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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 15 Apr 2015.

Inter-alpha-trypsin inhibitor heavy chain family, member 4

gp120
The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: CD4, CAN, CD45, Envelope Protein, HAD
Papers on gp120
Analysis of the pharmacokinetic interactions between BMS-626529, the active moiety of the HIV-1 attachment inhibitor prodrug BMS-663068, and ritonavir or ritonavir-boosted atazanavir in healthy subjects.
New
Savant Landry et al., Princeton, United States. In Antimicrob Agents Chemother, 13 May 2015
OBJECTIVES: BMS-663068 is a prodrug of BMS-626529, a first-in-class attachment inhibitor that binds directly to HIV-1 gp120, preventing initial viral attachment and entry into host CD4+ T cells.
Peptide Triazole Inactivators of HIV-1 Utilize a Conserved Two-Cavity Binding Site at the Junction of the Inner and Outer Domains of Env gp120.
New
Chaiken et al., In J Med Chem, 10 May 2015
UNASSIGNED: We used coordinated mutagenesis, synthetic design and flexible docking to investigate the structural mechanism of Env gp120 encounter by peptide triazole (PT) inactivators of HIV-1.
Rapid screening and identification of active ingredients in licorice extract interacting with V3 loop region of HIV-1 gp120 using ACE and CE-MS.
New
Ling et al., Beijing, China. In J Pharm Biomed Anal, 27 Apr 2015
UNASSIGNED: The binding of envelope protein gp120 to glycosphingolipids is very important during the human immunodeficiency virus entering into the host cell.
Manipulating the selection forces during affinity maturation to generate cross-reactive HIV antibodies.
New
Impact
Chakraborty et al., Cambridge, United States. In Cell, 12 Mar 2015
Our calculations predict, and experiments in mice with variant gp120 constructs of the HIV envelope protein confirm, that sequential immunization with antigen variants is preferred over a cocktail for induction of cross-reactive antibodies focused on the shared CD4 binding site epitope.
The Anti-Inflammatory Activity of Curcumin Protects the Genital Mucosal Epithelial Barrier from Disruption and Blocks Replication of HIV-1 and HSV-2.
New
Kaushic et al., Hamilton, Canada. In Plos One, Dec 2014
Primary, human genital epithelial cells (GECs) were pretreated with curcumin and exposed to HIV-1 or HIV glycoprotein 120 (gp120), both of which have been shown to disrupt epithelial tight junction proteins, including ZO-1 and occludin.
Recent strategies targeting HIV glycans in vaccine design.
Review
New
Krauss et al., Waltham, United States. In Nat Chem Biol, Dec 2014
These antibodies bind conserved vulnerable sites on the viral envelope glycoprotein gp120, and identification of these sites has provided exciting clues about the design of potentially effective vaccines.
Receptor binding domain based HIV vaccines.
Review
New
Jiang et al., Wuhan, China. In Biomed Res Int, Dec 2014
Therefore, we describe the receptor binding domain of gp120 as a target for developing AIDS vaccines.
Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions.
New
Impact
Mothes et al., New Haven, United States. In Science, Dec 2014
To enable the direct imaging of conformational dynamics within Env, we introduced fluorophores into variable regions of the glycoprotein gp120 subunit and measured single-molecule fluorescence resonance energy transfer within the context of native trimers on the surface of HIV-1 virions.
Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface.
New
Impact
Connors et al., Bethesda, United States. In Nature, Dec 2014
Mutagenesis and a reconstruction by negative-stain electron microscopy of the Fab in complex with trimer revealed that it bound to a conserved epitope, which stretched across gp120 and gp41.
[A novel immunization strategy to induce strong humoral responses against HIV-1 using combined DNA, recombinant vaccinia virus and protein vaccines].
New
Liu et al., In Bing Du Xue Bao, Nov 2014
The DNA-rTV-gp140 immune regimen induced higher titers and affinity levels of HIV-1 gp120/gp140 antibodies and stronger V1V2-gp70 antibodies than the rTV-gp140 regimen.
Structure and immune recognition of trimeric pre-fusion HIV-1 Env.
New
Impact
Kwong et al., Bethesda, United States. In Nature, Nov 2014
The human immunodeficiency virus type 1 (HIV-1) envelope (Env) spike, comprising three gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by rearranging from a mature unliganded state, through receptor-bound intermediates, to a post-fusion state.
Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers.
New
Impact
Ward et al., Los Angeles, United States. In Immunity, Jun 2014
The PGT151 epitope is comprised of residues and glycans at the interface of gp41 and gp120 within a single protomer and glycans from both subunits of a second protomer and represents a neutralizing epitope that is dependent on both gp120 and gp41.
Epitope target structures of Fc-mediated effector function during HIV-1 acquisition.
Review
New
Devico et al., Baltimore, United States. In Curr Opin Hiv Aids, May 2014
Further, several studies implicate highly conserved epitopes in the C1 region of gp120 as targets of these antibodies.
Role of neurotrophic factor alterations in the neurodegenerative process in HIV associated neurocognitive disorders.
Review
New
Masliah et al., San Diego, United States. In J Neuroimmune Pharmacol, Mar 2014
Here, we report FGF overexpression curtails gp120-induced neurotoxicity in a double transgenic mouse model.
Natural Scrub Typhus Antibody Suppresses HIV CXCR4(X4) Viruses.
Review
Philpott et al., Honolulu, United States. In Infect Dis Rep, 2013
Sera from STinfected mice recognized a target that co-localized with X4 HIV gp120 in immunofluorescent experiments.
ITI-H4, as a biomarker in the serum of recurrent pregnancy loss (RPL) patients.
GeneRIF
Baek et al., Seoul, South Korea. In Mol Biosyst, 2011
Findings suggest that ITI-H4 expression may be used as a biomarker, which could facilitate the development of novel diagnostic and therapeutic tools.
Inter-alpha-trypsin inhibitor heavy chain 4 is a novel marker of acute ischemic stroke.
GeneRIF
Daginawala et al., Nāgpur, India. In Clin Chim Acta, 2009
ITIH4 is an anti-inflammatory protein, and suggests that further investigation into its potential use in the diagnosis and prognosis of acute ischemic stroke is warranted.
Proteomic techniques identify urine proteins that differentiate patients with interstitial cystitis from asymptomatic control subjects.
GeneRIF
Merchant et al., Arlington, United States. In Am J Obstet Gynecol, 2008
The inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) protein was significantly present more in interstial cystitis than controls
BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4.
GeneRIF
Blond et al., Chicago, United States. In Biochem Biophys Res Commun, 2006
ITIH4 and MTJ1 co-immunoprecipitate from total liver protein extracts and SANT domain of HTJ1 protects the ITIH4(588-930) recombinant fragment
Hypercholesterolemia associated with splice-junction variation of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) gene.
GeneRIF
Saito et al., Kawasaki, Japan. In J Hum Genet, 2003
Genetic variation at ITIH4 locus is one of the likely candidate determinants for plasma cholesterol metabolisms
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