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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.


gp200, PODXL, podocalyxin-like protein 1, PCLP1, PCLP
This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD45, CAN, CD34, ACID, V1a
Papers on gp200
Podocalyxin-like protein 1 functions as an immunomodulatory molecule in breast cancer cells.
Larrucea et al., Barakaldo, Spain. In Cancer Lett, Dec 2015
Podocalyxin-like protein 1 (PCLP1), a CD34-related sialomucin involved in the regulation of cellular morphology and adhesion, is expressed by a number of normal cells and various tumor cells.
Distinct kinetic and mechanical properties govern mucin 16- and podocalyxin-mediated tumor cell adhesion to E- and L-selectin in shear flow.
Konstantopoulos et al., Baltimore, United States. In Oncotarget, Oct 2015
We recently identified sialofucosylated mucin16 (MUC16) and podocalyxin (PODXL) as the major functional E- and L-selectin ligands expressed on the surface of metastatic pancreatic cancer cells.
Cdc42 is required for cytoskeletal support of endothelial cell adhesion during blood vessel formation in mice.
Cleaver et al., Dallas, United States. In Development, Oct 2015
Endothelial polarity is also rapidly lost upon Cdc42 deletion, as seen by failed localization of apical podocalyxin (PODXL) and basal actin.
Identification of miR-199a-5p target genes in the skin keratinocyte and their expression in cutaneous squamous cell carcinoma.
Yoon et al., Seoul, South Korea. In J Dermatol Sci, Aug 2015
RESULTS: We identified new target genes, Bcam, Fzd6, and Wnt7a, as well as previously known targets, Ddr1 and Podxl.
The Role of Endometrial Selectins and Their Ligands on Bovine Conceptus Attachment to the Uterine Epithelium During Peri-Implantation Period.
Imakawa et al., Tokyo, Japan. In Biol Reprod, Aug 2015
Through the RNA-sequence analysis of bovine conceptuses on Days 17, 20, and 22 (Day 0 = day of estrus), only the SELL ligand, podocalyxin (PODXL), and P-selectin (SELP) ligand, SELPLG, were found.
Prognostic and predictive significance of podocalyxin-like protein expression in pancreatic and periampullary adenocarcinoma.
Eberhard et al., Lund, Sweden. In Bmc Clin Pathol, 2014
Membranous expression of podocalyxin-like 1(PODXL), which is a cell-adhesion glycoprotein and stem cell marker, has been found to correlate with an aggressive tumour phenotype and adverse outcome in several cancer types.
Podocalyxin as a Prognostic Marker in Gastric Cancer.
Haglund et al., Helsinki, Finland. In Plos One, 2014
BACKGROUND: Podocalyxin-like 1 (PODXL) is a cell-adhesion glycoprotein associated with aggressive tumor phenotype and poor prognosis in several forms of cancer.
Co-Expression of Ezrin-CLIC5-Podocalyxin Is Associated with Migration and Invasiveness in Hepatocellular Carcinoma.
Villa-Treviño et al., Oaxaca de Juárez, Mexico. In Plos One, 2014
Ezrin (EZR) and Podocalyxin (PODXL) are proteins associated with invasion, migration and poor prognosis in various types of cancer.
Involvement of platelet-tumor cell interaction in immune evasion. Potential role of podocalyxin-like protein 1.
Larrucea et al., Barakaldo, Spain. In Front Oncol, 2013
Podocalyxin-like protein 1 (PCLP1) is a selectin-ligand protein in which overexpression has been associated with several aggressive cancers.
Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1.
Kerjaschki et al., Vienna, Austria. In Nat Med, 2013
Decreased expression levels of WT1 lead to downregulation of its target genes PODXL (podocalyxin) and NPHS1 (nephrin), as well as several other genes crucial for the architecture of podocytes, initiating a catastrophic collapse of the entire podocyte-stabilizing system.
Sialofucosylated podocalyxin is a functional E- and L-selectin ligand expressed by metastatic pancreatic cancer cells.
Konstantopoulos et al., Baltimore, United States. In Am J Physiol Cell Physiol, 2012
Sialofucosylated PODXL is a functional E-and L-selectin ligand expressed by metastatic pancreatic cancer cells.
miR-199b-5p directly targets PODXL and DDR1 and decreased levels of miR-199b-5p correlate with elevated expressions of PODXL and DDR1 in acute myeloid leukemia.
Sathyanarayana et al., In Am J Hematol, 2012
Most AML patients had a significant decrease in miR-199b-5p levels with elevated PODXL & DDR1 expressions. Both PODXL & DDR1 are targets of miR-199b-5p.
The anti-adhesive mucin podocalyxin may help initiate the transperitoneal metastasis of high grade serous ovarian carcinoma.
Roskelley et al., Vancouver, Canada. In Clin Exp Metastasis, 2012
podocalyxin's ability to facilitate the formation of non-adhesive membrane domains may contribute to the formation of free-floating high grade serous tumor nodules during the initial steps of transperitoneal metastasis.
Overexpression of podocalyxin-like protein is an independent factor of poor prognosis in colorectal cancer.
Jirström et al., Lund, Sweden. In Br J Cancer, 2011
Podocalyxin-like 1 expression is an independent factor of poor prognosis in colorectal carcinoma.
Diminished thrombogenic responses by deletion of the Podocalyxin Gene in mouse megakaryocytes.
Parrilla et al., Madrid, Spain. In Plos One, 2010
platelet Podxl is involved in the control of hemostasis acting as a platelet co-stimulator, likely due to its pro-adhesive properties
[Interaction involving the thymus and the hypothalamus-pituitary axis, immunomodulation by hormones].
Marković, In Srp Arh Celok Lek, 2004
Cortical RE cells express a surface antigen, gp200-MR6, which plays a significant role in thymocyte differentiation.
Neuroendocrine influence on thymic haematopoiesis via the reticulo-epithelial cellular network.
Bodey, Los Angeles, United States. In Expert Opin Ther Targets, 2002
Cortical RE cells express a surface antigen, gp200-MR6, which plays a significant role of thymocyte differentiation.
CD164--a novel sialomucin on CD34+ cells.
Chan et al., Oxford, United Kingdom. In Leuk Lymphoma, 2000
Recently, sialomucins have assumed some importance in hematopoiesis, with six of these receptors, CD34, PSGL-1, CD43, PCLP, CD45RA and CD164, having been identified on primitive hematopoietic precursor cells and/or their associated stromal/endothelial elements.
Identification of podocalyxin-like protein 1 as a novel cell surface marker for hemangioblasts in the murine aorta-gonad-mesonephros region.
Miyajima et al., Tokyo, Japan. In Immunity, 1999
We molecularly cloned podocalyxin-like protein 1 (PCLP1) as a novel surface marker for endothelial-like cells in the aorta-gonad-mesonephros (AGM) region of mouse embryos, where long-term repopulating hematopoietic stem cells (LTR-HSCs) are known to arise.
Strategies of chemoprevention based on antigenic and molecular markers of early and premalignant lesions of the bladder.
LaRue et al., Québec, Canada. In J Cell Biochem Suppl, 1991
The mucinous antigen M344 and the gp200 surface antigen 19A211 are preferentially expressed on papillary superficial tumors and carcinoma in situ lesions of the bladder.
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