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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 04 Oct 2015.

Inter-alpha-trypsin inhibitor heavy chain family, member 4

The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: CD4, Envelope Protein, CD45, CAN, ACID
Papers on gp120
The C4 region as a target for HIV entry inhibitors - NMR Mapping of the interacting segments of T20 and gp120.
Anglister et al., Israel. In Febs J, 02 Nov 2015
In addition to binding to gp41, T20 was found to bind to gp120 of X4 viruses and this binding was suggested to be responsible for an alternative mechanism for HIV-1 inhibition by this peptide.
Safety and efficacy of the HIV-1 attachment inhibitor prodrug BMS-663068 in treatment-experienced individuals: 24 week results of AI438011, a phase 2b, randomised controlled trial.
AI438011 study team et al., San Francisco, United States. In Lancet Hiv, 31 Oct 2015
BACKGROUND: BMS-663068 is an oral prodrug of BMS-626529, an attachment inhibitor that binds to HIV-1 gp120, blocking viral attachment to host CD4 cells.
Inhibition of Mitochondrial Fission Protein Reduced Mechanical Allodynia and Suppressed Spinal Mitochondrial Superoxide Induced by Perineural Human Immunodeficiency Virus gp120 in Rats.
Hao et al., Asahikawa, Japan. In Anesth Analg, 28 Oct 2015
In the present study, we investigated the role of mitochondrial dynamin-related protein 1 (Drp1, a GTPase that mediates mitochondrial fission) in the perineural HIV coat glycoprotein gp120-induced neuropathic pain state.
Novel p75 neurotrophin receptor ligand stabilizes neuronal calcium, preserves mitochondrial movement and protects against HIV associated neuropathogenesis.
Longo et al., Stanford, United States. In Exp Neurol, 27 Oct 2015
To better understand the pathogenic mechanisms and the neuroprotective potential of neurotrophin ligands, we evaluated neuronal damage, calcium homeostasis and mitochondrial functions after exposure of cultured rat neurons directly to HIV gp120 or to conditioned medium from human monocyte-derived macrophages treated with gp120.
Broadly Neutralizing Antibody 8ANC195 Recognizes Closed and Open States of HIV-1 Env.
Bjorkman et al., Pasadena, United States. In Cell, 10 Oct 2015
The 8ANC195 epitope, defined by crystal and electron microscopy (EM) structures of bNAb 8ANC195 complexed with monomeric gp120 and trimeric Env, respectively, spans the gp120 and gp41 Env subunits.
HIV-1 VACCINES. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies.
Haynes et al., Durham, United States. In Science, 14 Sep 2015
HIV-1-reactive plasma Ab titers were higher to Env gp41 than to gp120, and repertoire analysis demonstrated that 93% of HIV-1-reactive Abs from memory B cells responded to Env gp41.
Neuropathological sequelae of Human Immunodeficiency Virus and apathy: A review of neuropsychological and neuroimaging studies.
Antoni et al., Coral Gables, United States. In Neurosci Biobehav Rev, Aug 2015
Available literatures demonstrate that the emergence of apathy with other neurocognitive and neuropsychiatric symptoms may be attributed to neurotoxic effects of viral proliferation, e.g., aggregative effect of Tat and gp120 on apoptosis, transport and other enzymatic reactions amongst dopaminergic neurons and neuroglia.
HIV-1 VACCINES. Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen.
Nemazee et al., Los Angeles, United States. In Science, Aug 2015
Induced antibodies showed characteristics of VRC01-class bnAbs, including a short CDRL3 (light-chain complementarity-determining region 3) and mutations that favored binding to near-native HIV-1 gp120 constructs.
Prospects for a globally effective HIV-1 vaccine.
Kim et al., Bethesda, United States. In Vaccine, Jul 2015
A correlates analysis compared vaccine-induced immune responses in vaccinated-infected and vaccinated-uninfected volunteers suggested that IgG specific for the V1V2 region of gp120 was associated with reduced risk of HIV-1 infection and that plasma Env IgA was directly correlated with infection risk.
Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
Kwong et al., Bethesda, United States. In Cell, Jul 2015
The site on the HIV-1 gp120 glycoprotein that binds the CD4 receptor is recognized by broadly reactive antibodies, several of which neutralize over 90% of HIV-1 strains.
Manipulating the selection forces during affinity maturation to generate cross-reactive HIV antibodies.
Chakraborty et al., Cambridge, United States. In Cell, Mar 2015
Our calculations predict, and experiments in mice with variant gp120 constructs of the HIV envelope protein confirm, that sequential immunization with antigen variants is preferred over a cocktail for induction of cross-reactive antibodies focused on the shared CD4 binding site epitope.
Dose-response curve slope helps predict therapeutic potency and breadth of HIV broadly neutralizing antibodies.
Lee et al., Los Angeles, United States. In Nat Commun, Dec 2014
With few exceptions, CD4-binding site and V3-glycan bnAbs exhibit slopes >1, indicative of higher expected therapeutic effectiveness, whereas V2-glycan, gp41 membrane-proximal external region (MPER) and gp120-gp41 bnAbs exhibit less favourable slopes <1.
Aptamer-siRNA chimeras for HIV.
Rossi et al., Duarte, United States. In Adv Exp Med Biol, Dec 2014
So far, aptamers against either HIV-1 gp120 or CD4 have been eagerly evaluated as the aptamer portion of the aptamer-siRNA chimeras for the treatment or prevention of HIV-1.
Receptor binding domain based HIV vaccines.
Jiang et al., Wuhan, China. In Biomed Res Int, Dec 2014
Therefore, we describe the receptor binding domain of gp120 as a target for developing AIDS vaccines.
HIV-1 and its resistance to peptidic carbohydrate-binding agents (CBAs): an overview.
Schols et al., Leuven, Belgium. In Molecules, 2013
It has been shown that long-term CBA pressure in vitro can result in mutant HIV-1 isolates with several N-linked glycan deletions on gp120.
ITI-H4, as a biomarker in the serum of recurrent pregnancy loss (RPL) patients.
Baek et al., Seoul, South Korea. In Mol Biosyst, 2011
Findings suggest that ITI-H4 expression may be used as a biomarker, which could facilitate the development of novel diagnostic and therapeutic tools.
Inter-alpha-trypsin inhibitor heavy chain 4 is a novel marker of acute ischemic stroke.
Daginawala et al., Nāgpur, India. In Clin Chim Acta, 2009
ITIH4 is an anti-inflammatory protein, and suggests that further investigation into its potential use in the diagnosis and prognosis of acute ischemic stroke is warranted.
Proteomic techniques identify urine proteins that differentiate patients with interstitial cystitis from asymptomatic control subjects.
Merchant et al., Arlington, United States. In Am J Obstet Gynecol, 2008
The inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) protein was significantly present more in interstial cystitis than controls
BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4.
Blond et al., Chicago, United States. In Biochem Biophys Res Commun, 2006
ITIH4 and MTJ1 co-immunoprecipitate from total liver protein extracts and SANT domain of HTJ1 protects the ITIH4(588-930) recombinant fragment
Hypercholesterolemia associated with splice-junction variation of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) gene.
Saito et al., Kawasaki, Japan. In J Hum Genet, 2003
Genetic variation at ITIH4 locus is one of the likely candidate determinants for plasma cholesterol metabolisms
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