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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Glycophorin C

GPC, glycophorin C
Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: CAN, ACID, Glycophorin, HAD, V1a
Papers using GPC antibodies
Bioextrusion for tissue engineering applications
Supplier
Chiellini Federica et al., In International Journal of Biomaterials, 2007
... Chloroform used for GPC analysis was purchased from Sigma Aldrich.
Plasmacytoid dendritic cell precursors/type I interferon-producing cells sense viral infection by Toll-like receptor (TLR) 7 and TLR9
Supplier
Gupta Sudhir et al., In Aging (Albany NY), 2004
... in GC Reaction Buffer containing 60 units of GpC Methyltransferase (M.CviPI) and 160 μM S-adenosylmethionine from New England Biolabs (Ipswich, MA) at 37 ...
Papers on GPC
Synthesis, characterization and anticorrosion potentials of chitosan-g-PEG assembled on silver nanoparticles.
New
Tawfik et al., Cairo, Egypt. In Int J Biol Macromol, Feb 2016
The synthesized Ch-g-mPEG was characterized using gel permeation chromatography (GPC), Fourier transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance ((1)H NMR), and X-ray diffraction (XRD) techniques.
Biocompatible, Biodegradable, and Electroactive Polyurethane-Urea Elastomers with Tunable Hydrophilicity for Skeletal Muscle Tissue Engineering.
New
Ma et al., Xi'an, China. In Acs Appl Mater Interfaces, Jan 2016
The chemical structure, thermal properties, surface morphology, and processability of the PUU copolymers were characterized by NMR, FT-IR, gel permeation chromatography (GPC), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), atomic force microscopy (AFM), and solubility testing, respectively.
Analysis of assembly and budding of Lujo virus.
New
Yasuda et al., South Africa. In J Virol, Jan 2016
We analyzed its mechanism of viral release driven by matrix protein (Z) and glycoprotein (GPC).
ALTERATIONS OF RBC MEMBRANE PROTEINS IN DIABETIC PATIENTS WITH AND WITHOUT PERIODONTITIS.
New
Sanikidze et al., Tbilisi, Georgia. In Georgian Med News, Nov 2015
Reducing the negative charge (apparently caused by a decrease in the carring negative charge glycophorin C and band 3 protein content) and high molecular fraction (weight of 200, 116, 97, 55 kDa) proteins (due to a low content of Band 4.1, band 4.2, band 3 proteins, adducin and ankyrin, actively involved in the regulation of RBCs mechanical stability, deformability and shape) in RBCs membrane in patients with diabetes type-1 suffering from periodontitis, contributes to violation of RBC-RBC interactions as well disorders of their deformability and may induce adhesion of RBCs to the endothelium and disorders of blood circulation.
Arenavirus Quasispecies and Their Biological Implications.
Review
New
de la Torre et al., Los Angeles, United States. In Curr Top Microbiol Immunol, Nov 2015
The S genomic RNA encodes the virus nucleoprotein (NP) and the precursor (GPC) of the virus surface glycoprotein that mediates virus receptor recognition and cell entry via endocytosis.
Glypican-3 is a biomarker and a therapeutic target of hepatocellular carcinoma.
Review
New
Yao et al., Nantong, China. In Hepatobiliary Pancreat Dis Int, Aug 2015
This review summarized the recent studies of oncofetal glypican-3 (GPC-3), a membrane-associated heparan sulfate proteoglycan, in the diagnosis and treatment of HCC.
Current concepts in the immunohistochemical evaluation of liver tumors.
Review
New
Lagana et al., New York City, United States. In World J Hepatol, Jul 2015
A panel of immunohistochemical stains including glypican-3 (GPC-3), heat shock protein 70, and GS are useful in distinguishing HCC from non-malignant dysplastic nodules.
How unique is pure erythroid leukaemia? A retrospective analysis of seven cases and review of the literature.
