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Colony stimulating factor 2

GM-CSF, granulocyte-macrophage colony stimulating factor
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CsF, CAN, Interleukin-6, IL-10, IL-4
Papers on GM-CSF
Still Alive and Kicking: In-Vitro-Generated GM-CSF Dendritic Cells!
New
Impact
Romani et al., Würzburg, Germany. In Immunity, 19 Feb 2016
UNASSIGNED: In a recent article (Helft et al., 2015), murine bone marrow (BM) cultures with granulocyte-macrophage colony-stimulating factor (GM-CSF) were analyzed for macrophage ("GM-Mac") and dendritic cell ("GM-DC") subsets, and the GM-DC subset was compared with conventional or classical DC (cDC) subsets isolated from peripheral and lymphoid organs of mice.
A Matter of Perspective: Moving from a Pre-omic to a Systems-Biology Vantage of Monocyte-Derived Cell Function and Nomenclature.
New
Impact
Malissen et al., Gent, Belgium. In Immunity, 19 Feb 2016
UNASSIGNED: In response to the comments by Lutz and colleagues to our recent preview of the paper from Helft and colleagues (Helft et al., 2015), we wish to respectfully point out that granulocyte-macrophage colony-stimulating factor (GM-CSF) bone-marrow (BM) cultures have indeed allowed conceptual advances essential for our current understanding of the immunobiology of myeloid cells.
IL-36R signalling activates intestinal epithelial cells and fibroblasts and promotes mucosal healing in vivo.
New
Neufert et al., Erlangen, Germany. In Gut, 18 Feb 2016
Mechanistically, IL-36R ligands released upon mucosal damage activated IL-36R(+) colonic fibroblasts via Myd88 thereby inducing expression of chemokines, granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-6.
ORF3 of Hepatitis E Virus Inhibits the Expression of Proinflammatory Cytokines and Chemotactic Factors in LPS-Stimulated Human PMA-THP1 Cells by Inhibiting NF-κB Pathway.
New
Zhang et al., Chongqing, China. In Viral Immunol, 15 Feb 2016
In this study, the ELISA assay was used to detect protein levels, and we found that HEV open reading frame 3 (ORF3) protein inhibited the expression of proinflammatory cytokines (tumor necrosis factor-alpha [TNF-α], interleukin [IL]-1β, IL-6, IL-8, IL-12p40, and IL-18) and chemotactic factors (nitric oxide [NO], interferon-inducible protein-10 (IP-10), macrophage inflammatory protein (MIP)-1α, monocyte chemoattractant protein-1 (MCP-1), granulocyte colony-stimulating factor (G-CSF), granulocyte macrophage colony-stimulating factor (GM-CSF)] in lipopolysaccharide (LPS)-stimulated human PMA-THP1 cells.
Multi-analyte profiling in human carotid atherosclerosis uncovers pro-inflammatory macrophage programming in plaques.
New
Monaco et al., Oxford, United Kingdom. In Thromb Haemost, 14 Feb 2016
The in vitro production of a specific network of mediators was found to be significantly higher in symptomatic than asymptomatic plaques, including: tumour necrosis factor α, interleukin (IL) 1β, IL-6, granulocyte-macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF), CCL5, CCL20, CXCL9, matrix metalloproteinase (MMP)-3 and MMP-9.
Secretion of wound healing mediators by single and bi-layer skin substitutes.
New
Idrus et al., Kuala Lumpur, Malaysia. In Cytotechnology, 14 Feb 2016
However, all three skin substitutes also secreted CCL2, CCL5, CCL11, GM-CSF, IL8, IL-1α, TNF-α, ICAM-1, FGF-β, TGF-β, HGF, VEGF-α and PDGF-BB factors, but no significant difference was seen.
Immunomodulatory effect of mesenchymal stem cells on the immune response of macrophages stimulated by Aspergillus fumigatus conidia.
New
Choi et al., Seoul, South Korea. In Med Mycol, 14 Feb 2016
In addition, we evaluated the effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) on the MSC-related cytokine response and fungal growth.
Timing of the loss of PTEN protein determines disease severity in a mouse model of myeloid malignancy.
New
Emanuel et al., Little Rock, United States. In Blood, 13 Feb 2016
Previous murine models demonstrated how those genes contributed to the selective hypersensitivity of JMML cells to GM-CSF, a unifying characteristic in the disease.
