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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Golgin A6 family, member A

Golgin linked to PML, GLP
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The protein encoded by this gene is a member of the golgin family of proteins, whose members localize to the Golgi. This gene is found in a large, low copy repeat sequence or duplicon that is found in multiple copies, that are greather than 90% similar, on chromosome 15. Duplicons are associated with deletions, inversions and other chromosome rearrangements that underlie genomic disease. The protein encoded by this gene is thought to be a functional golgin protein while the majority of the related copies of this gene are thought to be transcribed pseudogenes. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: E4, Glucagon, Insulin, HAD, CAN
Papers on Golgin linked to PML
Intestinal Bile Acid Composition Modulates Prohormone Convertase 1/3 (PC1/3) Expression and Consequent GLP-1 Production in male mice.
New
Itoh et al., Tokyo, Japan. In Endocrinology, Feb 2016
Although the mechanisms underlying these effects are still enigmatic, GLP-1 appears to be involved.
Puerarin protects pancreatic β-cells in obese diabetic mice via activation of GLP-1R signaling.
New
Shu et al., Nanjing, China. In Mol Endocrinol, Feb 2016
Glucagon-like peptide 1 receptor (GLP-1R) signaling plays an important role in β-cell survival and function.
A Protein Preload Enhances the Glucose-Lowering Efficacy of Vildagliptin in Type 2 Diabetes.
New
Rayner et al., Adelaide, Australia. In Diabetes Care, Feb 2016
Compared with both PLBO/WHEY and VILD/CTRL, VILD/WHEY was associated with higher plasma intact GLP-1 and GIP, slower gastric emptying, and lower postprandial glycemia (P < 0.05 each).
GLP-1 based therapies: clinical implications for gastroenterologists.
Review
New
Cahen et al., Amsterdam, Netherlands. In Gut, Feb 2016
UNASSIGNED: The gut-derived incretin hormone, glucagon-like peptide 1 (GLP-1) lowers postprandial blood glucose levels by stimulating insulin and inhibiting glucagon secretion.
Effects of endogenous GLP-1 and GIP on glucose tolerance after Roux-en-Y gastric bypass surgery.
New
Madsbad et al., Copenhagen, Denmark. In Am J Physiol Endocrinol Metab, Feb 2016
UNASSIGNED: Exaggerated secretion of glucagon-like peptide 1 (GLP-1) is important for postprandial glucose tolerance after Roux-en-Y gastric bypass (RYGB), whereas the role of glucose-dependent insulinotropic polypeptide (GIP) remains to be resolved.
Drug development from the bench to the pharmacy: with special reference to dipeptidyl peptidase-4 inhibitor development.
Review
New
Carr, Ballerup, Denmark. In Diabet Med, Feb 2016
Glucagon-like peptide 1 (GLP-1), a hormone with a spectrum of favourable metabolic actions, including glucose-dependent stimulation of insulin and inhibition of glucagon secretion, provided the endocrine basis from which the idea of using DPP-4 inhibitors as anti-diabetic agents was developed.
IDegLira: Redefining insulin optimisation using a single injection in patients with type 2 diabetes.
Review
New
Hughes, Ryde, United Kingdom. In Prim Care Diabetes, Feb 2016
With complementary modes of action, glucagon-like peptide-1 receptor agonists (GLP-1RAs) and a basal insulin in combination offer an alternative to basal-bolus therapy in T2D.
TCF1 links GIPR signaling to the control of beta cell function and survival.
New
Impact
Drucker et al., Toronto, Canada. In Nat Med, Jan 2016
The glucagon-like peptide-1 (GLP-1) receptor and the glucose-dependent insulinotropic polypeptide (GIP) receptor transduce nutrient-stimulated signals to control beta cell function.
Lixisenatide in type 2 diabetes: latest evidence and clinical usefulness.
Review
New
Trujillo et al., Aurora, United States. In Ther Adv Chronic Dis, Jan 2016
Glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) are an appealing treatment option as they improve glycemic control, reduce weight, and limit the risk of hypoglycemia.
Murine GPRC6A Mediates Cellular Responses to L-Amino Acids, but Not Osteocalcin Variants.
New
Langmead et al., Australia. In Plos One, Dec 2015
Using cell signalling, and glucagon-like peptide (GLP)-1 and insulin release assays, our results confirm that basic L-amino acids act as agonists of the murine GPRC6A receptor in both recombinant cells and immortalised entero-endocrine and pancreatic β-cells.
Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease.
Review
New
Impact
D'Alessio et al., Cincinnati, United States. In Physiol Rev, Apr 2015
Of these, glucagon and GLP-1 have received the most attention because of important roles in glucose metabolism, involvement in diabetes and other disorders, and application to therapeutics.
GLP-1R agonists promote normal and neoplastic intestinal growth through mechanisms requiring Fgf7.
New
Impact
Drucker et al., Toronto, Canada. In Cell Metab, Apr 2015
Glucagon-like peptide-1 (GLP-1) secreted from enteroendocrine L cells promotes nutrient disposal via the incretin effect.
A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents.
Impact
Tschöp et al., München, Germany. In Nat Med, 2015
We report the discovery of a new monomeric peptide that reduces body weight and diabetic complications in rodent models of obesity by acting as an agonist at three key metabolically-related peptide hormone receptors: glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon receptors.
Enteroendocrine MC4R and energy balance: linking the long and the short of it.
Impact
Batterham et al., London, United Kingdom. In Cell Metab, 2015
(2014) identify that MC4Rs expressed on intestinal enteroendocrine L cells regulate PYY and GLP-1 secretion, two gut hormones implicated in the regulation of energy and glucose homeostasis.
Medicinal Plants Qua Glucagon-Like Peptide-1 Secretagogue via Intestinal Nutrient Sensors.
Review
Jang et al., Seoul, South Korea. In Evid Based Complement Alternat Med, 2014
Glucagon-like peptide-1 (GLP-1) participates in glucose homeostasis and feeding behavior.
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