Fluorescent CD4 probe for potential HIV-1 gp120 protein detection.
Tempe, United States. In Bioorg Med Chem Lett, 07 Mar 2015
This fluoresence was quenched after Evans blue (EB) inhibitor or HIV-1 gp120 protein binding, presumably as a consequence of changes in the distance and dipole orientation between the donor and acceptor; the emission intensity at 420nm decreased in a concentration-dependent fashion.
Recent strategies targeting HIV glycans in vaccine design.
Waltham, United States. In Nat Chem Biol, Dec 2014
These antibodies bind conserved vulnerable sites on the viral envelope glycoprotein gp120, and identification of these sites has provided exciting clues about the design of potentially effective vaccines.
Structure and immune recognition of trimeric pre-fusion HIV-1 Env.
Bethesda, United States. In Nature, Nov 2014
The human immunodeficiency virus type 1 (HIV-1) envelope (Env) spike, comprising three gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by rearranging from a mature unliganded state, through receptor-bound intermediates, to a post-fusion state.