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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Oct 2014.

ST3 beta-galactoside alpha-2,3-sialyltransferase 5

GM3 synthase, ST3Gal5, ganglioside GM3 synthase
Ganglioside GM3 is known to participate in the induction of cell differentiation, modulation of cell proliferation, maintenance of fibroblast morphology, signal transduction, and integrin-mediated cell adhesion. The protein encoded by this gene is a type II membrane protein which catalyzes the formation of GM3 using lactosylceramide as the substrate. The encoded protein is a member of glycosyltransferase family 29 and may be localized to the Golgi apparatus. Mutation in this gene has been associated with Amish infantile epilepsy syndrome. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, sialyltransferase, HAD, CAN, glycosyltransferase
Papers on GM3 synthase
Ganglioside GM3 depletion reverses impaired wound healing in diabetic mice by activating IGF-1 and insulin receptors.
New
Paller et al., Chicago, United States. In J Invest Dermatol, May 2014
GM3 synthase (GM3S) expression is increased in human diabetic foot skin, ob/ob and diet-induced obese diabetic mouse skin, and in mouse KCs exposed to increased glucose.
Modification of sialylation is associated with multidrug resistance in human acute myeloid leukemia.
New
Jia et al., Dalian, China. In Oncogene, Mar 2014
The expression levels of ST3GAL5 and ST8SIA4 were detected, which were overexpressed in HL60 and HL60/adriamycin-resistant (ADR) cells.
Expression machinery of GM4: the excess amounts of GM3/GM4S synthase (ST3GAL5) are necessary for GM4 synthesis in mammalian cells.
New
Inokuchi et al., Sendai, Japan. In Glycoconj J, Feb 2014
Recently, the enzyme GM3 synthase was found to be responsible for the synthesis of GM4 in vitro and in vivo, yet the mechanism behind GM4 expression in cells remains unclear.
Inhibition of GM3 synthase attenuates neuropathology of niemann-pick disease type C by affecting sphingolipid metabolism.
New
Jin et al., Taegu, South Korea. In Mol Cells, Feb 2014
Here we derived NP-C mice with complete and partial deletion of the Siat9 (encoding GM3 synthase) gene in order to investigate the role of ganglioside in NP-C pathogenesis.
Depletion of gangliosides enhances cartilage degradation in mice.
New
Iwasaki et al., Sapporo, Japan. In Osteoarthritis Cartilage, Feb 2014
DESIGN: Both age-associated and instability-induced OA models were generated using GM3 synthase knockout (GM3S(-/-)) mice.
A mutation in a ganglioside biosynthetic enzyme, ST3GAL5, results in salt & pepper syndrome, a neurocutaneous disorder with altered glycolipid and glycoprotein glycosylation.
New
Schwartz et al., Greenwood, United States. In Hum Mol Genet, Feb 2014
Sanger sequencing confirmed a homozygous c.994G>A transition (p.E332K) in the ST3GAL5 gene, which encodes for a sialyltransferase also known as GM3 synthase.
Mutations in B4GALNT1 (GM2 synthase) underlie a new disorder of ganglioside biosynthesis.
New
Crosby et al., Exeter, United Kingdom. In Brain, Dec 2013
This disease, because of defects in the first step of ganglioside biosynthesis (GM3 synthase), results in a severe epileptic disorder found at high frequency amongst the Old Order Amish.
Heterogeneity of gangliosides among T cell subsets.
Review
New
Suzuki et al., Sendai, Japan. In Cell Mol Life Sci, Sep 2013
Ganglioside GM3 synthase-deficient mice lacking a-series gangliosides neither exhibited the TCR-dependent activation of CD4(+) T nor developed ovalbumin-induced allergic airway inflammation.
[Activation of ganglioside GM3 biosynthesis in human blood mononuclear cells in atherosclerosis].
New
Prokazova et al., In Biomed Khim, Jul 2013
Using blood monocytes and lymphocytes from atherosclerotic patients and healthy subjects we have investigated activity of GM3 synthase, cellular levels of ganglioside GM3 and its role in monocyte adhesion to cultured human umbilical vein endothelial cells (HUVEC).
Differential expression profiles of glycosphingolipids in human breast cancer stem cells vs. cancer non-stem cells.
