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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 24 Oct 2014.

Inter-alpha-trypsin inhibitor heavy chain family, member 4

gp120
The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: CD4, CD45, CAN, Envelope Protein, ACID
Papers on gp120
The HIV-1 gp120 CD4-bound conformation is preferentially targeted by ADCC-mediating antibodies in sera from HIV-1-infected individuals.
New
Finzi et al., Montréal, Canada. In J Virol, 22 Nov 2014
UNLABELLED: Recent studies have linked antibody Fc-mediated effector functions with protection or control of HIV-1 and SIV infections.
Global shape and ligand binding efficiency of the HIV-1 neutralizing antibodies differs from the ones which cannot neutralize.
New
Ashish et al., India. In J Biol Chem, 20 Nov 2014
Chromatography and SAXS results of papain digested products revealed that 1) the Fab/Fc or Fab/Fab interactions in unliganded mAbs are retained in digested products, and 2) while anti-gp120 non-nmAbs could bind two gp120 molecules, nmAbs could bind only one gp120.
Lessons from the RV144 Thai Phase III HIV-1 Vaccine Trial and the Search for Correlates of Protection.
New
Michael et al., Silver Spring, United States. In Annu Rev Med, 17 Nov 2014
The prespecified analysis of immune correlates of risk showed that antibodies directed against the V1V2 region of gp120, in particular the IgG1 and IgG3 subclass mediating antibody-dependent cellmediated cytotoxicity, seem to play a predominant role in protection against HIV-1 acquisition and that plasma envelope (Env)-specific IgA antibodies were directly correlated with risk.
Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions.
New
Impact
Mothes et al., New Haven, United States. In Science, 08 Nov 2014
To enable the direct imaging of conformational dynamics within Env we introduced fluorophores into variable regions of the gp120 subunit and measured single-molecule fluorescence resonance energy transfer (smFRET) within the context of native trimers on the surface of HIV-1 virions.
Structure and immune recognition of trimeric pre-fusion HIV-1 Env.
New
Impact
Kwong et al., Bethesda, United States. In Nature, 08 Nov 2014
UNLABELLED: The human immunodeficiency virus type 1 (HIV-1) envelope (Env) spike, comprising three gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by rearranging from a mature unliganded state, through receptor-bound intermediates, to a post-fusion state.
Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface.
New
Impact
Connors et al., Bethesda, United States. In Nature, 03 Oct 2014
Mutagenesis and a reconstruction by negative-stain electron microscopy of the Fab in complex with trimer revealed that it bound to a conserved epitope, which stretched across gp120 and gp41.
Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers.
New
Impact
Ward et al., Los Angeles, United States. In Immunity, Jun 2014
The PGT151 epitope is comprised of residues and glycans at the interface of gp41 and gp120 within a single protomer and glycans from both subunits of a second protomer and represents a neutralizing epitope that is dependent on both gp120 and gp41.
Discovery of protective B-cell epitopes for development of antimicrobial vaccines and antibody therapeutics.
Review
New
Yang et al., Boston, United States. In Immunology, May 2014
Examples include the V-shaped Ab52 glycan epitope in the O-antigen of Francisella tularensis, the concave CR6261 peptidic epitope in the haemagglutinin stem of influenza virus H1N1, and the convex/concave PG16 glycopeptidic epitope in the gp120 V1/V2 loop of HIV type 1.
Structure-based design, synthesis and validation of CD4-mimetic small molecule inhibitors of HIV-1 entry: conversion of a viral entry agonist to an antagonist.
New
Impact
Smith et al., Philadelphia, United States. In Acc Chem Res, May 2014
Entry of the human immunodeficiency virus (HIV) into target T-cells entails an interaction between CD4 on the host T-cell and gp120, a component of the trimeric envelope glycoprotein spike on the virion surface.
HIV-1 Vaccines: Challenges and New perspectives.
Review
New
Kim et al., Bethesda, United States. In Hum Vaccin Immunother, Apr 2014
The correlate of risk analysis showed that IgG antibodies against the gp120 V2 loop correlated with decreased risk of HIV infection, while Env-specific IgA directly correlated with increased risk.
Atomic force microscopy fishing and mass spectrometry identification of gp120 on immobilized aptamers.
New
Archakov et al., Moscow, Russia. In Int J Nanomedicine, Dec 2013
Atomic force microscopy (AFM) was applied to carry out direct and label-free detection of gp120 human immunodeficiency virus type 1 envelope glycoprotein as a target protein.
Cross-Border Sexual Transmission of the Newly Emerging HIV-1 Clade CRF51_01B.
New
Tee et al., Kuala Lumpur, Malaysia. In Plos One, Dec 2013
Spatial and temporal information from Bayesian MCMC coalescent and maximum likelihood analysis of the protease, gp120 and gp41 genes suggest that Singapore is probably the country of origin of CRF51_01B (as early as in the mid-1990s) and featured a Malaysian who acquired the infection through heterosexual contact as host for its ancestral lineages.
Epitope specificity of human immunodeficiency virus-1 antibody dependent cellular cytotoxicity [ADCC] responses.
Review
New
Ferrari et al., Durham, United States. In Curr Hiv Res, Jul 2013
ADCC antibody responses have been mapped to multiple linear and conformational epitopes within the HIV-1 envelope glycoproteins gp120 and gp41.
Natural Scrub Typhus Antibody Suppresses HIV CXCR4(X4) Viruses.
Review
New
Philpott et al., Honolulu, United States. In Infect Dis Rep, Feb 2013
Sera from STinfected mice recognized a target that co-localized with X4 HIV gp120 in immunofluorescent experiments.
Human immunodeficiency virus and heparan sulfate: from attachment to entry inhibition.
Review
Lortat-Jacob et al., Grenoble, France. In Front Immunol, 2012
Infection starts when gp120, the viral envelope glycoprotein, binds to CD4 and to a chemokine receptor usually CCR5 or CXCR4.
ITI-H4, as a biomarker in the serum of recurrent pregnancy loss (RPL) patients.
GeneRIF
Baek et al., Seoul, South Korea. In Mol Biosyst, 2011
Findings suggest that ITI-H4 expression may be used as a biomarker, which could facilitate the development of novel diagnostic and therapeutic tools.
Inter-alpha-trypsin inhibitor heavy chain 4 is a novel marker of acute ischemic stroke.
GeneRIF
Daginawala et al., Nāgpur, India. In Clin Chim Acta, 2009
ITIH4 is an anti-inflammatory protein, and suggests that further investigation into its potential use in the diagnosis and prognosis of acute ischemic stroke is warranted.
Proteomic techniques identify urine proteins that differentiate patients with interstitial cystitis from asymptomatic control subjects.
GeneRIF
Merchant et al., Arlington, United States. In Am J Obstet Gynecol, 2008
The inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) protein was significantly present more in interstial cystitis than controls
BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4.
GeneRIF
Blond et al., Chicago, United States. In Biochem Biophys Res Commun, 2006
ITIH4 and MTJ1 co-immunoprecipitate from total liver protein extracts and SANT domain of HTJ1 protects the ITIH4(588-930) recombinant fragment
Hypercholesterolemia associated with splice-junction variation of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) gene.
GeneRIF
Saito et al., Kawasaki, Japan. In J Hum Genet, 2003
Genetic variation at ITIH4 locus is one of the likely candidate determinants for plasma cholesterol metabolisms
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