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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Colony stimulating factor 2 receptor, alpha, low-affinity

GMR, granulocyte-macrophage colony-stimulating factor receptor, GM-CSFR, CD116, CSF2RA, GM-CSFRalpha
The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CsF, GM-CSF, CAN, Interleukin-3, HAD
Papers using GMR antibodies
Genetic control of cuticle formation during embryonic development of Drosophila melanogaster.
Supplier
Lewin Alfred, In PLoS ONE, 2001
... P{Dfd-GMR-nvYFP}2; the strain carrying a chromosomal deletion for mbl ...
SOCS proteins: negative regulators of cytokine signaling.
Supplier
Hartl Dominik, In PLoS ONE, 2000
... 554538, 5 µl per sample), CD116-PE (BD Biosciences, Cat ...
Papers on GMR
M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment.
New
Laoui et al., Brussels, Belgium. In Cancer Res, Feb 2016
However, GM-CSFR signaling played an important role in fine-tuning the MHC-II(hi) phenotype.
The effects of vitamin A supplementation with measles vaccine on leucocyte counts and in vitro cytokine production.
New
Benn et al., Bissau, Guinea-Bissau. In Br J Nutr, Jan 2016
In previous VAS recipients, VAS was associated with increased IFN-γ responses to phytohaemagglutinin in females (geometric mean ratio (GMR): 3·97; 95 % CI 1·44, 10·90) but not in males (GMR 0·44; 95 % CI 0·14, 1·42); the opposite was observed in previously unsupplemented children.
Effects of P2Y12 receptor inhibition with or without aspirin on hemostatic system activation: a randomized trial in healthy subjects.
New
Kyrle et al., Vienna, Austria. In J Thromb Haemost, Jan 2016
Data are given as geometric mean ratio (GMR [95% confidence interval]) to describe the differences in the first 2 hours and as mean differences (Δ [95% confidence interval]) in AUC to discriminate differences in effects over the total observation time.
Experimental and theoretical investigation of the precise transduction mechanism in giant magnetoresistive biosensors.
New
Wang et al., Stanford, United States. In Sci Rep, Dec 2015
Giant magnetoresistive (GMR) biosensors consisting of many rectangular stripes are being developed for high sensitivity medical diagnostics of diseases at early stages, but many aspects of the sensing mechanism remain to be clarified.
The Role of Surfactant in Lung Disease and Host Defense against Pulmonary Infections.
Review
New
Mallampalli et al., Chi-lung, Taiwan. In Ann Am Thorac Soc, May 2015
Increased surfactant is seen in pulmonary alveolar proteinosis, a disorder characterized by a functional deficiency of the granulocyte-macrophage colony-stimulating factor receptor or development of granulocyte-macrophage colony-stimulating factor antibodies.
spargel, the PGC-1α homologue, in models of Parkinson disease in Drosophila melanogaster.
Staveley et al., St. John's, Canada. In Bmc Neurosci, 2014
RESULTS: Directed expression of srl-RNAi in the D. melanogaster eye causes abnormal ommatidia and bristle formation while eye specific expression of srl-EY does not produce the minor rough eye phenotype associated with high temperature GMR-Gal4 expression.
Pulmonary macrophage transplantation therapy.
Impact
Trapnell et al., Cincinnati, United States. In Nature, 2014
Here, using granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor-β-deficient (Csf2rb(-/-)) mice that develop a myeloid cell disorder identical to hereditary pulmonary alveolar proteinosis (hPAP) in children with CSF2RA or CSF2RB mutations, we show that pulmonary macrophage transplantation (PMT) of either wild-type or Csf2rb-gene-corrected macrophages without myeloablation was safe and well-tolerated and that one administration corrected the lung disease, secondary systemic manifestations and normalized disease-related biomarkers, and prevented disease-specific mortality.
Bioconjugated magnetic nanoparticles for the detection of bacteria.
Review
Carey et al., Kao-hsiung, Taiwan. In J Biomed Nanotechnol, 2013
Finally, future directions on bacteria detection using giant magnetoresistance (GMR) biosensors are discussed.
The pharmacological modulation of allergen-induced asthma.
