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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Premelanosome protein

gp100, Pmel17
This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011] (from NCBI)
Top mentioned proteins: tyrosinase, MART-1, CAN, Artemis, CD8
Papers using gp100 antibodies
Increased prevalence of regulatory T cells (Treg) is induced by pancreas adenocarcinoma
Supplier
Economou James S et al., In Journal of Hematology & Oncology, 2005
... )-restricted epitope of gp100 (25-33) presented on the surface of B16 melanoma, and OTII TCR transgenic mice whose transgenic receptor ...
Mesenchymal–epithelial interactions in the skin
Supplier
Hearing Vincent J. et al., In The Journal of Cell Biology, 2002
... ), αPEP13h for gp100 (1:4,000 dilution; Virador et al., 2001), and β-catenin (1:50 dilution; Cell Signaling Technology) ...
Papers on gp100
Effective clinical responses in metastatic melanoma patients after vaccination with primary myeloid dendritic cells.
New
de Vries et al., Amsterdam, Netherlands. In Clin Cancer Res, Jan 2016
EXPERIMENTAL DESIGN Fourteen stage IV melanoma patients, without previous systemic treatment for metastatic disease, received autologous CD1c+ myeloid DCs, activated by only brief (16h) ex vivo culture and loaded with tumor associated antigens of tyrosinase and gp100.
Desmoplastic Melanoma: An Updated Immunohistochemical Analysis of 40 cases with a Proposal for an Additional Panel of Stains for Diagnosis.
New
Suster et al., Milwaukee, United States. In J Cutan Pathol, Jan 2016
The purpose of this study was to analyze 40 cases of DM with a comprehensive panel of immunohistochemical markers (KBA.62, p16, Ezrin, WT-1, MITF-1, SOX-10, CD117, SOX-2, Nestin, PNL2, p75, MART-1, gp100 and S100p) to obtain a more complete understanding of the potential use of these antibodies in the diagnosis of DM.
Serum Immunoregulatory Proteins as Predictors of Overall Survival of Metastatic Melanoma Patients Treated with Ipilimumab.
New
Bahjat et al., Portland, United States. In Cancer Res, Jan 2016
We analyzed serum from patients with metastatic melanoma (247 of 273, 90.4%) randomly assigned to receive ipilimumab or gp100 peptide vaccine.
Co-potentiation of antigen recognition: A mechanism to boost weak T cell responses and provide immunotherapy in vivo.
New
Gil et al., Rochester, United States. In Sci Adv, Oct 2015
We identified Mono-7D6-Fab, which biophysically altered TCR/CD3 when bound and functionally enhanced immune reactivity to several weak antigens in vitro, including a gp100-derived peptide associated with melanoma.
Immunotherapy-induced leukoderma from treatment of melanoma with IL-2: a case report and a review of the literature.
Review
New
Yosipovitch et al., Jackson, United States. In Acta Derm Venereol, Feb 2015
MART-1/2, gp100, tyrosinase) have been presented on the surface of both normal and malignant melanocytes and mediate the development of MAL after cytotoxic CD8+ T cells attack both cell types.
PLX4032 Mediated Melanoma Associated Antigen Potentiation in Patient Derived Primary Melanoma Cells.
Tiwari et al., Valhalla, United States. In J Cancer, 2014
Expression of MAAs such as MART-1 and gp100 is modulated by the MAPK signaling pathway, which is often deregulated in melanoma.
Cancer vaccines: Trafficking of tumor-specific T cells to tumor after therapeutic vaccination.
Review
Overwijk et al., Houston, United States. In Int J Biochem Cell Biol, 2014
The vaccination site eventually became a T cell graveyard where T cells responded to chronically released gp100 peptide by releasing cytokines, including interferon-γ (IFN-γ), which in turn upregulated Fas ligand (FasL) on host cells, causing apoptosis of Fas(+) T cells.
Adoptive cell transfer for patients with metastatic melanoma: the potential and promise of cancer immunotherapy.
