Polyreactivity and Autoreactivity among HIV-1 Antibodies.
Durham, United States. In J Virol, 29 Nov 2014
Interestingly, four of nine bNAbs specific for the HIV-1 CD4 binding site (CD4bs) (VRC01, VRC02, CH106, and CH103) bind human ubiquitin ligase E3A (UBE3A) and UBE3A protein competitively inhibits gp120 binding to the VRC01 bNAb.
Structure and immune recognition of trimeric pre-fusion HIV-1 Env.
Bethesda, United States. In Nature, 23 Nov 2014
The human immunodeficiency virus type 1 (HIV-1) envelope (Env) spike, comprising three gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by rearranging from a mature unliganded state, through receptor-bound intermediates, to a post-fusion state.
Lessons from the RV144 Thai Phase III HIV-1 Vaccine Trial and the Search for Correlates of Protection.
Silver Spring, United States. In Annu Rev Med, 17 Nov 2014
The prespecified analysis of immune correlates of risk showed that antibodies directed against the V1V2 region of gp120, in particular the IgG1 and IgG3 subclass mediating antibody-dependent cellmediated cytotoxicity, seem to play a predominant role in protection against HIV-1 acquisition and that plasma envelope (Env)-specific IgA antibodies were directly correlated with risk.
HIV-1 Vaccines: Challenges and New perspectives.
Bethesda, United States. In Hum Vaccin Immunother, Apr 2014
The correlate of risk analysis showed that IgG antibodies against the gp120 V2 loop correlated with decreased risk of HIV infection, while Env-specific IgA directly correlated with increased risk.
Cross-Border Sexual Transmission of the Newly Emerging HIV-1 Clade CRF51_01B.
Kuala Lumpur, Malaysia. In Plos One, Dec 2013
Spatial and temporal information from Bayesian MCMC coalescent and maximum likelihood analysis of the protease, gp120 and gp41 genes suggest that Singapore is probably the country of origin of CRF51_01B (as early as in the mid-1990s) and featured a Malaysian who acquired the infection through heterosexual contact as host for its ancestral lineages.