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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 15 May 2015.

Inter-alpha-trypsin inhibitor heavy chain family, member 4

gp120
The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: CD4, CAN, CD45, Envelope Protein, HAD
Papers on gp120
Frequency of coreceptor tropism in PBMC samples from HIV-1 recently infected blood donors by massively parallel sequencing: the REDS II study.
New
Sanabani et al., São Paulo, Brazil. In Virol J, 14 Jun 2015
BACKGROUND: The interaction of HIV-1 and target cells involves sequential binding of the viral gp120 Env protein to the CD4 receptor and a chemokine co-receptor (either CCR5 or CXCR4).
Adenovirus-vectored broadly neutralizing antibodies directed against gp120 prevent HIV-1 acquisition in humanized mice.
New
Sutton et al., New Haven, United States. In Hum Gene Ther, 08 Jun 2015
UNASSIGNED: Despite nearly three decades of research, a safe and effective vaccine against human immunodeficiency virus type 1 (HIV-1) has yet to be achieved.
Prevention vaginally of HIV-1 transmission in humanized BLT mice and mode of antiviral action of polyanionic carbosilane dendrimer G2-S16.
New
Muñoz-Fernández et al., Madrid, Spain. In Nanomedicine, 07 Jun 2015
Second-generation polyanionic carbosilane dendrimer G2-S16 with silica core and 16 sulfonate end-groups exerts anti-HIV-1 activity at an early stage of viral replication, blocking the gp120/CD4 interaction and acting on the virus.
Conformational instability governed by disulfide bonds partitions the dominant from subdominant helper T-cell responses specific for HIV-1 envelope glycoprotein gp120.
New
Landry et al., New Orleans, United States. In Vaccine, 02 Jun 2015
In this study, three gp120 (strain JR-FL) variants were constructed, in which deletions of single outer-domain disulfide bonds were expected to introduce local conformational flexibility and promote presentation of additional CD4(+) T-cell epitopes.
Neuropathological Sequelae of Human Immunodeficiency Virus and Apathy: A Review of Neuropsychological and Neuroimaging Studies.
Review
New
Antoni et al., Coral Gables, United States. In Neurosci Biobehav Rev, 02 Jun 2015
Available literatures demonstrate that the emergence of apathy with other neurocognitive and neuropsychiatric symptoms may be attributed to neurotoxic effects of viral proliferation, e.g., aggregative effect of Tat and gp120 on apoptosis, transport and other enzymatic reactions amongst dopaminergic neurons and neuroglia.
Correction: CD169-Mediated Trafficking of HIV to Plasma Membrane Invaginations in Dendritic Cells Attenuates Efficacy of Anti-gp120 Broadly Neutralizing Antibodies.
New
PLOS Pathogens Staff, In Plos Pathog, 31 May 2015
UNASSIGNED: [This corrects the article DOI: 10.1371/journal.ppat.1004751.].
Manipulating the selection forces during affinity maturation to generate cross-reactive HIV antibodies.
New
Impact
Chakraborty et al., Cambridge, United States. In Cell, Mar 2015
Our calculations predict, and experiments in mice with variant gp120 constructs of the HIV envelope protein confirm, that sequential immunization with antigen variants is preferred over a cocktail for induction of cross-reactive antibodies focused on the shared CD4 binding site epitope.
Receptor binding domain based HIV vaccines.
Review
New
Jiang et al., Wuhan, China. In Biomed Res Int, Dec 2014
Therefore, we describe the receptor binding domain of gp120 as a target for developing AIDS vaccines.
Recent strategies targeting HIV glycans in vaccine design.
Review
New
Krauss et al., Waltham, United States. In Nat Chem Biol, Dec 2014
These antibodies bind conserved vulnerable sites on the viral envelope glycoprotein gp120, and identification of these sites has provided exciting clues about the design of potentially effective vaccines.
Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions.
New
Impact
Mothes et al., New Haven, United States. In Science, Dec 2014
To enable the direct imaging of conformational dynamics within Env, we introduced fluorophores into variable regions of the glycoprotein gp120 subunit and measured single-molecule fluorescence resonance energy transfer within the context of native trimers on the surface of HIV-1 virions.
Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface.
New
Impact
Connors et al., Bethesda, United States. In Nature, Dec 2014
Mutagenesis and a reconstruction by negative-stain electron microscopy of the Fab in complex with trimer revealed that it bound to a conserved epitope, which stretched across gp120 and gp41.
Structure and immune recognition of trimeric pre-fusion HIV-1 Env.
New
Impact
Kwong et al., Bethesda, United States. In Nature, Nov 2014
The human immunodeficiency virus type 1 (HIV-1) envelope (Env) spike, comprising three gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by rearranging from a mature unliganded state, through receptor-bound intermediates, to a post-fusion state.
Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers.
New
Impact
Ward et al., Los Angeles, United States. In Immunity, Jun 2014
The PGT151 epitope is comprised of residues and glycans at the interface of gp41 and gp120 within a single protomer and glycans from both subunits of a second protomer and represents a neutralizing epitope that is dependent on both gp120 and gp41.
Epitope target structures of Fc-mediated effector function during HIV-1 acquisition.
Review
New
Devico et al., Baltimore, United States. In Curr Opin Hiv Aids, May 2014
Further, several studies implicate highly conserved epitopes in the C1 region of gp120 as targets of these antibodies.
Role of neurotrophic factor alterations in the neurodegenerative process in HIV associated neurocognitive disorders.
Review
New
Masliah et al., San Diego, United States. In J Neuroimmune Pharmacol, Mar 2014
Here, we report FGF overexpression curtails gp120-induced neurotoxicity in a double transgenic mouse model.
ITI-H4, as a biomarker in the serum of recurrent pregnancy loss (RPL) patients.
GeneRIF
Baek et al., Seoul, South Korea. In Mol Biosyst, 2011
Findings suggest that ITI-H4 expression may be used as a biomarker, which could facilitate the development of novel diagnostic and therapeutic tools.
Inter-alpha-trypsin inhibitor heavy chain 4 is a novel marker of acute ischemic stroke.
GeneRIF
Daginawala et al., Nāgpur, India. In Clin Chim Acta, 2009
ITIH4 is an anti-inflammatory protein, and suggests that further investigation into its potential use in the diagnosis and prognosis of acute ischemic stroke is warranted.
Proteomic techniques identify urine proteins that differentiate patients with interstitial cystitis from asymptomatic control subjects.
GeneRIF
Merchant et al., Arlington, United States. In Am J Obstet Gynecol, 2008
The inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) protein was significantly present more in interstial cystitis than controls
BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4.
GeneRIF
Blond et al., Chicago, United States. In Biochem Biophys Res Commun, 2006
ITIH4 and MTJ1 co-immunoprecipitate from total liver protein extracts and SANT domain of HTJ1 protects the ITIH4(588-930) recombinant fragment
Hypercholesterolemia associated with splice-junction variation of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) gene.
GeneRIF
Saito et al., Kawasaki, Japan. In J Hum Genet, 2003
Genetic variation at ITIH4 locus is one of the likely candidate determinants for plasma cholesterol metabolisms
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