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Inter-alpha-trypsin inhibitor heavy chain family, member 4

gp120
The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: CD4, Envelope Protein, CD45, CAN, ACID
Papers on gp120
Isolation of an HIV-1 neutralizing peptide mimicking the CXCR4 and CCR5 surface from the heavy-chain complementary determining region 3 repertoire of a viremic controller.
New
Deroo et al., Luxembourg, Luxembourg. In Aids, Feb 2016
RESULTS: Screening of phage libraries against recombinant gp120 led to the identification of an HCDR3-derived peptide sequence (LRTV-1) displaying antiviral properties against both X4 and R5 viruses.
Vaccine Induction of Lymph Node-Resident Simian Immunodeficiency Virus Env-Specific T Follicular Helper Cells in Rhesus Macaques.
New
Robert-Guroff et al., Bethesda, United States. In J Immunol, Feb 2016
Macaques were primed twice mucosally with adenovirus 5 host range mutant recombinants encoding SIV Env, Rev, Gag, and Nef followed by two i.m. boosts with monomeric SIV gp120 or oligomeric SIV gp140 proteins.
Conformational Epitope-Specific Broadly Neutralizing Plasma Antibodies Obtained from an HIV-1 Clade C Infected Elite Neutralizer Mediate Autologous Virus Escape through Mutations in V1 Loop.
New
Bhattacharya et al., Farīdābād, India. In J Virol, Feb 2016
Mapping studies using gp120 core protein, single residue knockout mutants and chimeric viruses revealed that G37080 BCN plasma lacks specificities to the CD4 binding site, gp41 membrane proximal external region, N160, N332 glycans as well as R166 and K169 in V1-V3 region and are known predominant targets for BCN antibodies.
Modulation of apoptosis and viral latency- an axis to be well understood for successful cure of HIV.
New
Gaur et al., In J Gen Virol, Feb 2016
HIV-1encoded proteins such as the envelope gp120 (glycoprotein gp120), Tat (trans-activator of transcription), Nef (negative regulatory factor), Vpr (viral protein R), Vpu (viral protein unique) and protease are known to be effective in modulating host cell signaling pathways that lead to an alteration in apoptosis of both HIV-infected and uninfected bystander cells.
Prospects for a Globally Effective HIV-1 Vaccine.
Review
New
Kim et al., Bethesda, United States. In Am J Prev Med, Dec 2015
A correlates analysis comparing vaccine-induced immune responses in vaccinated-infected and vaccinated-uninfected volunteers suggested that IgG specific for the V1V2 region of gp120 was associated with reduced risk of HIV-1 infection and that plasma Env IgA was directly correlated with infection risk.
In vitro eradication of citrullinated protein specific B-lymphocytes of rheumatoid arthritis patients by targeted bifunctional nanoparticles.
New
Sármay et al., Budapest, Hungary. In Arthritis Res Ther, Dec 2015
Complement dependent cytotoxicity (CDC) was induced by a modified peptide derived from gp120 of HIV-1.
Human immunodeficiency virus/acquired immune deficiency syndrome: Using drug from mathematical perceptive.
Review
New
Roy et al., Calcutta, India. In World J Virol, Dec 2015
These components may be categorized as attachment of the viral surface envelope protein subunit, gp120, to the CD4(+) receptor and chemokine coreceptors, CCR5 and CXCR4, present on T cell surface.
Broadly Neutralizing Antibody 8ANC195 Recognizes Closed and Open States of HIV-1 Env.
New
Impact
Bjorkman et al., Pasadena, United States. In Cell, Oct 2015
The 8ANC195 epitope, defined by crystal and electron microscopy (EM) structures of bNAb 8ANC195 complexed with monomeric gp120 and trimeric Env, respectively, spans the gp120 and gp41 Env subunits.
HIV-1 VACCINES. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies.
New
Impact
Haynes et al., Durham, United States. In Science, Sep 2015
HIV-1-reactive plasma Ab titers were higher to Env gp41 than to gp120, and repertoire analysis demonstrated that 93% of HIV-1-reactive Abs from memory B cells responded to Env gp41.