Review
Rosenberg et al., Bethesda, United States. In Cancer Control, 2013
Pilot trials using TCR-engineered cells against melanoma-associated antigens MART-1 and gp100 and the cancer-testis antigen NY-ESO-1 have shown clinical responses in patients with melanoma.
Persistent antigen at vaccination sites induces tumor-specific CD8⁺ T cell sequestration, dysfunction and deletion.
Impact
Overwijk et al., Houston, United States. In Nat Med, 2013
To understand why cancer vaccine-induced T cells often do not eradicate tumors, we studied immune responses in mice vaccinated with gp100 melanoma peptide in incomplete Freund's adjuvant (peptide/IFA), which is commonly used in clinical cancer vaccine trials.
[Antibody therapies for melanoma].
Review
Okuyama et al., Chinju, South Korea. In Nihon Rinsho, 2012
Although 10 mg/kg of ipilimumab showed 10-15% of objective response, phase 3 study of ipilimumab with gp100 vaccination or with dacarbazine showed prolonged survival.
How recent advances in immunotherapy are changing the standard of care for patients with metastatic melanoma.
Review
Wolchok, New York City, United States. In Ann Oncol, 2012
Among the pretreated patients, ipilimumab monotherapy significantly improved median OS (Hazard ratio (HR): 0.66, P = 0.003) from 6.4 months in gp100 vaccine controls to 10.1 months.
The melanosomal protein PMEL17 as a target for antibody drug conjugate therapy in melanoma.
GeneRIF
Polakis et al., San Francisco, United States. In J Biol Chem, 2012
An antibody drug conjugate reactive with PMEL17 exhibits target-dependent tumor cell killing in vitro and in vivo.
MART-1- and gp100-expressing and -non-expressing melanoma cells are equally proliferative in tumors and clonogenic in vitro.
GeneRIF
Mordoh et al., Buenos Aires, Argentina. In J Invest Dermatol, 2012
MART-1- and gp100-expressing and -non-expressing melanoma cells are equally proliferative in tumors and clonogenic in vitro.
Probing fibril dissolution of the repeat domain of a functional amyloid, Pmel17, on the microscopic and residue level.
GeneRIF
Lee et al., Bethesda, United States. In Biochemistry, 2012
Pmel17 repeat domain fibril dissolution is pH dependent
The yin and yang of amyloid: insights from α-synuclein and repeat domain of Pmel17.
GeneRIF
Lee et al., Bethesda, United States. In Phys Chem Chem Phys, 2012
This is a review on two human amyloidogenic polypeptides, one associated with Parkinson's disease, alpha-synuclein (alpha-syn), and the other important for melanin synthesis, the repeat domain (RPT) from Pmel17.[Review]
Mutations in or near the transmembrane domain alter PMEL amyloid formation from functional to pathogenic.
GeneRIF
Marks et al., Philadelphia, United States. In Plos Genet, 2011
the DW and HoSi mutations alter PMEL TMD oligomerization and/or association with membranes, with consequent formation of aberrantly packed fibrils. PMEL mutations can model the conversion between physiological and pathological amyloid
gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma.
Impact
Hwu et al., Goshen, United States. In N Engl J Med, 2011
In a previous phase 2 study, patients with metastatic melanoma receiving high-dose interleukin-2 plus the gp100:209-217(210M) peptide vaccine had a higher rate of response than the rate that is expected among patients who are treated with interleukin-2 alone.
Improved survival with ipilimumab in patients with metastatic melanoma.
Impact
Urba et al., Boston, United States. In N Engl J Med, 2010
In this phase 3 study, ipilimumab--which blocks cytotoxic T-lymphocyte-associated antigen 4 to potentiate an antitumor T-cell response--administered with or without a glycoprotein 100 (gp100) peptide vaccine was compared with gp100 alone in patients with previously treated metastatic melanoma.
Helper T-cell responses and clinical activity of a melanoma vaccine with multiple peptides from MAGE and melanocytic differentiation antigens.
Impact
Rehm et al., Charlottesville, United States. In J Clin Oncol, 2008
Source proteins for these peptides include MAGE proteins, MART-1/MelanA, gp100, and tyrosinase.
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