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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 27 Feb 2015.

Inter-alpha-trypsin inhibitor heavy chain family, member 4

gp120
The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: CD4, CAN, CD45, Envelope Protein, HAD
Papers on gp120
Antibody Maturation in Women who Acquire HIV Infection While Using Antiretroviral Pre-Exposure Prophylaxis.
New
Quinn et al., Baltimore, United States. In J Infect Dis, 23 Mar 2015
Women assigned to tenofovir gel demonstrated slower antibody avidity maturation as determined by the Bio-Rad (p=0.04) and gp120 Bio-Plex (p=0.028)
HIV-1 gp120 dimers decrease the overall affinity of gp120 preparations for CD4-induced ligands.
New
Finzi et al., Montréal, Canada. In J Virol Methods, 21 Mar 2015
To facilitate these studies, expression of the HIV-1 gp120 envelope glycoprotein has been done in several over-expression settings.
An extended CCR5-ECL2 peptide forms a helix that binds HIV-1 gp120 through non-specific hydrophobic interactions.
New
Anglister et al., Israel. In Febs J, 20 Mar 2015
The CCR5 N-terminal segment, the second extracellular loop (ECL2) and the transmembrane helices have been implicated in binding the envelope glycoprotein gp120.
Manipulating the Selection Forces during Affinity Maturation to Generate Cross-Reactive HIV Antibodies.
New
Impact
Chakraborty et al., Cambridge, United States. In Cell, 12 Mar 2015
Our calculations predict, and experiments in mice with variant gp120 constructs of the HIV envelope protein confirm, that sequential immunization with antigen variants is preferred over a cocktail for induction of cross-reactive antibodies focused on the shared CD4 binding site epitope.
Conformational Sampling of Oligosaccharides Using Hamiltonian Replica Exchange with Two-Dimensional Dihedral Biasing Potentials and the Weighted Histogram Analysis Method (WHAM).
New
MacKerell et al., Baltimore, United States. In J Chem Theory Comput, 10 Mar 2015
The method is applied to a branched N-glycan found on the HIV gp120 protein, and a linear N-glycan.
Fluorescent CD4 probe for potential HIV-1 gp120 protein detection.
New
Chen et al., Tempe, United States. In Bioorg Med Chem Lett, 07 Mar 2015
This fluoresence was quenched after Evans blue (EB) inhibitor or HIV-1 gp120 protein binding, presumably as a consequence of changes in the distance and dipole orientation between the donor and acceptor; the emission intensity at 420nm decreased in a concentration-dependent fashion.
Recent strategies targeting HIV glycans in vaccine design.
Review
New
Krauss et al., Waltham, United States. In Nat Chem Biol, Dec 2014
These antibodies bind conserved vulnerable sites on the viral envelope glycoprotein gp120, and identification of these sites has provided exciting clues about the design of potentially effective vaccines.
Receptor Binding Domain Based HIV Vaccines.
Review
New
Jiang et al., Wuhan, China. In Biomed Res Int, Dec 2014
Therefore, we describe the receptor binding domain of gp120 as a target for developing AIDS vaccines.
Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions.
New
Impact
Mothes et al., New Haven, United States. In Science, Dec 2014
To enable the direct imaging of conformational dynamics within Env, we introduced fluorophores into variable regions of the glycoprotein gp120 subunit and measured single-molecule fluorescence resonance energy transfer within the context of native trimers on the surface of HIV-1 virions.
Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface.
New
Impact
Connors et al., Bethesda, United States. In Nature, Dec 2014
Mutagenesis and a reconstruction by negative-stain electron microscopy of the Fab in complex with trimer revealed that it bound to a conserved epitope, which stretched across gp120 and gp41.
Structure and immune recognition of trimeric pre-fusion HIV-1 Env.
New
Impact
Kwong et al., Bethesda, United States. In Nature, Nov 2014
The human immunodeficiency virus type 1 (HIV-1) envelope (Env) spike, comprising three gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by rearranging from a mature unliganded state, through receptor-bound intermediates, to a post-fusion state.
Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers.
New
Impact
Ward et al., Los Angeles, United States. In Immunity, Jun 2014
The PGT151 epitope is comprised of residues and glycans at the interface of gp41 and gp120 within a single protomer and glycans from both subunits of a second protomer and represents a neutralizing epitope that is dependent on both gp120 and gp41.
Epitope target structures of Fc-mediated effector function during HIV-1 acquisition.
Review
New
Devico et al., Baltimore, United States. In Curr Opin Hiv Aids, May 2014
Further, several studies implicate highly conserved epitopes in the C1 region of gp120 as targets of these antibodies.
Role of neurotrophic factor alterations in the neurodegenerative process in HIV associated neurocognitive disorders.
Review
New
Masliah et al., San Diego, United States. In J Neuroimmune Pharmacol, Mar 2014
Here, we report FGF overexpression curtails gp120-induced neurotoxicity in a double transgenic mouse model.
Natural Scrub Typhus Antibody Suppresses HIV CXCR4(X4) Viruses.
Review
Philpott et al., Honolulu, United States. In Infect Dis Rep, 2013
Sera from STinfected mice recognized a target that co-localized with X4 HIV gp120 in immunofluorescent experiments.
ITI-H4, as a biomarker in the serum of recurrent pregnancy loss (RPL) patients.
GeneRIF
Baek et al., Seoul, South Korea. In Mol Biosyst, 2011
Findings suggest that ITI-H4 expression may be used as a biomarker, which could facilitate the development of novel diagnostic and therapeutic tools.
Inter-alpha-trypsin inhibitor heavy chain 4 is a novel marker of acute ischemic stroke.
GeneRIF
Daginawala et al., Nāgpur, India. In Clin Chim Acta, 2009
ITIH4 is an anti-inflammatory protein, and suggests that further investigation into its potential use in the diagnosis and prognosis of acute ischemic stroke is warranted.
Proteomic techniques identify urine proteins that differentiate patients with interstitial cystitis from asymptomatic control subjects.
GeneRIF
Merchant et al., Arlington, United States. In Am J Obstet Gynecol, 2008
The inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) protein was significantly present more in interstial cystitis than controls
BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4.
GeneRIF
Blond et al., Chicago, United States. In Biochem Biophys Res Commun, 2006
ITIH4 and MTJ1 co-immunoprecipitate from total liver protein extracts and SANT domain of HTJ1 protects the ITIH4(588-930) recombinant fragment
Hypercholesterolemia associated with splice-junction variation of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) gene.
GeneRIF
Saito et al., Kawasaki, Japan. In J Hum Genet, 2003
Genetic variation at ITIH4 locus is one of the likely candidate determinants for plasma cholesterol metabolisms
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