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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Glutamyl aminopeptidase

gp160, placental alkaline phosphatase, PLAP, aminopeptidase A, oxytocinase
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, aminopeptidase, HAD, Envelope Protein, gp120
Papers using gp160 antibodies
PKCalpha expression is a marker for breast cancer aggressiveness.
Supplier
Federici Massimo, In PLoS ONE, 2009
... Mouse monoclonal antibodies against α-tubulin (B-5-1-2) and PLAP (8B6) were from Sigma, mouse monoclonal anti-phosphoERK1/2 (Thr202/Tyr204) was from Cell Signaling, and rabbit polyclonal anti-ERK1/2 ...
GPI-anchored proteins are directly targeted to the apical surface in fully polarized MDCK cells
Supplier
Zurzolo Chiara et al., In The Journal of Cell Biology, 1991
... following companies: polyclonal anti-GFP from CLONTECH Laboratories, Inc.; monoclonal anti-GFP and Cy-5 transferrin from Invitrogen; anti-PLAP from Rockland Biosciences; and anti–Na, K-ATPase ...
Papers on gp160
Asymmetrical cross-talk between the endoplasmic reticulum stress and oxidative stress caused by dextrose.
New
Haas et al., Jacksonville, United States. In Life Sci, Feb 2016
ER stress was measured using the placental alkaline phosphatase assay and superoxide (SO) generation was measured using the superoxide-reactive probe 2-methyl-6-(4-methoxyphenyl)-3,7-dihydroimidazo[1,2-A]pyrazin-3-one hydrochloride chemiluminescence.
Effect of the maturation of neutralizing antibodies on human immunodeficiency virus (HIV) envelope evolution in HIV-infected subjects.
New
Wang et al., Beijing, China. In Infect Genet Evol, Jan 2016
UNASSIGNED: Delineating the course of NAb (neutralizing antibody) development in natural infection may provide clues for NAb-targeted HIV-1 vaccine design.
Ovarian dysgerminoma with normal serum tumour markers presenting in a child with precocious puberty.
New
Jundi et al., Aţ Ţā'if, Saudi Arabia. In J Cancer Res Ther, Jul 2015
Immunohistochemical stainings were positive for placental alkaline phosphatase (PALP), CD 117(c-kit) and calretinin focally but was negative for cancer antigen-125 (CA-125), B-hCG, S-100, carcinoembryonic antigen (CEA), and leukocyte common antigen (LCA).
Intratubular germ cell neoplasia of the testis: a brief review.
Review
New
Akhtar et al., Riyadh, Saudi Arabia. In Adv Anat Pathol, May 2015
These tumor cells continue to manifest protein expression pattern that resembles primitive germ cells (PLAP, c-KIT, OCT3/4).
New approaches in the treatment of hypertension.
Review
New
Schmieder et al., Jishou, China. In Circ Res, Apr 2015
New drug classes, eg, inhibitors of vasopeptidases, aldosterone synthase and soluble epoxide hydrolase, agonists of natriuretic peptide A and vasoactive intestinal peptide receptor 2, and a novel mineralocorticoid receptor antagonist are in phase II/III of development, while inhibitors of aminopeptidase A, dopamine β-hydroxylase, and the intestinal Na(+)/H(+) exchanger 3, agonists of components of the angiotensin-converting enzyme 2/angiotensin(1-7)/Mas receptor axis and vaccines directed toward angiotensin II and its type 1 receptor are in phase I or preclinical development.
Hypertension: renin-angiotensin-aldosterone system alterations.
Review
New
Danser et al., Rotterdam, Netherlands. In Circ Res, Apr 2015
Finally, apart from the deleterious ACE-Ang II-Ang II type 1 receptor arm, animal studies support the existence of protective aminopeptidase A-Ang III-Ang II type 2 receptor and ACE2-Ang-(1 to 7)-Mas receptor arms, paving the way for multiple new treatment options.
New insights into the role of sex steroid hormones in pregnancy: possible therapeutic approach by sex steroid hormones for the treatment of both preeclampsia and preterm labor.
Review
New
Mizutani et al., Nagoya, Japan. In Exp Clin Endocrinol Diabetes, Mar 2015
Since these hormones are biologically active, the leakage of these hormones into the maternal circulation is regulated by degradation activity by placental aminopeptidases, in order to maintain the balance between carriage of pregnancy and onset of labor.Because the concentration of these hormones, being regulated by the amount of endogenous production and by physiological degradation by enzymes in the blood and tissue, the balance between production and degradation is a definitive element for maintaining normal gestation and term delivery.The changes of the balance between fetal angiotensin II (A-II) and vasopressin (AVP) andA-II and AVP degrading enzymes, between aminopeptidase A (APA) and placental leucine aminopeptidase( P-LAP) - in the placenta and maternal blood due to fetal stress such as hypoxia - are the provable causes of preeclampsia or preterm labor.Induction of APA and P-LAP by estradiol benzoate (E2) and progesterone (P) from placenta has been demonstrated.
