gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Guanine monphosphate synthetase

GMP synthetase, GMPS, GMP synthase
In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, XMP, STEP
Papers on GMP synthetase
Pharmacological targeting of guanosine monophosphate synthase suppresses melanoma cell invasion and tumorigenicity.
New
Nikiforov et al., Buffalo, United States. In Cell Death Differ, Nov 2015
Here, we report that guanosine monophosphate synthase (GMPS), an enzyme required for the de novo biosynthesis of GMP, has a major role in invasion and tumorigenicity of cells derived from either BRAF(V600E) or NRAS(Q61R) human metastatic melanomas.
GMP synthase is essential for viability and infectivity of Trypanosoma brucei despite a redundant purine salvage pathway.
New
Phillips et al., Dallas, United States. In Mol Microbiol, Sep 2015
The purine salvage pathway is redundant and contains two routes to guanosine-5'-monophosphate (GMP) formation: conversion from xanthosine-5'-monophosphate (XMP) by GMP synthase (GMPS) or direct salvage of guanine by hypoxanthine-guanine phosphoribosyltransferase (HGPRT).
Deubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling.
New
Zhang et al., Nanjing, China. In Dev Cell, Aug 2015
Furthermore, we find that Usp7 forms a complex with GMP-synthetase (GMPS) to promote Hh pathway activity.
Hydrogen-sulfide-mediated vasodilatory effect of nucleoside 5'-monophosphorothioates in perivascular adipose tissue.
New
Hałas et al., Lublin, Poland. In Can J Physiol Pharmacol, Jul 2015
We examined whether the sulfur-containing AMP and GMP analogs AMPS and GMPS can serve as the H2S donors in PVAT.
Crystal Structure of USP7 Ubiquitin-like Domains with an ICP0 Peptide Reveals a Novel Mechanism Used by Viral and Cellular Proteins to Target USP7.
New
Saridakis et al., Toronto, Canada. In Plos Pathog, Jun 2015
Several USP7 partners, including ICP0, GMPS, and UHRF1, interact through its C-terminal domain (CTD), which contains five ubiquitin-like (Ubl) structures.
Elevated level of the second messenger c-di-GMP in Comamonas testosteroni enhances biofilm formation and biofilm-based biodegradation of 3-chloroaniline.
New
Cao et al., Singapore, Singapore. In Appl Microbiol Biotechnol, Feb 2015
To elucidate the impacts of elevating c-di-GMP level on environmental bioprocesses, we constructed a Comamonas testosteroni strain constitutively expressing a c-di-GMP synthase YedQ from Escherichia coli and examined its capability in biofilm formation and biodegradation of 3-chloroaniline (3-CA).
Transmission of the PabI family of restriction DNA glycosylase genes: mobility and long-term inheritance.
Kobayashi et al., Tokyo, Japan. In Bmc Genomics, 2014
One R.PabI and M.PabI homolog gene pair is observed immediately after the GMP synthase gene in both Campylobacter and Helicobacter, representing orthologs beyond genera.
Active site coupling in Plasmodium falciparum GMP synthetase is triggered by domain rotation.
Aghajari et al., Lyon, France. In Nat Commun, 2014
GMP synthetase (GMPS), a key enzyme in the purine biosynthetic pathway performs catalysis through a coordinated process across two catalytic pockets for which the mechanism remains unclear.
LV Dyssynchrony Assessed With Phase Analysis on Gated Myocardial Perfusion SPECT Can Predict Response to CRT in Patients With End-Stage Heart Failure.
Haghjoo et al., Tehrān, Iran. In Res Cardiovasc Med, 2014
Phase analysis was developed to allow assessment of LV dyssynchrony by gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (GMPS).
A structural basis for the regulation of an H-NOX-associated cyclic-di-GMP synthase/phosphodiesterase enzyme by nitric oxide-bound H-NOX.
Boon et al., Stony Brook, United States. In Biochemistry, 2014
Biofilms are surface-attached communities of bacteria enclosed in a polysaccharide matrix.
Nucleoside monophosphorothioates as the new hydrogen sulfide precursors with unique properties.
Wojtak et al., Lublin, Poland. In Pharmacol Res, 2014
Recently, it has been demonstrated that synthetic nucleotide analogs, adenosine- and guanosine 5'-monophosphorothioates (AMPS and GMPS) can be converted to H2S and AMP or GMP, respectively, by purified histidine triad nucleotide-binding (Hint) proteins.
The role of UBL domains in ubiquitin-specific proteases.
Review
Sixma et al., Amsterdam, Netherlands. In Biochem Soc Trans, 2012
On the other, the activation of USP7 is increased, when the UBL-activated state is stabilized by allosteric binding of GMP synthetase.
Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase.
GeneRIF
Sixma et al., Amsterdam, Netherlands. In Mol Cell, 2011
analysis of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase
The use of nuclear imaging for cardiac resynchronization therapy.
Review
Garcia et al., Atlanta, United States. In Curr Cardiol Rep, 2010
Phase analysis allows nuclear cardiology modalities, such as gated blood-pool imaging and gated myocardial perfusion single photon emission computed tomography (GMPS), to assess LV dyssynchrony.
Diversity and distribution of hemerythrin-like proteins in prokaryotes.
Review
Ward et al., Edinburgh, United Kingdom. In Fems Microbiol Lett, 2008
Some of these are short proteins as in eukaryotes; others appear to consist of a hemerythrin domain fused to another domain, generally a putative signal transduction domain such as a methyl-accepting chemotaxis protein, a histidine kinase, or a GGDEF protein (cyclic di-GMP synthase).
The bile/arsenite/riboflavin transporter (BART) superfamily.
Review
Saier et al., San Diego, United States. In Febs J, 2007
The other two families [sensor histidine kinase (SHK) and kinase/phosphatase/synthetase/hydrolase (KPSH)] have a single 5 TMS unit preceded by an N-terminal TMS and followed by a hydrophilic sensor histidine kinase domain (the SHK family) or catalytic domains resembling sensor kinase, phosphatase, cyclic di-GMP synthetase and cyclic di-GMP hydrolase catalytic domains, as well as various noncatalytic domains (the KPSH family).
share on facebooktweetadd +1mail to friends