Autoantibodies in Chinese patients with chronic hepatitis B: prevalence and clinical associations.
Beijing, China. In World J Gastroenterol, Feb 2015
The AIH-related autoantibody profile included homogeneous anti-nuclear antibodies (ANA-H), smooth-muscle antibodies, anti-liver kidney microsome type 1, anti-liver cytosolic antigen type 1, and anti-soluble liver antigen/liver pancreas; the PBC-related antibodies were characterized by ANA-nuclear dots/membranous rim-like, anti-mitochondrial antibodies-M2 (AMA-M2), anti-BPO (recombinant antigen targeted by AMA-M2), anti-Sp100, anti-promyelocytic leukemia protein (anti-PML), and anti-gp210.
Primary biliary cirrhosis in adults.
Lexington, United States. In Expert Rev Gastroenterol Hepatol, 2014
Certain findings such as fatigue, anti-nuclear antibodies, anti-centromere antibodies and the GP210 antinuclear antibody predict a poor outcome.
Primary biliary cirrhosis and the nuclear pore complex.
Davis, United States. In Autoimmun Rev, 2012
Autoantibodies against the integral membrane glycoprotein gp210 and nucleoporin p62 appear to be highly specific for PBC, an autoimmune disease characterized by progressive destruction of intrahepatic biliary epithelial cells.
Antinuclear antibodies as ancillary markers in primary biliary cirrhosis.
Bologna, Italy. In Expert Rev Mol Diagn, 2012
The target antigens of the multiple nuclear dots pattern have been identified as Sp100 and promyelocytic leukemia protein, whereas the rim-like/membranous pattern is given by autoantibodies recognizing multiple proteins such as gp210, nucleoporin p62 and the lamin B receptor.