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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 03 Jul 2015.

Inter-alpha-trypsin inhibitor heavy chain family, member 4

gp120
The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: CD4, CD45, CAN, Envelope Protein, HAD
Papers on gp120
Developing a Successful HIV Vaccine.
New
Gallo, Baltimore, United States. In J Infect Dis, 15 Aug 2015
Immunogens targeting gp120 have been developed that block infection in monkeys and mimic the modest success of the RV144 clinical trial in that protection is short-lived following a decline in antibody-depending cell-mediated cytotoxicity-like antibodies.
P2X1 receptor antagonists inhibit HIV-1 fusion by blocking virus-coreceptor interactions.
New
Melikyan et al., Atlanta, United States. In J Virol, 01 Aug 2015
NF279 also antagonizes the signaling function of CCR5, CXCR4 and another chemokine receptor, as evidenced by the suppression of calcium responses elicited by specific ligands and by recombinant gp120.
Prospects for a globally effective HIV-1 vaccine.
Review
New
Kim et al., Bethesda, United States. In Vaccine, 19 Jul 2015
A correlates analysis compared vaccine-induced immune responses in vaccinated-infected and vaccinated-uninfected volunteers suggested that IgG specific for the V1V2 region of gp120 was associated with reduced risk of HIV-1 infection and that plasma Env IgA was directly correlated with infection risk.
Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen.
New
Impact
Nemazee et al., Los Angeles, United States. In Science, 18 Jul 2015
Induced antibodies showed characteristics of VRC01-class bnAbs, including a short light chain complementarity determining region 3 (CDRL3) and mutations that favored binding to near-native HIV-1 gp120 constructs.
Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
New
Impact
Kwong et al., Bethesda, United States. In Cell, 04 Jul 2015
The site on the HIV-1 gp120 glycoprotein that binds the CD4 receptor is recognized by broadly reactive antibodies, several of which neutralize over 90% of HIV-1 strains.
Neuropathological Sequelae of Human Immunodeficiency Virus and Apathy: A Review of Neuropsychological and Neuroimaging Studies.
Review
New
Antoni et al., Coral Gables, United States. In Neurosci Biobehav Rev, 02 Jun 2015
Available literatures demonstrate that the emergence of apathy with other neurocognitive and neuropsychiatric symptoms may be attributed to neurotoxic effects of viral proliferation, e.g., aggregative effect of Tat and gp120 on apoptosis, transport and other enzymatic reactions amongst dopaminergic neurons and neuroglia.
Manipulating the selection forces during affinity maturation to generate cross-reactive HIV antibodies.
New
Impact
Chakraborty et al., Cambridge, United States. In Cell, Mar 2015
Our calculations predict, and experiments in mice with variant gp120 constructs of the HIV envelope protein confirm, that sequential immunization with antigen variants is preferred over a cocktail for induction of cross-reactive antibodies focused on the shared CD4 binding site epitope.
HIV-1 gp120 influences the expression of microRNAs in human monocyte-derived dendritic cells via STAT3 activation.
New
Gessani et al., Roma, Italy. In Bmc Genomics, Dec 2014
RESULTS: We provide evidence that exposure of monocyte-derived dendritic cells (MDDCs) to recombinant HIV-1 R5 gp120, but not to CCR5 natural ligand CCL4, influences the expression of a panel of miRs (i.e., miR-21, miR-155 and miR-181b) regulated by STAT3 and potentially targeting genes belonging to the STAT3 signaling pathway.
Receptor binding domain based HIV vaccines.
Review
New
Jiang et al., Wuhan, China. In Biomed Res Int, Dec 2014
Therefore, we describe the receptor binding domain of gp120 as a target for developing AIDS vaccines.
Recent strategies targeting HIV glycans in vaccine design.
Review
New
Krauss et al., Waltham, United States. In Nat Chem Biol, Dec 2014
These antibodies bind conserved vulnerable sites on the viral envelope glycoprotein gp120, and identification of these sites has provided exciting clues about the design of potentially effective vaccines.
The Low-Cost Compound Lignosulfonic Acid (LA) Exhibits Broad-Spectrum Anti-HIV and Anti-HSV Activity and Has Potential for Microbicidal Applications.
New
Schols et al., Leuven, Belgium. In Plos One, Dec 2014
No antiviral activity was observed against the non-enveloped viruses Coxsackie type B4 and Reovirus type 1. LA is defined as a HIV entry inhibitor since it interfered with gp120 binding to the cell surface of T cells.
Several N-Glycans on the HIV Envelope Glycoprotein gp120 Preferentially Locate Near Disulphide Bridges and Are Required for Efficient Infectivity and Virus Transmission.
New
Balzarini et al., Leuven, Belgium. In Plos One, Dec 2014
The HIV envelope glycoprotein gp120 contains nine disulphide bridges and is highly glycosylated, carrying on average 24 N-linked glycans.
Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions.
New
Impact
Mothes et al., New Haven, United States. In Science, Dec 2014
To enable the direct imaging of conformational dynamics within Env, we introduced fluorophores into variable regions of the glycoprotein gp120 subunit and measured single-molecule fluorescence resonance energy transfer within the context of native trimers on the surface of HIV-1 virions.
Discovery of small molecular inhibitors targeting HIV-1 gp120-CD4 interaction drived from BMS-378806.
Review
New
Liu et al., Jinan, China. In Eur J Med Chem, Nov 2014
Especially, the attachment of HIV-1 envelope glycoprotein gp120 to the host cell receptor CD4 is the first key step during entry process, representing a promising antiviral therapeutic target.
Structure and immune recognition of trimeric pre-fusion HIV-1 Env.
New
Impact
Kwong et al., Bethesda, United States. In Nature, Nov 2014
The human immunodeficiency virus type 1 (HIV-1) envelope (Env) spike, comprising three gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by rearranging from a mature unliganded state, through receptor-bound intermediates, to a post-fusion state.
ITI-H4, as a biomarker in the serum of recurrent pregnancy loss (RPL) patients.
GeneRIF
Baek et al., Seoul, South Korea. In Mol Biosyst, 2011
Findings suggest that ITI-H4 expression may be used as a biomarker, which could facilitate the development of novel diagnostic and therapeutic tools.
Inter-alpha-trypsin inhibitor heavy chain 4 is a novel marker of acute ischemic stroke.
GeneRIF
Daginawala et al., Nāgpur, India. In Clin Chim Acta, 2009
ITIH4 is an anti-inflammatory protein, and suggests that further investigation into its potential use in the diagnosis and prognosis of acute ischemic stroke is warranted.
Proteomic techniques identify urine proteins that differentiate patients with interstitial cystitis from asymptomatic control subjects.
GeneRIF
Merchant et al., Arlington, United States. In Am J Obstet Gynecol, 2008
The inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) protein was significantly present more in interstial cystitis than controls
BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4.
GeneRIF
Blond et al., Chicago, United States. In Biochem Biophys Res Commun, 2006
ITIH4 and MTJ1 co-immunoprecipitate from total liver protein extracts and SANT domain of HTJ1 protects the ITIH4(588-930) recombinant fragment
Hypercholesterolemia associated with splice-junction variation of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) gene.
GeneRIF
Saito et al., Kawasaki, Japan. In J Hum Genet, 2003
Genetic variation at ITIH4 locus is one of the likely candidate determinants for plasma cholesterol metabolisms
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