HIV-1 VACCINES. Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen.
New
Impact
Nemazee et al., Los Angeles, United States. In Science, Aug 2015
Induced antibodies showed characteristics of VRC01-class bnAbs, including a short CDRL3 (light-chain complementarity-determining region 3) and mutations that favored binding to near-native HIV-1 gp120 constructs.
Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
New
Impact
Kwong et al., Bethesda, United States. In Cell, Jul 2015
The site on the HIV-1 gp120 glycoprotein that binds the CD4 receptor is recognized by broadly reactive antibodies, several of which neutralize over 90% of HIV-1 strains.
Manipulating the selection forces during affinity maturation to generate cross-reactive HIV antibodies.
New
Impact
Chakraborty et al., Cambridge, United States. In Cell, Mar 2015
Our calculations predict, and experiments in mice with variant gp120 constructs of the HIV envelope protein confirm, that sequential immunization with antigen variants is preferred over a cocktail for induction of cross-reactive antibodies focused on the shared CD4 binding site epitope.
Maraviroc: a review of its use in HIV infection and beyond.
Review
Kanmogne et al., Omaha, United States. In Drug Des Devel Ther, 2014
The human immunodeficiency virus-1 (HIV-1) enters target cells by binding its envelope glycoprotein gp120 to the CD4 receptor and/or coreceptors such as C-C chemokine receptor type 5 (CCR5; R5) and C-X-C chemokine receptor type 4 (CXCR4; X4), and R5-tropic viruses predominate during the early stages of infection.
Diversity and Inter-Connections in the CXCR4 Chemokine Receptor/Ligand Family: Molecular Perspectives.
Review
Noels et al., Aachen, Germany. In Front Immunol, 2014
Also, extracellular ubiquitin (eUb) and the viral protein gp120 (HIV) have been reported as CXCR4 ligands, whereas viral chemokine vMIP-II (Herpesvirus) and human β3-defensin (HBD-3) have been identified as CXCR4 antagonists.
Role of Oxidative Stress in HIV-1-Associated Neurocognitive Disorder and Protection by Gene Delivery of Antioxidant Enzymes.
Review
Strayer et al., Philadelphia, United States. In Antioxidants (basel), 2013
Neurons themselves are rarely infected by HIV-1, but HIV-1 infects resident microglia, periventricular macrophages, leading to increased production of cytokines and to release of HIV-1 proteins, the most likely neurotoxins, among which are the envelope glycoprotein gp120 and HIV-1 trans-acting protein Tat.
ITI-H4, as a biomarker in the serum of recurrent pregnancy loss (RPL) patients.
GeneRIF
Baek et al., Seoul, South Korea. In Mol Biosyst, 2011
Findings suggest that ITI-H4 expression may be used as a biomarker, which could facilitate the development of novel diagnostic and therapeutic tools.
Inter-alpha-trypsin inhibitor heavy chain 4 is a novel marker of acute ischemic stroke.
GeneRIF
Daginawala et al., Nāgpur, India. In Clin Chim Acta, 2009
ITIH4 is an anti-inflammatory protein, and suggests that further investigation into its potential use in the diagnosis and prognosis of acute ischemic stroke is warranted.
Proteomic techniques identify urine proteins that differentiate patients with interstitial cystitis from asymptomatic control subjects.
GeneRIF
Merchant et al., Arlington, United States. In Am J Obstet Gynecol, 2008
The inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) protein was significantly present more in interstial cystitis than controls
BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4.
GeneRIF
Blond et al., Chicago, United States. In Biochem Biophys Res Commun, 2006
ITIH4 and MTJ1 co-immunoprecipitate from total liver protein extracts and SANT domain of HTJ1 protects the ITIH4(588-930) recombinant fragment
Hypercholesterolemia associated with splice-junction variation of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) gene.
GeneRIF
Saito et al., Kawasaki, Japan. In J Hum Genet, 2003
Genetic variation at ITIH4 locus is one of the likely candidate determinants for plasma cholesterol metabolisms
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