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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Autocrine motility factor receptor

gp78, autocrine motility factor receptor, AMFR, AMF receptor
This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, is a tumor motility-stimulating protein secreted by tumor cells. The encoded receptor is also a member of the E3 ubiquitin ligase family of proteins. It catalyzes ubiquitination and endoplasmic reticulum-associated degradation of specific proteins. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: Ubiquitin, V1a, CD45, HAD, CAN
Papers using gp78 antibodies
USP25, a novel gene encoding a deubiquitinating enzyme, is located in the gene-poor region 21q11.2.
Supplier
Menéndez-Arias Luis, In PLoS ONE, 1998
... used at 1∶4000 dilution; mouse anti-E4B from BD Biosciences, was used at 1∶500 dilution; rabbit anti-GP78/AMFR from Cell Signaling, was used at 1∶1000 ...
Papers on gp78
Ubiquitin mediated regulation of the E3 ligase GP78 by Mahogunin in trans affects mitochondrial homeostasis.
New
Chakrabarti et al., Calcutta, India. In J Cell Sci, Feb 2016
This study elucidates a novel interaction of the cytosolic E3 ligase, MGRN1 with the ER ubiquitin E3 ligase, GP78.
Tracking the conversion of nitrogen during pyrolysis of antibiotic mycelial fermentation residues using XPS and TG-FTIR-MS technology.
New
Chen et al., Shanghai, China. In Environ Pollut, Jan 2016
Nitrogen (N), which is an environmental sensitivity element, is largely retained in AMFR samples derived from fermentation substrates.
gp78 functions downstream of Hrd1 to promote degradation of misfolded proteins of the endoplasmic reticulum.
New
Ye et al., Bethesda, United States. In Mol Biol Cell, Jan 2016
Hrd1 and gp78 are mammalian ubiquitin ligases homologous to Hrd1p, an ubiquitin ligase essential for ERAD in Saccharomyces cerevisiae.
Increased Expression of the Autocrine Motility Factor is Associated With Poor Prognosis in Patients With Clear Cell-Renal Cell Carcinoma.
New
Battaglia et al., Bari, Italy. In Medicine (baltimore), Nov 2015
Glucose-6-phosphate isomerase (GPI), also known as phosphoglucose isomerase, was initially identified as the second glycolytic enzyme that catalyzes the interconversion of glucose-6-phosphate to fructose-6-phosphate. Later studies demonstrated that GPI was the same as the autocrine motility factor (AMF), and that it mediates its biological effects through the interaction with its surface receptor (AMFR/gp78).
The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING.
Impact
Wang et al., Shanghai, China. In Immunity, 2015
We report here that, upon cytoplasmic DNA stimulation, the endoplasmic reticulum (ER) protein AMFR was recruited to and interacted with STING in an insulin-induced gene 1 (INSIG1)-dependent manner.
Neuroleukin/Autocrine Motility Factor Receptor Pathway Promotes Proliferation of Articular Chondrocytes through Activation of AKT and Smad2/3.
Liu et al., Dalian, China. In Sci Rep, 2014
Neuroleukin (NLK) is a multifunctional protein that stimulates cell growth and migration, together with its receptor autocrine motility factor receptor (AMFR, also called gp78).
Ubiquitin ligases in cholesterol metabolism.
Review
Song et al., Shanghai, China. In Diabetes Metab J, 2014
More and more ubiquitin ligases have been identified including gp78, Hrd1, TRC8, TEB4, Fbw7, and inducible degrader of low density lipoprotein receptor.
Hepatic cytochrome P450 ubiquitination: conformational phosphodegrons for E2/E3 recognition?
Review
Guan et al., San Francisco, United States. In Iubmb Life, 2014
Indeed, we have shown that both CYP3A4 and CYP2E1 incur ERAD-C, during which they are first phosphorylated by protein kinases A and C, which greatly enhance/accelerate their ubiquitination by UBC7/gp78 and UbcH5a/CHIP/Hsp70/Hsp40 E2/E3 ubiquitin ligase complexes.
Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis.
Impact
Song et al., Shanghai, China. In Cell Metab, 2012
gp78 is a membrane-anchored ubiquitin ligase mediating the degradation of HMG-CoA reductase (HMGCR) and Insig-1.
gp78: a multifaceted ubiquitin ligase that integrates a unique protein degradation pathway from the endoplasmic reticulum.
Review
Fang et al., Baltimore, United States. In Curr Protein Pept Sci, 2012
gp78 is an E3 ubiquitin ligase that integrates these ERAD steps by nucleating a unique degradation machine, which uses the p97/VCP-Npl4 complex for retrotranslocation instead of the wellknown p97/VCP-Ufd1-Npl4 complex.
RING finger palmitoylation of the endoplasmic reticulum Gp78 E3 ubiquitin ligase.
GeneRIF
Nabi et al., Vancouver, Canada. In Febs Lett, 2012
Palmitoylation of RING finger cysteines therefore regulates gp78 distribution to the peripheral ER
Autocrine motility factor receptor is involved in the process of learning and memory in the central nervous system.
GeneRIF
Zhang et al., Beijing, China. In Behav Brain Res, 2012
AMFR is involved in the process of learning and memory in the central nervous system.
The Gp78 ubiquitin ligase: probing endoplasmic reticulum complexity.
Review
Nabi et al., Vancouver, Canada. In Protoplasma, 2012
In this review, we will discuss the sub-organization of the ER in different domains focusing on the localization and role of the gp78 ubiquitin ligase in the mitochondria-associated smooth ER and on the evidence for a quality control ERAD domain.
The autocrine motility factor receptor is overexpressed on the surface of B cells in Binet C chronic lymphocytic leukemia.
GeneRIF
Wadenvik et al., Göteborg, Sweden. In Med Oncol, 2011
cell surface expression of AMFR is associated with progression in Chronic lymphocytic leukemia
Urban planning of the endoplasmic reticulum (ER): how diverse mechanisms segregate the many functions of the ER.
Review
Simmen et al., Canada. In Biochim Biophys Acta, 2011
The crucial roles of ER domain formation for cell physiology are highlighted with the specific targeting of the tumor metastasis regulator gp78 to ERAD-mediating membranes or of the promyelocytic leukemia protein to the MAM.
Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
GeneRIF
DeBose-Boyd et al., Dallas, United States. In J Biol Chem, 2011
identify two ER membrane proteins, SPFH2 and TMUB1, as associated proteins of gp78, a membrane-bound ubiquitin ligase that mediates sterol-accelerated ERAD of the cholesterol biosynthetic enzyme HMG-CoA reductase.
Liver cytochrome P450 3A ubiquitination in vivo by gp78/autocrine motility factor receptor and C terminus of Hsp70-interacting protein (CHIP) E3 ubiquitin ligases: physiological and pharmacological relevance.
GeneRIF
Correia et al., San Francisco, United States. In J Biol Chem, 2010
Data show that CYP3A ubiquitination in vivo by gp78/autocrine motility factor receptor and C terminus of Hsp70-interacting protein/CHIP E3 ubiquitin ligases.
The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation.
Impact
GeneRIF
Weissman et al., Frederick, United States. In Nat Med, 2007
gp78 promotes sarcoma metastasis by targeting KAI1 for degradation
Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase.
Impact
GeneRIF
Song et al., Shanghai, China. In Cell Metab, 2007
This study identifies Ufd1 as a cofactor of gp78, reveals an unappreciated function of Ufd1 in the ubiquitination reaction during endoplasmic reticulum -associated degradation, and illustrates that Ufd1 plays a critical role in cholesterol metabolism.
A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate.
Impact
GeneRIF
Ye et al., Bethesda, United States. In Nature, 2007
Ube2g2/gp78-mediated polyubiquitination involves preassembly of Lys 48-linked ubiquitin chains at the catalytic cysteine of Ube2g2
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