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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Glycoprotein 2

GP2
GPI-linked protein that is a major component of pancreatic zymogen granule membranes [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CD45, Gp, ACID, CAN, HAD
Papers using GP2 antibodies
The efficient generation of cell lines from bovine parthenotes
Supplier
Verma Paul J. et al., In Stem Cells International, 2009
... GP2 293 cells (Clontech; Scientifix, Cheltenham, Australia) were ...
A critical role for Lyn in acute myeloid leukemia
Supplier
Dai Zonghan et al., In Carcinogenesis, 2007
... Retroviral packaging cell line GP2-293 (ClonTech, Mountain View, CA) was ...
Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I
Supplier
Pietrzik Claus U. et al., In Cellular and Molecular Life Sciences, 1995
... by double transfection of pLBCX with pVSV-G at a 1:1 ratio into the packaging cell line GP2-293 (Clontech, Mountain View, CA, USA) ...
Papers on GP2
Antiviral Indolosesquiterpenoid Xiamycins C-E from a Halophilic Actinomycete.
New
Oh et al., Seoul, South Korea. In J Nat Prod, Jan 2016
Quantitative real-time PCR data revealed the inhibitory effect of 2 on genes encoding essential structural proteins (GP6 nucleocapsid, GP2 spike, and GP5 membrane) for PEDV replication in a dose-dependent manner.
Evaluation of Medicago sativa L. sprouts as antihyperlipidemic and antihyperglycemic agent.
New
Abdel-Naim et al., Cairo, Egypt. In Pak J Pharm Sci, Nov 2015
Experimental animals were divided into the following groups: GP1 (normal), GP2 (STZ-hyperlipidemic), GP3 (rouvastatin), GP4 (metformin), GP 5-9 (diabetic treated with methanolic, petroleum ether, chloroform, ethyl acetate and butanol extracts).
Systematic review: new serological markers (anti-glycan, anti-GP2, anti-GM-CSF Ab) in the prediction of IBD patient outcomes.
Review
New
Paul et al., Saint-Étienne, France. In Autoimmun Rev, Mar 2015
However, many recent data suggest the potential role of new serological markers (anti-glycan (ACCA, ALCA, AMCA, anti-L and anti-C), anti-GP2 and anti-GM-CSF Ab).
Soluble RANKL expression in Lactococcus lactis and investigation of its potential as an oral vaccine adjuvant.
Choi et al., Seoul, South Korea. In Bmc Immunol, 2014
M cell development in response to oral administration of recombinant L. lactis was determined by 1.51-fold higher immunohistochemical expression of M cell marker GP-2, compared to that of non-treatment group.
Oral Norovirus Infection Is Blocked in Mice Lacking Peyer's Patches and Mature M Cells.
Wobus et al., Ann Arbor, United States. In J Virol, 2014
To define the importance of Peyer's patch (PP) M cells during MNV pathogenesis, we used a model of BALB/c mice deficient in recombination-activating gene 2 (Rag2) and the common gamma chain (γc) (Rag-γc(-/-)), which lack gut-associated lymphoid tissues (GALT), such as Peyer's patches, and mature GP2(+) M cells.
Isolation and Genetic Analysis of Multidrug Resistant Bacteria from Diabetic Foot Ulcers.
Kumar et al., Benares, India. In Front Microbiol, 2014
In addition to the presence of class 1 integron, six β-lactamase resistance encoding genes namely bla TEM, bla SHV, bla OXA, bla CTX-M-gp1, bla CTX-M-gp2, and bla CTX-M-gp9 and two methicillin resistance genes namely mecA and femA and vancomycin resistance encoding genes (vanA and vanB) were identified in different isolates.
Serological studies in inflammatory bowel disease: how important are they?
Review
Lakatos et al., Budapest, Hungary. In Curr Opin Gastroenterol, 2014
Anti-Saccharomyces cerevisiae antibody remains the most accurate single marker, and recently identified exocrine pancreas antibodies (GP2 and CUZD1) have been suggested as evidence for a role of antibodies in the pathogenesis of Crohn's disease.
Crohn's disease specific pancreatic antibodies: clinical and pathophysiological challenges.
Review
Laass et al., In Clin Chem Lab Med, 2014
Glycoprotein 2 (GP2) has been identified as a major autoantigenic target of the so-called pancreatic antibodies.
Glycoprotein 2 antibodies in Crohn's disease.