Review
New
Juneja et al., Melbourne, Australia. In J Clin Pathol, Apr 2015
The leukaemic blasts frequently expressed glycophorin C (100%), CD117 (83%) and were myeloperoxidase negative (83%).
Modulation of Biofilm Exopolysaccharides by the Streptococcus mutans vicX Gene.
Hu et al., Chengdu, China. In Front Microbiol, 2014
Gel permeation chromatography (GPC) showed that the WIG isolated from the SmuvicX biofilms had a much lower molecular weight compared with the UA159 strain indicating differences in polysaccharide chain lengths.
Down-regulating glypican-3 expression: molecular-targeted therapy for hepatocellular carcinoma.
Review
Yao et al., Nantong, China. In Mini Rev Med Chem, 2013
Glypican-3 (GPC-3), a membrane-associated heparan sulfate proteoglycan, plays a crucial role in cell proliferation and metastasis, particularly in progression.
Molecular evolution of GYPC: evidence for recent structural innovation and positive selection in humans.
GeneRIF
Gansner et al., United States. In Mol Biol Evol, 2009
The molecular evolution of GYPC among the Hominoidea (Greater and Lesser Apes) and the pattern of polymorphism at the locus in a global human sample, were examined.
The Gerbich blood group system: a review.
Review
GeneRIF
Reid et al., In Immunohematology, 2009
The Gerbich blood group system
Identification of a physiologically relevant endogenous ligand for PPARalpha in liver.
Impact
Semenkovich et al., Saint Louis, United States. In Cell, 2009
Mass spectrometry identified the species as 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC).
[Relationship between expression of GYPC and TRIP3 genes and prognosis of acute lymphoblastic leukemia in children].
GeneRIF
Guo et al., Harbin, China. In Zhongguo Dang Dai Er Ke Za Zhi, 2009
A high GYPC gene expression is associated with an unfavorable outcome, in contrast, a high TRIP3 gene expression is associated with a favorable outcome in childhood ALL.
Glycophorin C delta(exon3) is not associated with protection against severe anaemia in Papua New Guinea.
GeneRIF
Michon et al., Goroka, Papua New Guinea. In P N G Med J, 2008
Glycophorin C delta (exon3) is not associated with protection against severe anaemia in Papua New Guinea.
A NAC Gene regulating senescence improves grain protein, zinc, and iron content in wheat.
Impact
Dubcovsky et al., Davis, United States. In Science, 2006
We report here the positional cloning of Gpc-B1, a wheat quantitative trait locus associated with increased grain protein, zinc, and iron content.
Glycophorin C (Gerbich antigen blood group) and band 3 polymorphisms in two malaria holoendemic regions of Papua New Guinea.
GeneRIF
Zimmerman et al., Cleveland, United States. In Am J Hematol, 2004
Neither mutation was associated with altered susceptibility to asymptomatic Plasmodium falciparum or P. vivax infection. Contribution of these erythrocyte polymorphisms to susceptibility to clinical malaria morbidity requires further study.
Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations.
Impact
GeneRIF
Cowman et al., Melbourne, Australia. In Nat Med, 2003
Data show that the receptor for Plasmodium falciparum erythrocyte-binding antigen 140 (EBA140) is glycophorin C (GYPC) and that this interaction mediates a principal P. falciparum invasion pathway into human erythrocytes.
Distinct roles for Galpha and Gbetagamma in regulating spindle position and orientation in Caenorhabditis elegans embryos.
Impact
Ahringer et al., Cambridge, United Kingdom. In Nat Cell Biol, 2001
Here we show that GOA-1 (a Galphao) and the related GPA-16 are the functionally redundant Galpha subunits and that GPC-2 is the relevant Ggamma subunit that is required for spindle orientation in the early embryo.
A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and function.
Impact
Bellen et al., Basel, Switzerland. In Cell, 1997
NRX is a transmembrane protein with a cytoplasmic domain homologous to glycophorin C, a protein required for anchoring protein 4.1 in the red blood cell.
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