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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Glypican 3

GPC3, glypican-3
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: CAN, AFP, HAD, HCCS, GPC
Papers on GPC3
Combined use of heat-shock protein 70 and glutamine synthetase is useful in the distinction of typical hepatocellular adenoma from atypical hepatocellular neoplasms and well-differentiated hepatocellular carcinoma.
New
Kakar et al., San Francisco, United States. In Mod Pathol, Feb 2016
This study evaluates the efficacy of combined use of heat-shock protein 70 (HSP70), glutamine synthetase (GS) and glypican-3 in this setting.
Expression profile and prognostic value of glypican-3 in post-operative South Korean hepatocellular carcinoma patients.
New
Jeong et al., Seoul, South Korea. In Apmis, Feb 2016
Glypican-3 (GPC3) has been suggested as a prognostic biomarker for post-operative survival.
Glypican-3 is a prognostic factor and an immunotherapeutic target in hepatocellular carcinoma.
Review
New
Kataoka et al., Miyazaki, Japan. In World J Gastroenterol, Feb 2016
Glypican-3 (GPC3) is a cell surface oncofetal proteoglycan that is anchored by glycosylphosphatidylinositol.
A phase I/IIa study of adjuvant immunotherapy with tumour antigen-pulsed dendritic cells in patients with hepatocellular carcinoma.
New
Kim et al., Seoul, South Korea. In Br J Cancer, Jan 2016
Dendritic cell vaccines pulsed with cytoplasmic transduction peptide-attached alpha-fetoprotein, glypican-3 and melanoma-associated antigen 1 recombinant fusion proteins were injected subcutaneously near to inguinal lymph nodes.
Distinctive findings in a boy with Simpson-Golabi-Behmel syndrome.
New
Bouden et al., Manouba, Tunisia. In Am J Med Genet A, Jan 2016
We report the case of a 6-year-old boy, with confirmed deletion of 6-8 exons of the glypican-3 gene (GPC3) who presents three distinctive findings: the persistence of the craniopharyngeal canal, an immune-allergic specificity, and a scarcely behavioral phenotype consisting in the association of Austim Spectrum Disorder with accompanying mild intellectual disability and language impairments.
Cell surface heparan sulfate proteoglycans as novel markers of human neural stem cell fate determination.
New
Haupt et al., Brisbane, Australia. In Stem Cell Res, Jan 2016
Furthermore, neuronal differentiation of the cells upregulated SDC4, GPC1, GPC2, GPC3 and GPC6 expression with increased GPC4 expression observed under astrocyte culture conditions.
Adoptive immunotherapy using T lymphocytes redirected to glypican-3 for the treatment of lung squamous cell carcinoma.
New
Li et al., Shanghai, China. In Oncotarget, Jan 2016
Therefore, in this study, we explored the antitumor potential of third-generation glypican 3 (GPC3)-redirected chimeric antigen receptor (CAR)-engineered T lymphocytes (CARgpc3 T cells) in tumor models of LSCC.
Iron-Oxide-Based Nanovector for Tumor Targeted siRNA Delivery in an Orthotopic Hepatocellular Carcinoma Xenograft Mouse Model.
New
Zhang et al., Seattle, United States. In Small, Jan 2016
The nanovector (NP-siRNA-GPC3 Ab) is made of an iron oxide core coated with chitosan-polyethylene glycol (PEG) grafted polyethyleneimine copolymer, which is further functionalized with siRNA and conjugated with a monoclonal antibody (Ab) against human glypican-3 (GPC3) receptor highly expressed in HCC.
Identification of genomic aberrations in hemangioblastoma by droplet digital PCR and SNP microarray highlights novel candidate genes and pathways for pathogenesis.
New
Toren et al., Tel Aviv-Yafo, Israel. In Bmc Genomics, Dec 2015
CONCLUSIONS: Our findings provide the first high-resolution genome-wide view of chromosomal changes in hemangioblastoma and identify 23 candidate genes: EGFR, PRDM16, PTPN11, HOXD11, HOXD13, FLT3, PTCH, FGFR1, FOXP1, GPC3, HOXC13, HOXC11, MKL1, CHEK2, IRF4, GPHN, IKZF1, RB1, HOXA9, and micro RNA, such as hsa-mir-196a-2 for hemangioblastoma pathogenesis.
