High-dimensional analysis of the murine myeloid cell system.
Singapore, Singapore. In Nat Immunol, 31 Dec 2014
Using mice that cannot sense granulocyte macrophage-colony stimulating factor GM-CSF (Csf2rb(-/-)), which have discrete alterations in myeloid development, we confirmed differences in barrier tissue dendritic cells, lung macrophages and eosinophils.
Producing GM-CSF: a unique T helper subset?
New Haven, United States. In Cell Res, 21 Dec 2014
UNLABELLED: GM-CSF-producing helper T cells have previously been identified to serve a nonredundant function in the initiation of autoimmune inflammation.
Pulmonary macrophage transplantation therapy.
Cincinnati, United States. In Nature, 23 Nov 2014
Here, using granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor-β-deficient (Csf2rb(-/-)) mice that develop a myeloid cell disorder identical to hereditary pulmonary alveolar proteinosis (hPAP) in children with CSF2RA or CSF2RB mutations, we show that pulmonary macrophage transplantation (PMT) of either wild-type or Csf2rb-gene-corrected macrophages without myeloablation was safe and well-tolerated and that one administration corrected the lung disease, secondary systemic manifestations and normalized disease-related biomarkers, and prevented disease-specific mortality.
Secondary pulmonary alveolar proteinosis in hematologic malignancies.
Weston, United States. In Hematol Oncol Stem Cell Ther, 06 Nov 2014
Idiopathic PAP occurs as a result of auto-antibodies directed against granulocyte-macrophage colony stimulating factor (GM-CSF) impeding the surfactant clearing function of alveolar macrophages leading to progressive respiratory failure.