Review
O'Byrne et al., Hamilton, Canada. In Inflammopharmacology, 2013
Examples are TPI ASM8, an inhaled anti-sense oligonucleotide drug product, which attenuated both early and LARs via inhibition of the target gene mRNA of chemokine receptor 3, and the common β chain of interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor receptor.
Negative effects of GM-CSF signaling in a murine model of t(8;21)-induced leukemia.
GeneRIF
Zhang et al., San Diego, United States. In Blood, 2012
Loss of the CSF2RA gene may be a critical mutation explaining the high incidence of loss of sex chromosomes associated with the t(8;21)(q22;q22) translocation.
Stage-specific changes in the levels of granulocyte-macrophage colony-stimulating factor and its receptor in the biological fluid and organ of mouse fetuses.
GeneRIF
Otani et al., Izumo, Japan. In Congenit Anom (kyoto), 2011
GM-CSFRalpha levels peaked between E13 and E15 in the brain.
Defective leukocyte GM-CSF receptor (CD116) expression and function in inflammatory bowel disease.
GeneRIF
Colgan et al., Aurora, United States. In Gastroenterology, 2011
Identify defective expression and function of CD116 as a distinguishing feature of IBD and implicate an associated defect in innate immune responses toward granulocyte-macrophage colony-stimulating factor.
Quantification of protein interactions and solution transport using high-density GMR sensor arrays.
Impact
Wang et al., Stanford, United States. In Nat Nanotechnol, 2011
Monitoring the kinetics of protein interactions on a high-density sensor array is vital to drug development and proteomic analysis.
High expression of 67-kDa laminin receptor relates to the proliferation of leukemia cells and increases expression of GM-CSF receptor.
GeneRIF
Tomonaga et al., Nagasaki, Japan. In Exp Hematol, 2011
67-kDa laminin receptor expression influenced the characteristics of leukemia cells toward an aggressive phenotype and increased the number of granulocyte-macrophage colony-stimulating factor receptors
Immune dysregulation in the pathogenesis of pulmonary alveolar proteinosis.
Review
Huston et al., Houston, United States. In Curr Allergy Asthma Rep, 2010
The underlying molecular mechanisms causing deficiencies in GM-CSF signaling are as follows: 1) high levels of neutralizing GM-CSF autoantibodies observed in autoimmune PAP; 2) mutations in CSF2RA, the gene encoding the alpha chain of the GM-CSF receptor, observed in hereditary PAP; and 3) reduced numbers and function of alveolar macrophages as a result of other clinical diseases seen in secondary PAP.
The Ig-like domain of human GM-CSF receptor alpha plays a critical role in cytokine binding and receptor activation.
GeneRIF
Young et al., Canberra, Australia. In Biochem J, 2010
Data show that Deletion of the Ig-like domain of GM-CSFRalpha abolished direct GM-CSF binding and decreased growth signalling in the presence of hbetac.
Pulmonary alveolar proteinosis, a primary immunodeficiency of impaired GM-CSF stimulation of macrophages.
Review
Suzuki et al., Cincinnati, United States. In Curr Opin Immunol, 2009
It occurs in various clinical settings that disrupt surfactant catabolism in alveolar macrophages, including a relatively more common autoimmune disease caused by GM-CSF autoantibodies and a rare congenital disease caused by CSF2RA mutations.
Origin of the lamina propria dendritic cell network.
Impact
Merad et al., New York City, United States. In Immunity, 2009
In contrast, common DC progenitors (CDP) and pre-DCs, which give rise to lymphoid organ DCs but not to monocytes, differentiated exclusively into CD103(+)CX(3)CR1(-) lamina propria DCs under the control of Flt3 and granulocyte-macrophage-colony-stimulating factor receptor (GM-CSFR) ligands.
PU. 1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation.
Impact
Simon et al., Chicago, United States. In Immunity, 1995
Early genes such as GM-CSFR, G-CSFR, and myeloperoxidase are expressed in PU.1-/- embryos and differentiated PU.1-/- ES cells.
A human pseudoautosomal gene, ADP/ATP translocase, escapes X-inactivation whereas a homologue on Xq is subject to X-inactivation.
Impact
Rappold et al., Heidelberg, Germany. In Nat Genet, 1993
This gene, ANT3, is located approximately 1,300 kilobases from the telomere, proximal to the pseudoautosomal gene CSF2RA, and escapes X-inactivation.
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