Biomarkers for the early diagnosis of hepatocellular carcinoma.
Review
New
Nakatsura et al., Yokohama, Japan. In World J Gastroenterol, Nov 2015
The most promising biomarkers, such as glypican-3, osteopontin, Golgi protein-73 and nucleic acids including microRNAs, are most likely to become clinically validated in the near future.
Glypican-3 is a biomarker and a therapeutic target of hepatocellular carcinoma.
Review
New
Yao et al., Nantong, China. In Hepatobiliary Pancreat Dis Int, Aug 2015
This review summarized the recent studies of oncofetal glypican-3 (GPC-3), a membrane-associated heparan sulfate proteoglycan, in the diagnosis and treatment of HCC.
Current concepts in the immunohistochemical evaluation of liver tumors.
Review
New
Lagana et al., New York City, United States. In World J Hepatol, Jul 2015
A panel of immunohistochemical stains including glypican-3 (GPC-3), heat shock protein 70, and GS are useful in distinguishing HCC from non-malignant dysplastic nodules.
Current trends and recent advances in diagnosis, therapy, and prevention of hepatocellular carcinoma.
Review
Kuo et al., Tainan City, Taiwan. In Asian Pac J Cancer Prev, 2014
Based on in-depth reviews of serological diagnosis of HCC, in addition to AFP, there are other biomarkers: Lens culinaris agglutinin-reactive AFP (AFP-L3), des- carboxyprothrombin (DCP), tyrosine kinase with Ig and eprdermal growth factor (EGF) homology domains 2 (TIE2)-espressing monocytes (TEMs), glypican-3 (GPC3), Golgi protein 73 (GP73), interleukin-6 (IL-6), and squamous cell carcinoma antigen (SCCA) have been proposed as biomarkers for the early detection of HCC.
Immunohistochemical expression of glypican 3 in endometrial carcinoma and correlation with prognostic parameters.
Raboh et al., Cairo, Egypt. In Int J Clin Exp Pathol, 2014
Glypican 3 is one of six mammalian members of the glypican family of proteoglycans.
Arginase-1: a novel immunohistochemical marker of hepatocellular differentiation in fine needle aspiration cytology.
GeneRIF
Siddiqui et al., Atlanta, United States. In Cancer Cytopathol, 2012
Loss of glypican 3 is associated with metastasis in hepatocellular carcinoma.
Diagnostic utility of CD117, CD133, SALL4, OCT4, TCL1 and glypican-3 in malignant germ cell tumors of the ovary.
GeneRIF
Kikkawa et al., Nagoya, Japan. In J Obstet Gynaecol Res, 2012
glypican 3 is strongly positive in yolk sac tumors but is not as specific a tumor marker as SALL4 for that tumor type.
Silencing glypican-3 expression induces apoptosis in human hepatocellular carcinoma cells.
GeneRIF
Zeng et al., Lanzhou, China. In Biochem Biophys Res Commun, 2012
The results suggest that GPC3 regulates cell proliferation by enhancing the resistance to apoptosis through the dysfunction of the Bax/Bcl-2/cytochrome c/caspase-3 signaling pathway and therefore plays a critical role in the tumorigenesis of hepatocellular carcinoma.
MiR-219-5p inhibits hepatocellular carcinoma cell proliferation by targeting glypican-3.
GeneRIF
Luo et al., Guangzhou, China. In Febs Lett, 2012
These findings indicate that miR-219-5p exerts tumor-suppressive effects in hepatic carcinogenesis through negative regulation of glypican 3 expression [MiR-219-5p].
Glypican-3 is a marker for solid pseudopapillary neoplasm of the pancreas.
GeneRIF
Libbrecht et al., In Histopathology, 2011
GPC3 is a helpful ancillary diagnostic marker for pancreatic solid pseudopapillary neoplasm
Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome.
Impact
Schlessinger et al., Saint Louis, United States. In Nat Genet, 1996
The breakpoints occur near the 5' and 3' ends of a gene, GPC3, that spans more than 500 kilobases in Xq26; in three families, different microdeletions encompassing exons cosegregate with SGBS.
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