic and prognostic significance of the expression levels of the glypican 5 and glypican 6 genes (GPC5 and GPC6, respectively) in gastric cancer.
Transcriptional Dynamics of Immortalized Human Mesenchymal Stem Cells during Transformation.
Akagi et al., Ibaraki, Japan. In Plos One, 2014
In particular, glypican-5 (GPC5), which encodes a cell-surface proteoglycan that might be a biomarker for sarcoma, was expressed at high levels in association with transformation.
Proteoglycan-based diversification of disease outcome in head and neck cancer patients identifies NG2/CSPG4 and syndecan-2 as unique relapse and overall survival predicting factors.
Perris et al., Bologna, Italy. In Bmc Cancer, 2014
RESULTS: HNSCC lesions were indeed found to exhibit a widely aberrant PG expression pattern characterized by a variable expression of all PGs and a characteristic de novo transcription/translation of GPC2, GPC5 and NG2/CSPG4 respectively in 36%, 72% and 71% on 119 cases.
The MicroRNA-217 Functions as a Potential Tumor Suppressor in Gastric Cancer by Targeting GPC5.
Gao et al., Kunming, China. In Plos One, 2014
Moreover, Glypican-5 (GPC5), a new ocncogene, was identified as the potential target of miR-217.
Polymorphisms in C-reactive protein and Glypican-5 are associated with lung cancer risk and Gartrokine-1 influences Cisplatin-based chemotherapy response in a Chinese Han population.
Chen et al., Xi'an, China. In Dis Markers, 2014
Gender-specific analysis in each model showed that genotypes "T/T" and "C/C" in rs2352028 of the Glypican 5 (GPC5) were associated with increased LC risk in males.
The role of glypicans in Hedgehog signaling.
Review
Capurro et al., Canada. In Matrix Biol, 2014
In addition, we will discuss the mechanism by which loss-of-function GPC3 mutations alter Hh signaling in the Simpson-Golabi-Behmel overgrowth syndrome, and the molecular basis of the GPC5-induced stimulation of Hh signaling and tumor progression in rhabdomyosarcomas.
Post-axial polydactyly type A2, overgrowth and autistic traits associated with a chromosome 13q31.3 microduplication encompassing miR-17-92 and GPC5.
Review
Bonafé et al., Toronto, Canada. In Eur J Med Genet, 2013
Microdeletions leading to haploinsufficiency of miR17∼92, a cluster of micro RNA genes closely linked to GPC5 in both mouse and human genomes, has recently been associated with digital anomalies in the Feingold like syndrome.
GPC5 rs2352028 polymorphism and risk of lung cancer in Han Chinese.
GeneRIF
Liu et al., Chicago, United States. In Cancer Invest, 2012
findings suggested that SNP rs2352028 in GPC5 might confer a slight risk to lung cancer/adenocarcinoma
Common variation in GPC5 is associated with acquired nephrotic syndrome.
Impact
Noiri et al., Tokyo, Japan. In Nat Genet, 2011
Here we identify an association between variants in GPC5, encoding glypican-5, and acquired nephrotic syndrome through a genome-wide association study and replication analysis (P value under a recessive model (P(rec)) = 6.0 × 10(-11), odds ratio = 2.54).
Glypican-5 stimulates rhabdomyosarcoma cell proliferation by activating Hedgehog signaling.
GeneRIF
Filmus et al., Toronto, Canada. In J Cell Biol, 2011
GPC5 stimulates Hh signaling by facilitating/stabilizing the interaction between Hh and Ptc1.
The genetics of multiple sclerosis: an update 2010.
Review
Akkad et al., Bochum, Germany. In Mol Cell Probes, 2010
In particular, GPC5 has already been confirmed to be an IFNb response gene in an independent study.
Association to the Glypican-5 gene in multiple sclerosis.
GeneRIF
Harbo et al., Oslo, Norway. In J Neuroimmunol, 2010
This study supports that multiple sclerosis susceptibility at 13q31-32 may localize to the Glypican-5 gene.
GPC5 rs2352028 variant and risk of lung cancer in never smokers.
Impact
GeneRIF
Brennan et al., In Lancet Oncol, 2010
No association between GPC5rs2352028 variant and lung cancer in never smokers in meta-analysis of 7 genome-wide association studies under the random effects model.
IFN-beta pharmacogenomics in multiple sclerosis.
Review
Comabella et al., Leioa, Spain. In Pharmacogenomics, 2010
One hit, glypican 5 (GPC5), was recently replicated in an independent study of IFN-beta responsiveness.
Genetic variants and risk of lung cancer in never smokers: a genome-wide association study.
Impact
GeneRIF
Yang et al., Rochester, United States. In Lancet Oncol, 2010
GPC5 polymorphism associated with susceptibility to lung cancer in never smokers
Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest.
GeneRIF
Chugh et al., Baltimore, United States. In Plos One, 2009
GPC5 is a novel genetic locus protective against sudden cardiac arrest
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