Enhanced Immune Responses to HIV-1 Envelope Elicited by a Vaccine Regimen Consisting of Priming with Newcastle Disease Virus Expressing HIV gp160 and Boosting with gp120 and SOSIP gp140 Proteins.
Samal et al., College Park, United States. In J Virol, 2014
Newcastle disease virus (NDV) expressing HIV-1 BaL gp160 was evaluated either alone or with monomeric BaL gp120 and BaL SOSIP gp140 protein in a prime-boost combination in guinea pigs to enhance envelope (Env)-specific humoral and mucosal immune responses.
Isolated Large Cell Calcifying Sertoli Cell Tumor in a Young Boy, not Associated with Peutz-Jeghers Syndrome or Carney Complex.
Stratakis et al., Bethesda, United States. In Ann Clin Lab Res, 2014
His tumor was studied by immunohistochemistry for the expression of calretinin, NY-ESO-1, inhibin, CD99, S100, PLAP, AE1/AE3, Bcl-2, p53, and Mib1.
Intracranial multiple germ cell tumors: a case report and review of literature.
Review
Huang et al., Changsha, China. In Int J Clin Exp Pathol, 2013
Immunohistochemical analysis results demonstrated that the tumor cells were positive for CD117 and placental alkaline phosphatase (PLAP).
Down-regulation of NF-κB transcriptional activity in HIV-associated kidney disease by BRD4 inhibition.
GeneRIF
Zhou et al., New York City, United States. In J Biol Chem, 2012
Down-regulation of NF-kappaB transcriptional activity in HIV-associated kidney disease by BRD4 inhibition.
Activity and inhibition of prostasin and matriptase on apical and basolateral surfaces of human airway epithelial cells.
GeneRIF
Caughey et al., San Francisco, United States. In Am J Physiol Lung Cell Mol Physiol, 2012
prostasin is present, mature and active on the apical surface of wild-type and cystic fibrosis bronchial epithelial cells
Genetic lesions of the TRAF3 and MAP3K14 genes in classical Hodgkin lymphoma.
GeneRIF
Küppers et al., Essen, Germany. In Br J Haematol, 2012
Genetic lesions of the TRAF3 and MAP3K14 genes in classical Hodgkin lymphoma.
BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain.
GeneRIF
Singer et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 2012
BRD4 is an atypical kinase that binds to the carboxyl-terminal domain (CTD) of RNA polymerase II and directly phosphorylates its serine 2 (Ser2) sites both in vitro and in vivo under conditions where other CTD kinases are inactive.
Bromodomain protein Brd4 associated with acetylated chromatin is important for maintenance of higher-order chromatin structure.
GeneRIF
You et al., Philadelphia, United States. In J Biol Chem, 2012
novel structural role of Brd4 in supporting the higher chromatin architecture
Gas-inducible transgene expression in mammalian cells and mice.
Impact
Fussenegger et al., Zürich, Switzerland. In Nat Biotechnol, 2004
Mice implanted with microencapsulated cells engineered for acetaldehyde-inducible regulation (AIR) of the human glycoprotein secreted placental alkaline phosphatase showed adjustable serum phosphatase levels after exposure to different gaseous acetaldehyde concentrations.
Aminopeptidase A is a functional target in angiogenic blood vessels.
Impact
Arap et al., Houston, United States. In Cancer Cell, 2004
We show that a membrane-associated protease, aminopeptidase A (APA), is upregulated and enzymatically active in blood vessels of human tumors.
Clinical impact of germ cell tumor cells in apheresis products of patients receiving high-dose chemotherapy.
Impact
Looijenga et al., Tübingen, Germany. In J Clin Oncol, 2001
PBSC preparations from 57 patients were investigated for the presence of contaminating tumor cells using this set of targets, including beta human chorionic gonadotropin (beta-hCG), fibronectin (EDB variant), epidermal growth factor receptor (EGFR), CD44 (v8 to 10 variant), germ cell and placental alkaline phosphatase (AP), human endogenous retrovirus type K (ENV and GAG), and XIST.
Retention of prominin in microvilli reveals distinct cholesterol-based lipid micro-domains in the apical plasma membrane.
Impact
Huttner et al., Heidelberg, Germany. In Nat Cell Biol, 2000
Membrane cholesterol-sphingolipid 'rafts', which are characterized by their insolubility in the non-ionic detergent Triton X-100 in the cold, have been implicated in the sorting of certain membrane proteins, such as placental alkaline phosphatase (PLAP), to the apical plasma membrane domain of epithelial cells.
Erratum.
Impact
In Science, 1990
1236) of the report "Induction of CD4(+) human cytolytic T cells specific for HIV-infected cells by a gp160 subunit vaccine" by R. J. Orentas et al. (8 June, p. 1234), the labels for HIV-infected and mock-infected cells were reversed.
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