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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Oct 2014.

Inter-alpha-trypsin inhibitor heavy chain family, member 4

gp120
The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: CD4, CD45, CAN, Envelope Protein, ACID
Papers on gp120
Blocking interaction of viral gp120 and CD4-expressing T cells by single-stranded DNA aptamers.
New
Zu et al., Houston, United States. In Int J Biochem Cell Biol, Jun 2014
Importantly, the aptamers selectively bound CD4 on human cells and disrupted the interaction of viral gp120 to CD4 receptors, which is a prerequisite step of HIV-1 infection.
Peptides derived from HIV-1 gp120 co-receptor binding domain form amyloid fibrils and enhance HIV-1 infection.
New
Liu et al., Guangzhou, China. In Febs Lett, Jun 2014
We found peptides derived from the HIV-1 gp120 co-receptor binding region, which are defined as enhancing peptides (EPs), could form amyloid fibrils and remarkably enhance HIV-1 infection.
Epitope target structures of Fc-mediated effector function during HIV-1 acquisition.
New
Devico et al., Baltimore, United States. In Curr Opin Hiv Aids, May 2014
Further, several studies implicate highly conserved epitopes in the C1 region of gp120 as targets of these antibodies.
Elucidating a key component of cancer metastasis: CXCL12 (SDF-1α) binding to CXCR4.
New
Floudas et al., Princeton, United States. In J Chem Inf Model, May 2014
We also recently utilized this protocol to elucidate the binding of an HIV-1 gp120 V3 loop in complex with CXCR4, and a comparison between the molecular recognition of CXCR4 by CXCL12 and the HIV-1 gp120 V3 loop shows that both CXCL12 and the HIV-1 gp120 V3 loop share the same CXCR4 binding pocket, as they mostly interact with the same CXCR4 residues.
Structure-based design, synthesis and validation of CD4-mimetic small molecule inhibitors of HIV-1 entry: conversion of a viral entry agonist to an antagonist.
New
Impact
Smith et al., Philadelphia, United States. In Acc Chem Res, May 2014
Entry of the human immunodeficiency virus (HIV) into target T-cells entails an interaction between CD4 on the host T-cell and gp120, a component of the trimeric envelope glycoprotein spike on the virion surface.
HIV-1 Vaccines: Challenges and New perspectives.
Review
New
Kim et al., Bethesda, United States. In Hum Vaccin Immunother, Apr 2014
The correlate of risk analysis showed that IgG antibodies against the gp120 V2 loop correlated with decreased risk of HIV infection, while Env-specific IgA directly correlated with increased risk.
Crystal structure of a soluble cleaved HIV-1 envelope trimer.
New
Impact
Wilson et al., Los Angeles, United States. In Science, Jan 2014
The structure shows a prefusion state of gp41, the interaction between the component gp120 and gp41 subunits, and how a close association between the gp120 V1/V2/V3 loops stabilizes the trimer apex around the threefold axis.
Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer.
New
Impact
Ward et al., Los Angeles, United States. In Science, Jan 2014
The structure also provides insights into trimer assembly, gp120-gp41 interactions, and the CD4bs epitope cluster for bnAbs, which covers a more extensive area and defines a more complex site of vulnerability than previously described.
Alterations in HIV-1 gp120 V3 region are necessary but not sufficient for coreceptor switching in CRF07_BC in China.
New
Shao et al., Beijing, China. In Plos One, Dec 2013
The most predominant HIV-1 strains in China's current epidemic is the Circulating Recombinant Form 07_BC (CRF07_BC).
The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression.
New
Impact
Fauci et al., Bethesda, United States. In Nat Immunol, Dec 2013
The HIV-1 envelope protein gp120 binds to and signals through integrin α4β7 on T cells.
Strategic addition of an N-linked glycan to a monoclonal antibody improves its HIV-1-neutralizing activity.
New
Impact
Ho et al., New York City, United States. In Nat Biotechnol, Nov 2013
However, HIV-1 strains with mutations resulting in loss of an N-linked glycan from the V5 loop of the envelope glycoprotein gp120 are resistant to ibalizumab.
Novel directions in HIV-1 vaccines revealed from clinical trials.
Review
New
Russell et al., Bethesda, United States. In Curr Opin Hiv Aids, Sep 2013
The correlate of risk analysis showed that IgG antibodies against the gp120 V2 loop inversely correlated with a decreased risk of infection, whereas Env-specific IgA directly correlated with risk.
Natural Scrub Typhus Antibody Suppresses HIV CXCR4(X4) Viruses.
Review
New
Philpott et al., Honolulu, United States. In Infect Dis Rep, Feb 2013
Sera from STinfected mice recognized a target that co-localized with X4 HIV gp120 in immunofluorescent experiments.
Human immunodeficiency virus and heparan sulfate: from attachment to entry inhibition.
Review
Lortat-Jacob et al., Grenoble, France. In Front Immunol, 2012
Infection starts when gp120, the viral envelope glycoprotein, binds to CD4 and to a chemokine receptor usually CCR5 or CXCR4.
Dendrimers as potential therapeutic tools in HIV inhibition.
Review
Li et al., Nanjing, China. In Molecules, 2012
On the one hand, dendrimers with functional end groups combine with the gp120 of HIV and CD4 molecule of host cell to suppress the attachment of HIV to the host cell.
ITI-H4, as a biomarker in the serum of recurrent pregnancy loss (RPL) patients.
GeneRIF
Baek et al., Seoul, South Korea. In Mol Biosyst, 2011
Findings suggest that ITI-H4 expression may be used as a biomarker, which could facilitate the development of novel diagnostic and therapeutic tools.
Inter-alpha-trypsin inhibitor heavy chain 4 is a novel marker of acute ischemic stroke.
GeneRIF
Daginawala et al., Nāgpur, India. In Clin Chim Acta, 2009
ITIH4 is an anti-inflammatory protein, and suggests that further investigation into its potential use in the diagnosis and prognosis of acute ischemic stroke is warranted.
Proteomic techniques identify urine proteins that differentiate patients with interstitial cystitis from asymptomatic control subjects.
GeneRIF
Merchant et al., Arlington, United States. In Am J Obstet Gynecol, 2008
The inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) protein was significantly present more in interstial cystitis than controls
BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4.
GeneRIF
Blond et al., Chicago, United States. In Biochem Biophys Res Commun, 2006
ITIH4 and MTJ1 co-immunoprecipitate from total liver protein extracts and SANT domain of HTJ1 protects the ITIH4(588-930) recombinant fragment
Hypercholesterolemia associated with splice-junction variation of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) gene.
GeneRIF
Saito et al., Kawasaki, Japan. In J Hum Genet, 2003
Genetic variation at ITIH4 locus is one of the likely candidate determinants for plasma cholesterol metabolisms
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