Elucidating a key component of cancer metastasis: CXCL12 (SDF-1α) binding to CXCR4.
Princeton, United States. In J Chem Inf Model, May 2014
We also recently utilized this protocol to elucidate the binding of an HIV-1 gp120 V3 loop in complex with CXCR4, and a comparison between the molecular recognition of CXCR4 by CXCL12 and the HIV-1 gp120 V3 loop shows that both CXCL12 and the HIV-1 gp120 V3 loop share the same CXCR4 binding pocket, as they mostly interact with the same CXCR4 residues.
HIV-1 Vaccines: Challenges and New perspectives.
Bethesda, United States. In Hum Vaccin Immunother, Apr 2014
The correlate of risk analysis showed that IgG antibodies against the gp120 V2 loop correlated with decreased risk of HIV infection, while Env-specific IgA directly correlated with increased risk.
Crystal structure of a soluble cleaved HIV-1 envelope trimer.
Los Angeles, United States. In Science, Jan 2014
The structure shows a prefusion state of gp41, the interaction between the component gp120 and gp41 subunits, and how a close association between the gp120 V1/V2/V3 loops stabilizes the trimer apex around the threefold axis.