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Gonadotropin-releasing hormone receptor

GnRH receptor, gonadotropin-releasing hormone receptor, GnRHR
This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Gonadotropin-Releasing Hormone, CAN, HAD, FSH, V1a
Papers on GnRH receptor
Childhood growth in boys with congenital hypogonadotropic hypogonadism.
Raivio et al., Helsinki, Finland. In Pediatr Res, Jan 2016
Genetically verified diagnosis of CHH was made in 15 (42%) patients (KAL1, FGFR1, GNRHR or PROK2).
GnRH and GnRH receptors in the pathophysiology of the human female reproductive system.
Limonta et al., Milano, Italy. In Hum Reprod Update, Jan 2016
The more recent identification of a GnRH/GnRH receptor (GnRHR) system in both the human endometrium and ovary has widened the spectrum of action of the peptide and of its analogues beyond its hypothalamic function.
Spectrum of Phenotype and Genotype of Congenital Isolated Hypogonadotropic Hypogonadism in Asian Indians.
Shah et al., Aurangābād, India. In Clin Endocrinol (oxf), Jan 2016
DESIGN, SETTING & SUBJECTS: A cohort of 135 IHH probands were characterised phenotypically for reproductive and non reproductive features and screened for rare sequence variations (RSVs) in five genes KAL1, FGFR1, FGF8, GNRHR and KISS1R.
Corticosterone blocks ovarian cyclicity and the LH surge via decreased kisspeptin neuron activation in female mice.
Breen et al., San Diego, United States. In Endocrinology, Jan 2016
In addition, corticosterone blunted pituitary expression of the genes encoding the GnRH receptor and LHβ, indicating inhibition of gonadotropes during the blockage of the LH surge.
Persistent GnRH receptor activation in pituitary αT3-1 cells analyzed with a label-free technology.
Heitman et al., Leiden, Netherlands. In Biosens Bioelectron, Jan 2016
In this study, we examined the activation profiles of the endogenous ligand, GnRH and a well-known marketed analog, buserelin using a label-free assay in pituitary αT3-1 cells with endogenous GnRH receptor expression.
GnRH regulates trophoblast invasion via RUNX2-mediated MMP2/9 expression.
Leung et al., Vancouver, Canada. In Mol Hum Reprod, Jan 2016
WIDER IMPLICATIONS OF THE FINDINGS: Our findings provide important insight into the functions of the GnRH - GnRH receptor system in early implantation and placentation.
Genetics of Hypogonadotropic Hypogonadism.
Kotan et al., In Endocr Dev, Dec 2015
GNRHR and TACR3 should be the first two genes to be screened in a clinical setting for equivocal cases such as constitutional delay in puberty versus idiopathic HH.
Pregnancy, Primary Aldosteronism, and Adrenal CTNNB1 Mutations.
Brown et al., Cambridge, United Kingdom. In N Engl J Med, Nov 2015
Their aldosterone-producing adenomas harbored activating mutations of CTNNB1, encoding β-catenin in the Wnt cell-differentiation pathway, and expressed LHCGR and GNRHR, encoding gonadal receptors, at levels that were more than 100 times as high as the levels in other aldosterone-producing adenomas.
Minireview: Activin Signaling in Gonadotropes: What Does the FOX say… to the SMAD?
Bernard et al., Toronto, Canada. In Mol Endocrinol, Jul 2015
According to subsequent in vitro observations, activins also stimulate the transcription of the GnRH receptor (Gnrhr) and the activin antagonist, follistatin (Fst).
ADT risks and side effects in advanced prostate cancer: cardiovascular and acute renal injury.
Moul et al., In Oncology (williston Park), 2015
We discuss possible mechanisms by which such events might be mediated, including the roles of testosterone and the GnRH receptor, and consider current guidelines in light of these data.
KISS1R: Hallmarks of an Effective Regulator of the Neuroendocrine Axis.
Babwah et al., Pretoria, South Africa. In Neuroendocrinology, 2014
Finally, the potential for the utilization of KP and analogs in stimulating and inhibiting the reproductive hormone cascade as an alternative to targeting the downstream GnRH receptor is discussed.
GnRH receptors in cancer: from cell biology to novel targeted therapeutic strategies.
Moretti et al., Milano, Italy. In Endocr Rev, 2012
The crucial role of pituitary GnRH receptors (GnRH-R) in the control of reproductive functions is well established.
Single nucleotide polymorphisms in the regulatory region of gonadotropin-releasing hormone receptor gene and breast cancer susceptibility.
Ortmann et al., Regensburg, Germany. In Oncol Rep, 2012
A potential role of GnRHR gene polymorphisms in the development of breast cancer.
Selective cleavage of ErbB4 by G-protein-coupled gonadotropin-releasing hormone receptor in cultured hypothalamic neurons.
Yamamoto et al., Okinawa, Japan. In J Cell Physiol, 2012
Report down-regulation of ErbB4 expression in hypothalamic neurons induced by G-protein-coupled gonadotropin releasing hormone receptor stimulation.
Gonadotropin-releasing hormone/gonadotropin-releasing hormone receptor signaling in the placenta.
Norwitz et al., Boston, United States. In Curr Opin Endocrinol Diabetes Obes, 2011
molecular mechanisms involved in GnRH/GnRHR signaling at the maternal-fetal interface. {Review]
Congenital hypogonadotropic hypogonadism due to GnRH receptor mutations in three brothers reveal sites affecting conformation and coupling.
Young et al., Edinburgh, United Kingdom. In Plos One, 2011
Molecular deficiencies of the two novel GNRHR1 mutations lead to the CHH phenotype when present as a compound heterozygote.
Role of the transmembrane domain 4/extracellular loop 2 junction of the human gonadotropin-releasing hormone receptor in ligand binding and receptor conformational selection.
Lu et al., London, United Kingdom. In J Biol Chem, 2011
the TM4/ECL2 junction of GNRHR is crucial for peptide ligand binding and, consequently, for ligand-induced receptor conformational selection
A genetic basis for functional hypothalamic amenorrhea.
Pitteloud et al., Boston, United States. In N Engl J Med, 2011
RESULTS: Six heterozygous mutations were identified in 7 of the 55 patients with hypothalamic amenorrhea: two variants in the fibroblast growth factor receptor 1 gene FGFR1 (G260E and R756H), two in the prokineticin receptor 2 gene PROKR2 (R85H and L173R), one in the GnRH receptor gene GNRHR (R262Q), and one in the Kallmann syndrome 1 sequence gene KAL1 (V371I).
Molecular biology of gonadotropin-releasing hormone (GnRH)-I, GnRH-II, and their receptors in humans.
Leung et al., Vancouver, Canada. In Endocr Rev, 2005
However, to date, only one conventional GnRH receptor subtype (type I GnRH receptor) uniquely lacking a carboxyl-terminal tail has been found in the human body.
Gonadotropin-releasing hormone receptors.
Maudsley et al., Edinburgh, United Kingdom. In Endocr Rev, 2004
Although the predominant coupling of the type I GnRH receptor in the gonadotrope is through productive G(q) stimulation, signal transduction can occur via other G proteins and potentially by G protein-independent means.
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