Prospects for a globally effective HIV-1 vaccine.
Bethesda, United States. In Vaccine, 19 Jul 2015
A correlates analysis compared vaccine-induced immune responses in vaccinated-infected and vaccinated-uninfected volunteers suggested that IgG specific for the V1V2 region of gp120 was associated with reduced risk of HIV-1 infection and that plasma Env IgA was directly correlated with infection risk.
[Construction and identification of HSV-1 vector vaccine carrying HIV-1 antigen].
In Sheng Wu Gong Cheng Xue Bao, Mar 2015
The recombinant HSV was purified from the Vero cells transfected with the recombinant DNA, the unique DNA fragment was detected from the genome of recombination HSV by Southern blotting; gp120 and gp41 were detected from the infected cells by Western blotting, and the recombinant HSV retained replication competent in mammalian cells.
Aptamer-siRNA chimeras for HIV.
Duarte, United States. In Adv Exp Med Biol, Dec 2014
So far, aptamers against either HIV-1 gp120 or CD4 have been eagerly evaluated as the aptamer portion of the aptamer-siRNA chimeras for the treatment or prevention of HIV-1.
Recent strategies targeting HIV glycans in vaccine design.
Waltham, United States. In Nat Chem Biol, Dec 2014
These antibodies bind conserved vulnerable sites on the viral envelope glycoprotein gp120, and identification of these sites has provided exciting clues about the design of potentially effective vaccines.