miRNA proxy approach reveals hidden functions of glycosylation.
New York City, United States. In Proc Natl Acad Sci U S A, 09 Jul 2015
We focus on three enzymes, beta-1,3-glucosyltransferase (B3GLCT), beta-galactoside alpha-2,3-sialyltransferase 5 (ST3GAL5), and (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 (ST6GALNAC5), encoding glycans that are difficult to analyze by traditional methods.
GM3 and cancer.
Seattle, United States. In Glycoconj J, Feb 2015
Levels of mRNA for GM3 synthase were reduced in avian and mammalian cells transformed by oncoprotein "v-Jun", and overexpression of GM3 synthase in the transformed cells caused reversion from transformed to normal cell-like phenotype.
Heterogeneity of gangliosides among T cell subsets.
Sendai, Japan. In Cell Mol Life Sci, 2013
Ganglioside GM3 synthase-deficient mice lacking a-series gangliosides neither exhibited the TCR-dependent activation of CD4(+) T nor developed ovalbumin-induced allergic airway inflammation.
[The regulation of ganglioside GM3 synthesis].
Sendai, Japan. In Yakugaku Zasshi, 2011
Nevertheless, we have succeeded in detecting endogenous mouse GM3 synthase (GM3S), the primary glycosyltransferase responsible for the biosynthesis of ganglio-series gangliosides.
Regulation of human EGF receptor by lipids.
Dresden, Germany. In Proc Natl Acad Sci U S A, 2011
GM3 exhibits the potential to regulate the allosteric structural transition from inactive to a signaling EGFR dimer, by preventing the autophosphorylation of the intracellular kinase domain in response to ligand binding
Physiopathological function of hematoside (GM3 ganglioside).
Japan. In Proc Jpn Acad Ser B Phys Biol Sci, 2010
Since I was involved in the molecular cloning of GM3 synthase (SAT-I), which is the primary enzyme for the biosynthesis of gangliosides in 1998, my research group has been concentrating on our efforts to explore the physiological and pathological implications of gangliosides especially for GM3.
Insulin resistance as a membrane microdomain disorder.
Sendai, Japan. In Yakugaku Zasshi, 2007
We were able to extend these in vitro observations to living animals using obese Zucker fa/fa rats and ob/ob mice, in which the GM3 synthase mRNA levels in the white adipose tissues are significantly higher than in their lean controls.