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ST3 beta-galactoside alpha-2,3-sialyltransferase 5

GM3 synthase, ST3Gal5, ganglioside GM3 synthase
Ganglioside GM3 is known to participate in the induction of cell differentiation, modulation of cell proliferation, maintenance of fibroblast morphology, signal transduction, and integrin-mediated cell adhesion. The protein encoded by this gene is a type II membrane protein which catalyzes the formation of GM3 using lactosylceramide as the substrate. The encoded protein is a member of glycosyltransferase family 29 and may be localized to the Golgi apparatus. Mutation in this gene has been associated with Amish infantile epilepsy syndrome. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, sialyltransferase, HAD, CAN, glycosyltransferase
Papers on GM3 synthase
GM3 and cancer.
Handa et al., Seattle, United States. In Glycoconj J, 23 Feb 2015
Levels of mRNA for GM3 synthase were reduced in avian and mammalian cells transformed by oncoprotein "v-Jun", and overexpression of GM3 synthase in the transformed cells caused reversion from transformed to normal cell-like phenotype.
Control of homeostatic and pathogenic balance in adipose tissue by ganglioside GM3.
Inokuchi et al., Sendai, Japan. In Glycobiology, Nov 2014
The direct involvement of GM3 in insulin signaling is demonstrated by the fact that embryonic fibroblasts obtained from GM3 synthase (GM3S)-deficient mice have increased insulin signaling, when compared with wild-type embryonic fibroblasts, which in turn leads to enhanced adipogeneis.
Expression of leukocyte adhesion-related glycosyltransferase genes in acute coronary syndrome patients.
Curić et al., Slavonski Brod, Croatia. In Inflamm Res, Aug 2014
RESULTS: At the time of admittance ACS subjects had lower expression levels of FUT4, ST6GalNac4, ST6Gal1 and GM3 synthase (p < 0.05) than the control subjects, and moreover, after 8 days down-regulation of FUT7 and ST6GalNac3 was also observed (p < 0.05).
Ganglioside GM3 is required for caffeic acid phenethyl ester-induced megakaryocytic differentiation of human chronic myelogenous leukemia K562 cells.
Kim et al., Suwŏn, South Korea. In Biochem Cell Biol, Aug 2014
The transcriptional activity of lactosylceramide α-2,3-sialyltransferase (GM3 synthase) and synthesis of ganglioside GM3 were increased by CAPE treatment.
Modification of sialylation is associated with multidrug resistance in human acute myeloid leukemia.
Jia et al., Dalian, China. In Oncogene, Mar 2014
The expression levels of ST3GAL5 and ST8SIA4 were detected, which were overexpressed in HL60 and HL60/adriamycin-resistant (ADR) cells.
Depletion of gangliosides enhances cartilage degradation in mice.
Iwasaki et al., Sapporo, Japan. In Osteoarthritis Cartilage, Feb 2014
DESIGN: Both age-associated and instability-induced OA models were generated using GM3 synthase knockout (GM3S(-/-)) mice.
Inhibition of GM3 synthase attenuates neuropathology of Niemann-Pick disease Type C. by affecting sphingolipid metabolism.
Jin et al., Taegu, South Korea. In Mol Cells, Feb 2014
Here we derived NP-C mice with complete and partial deletion of the Siat9 (encoding GM3 synthase) gene in order to investigate the role of ganglioside in NP-C pathogenesis.
The ganglioside GM3 is associated with cisplatin-induced apoptosis in human colon cancer cells.
Kim et al., Suwŏn, South Korea. In Plos One, 2013
Interestingly, among the gangliosides, CDDP augmented the expression of only GM3 synthase and its product GM3.
Heterogeneity of gangliosides among T cell subsets.
Suzuki et al., Sendai, Japan. In Cell Mol Life Sci, 2013
Ganglioside GM3 synthase-deficient mice lacking a-series gangliosides neither exhibited the TCR-dependent activation of CD4(+) T nor developed ovalbumin-induced allergic airway inflammation.