Effect of Granulocyte-Macrophage Colony-Stimulating Factor on Prevention and Treatment of Invasive Fungal Disease in Recipients of Allogeneic Stem-Cell Transplantation: A Prospective Multicenter Randomized Phase IV Trial.
New
Impact
Wang et al., Fuzhou, China. In J Clin Oncol, 01 Jan 2016
PURPOSE: For recipients of allogeneic hematopoietic stem-cell transplantation (alloHSCT), we hypothesized that prophylactic therapy during neutropenia with granulocyte-macrophage colony-stimulating factor (GM-CSF) decreases invasive fungal disease (IFD).
Randomized, Placebo-Controlled, Phase III Trial of Yeast-Derived Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Versus Peptide Vaccination Versus GM-CSF Plus Peptide Vaccination Versus Placebo in Patients With No Evidence of Disease After Complete Surgical Resection of Locally Advanced and/or Stage IV Melanoma: A Trial of the Eastern Cooperative Oncology Group-American College of Radiology Imaging Network Cancer Research Group (E4697).
New
Impact
Kirkwood et al., Atlanta, United States. In J Clin Oncol, 01 Jan 2016
PURPOSE: We conducted a double-blind, placebo-controlled trial to evaluate the effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) and peptide vaccination (PV) on relapse-free survival (RFS) and overall survival (OS) in patients with resected high-risk melanoma.
IL-4 orchestrates STAT6-mediated DNA demethylation leading to dendritic cell differentiation.
New
Ballestar et al., Barcelona, Spain. In Genome Biol, 31 Dec 2015
In this context, interleukin 4 (IL-4) and granulocyte macrophage colony-stimulating factor (GM-CSF) drive dendritic cell differentiation, whereas GM-CSF alone leads to macrophage differentiation.
ILC3 GM-CSF production and mobilisation orchestrate acute intestinal inflammation.
New
Powrie et al., Oxford, United Kingdom. In Elife, 31 Dec 2015
ILC-driven colitis depends on production of granulocyte macrophage-colony stimulating factor (GM-CSF), which recruits and maintains intestinal inflammatory monocytes.
3,3'-Diindolylmethane Inhibits Flt3L/GM-CSF-induced-bone Marrow-derived CD103(+) Dendritic Cell Differentiation Regulating Phosphorylation of STAT3 and STAT5.
New
Jeong et al., Ch'angwŏn, South Korea. In Immune Netw, 31 Dec 2015
In this study, we found that AhR ligand 3,3'-diindolylmethane (DIM) inhibited the development of CD103(+) DCs from mouse bone marrow cells stimulated with Flt3L and GM-CSF.
The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity.
New
Impact
Becher et al., Zürich, Switzerland. In Immunity, Oct 2015
Granulocyte-macrophage colony-stimulating factor (GM-CSF) has emerged as a crucial cytokine produced by auto-reactive T helper (Th) cells that initiate tissue inflammation.
Up-regulation of Dectin-1 in airway epithelial cells promotes mice defense against invasive pulmonary aspergillosis.
Shi et al., China. In Int J Clin Exp Med, 2014
And also, the mice had higher production of TNF-α, GM-CSF and IL-1β, lower fungal burden, more recruitment of neutrophils into lungs and higher survival rate in response to A. fumigatus infection.
Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27.
GeneRIF
Fitzgerald et al., Ireland. In J Immunol, 2012
IL-27 is a key negative regulator of GM-CSF expression by T cells, which likely regulates inflammation in health and disease.
Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis.
GeneRIF
Peters-Golden et al., Ann Arbor, United States. In J Immunol, 2012
GM-CSF is a critical mediator of leukotriene B4 (LTB4)-enhanced PU.1 and dectin-1 expression required for fungi-protective host responses.
GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells.
Impact
GeneRIF
Merad et al., New York City, United States. In Immunity, 2012
Csf-2 is important in vaccine-induced CD8(+) T cell immunity through the regulation of nonlymphoid tissue DC homeostasis rather than control of inflammatory DCs in vivo.
Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer.
Impact
GeneRIF
Vonderheide et al., Philadelphia, United States. In Cancer Cell, 2012
Data suggest that tumor-derived GM-CSF is an important regulator of inflammation and immune suppression within the tumor microenvironment.
Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia.
Impact
GeneRIF
Bar-Sagi et al., New York City, United States. In Cancer Cell, 2012
Data show that an oncogenic Kras-dependent upregulation of GM-CSF in mouse pancreatic ductal epithelial cells (PDECs).
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