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Colony stimulating factor 2

GM-CSF, granulocyte-macrophage colony stimulating factor
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CsF, CAN, Interleukin-6, IL-10, IL-4
Papers on GM-CSF
The βc receptor family - Structural insights and their functional implications.
Review
New
Parker et al., Australia. In Cytokine, 31 Aug 2015
Granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3) and IL-5 are members of a small family of cytokines that share a beta receptor subunit (βc).
Differential capacity of human interleukin-4 and interferon-α monocyte-derived dendritic cells for cross-presentation of free versus cell-associated antigen.
New
van de Loosdrecht et al., Amsterdam, Netherlands. In Cancer Immunol Immunother, 28 Aug 2015
Recent reports suggest that MoDC cultured in the presence of GM-CSF supplemented with IFNα (IFNα MoDC), as compared to IL-4 (IL-4 MoDC), have an increased capacity to cross-present antigen to CD8(+) T cells.
The TNF Family Molecules LIGHT and Lymphotoxin αβ Induce a Distinct Steroid-Resistant Inflammatory Phenotype in Human Lung Epithelial Cells.
New
Croft et al., San Diego, United States. In J Immunol, 24 Aug 2015
Correspondingly, LIGHT and LTαβ strongly induced a limited but highly distinct set of inflammatory genes in all epithelial cells tested, namely the adhesion molecules ICAM-1 and VCAM-1; the chemokines CCL5, CCL20, CXCL1, CXCL3, CXCL5, and CXCL11; the cytokines IL-6, activin A and GM-CSF; and metalloproteinases matrix metalloproteinase-9 and a disintegrin and metalloproteinase domain-8.
Reshaping of Human Macrophage Polarization through Modulation of Glucose Catabolic Pathways.
New
Escribese et al., Madrid, Spain. In J Immunol, 24 Aug 2015
To dissect the acquisition of macrophage effector functions in the absence of activating cytokines, we assessed the bioenergetic profile of macrophages generated in the presence of GM-CSF (GM-MØ) or M-CSF (M-MØ), which do not release pro- or anti-inflammatory cytokines unless subjected to additional activating stimuli.
Messenger RNA encoding constitutively active toll-like receptor 4 enhances effector functions of human T cells.
New
Gross et al., Qiryat Gat, Israel. In Clin Exp Immunol, 23 Aug 2015
Furthermore, caTLR4 enhanced the anti-melanoma cytolytic activity of tumor-infiltrating lymphocytes and augmented the secretion of IFN-γ, TNF-α and GM-CSF for at least 4 days post-transfection.
Phloridzin derivatives inhibiting pro-inflammatory cytokine expression in human cystic fibrosis IB3-1 cells.
New
Lampronti et al., Ferrara, Italy. In Eur J Pharm Sci, 22 Aug 2015
The results of the present investigation show that of all the derivatives tested, Phloridzin tetraproprionate (F2) is the most interesting and has greatest potential as it demonstrates inhibitory effects on the expression and production of different cytokines involved in CF inflammation processes, including RANTES, VEGF, GM-CSF, IL-12, G-CSF, MIP-1b, IL-17, IL-10 and IP-10, without any correlated anti-proliferative and pro-apoptotic effects.
Granulocyte Macrophage Colony-Stimulating Factor-Activated Eosinophils Promote Interleukin-23 Driven Chronic Colitis.
New
Impact
Powrie et al., Oxford, United Kingdom. In Immunity, 21 Aug 2015
Most commonly associated with Th2 cell-mediated diseases, we describe a role for eosinophils as crucial effectors of the interleukin-23 (IL-23)-granulocyte macrophage colony-stimulating factor (GM-CSF) axis in colitis.
Stop Press: Eosinophils Drafted to Join the Th17 Team.
New
Impact
Foster et al., Newcastle, Australia. In Immunity, 21 Aug 2015
(2015) identify a new GM-CSF-dependent role for eosinophils in the pathogenesis of IL-23-Th17 cell-induced colitis.
