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ADAM metallopeptidase domain 7

gp83, ADAM7
This gene encodes a member of the ADAMs family of zinc proteases. These transmembrane proteins play roles in multiple processes including cell signaling, adhesion and migration. The encoded protein lacks protease activity and may play roles in protein-protein interactions and cell adhesion processes including sperm-egg fusion. Mutations in this gene may be involved in the progression of melanoma. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: metalloprotease, Gp, CAN, Neuraminidase, CD45
Papers on gp83
Reduced Fertility and Altered Epididymal and Sperm Integrity in Mice Lacking ADAM7.
New
Cho et al., Kwangju, South Korea. In Biol Reprod, Sep 2015
One of the genes predominantly expressed in the epididymis is ADAM7 (a disintegrin and metalloprotease 7).
Comparison of monovalent glycoprotein B with bivalent gB/pp65 (GP83) vaccine for congenital cytomegalovirus infection in a guinea pig model: Inclusion of GP83 reduces gB antibody response but both vaccine approaches provide equivalent protection against pup mortality.
New
Schleiss et al., Minneapolis, United States. In Vaccine, Aug 2015
Using a guinea pig cytomegalovirus (GPCMV) model, this study compared immunogenicity, pregnancy outcome, and congenital viral infection following pre-pregnancy immunization with a three-dose series of modified vaccinia virus Ankara (MVA)-vectored vaccines consisting either of gB administered alone, or simultaneously with a pp65 homolog (GP83)-expressing vaccine.
Immunization with Hexon modified adenoviral vectors integrated with gp83 epitope provides protection against Trypanosoma cruzi infection.
Matthews et al., Birmingham, United States. In Plos Negl Trop Dis, 2014
The antigen chosen was T. cruzi gp83, a ligand that is used by T. cruzi to attach to host cells to initiate infection.
Development of a novel, guinea pig-specific IFN-γ ELISPOT assay and characterization of guinea pig cytomegalovirus GP83-specific cellular immune responses following immunization with a modified vaccinia virus Ankara (MVA)-vectored GP83 vaccine.
Schleiss et al., Minneapolis, United States. In Vaccine, 2014
Using splenocytes harvested from animals vaccinated with a modified vaccinia virus Ankara (MVA) vector encoding the GPCMV GP83 (homolog of human CMV pp65 [gpUL83]) protein, we were able to enumerate and map antigen-specific responses, both in vaccinated as well as GPCMV-infected animals, using a panel of GP83-specific peptides.
An Attenuated CMV Vaccine with a Deletion in Tegument Protein GP83 (pp65 Homolog) Protects against Placental Infection and Improves Pregnancy Outcome in a Guinea Pig Challenge Model.
McGregor et al., Minneapolis, United States. In Future Virol, 2014
The objectives of this study were: 1) to assess in guinea pigs the protective efficacy against congenital infection and disease of a recombinant live, attenuated vaccine with a targeted deletion of the GPCMV homolog of the HCMV pUL83 tegument protein, GP83; and, 2) to compare the extent of placental infection in vaccine and control groups, using an in situ hybridization (ISH) assay.
Identification of a candidate prognostic gene signature by transcriptome analysis of matched pre- and post-treatment prostatic biopsies from patients with advanced prostate cancer.
Leung et al., Glasgow, United Kingdom. In Bmc Cancer, 2013
Of these, pathway analyses identified a panel of 7 genes (ADAM7, FAM72B, BUB1B, CCNB1, CCNB2, TTK, CDK1), including a cell cycle-related geneset, that were differentially-regulated following treatment with docetaxel and ADT.
New and paradoxical roles of matrix metalloproteinases in the tumor microenvironment.
López-Otín et al., Liège, Belgium. In Front Pharmacol, 2011
These studies have been further expanded by large-scale genomic analysis, revealing that the genes encoding metalloproteinases, such as MMP8, MMP27, ADAM7, and ADAM29, are recurrently mutated in specific tumors, while several ADAMTSs are epigenetically silenced in different cancers.
Regulation and use of the extracellular matrix by Trypanosoma cruzi during early infection.
Villalta et al., Nashville, United States. In Front Immunol, 2011
T. cruzi gp83, a ligand that mediates the attachment of trypanosomes to cells to initiate infection, up-regulates LAMC1 expression to enhance cellular infection.
Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma.
GeneRIF
Samuels et al., Bethesda, United States. In Hum Mutat, 2011
mutated ADAM27 and ADAM7 genes could play a role in melanoma progression.
Identification of heat shock protein 5, calnexin and integral membrane protein 2B as Adam7-interacting membrane proteins in mouse sperm.
GeneRIF
Cho et al., Kwangju, South Korea. In J Cell Physiol, 2011
Suggest that Adam7 functions in fertilization through the formation of a complex with heat shock protein 5, calnexin and Itm2b during capacitation in sperm.
Assessment of the Na/I symporter as a reporter gene to visualize oncolytic adenovirus propagation in peritoneal tumours.
Vassaux et al., London, United Kingdom. In Eur J Nucl Med Mol Imaging, 2010
METHODS: We generated AdAM7, a dl922-947 oncolytic adenovirus encoding the NIS coding sequence.
Gene network analysis during early infection of human coronary artery smooth muscle cells by Trypanosoma cruzi and Its gp83 ligand.
Villalta et al., Nashville, United States. In Chem Biodivers, 2010
To understand the genetic architectures of the early invasion process of T. cruzi, we conducted gene transcription microarray analysis, followed by gene network construction of the host cell response in primary human coronary artery smooth muscle (HCASM) cells infected with T. cruzi or exposed to T. cruzi gp83, a ligand used by the trypanosome to bind host cells.
REGULATION of the EXTRACELLULAR MATRIX INTERACTOME by Trypanosoma cruzi.
Villalta et al., Nashville, United States. In Open Parasitol J, 2009
T. cruzi gp83, a ligand that mediates the attachment of trypanosomes to cells to initiate infection, up-regulates LAMC1 expression to enhance cellular infection.
Conservation and divergence of ADAM family proteins in the Xenopus genome.
Desimone et al., Charlottesville, United States. In Bmc Evol Biol, 2009
However, we were unable to identify an orthologue for ADAM7 or 8.
ADAM7 is associated with epididymosomes and integrated into sperm plasma membrane.
GeneRIF
Cho et al., Kwangju, South Korea. In Mol Cells, 2009
This study provides new information regarding the unique mode of secretion and interaction of ADAM7 during the epididymis-to-sperm transfer process.
Three-cohort targeted gene screening reveals a non-synonymous TRKA polymorphism associated with schizophrenia.
Martens et al., Nijmegen, Netherlands. In J Psychiatr Res, 2009
Risk alleles are in TRKA (rs6336), BARD1 (rs28997576), LAMA5 (rs3810548), DKK2 (rs7037102), NOD2 (rs2066844) and RELN (rs2229860), whereas protective alleles are in NOD2 (rs2066845), NRG1 (rs10503929), ADAM7 (rs13259668) and TNR (rs859427).
Molecular, biochemical, and cellular characterization of epididymal ADAMs, ADAM7 and ADAM28.
GeneRIF
Cho et al., Kwangju, South Korea. In Biochem Biophys Res Commun, 2005
ADAM7, but not ADAM28, is transferred from the epididymis to the sperm surface and redistributed in the sperm head during acrosome reaction
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