New
Hakomori et al., Seattle, United States. In Proc Natl Acad Sci U S A, Apr 2013
We found that (i) Fuc-(n)Lc4Cer and Gb3Cer were drastically reduced in CSCs, whereas GD2, GD3, GM2, and GD1a were greatly increased in CSCs; (ii) among various glycosyltransferases tested, mRNA levels for ST3GAL5, B4GALNT1, ST8SIA1, and ST3GAL2 were increased in CSCs, which could explain the increased expression of GD3, GD2, GM2, and GD1a in CSCs; (iii) the majority of GD2+ cells and GD3+ cells were detected in the CD44(hi)/CD24(lo) cell population; and (iv) knockdown of ST8SIA1 and B4GALNT1 significantly reduced the expression of GD2 and GD3 and caused a phenotype change from CSC to a non-CSC, which was detected by reduced mammosphere formation and cell motility.
Regulation of human EGF receptor by lipids.
GeneRIF
Simons et al., Dresden, Germany. In Proc Natl Acad Sci U S A, 2011
GM3 exhibits the potential to regulate the allosteric structural transition from inactive to a signaling EGFR dimer, by preventing the autophosphorylation of the intracellular kinase domain in response to ligand binding
Transcriptional activation of human GM3 synthase (hST3Gal V) gene by valproic acid in ARPE-19 human retinal pigment epithelial cells.
GeneRIF
Lee et al., Pusan, South Korea. In Bmb Rep, 2011
Data demonstrate that valproic acid (VPA) transcriptionally regulates human GM3 synthase (hST3Gal V), which catalyzes ganglioside GM3 biosynthesis in ARPE-19 human retinal pigment epithelial cells.
Physiopathological function of hematoside (GM3 ganglioside).
Review
Inokuchi, Japan. In Proc Jpn Acad Ser B Phys Biol Sci, 2010
Since I was involved in the molecular cloning of GM3 synthase (SAT-I), which is the primary enzyme for the biosynthesis of gangliosides in 1998, my research group has been concentrating on our efforts to explore the physiological and pathological implications of gangliosides especially for GM3.
Two active and differently N-glycosylated isoforms of human ST3Gal-V are produced from the placental mRNA variant by a leaky scanning mechanism.
GeneRIF
Colombo et al., Milano, Italy. In Febs Lett, 2010
In vivo expression of the transcript gives rise to two human ST3Gal-V isoforms with distinct characteristics.
Elevated mRNA level of hST6Gal I and hST3Gal V positively correlates with the high risk of pediatric acute leukemia.
GeneRIF
Mandal et al., Calcutta, India. In Leuk Res, 2010
ST6Gal I and ST3Gal V were positively correlated with the high risk of pediatric acute leukemia.
GM3 synthase overexpression results in reduced cell motility and in caveolin-1 upregulation in human ovarian carcinoma cells.
GeneRIF
Sonnino et al., Milano, Italy. In Glycobiology, 2010
GM3 synthase overexpression results in reduced cell motility and in caveolin-1 upregulation in human ovarian carcinoma cells
Insulin resistance as a membrane microdomain disorder.
Review
Inokuchi, Sendai, Japan. In Yakugaku Zasshi, 2007
We were able to extend these in vitro observations to living animals using obese Zucker fa/fa rats and ob/ob mice, in which the GM3 synthase mRNA levels in the white adipose tissues are significantly higher than in their lean controls.
Genetic diseases of sphingolipid metabolism: pathological mechanisms and therapeutic options.
Review
Futerman et al., Israel. In Febs Lett, 2006
Although diseases in the pathway of sphingolipid degradation have been known for decades, the first disease in the biosynthetic pathway was only reported in 2004, when a form of infantile-onset symptomatic epilepsy was described as a genetic defect in GM3 synthase.
Insulin resistance as a membrane microdomain disorder.
Review
Inokuchi, Japan. In Biol Pharm Bull, 2006
We were able to extend these in vitro observations to living animals using obese Zucker fa/fa rats and ob/ob mice, in which the GM3 synthase mRNA levels in the white adipose tissues are significantly higher than in their lean controls.
Infantile-onset symptomatic epilepsy syndrome caused by a homozygous loss-of-function mutation of GM3 synthase.
Impact
GeneRIF
Crosby et al., London, United Kingdom. In Nat Genet, 2004
). We sequenced genes in the region and identified a nonsense mutation in SIAT9, which is predicted to result in the premature termination of the GM3 synthase enzyme (also called lactosylceramide alpha-2,3 sialyltransferase).
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