[Activation of ganglioside GM3 biosynthesis in human blood mononuclear cells in atherosclerosis].
Prokazova et al., In Biomed Khim, 2013
Using blood monocytes and lymphocytes from atherosclerotic patients and healthy subjects we have investigated activity of GM3 synthase, cellular levels of ganglioside GM3 and its role in monocyte adhesion to cultured human umbilical vein endothelial cells (HUVEC).
[The regulation of ganglioside GM3 synthesis].
Uemura, Sendai, Japan. In Yakugaku Zasshi, 2011
Nevertheless, we have succeeded in detecting endogenous mouse GM3 synthase (GM3S), the primary glycosyltransferase responsible for the biosynthesis of ganglio-series gangliosides.
Regulation of human EGF receptor by lipids.
Simons et al., Dresden, Germany. In Proc Natl Acad Sci U S A, 2011
GM3 exhibits the potential to regulate the allosteric structural transition from inactive to a signaling EGFR dimer, by preventing the autophosphorylation of the intracellular kinase domain in response to ligand binding
Transcriptional activation of human GM3 synthase (hST3Gal V) gene by valproic acid in ARPE-19 human retinal pigment epithelial cells.
Lee et al., Pusan, South Korea. In Bmb Rep, 2011
Data demonstrate that valproic acid (VPA) transcriptionally regulates human GM3 synthase (hST3Gal V), which catalyzes ganglioside GM3 biosynthesis in ARPE-19 human retinal pigment epithelial cells.
Physiopathological function of hematoside (GM3 ganglioside).
Inokuchi, Japan. In Proc Jpn Acad Ser B Phys Biol Sci, 2010
Since I was involved in the molecular cloning of GM3 synthase (SAT-I), which is the primary enzyme for the biosynthesis of gangliosides in 1998, my research group has been concentrating on our efforts to explore the physiological and pathological implications of gangliosides especially for GM3.
Two active and differently N-glycosylated isoforms of human ST3Gal-V are produced from the placental mRNA variant by a leaky scanning mechanism.
Colombo et al., Milano, Italy. In Febs Lett, 2010
In vivo expression of the transcript gives rise to two human ST3Gal-V isoforms with distinct characteristics.
Elevated mRNA level of hST6Gal I and hST3Gal V positively correlates with the high risk of pediatric acute leukemia.
Mandal et al., Calcutta, India. In Leuk Res, 2010
ST6Gal I and ST3Gal V were positively correlated with the high risk of pediatric acute leukemia.
GM3 synthase overexpression results in reduced cell motility and in caveolin-1 upregulation in human ovarian carcinoma cells.
Sonnino et al., Milano, Italy. In Glycobiology, 2010
GM3 synthase overexpression results in reduced cell motility and in caveolin-1 upregulation in human ovarian carcinoma cells
Insulin resistance as a membrane microdomain disorder.
Inokuchi, Sendai, Japan. In Yakugaku Zasshi, 2007
We were able to extend these in vitro observations to living animals using obese Zucker fa/fa rats and ob/ob mice, in which the GM3 synthase mRNA levels in the white adipose tissues are significantly higher than in their lean controls.
Genetic diseases of sphingolipid metabolism: pathological mechanisms and therapeutic options.
Futerman et al., Israel. In Febs Lett, 2006
Although diseases in the pathway of sphingolipid degradation have been known for decades, the first disease in the biosynthetic pathway was only reported in 2004, when a form of infantile-onset symptomatic epilepsy was described as a genetic defect in GM3 synthase.
Infantile-onset symptomatic epilepsy syndrome caused by a homozygous loss-of-function mutation of GM3 synthase.
Crosby et al., London, United Kingdom. In Nat Genet, 2004
). We sequenced genes in the region and identified a nonsense mutation in SIAT9, which is predicted to result in the premature termination of the GM3 synthase enzyme (also called lactosylceramide alpha-2,3 sialyltransferase).
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