GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 25 Jan 2016.
Inter-alpha-trypsin inhibitor heavy chain family, member 4
The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] (from
Robert-Guroff et al., Bethesda, United States. In J Immunol, 15 Feb 2016
Macaques were primed twice mucosally with adenovirus 5 host range mutant recombinants encoding SIV Env, Rev, Gag, and Nef followed by two i.m. boosts with monomeric SIV gp120 or oligomeric SIV gp140 proteins.
Bhattacharya et al., Farīdābād, India. In J Virol, 13 Feb 2016
Mapping studies using gp120 core protein, single residue knockout mutants and chimeric viruses revealed that G37080 BCN plasma lacks specificities to the CD4 binding site, gp41 membrane proximal external region, N160, N332 glycans as well as R166 and K169 in V1-V3 region and are known predominant targets for BCN antibodies.
HIV-1encoded proteins such as the envelope gp120 (glycoprotein gp120), Tat (trans-activator of transcription), Nef (negative regulatory factor), Vpr (viral protein R), Vpu (viral protein unique) and protease are known to be effective in modulating host cell signaling pathways that lead to an alteration in apoptosis of both HIV-infected and uninfected bystander cells.
Wyatt et al., Los Angeles, United States. In J Virol, 30 Jan 2016
Using the redesigned subtype B and C trimer representatives as respective foundations, we further stabilized the NFL TD trimers by engineering an intra-protomer disulfide linkage in the pre-bridging sheet, I201C-A433C (CC) that locks the gp120 in the receptor non-triggered state.
Kumar et al., Kansas City, United States. In Sci Rep, 31 Dec 2015
Various signaling molecules for IRE1α pathway were assessed using SVGA cells, primary astrocytes and gp120 transgenic mice, which demonstrated gp120-mediated increase in phosphorylated JNK, XBP-1 and AP-1 leading to upregulation of CHOP.
Nemazee et al., Los Angeles, United States. In Science, Aug 2015
Induced antibodies showed characteristics of VRC01-class bnAbs, including a short CDRL3 (light-chain complementarity-determining region 3) and mutations that favored binding to near-native HIV-1 gp120 constructs.
Chakraborty et al., Cambridge, United States. In Cell, Mar 2015
Our calculations predict, and experiments in mice with variant gp120 constructs of the HIV envelope protein confirm, that sequential immunization with antigen variants is preferred over a cocktail for induction of cross-reactive antibodies focused on the shared CD4 binding site epitope.
Strayer et al., Philadelphia, United States. In Antioxidants (basel), 2013
Neurons themselves are rarely infected by HIV-1, but HIV-1 infects resident microglia, periventricular macrophages, leading to increased production of cytokines and to release of HIV-1 proteins, the most likely neurotoxins, among which are the envelope glycoprotein gp120 and HIV-1 trans-acting protein Tat.