Review
Conrad et al., Senftenberg, Germany. In Adv Clin Chem, 2012
Utilizing immunoblotting and matrix-assisted laser desorption ionization time-of-flight mass spectrometry, the major zymogen granule membrane glycoprotein 2 (GP2) has been discovered as the main PAB autoantigen.
Envelope glycoprotein of arenaviruses.
Review
Pasquato et al., Lausanne, Switzerland. In Viruses, 2012
A crucial step in the arenavirus life-cycle is the biosynthesis and maturation of the GP precursor (GPC) by cellular signal peptidases and the cellular enzyme Subtilisin Kexin Isozyme-1 (SKI-1)/Site-1 Protease (S1P) yielding a tripartite mature GP complex formed by GP1/GP2 and a stable signal peptide (SSP).
Meta-analysis identifies common variants associated with body mass index in east Asians.
Impact
Shu et al., Nashville, United States. In Nat Genet, 2012
We identified ten BMI-associated loci at genome-wide significance (P < 5.0 × 10(-8)), including seven previously identified loci (FTO, SEC16B, MC4R, GIPR-QPCTL, ADCY3-DNAJC27, BDNF and MAP2K5) and three novel loci in or near the CDKAL1, PCSK1 and GP2 genes.
Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection.
Impact
Cunningham et al., Boston, United States. In Nature, 2011
Combined with the results of previous studies of GP structure and function, our findings support a model of EboV infection in which cleavage of the GP1 subunit by endosomal cathepsin proteases removes heavily glycosylated domains to expose the amino-terminal domain, which is a ligand for NPC1 and regulates membrane fusion by the GP2 subunit.
The zymogen granule protein 2 (GP2) binds to scavenger receptor expressed on endothelial cells I (SREC-I).
GeneRIF
Zlabinger et al., Vienna, Austria. In Cell Immunol, 2010
GP2 is a binding partner of the scavenger receptor expressed on endothelial cells I (SREC-I) but not of SR-AI and SR-BI. Dendritic cells express SREC-I and also bind and internalize GP2.
Genetic analysis of the glycoprotein 2 gene in patients with chronic pancreatitis.
GeneRIF
Férec et al., Brest, France. In Pancreas, 2010
GP2 gene is unlikely to play a major role in the etiology of chronic pancreatitis.
The c.1275A>G putative chronic pancreatitis-associated synonymous polymorphism in the glycoprotein 2 (GP2) gene decreases exon 9 inclusion.
GeneRIF
Férec et al., Brest, France. In Mol Genet Metab, 2010
This study represents the first detailed analysis of any variation in the GP2 gene and gives some support to the putative association of c.1275A>G with chronic pancreatitis disease protection.
Mutational analysis of the gene encoding the zymogen granule membrane glycoprotein 2 (GP2) in patients with chronic pancreatitis.
GeneRIF
Drenth et al., Berlin, Germany. In Pancreas, 2010
Data suggest that GP2 alterations do not alter the risk for the development of chronic pancreatitis.
Interleukins, laminin and Epstein - Barr virus latent membrane protein 1 (EBV LMP1) promote metastatic phenotype in nasopharyngeal carcinoma.
GeneRIF
Tan et al., Kuala Lumpur, Malaysia. In Bmc Cancer, 2009
EBV LMP1, laminin, MMP9 and IL-6 have roles in the promotion of invasion and metastasis in NPC
Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response.
Impact
GeneRIF
Ohno et al., Japan. In Nature, 2009
glycoprotein 2 (GP2), specifically expressed on the apical plasma membrane of M cells among enterocytes, serves as a transcytotic receptor for mucosal antigens
Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor.
Impact
Saphire et al., Los Angeles, United States. In Nature, 2008
Three GP1 viral attachment subunits assemble to form a chalice, cradled by the GP2 fusion subunits, while a novel glycan cap and projected mucin-like domain restrict access to the conserved receptor-binding site sequestered in the chalice bowl.
The ZP domain is a conserved module for polymerization of extracellular proteins.
Impact
Wassarman et al., New York City, United States. In Nat Cell Biol, 2002
Among these proteins are the mammalian sperm receptors ZP2 and ZP3, non-mammalian egg coat proteins, Tamm-Horsfall protein (THP), glycoprotein-2 (GP-2), alpha- and beta-tectorins, transforming growth factor (TGF)-beta receptor III and endoglin, DMBT-1 (deleted in malignant brain tumour-1), NompA (no-mechanoreceptor-potential-A), Dumpy and cuticlin-1 (refs 1,2).
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