Glypican-5 Increases Susceptibility to Nephrotic Damage in Diabetic Kidney.
Tokyo, Japan. In Am J Pathol, Jul 2015
We recently identified the gene for glypican-5 (GPC5), a cell-surface heparan sulfate proteoglycan, as conferring susceptibility for acquired nephrotic syndrome and additionally identified an association through a genome-wide association study between a variant in GPC5 and DN of type 2 diabetes mellitus.
The role of glypicans in Hedgehog signaling.
Canada. In Matrix Biol, 2014
In addition, we will discuss the mechanism by which loss-of-function GPC3 mutations alter Hh signaling in the Simpson-Golabi-Behmel overgrowth syndrome, and the molecular basis of the GPC5-induced stimulation of Hh signaling and tumor progression in rhabdomyosarcomas.