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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 04 Sep 2015.

Inter-alpha-trypsin inhibitor heavy chain family, member 4

The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: CD4, Envelope Protein, CD45, CAN, ACID
Papers on gp120
Macrocyclic Envelope Glycoprotein Antagonists that Irreversibly Inactivate HIV-1 before Host Cell Encounter.
Chaiken et al., In J Med Chem, 02 Oct 2015
Cyclic peptide triazoles (cPTs) retained the gp120 inhibitory and virus-inactivating signature of parent PTs, arguing that cyclization locked an active conformation.
A Novel Role of Proline Oxidase in HIV-1 Envelope Glycoprotein Induced Neuronal Autophagy.
Dash et al., United States. In J Biol Chem, 01 Oct 2015
This study for the first time demonstrates a role of POX in HIV-1 envelope glycoprotein (gp120) induced neuronal autophagy.
Development of Small-molecule HIV Entry Inhibitors Specifically Targeting gp120 or gp41.
Jiang et al., Shanghai, China. In Curr Top Med Chem, 01 Oct 2015
UNASSIGNED: Human immunodeficiency virus type 1 (HIV-1) envelope (Env) glycoprotein surface subunit gp120 and transmembrane subunit gp41 play important roles in HIV-1 entry, thus serving as key targets for the development of HIV-1 entry inhibitors.
Influences on the design and purification of soluble, recombinant native-like HIV-1 envelope glycoprotein trimers.
Moore et al., New York City, United States. In J Virol, 26 Sep 2015
The addition of a 20-residue flexible linker between the gp120 and gp41ECTO subunits to make the uncleaved 92UG037 gp140-FL20 construct is not sufficient to create a native-like trimer, but a small percentage of native-like trimers were produced when an I559P substitution in gp41ECTO was also present.
HIV-1 VACCINES. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies.
Haynes et al., Durham, United States. In Science, 14 Sep 2015
HIV-1-reactive plasma Ab titers were higher to Env gp41 than to gp120, and repertoire analysis demonstrated that 93% of HIV-1-reactive Abs from memory B cells responded to Env gp41.
Cocaine enhances HIV-1 gp120-induced lymphatic endothelial dysfunction in the lung.
Groopman et al., Boston, United States. In Physiol Rep, 31 Aug 2015
Using primary lung lymphatic endothelial cells (L-LECs), we examined how cocaine and HIV-1 gp120, alone and together, modulate signaling and functional properties of L-LECs.
Neuropathological sequelae of Human Immunodeficiency Virus and apathy: A review of neuropsychological and neuroimaging studies.
Antoni et al., Coral Gables, United States. In Neurosci Biobehav Rev, 31 Aug 2015
Available literatures demonstrate that the emergence of apathy with other neurocognitive and neuropsychiatric symptoms may be attributed to neurotoxic effects of viral proliferation, e.g., aggregative effect of Tat and gp120 on apoptosis, transport and other enzymatic reactions amongst dopaminergic neurons and neuroglia.
HIV-1 VACCINES. Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen.
Nemazee et al., Los Angeles, United States. In Science, 10 Aug 2015
Induced antibodies showed characteristics of VRC01-class bnAbs, including a short CDRL3 (light-chain complementarity-determining region 3) and mutations that favored binding to near-native HIV-1 gp120 constructs.
Prospects for a globally effective HIV-1 vaccine.
Kim et al., Bethesda, United States. In Vaccine, Jul 2015
A correlates analysis compared vaccine-induced immune responses in vaccinated-infected and vaccinated-uninfected volunteers suggested that IgG specific for the V1V2 region of gp120 was associated with reduced risk of HIV-1 infection and that plasma Env IgA was directly correlated with infection risk.
Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
Kwong et al., Bethesda, United States. In Cell, Jul 2015
The site on the HIV-1 gp120 glycoprotein that binds the CD4 receptor is recognized by broadly reactive antibodies, several of which neutralize over 90% of HIV-1 strains.
Manipulating the selection forces during affinity maturation to generate cross-reactive HIV antibodies.
Chakraborty et al., Cambridge, United States. In Cell, Mar 2015
Our calculations predict, and experiments in mice with variant gp120 constructs of the HIV envelope protein confirm, that sequential immunization with antigen variants is preferred over a cocktail for induction of cross-reactive antibodies focused on the shared CD4 binding site epitope.
Aptamer-siRNA chimeras for HIV.
Rossi et al., Duarte, United States. In Adv Exp Med Biol, Dec 2014
So far, aptamers against either HIV-1 gp120 or CD4 have been eagerly evaluated as the aptamer portion of the aptamer-siRNA chimeras for the treatment or prevention of HIV-1.
Receptor binding domain based HIV vaccines.
Jiang et al., Wuhan, China. In Biomed Res Int, Dec 2014
Therefore, we describe the receptor binding domain of gp120 as a target for developing AIDS vaccines.
Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions.
Mothes et al., New Haven, United States. In Science, Dec 2014
To enable the direct imaging of conformational dynamics within Env, we introduced fluorophores into variable regions of the glycoprotein gp120 subunit and measured single-molecule fluorescence resonance energy transfer within the context of native trimers on the surface of HIV-1 virions.
HIV-1 and its resistance to peptidic carbohydrate-binding agents (CBAs): an overview.
Schols et al., Leuven, Belgium. In Molecules, 2013
It has been shown that long-term CBA pressure in vitro can result in mutant HIV-1 isolates with several N-linked glycan deletions on gp120.
ITI-H4, as a biomarker in the serum of recurrent pregnancy loss (RPL) patients.
Baek et al., Seoul, South Korea. In Mol Biosyst, 2011
Findings suggest that ITI-H4 expression may be used as a biomarker, which could facilitate the development of novel diagnostic and therapeutic tools.
Inter-alpha-trypsin inhibitor heavy chain 4 is a novel marker of acute ischemic stroke.
Daginawala et al., Nāgpur, India. In Clin Chim Acta, 2009
ITIH4 is an anti-inflammatory protein, and suggests that further investigation into its potential use in the diagnosis and prognosis of acute ischemic stroke is warranted.
Proteomic techniques identify urine proteins that differentiate patients with interstitial cystitis from asymptomatic control subjects.
Merchant et al., Arlington, United States. In Am J Obstet Gynecol, 2008
The inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) protein was significantly present more in interstial cystitis than controls
BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4.
Blond et al., Chicago, United States. In Biochem Biophys Res Commun, 2006
ITIH4 and MTJ1 co-immunoprecipitate from total liver protein extracts and SANT domain of HTJ1 protects the ITIH4(588-930) recombinant fragment
Hypercholesterolemia associated with splice-junction variation of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) gene.
Saito et al., Kawasaki, Japan. In J Hum Genet, 2003
Genetic variation at ITIH4 locus is one of the likely candidate determinants for plasma cholesterol metabolisms
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