GM-CSF: An immune modulatory cytokine that can suppress autoimmunity.
Review
New
Prabhakar et al., Chicago, United States. In Cytokine, 22 Jul 2015
UNASSIGNED: GM-CSF was originally identified as a colony stimulating factor (CSF) because of its ability to induce granulocyte and macrophage populations from precursor cells.
GM-CSF Mouse Bone Marrow Cultures Comprise a Heterogeneous Population of CD11c(+)MHCII(+) Macrophages and Dendritic Cells.
New
Impact
Reis E Sousa et al., London, United Kingdom. In Immunity, 16 Jul 2015
A widely used protocol involves the culture of murine bone marrow (BM) cells with granulocyte-macrophage colony-stimulating factor (GM-CSF) to generate BM-derived DCs (BMDCs).
A Death Notice for In-Vitro-Generated GM-CSF Dendritic Cells?
New
Impact
Malissen et al., Gent, Belgium. In Immunity, 16 Jul 2015
Mouse bone marrow cells cultured with GM-CSF are often used to generate dendritic cells (DCs); in this issue of Immunity, Helft et al.
Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma.
New
Impact
Coffin et al., Chapel Hill, United States. In J Clin Oncol, 26 Jun 2015
PURPOSE: Talimogene laherparepvec (T-VEC) is a herpes simplex virus type 1-derived oncolytic immunotherapy designed to selectively replicate within tumors and produce granulocyte macrophage colony-stimulating factor (GM-CSF) to enhance systemic antitumor immune responses.
Innate Response Activator B cells: origins and functions.
Review
New
Swirski et al., Boston, United States. In Int Immunol, 08 Jun 2015
UNASSIGNED: Innate response activator (IRA) B cells are a subset of B-1a derived B cells that produce the growth factors GM-CSF and IL-3.
Treatment with granulocyte colony-stimulating factor in patients with repetitive implantation failures and/or recurrent spontaneous abortions.
Review
New
Würfel, München, Germany. In J Reprod Immunol, Apr 2015
Granulocyte colony-stimulating factor (G-CSF) belongs to the family of colony-stimulating factors (CSF).
Biological mechanisms underlying the ultraviolet radiation-induced formation of skin wrinkling and sagging II: over-expression of neprilysin plays an essential role.
Review
New
Ishida et al., Kasugai, Japan. In Int J Mol Sci, Dec 2014
We have also characterized epithelial-mesenchymal paracrine cytokine interactions between UVB-exposed-keratinocytes and dermal fibroblasts and found that interleukin-1α and granulocyte macrophage colony stimulatory factor (GM-CSF) are intrinsic cytokines secreted by UVB-exposed keratinocytes that stimulate the expression of neprilysin by fibroblasts.
Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27.
GeneRIF
Fitzgerald et al., Ireland. In J Immunol, 2012
IL-27 is a key negative regulator of GM-CSF expression by T cells, which likely regulates inflammation in health and disease.
Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis.
GeneRIF
Peters-Golden et al., Ann Arbor, United States. In J Immunol, 2012
GM-CSF is a critical mediator of leukotriene B4 (LTB4)-enhanced PU.1 and dectin-1 expression required for fungi-protective host responses.
GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells.
Impact
GeneRIF
Merad et al., New York City, United States. In Immunity, 2012
Csf-2 is important in vaccine-induced CD8(+) T cell immunity through the regulation of nonlymphoid tissue DC homeostasis rather than control of inflammatory DCs in vivo.
Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer.
Impact
GeneRIF
Vonderheide et al., Philadelphia, United States. In Cancer Cell, 2012
Data suggest that tumor-derived GM-CSF is an important regulator of inflammation and immune suppression within the tumor microenvironment.
Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia.
Impact
GeneRIF
Bar-Sagi et al., New York City, United States. In Cancer Cell, 2012
Data show that an oncogenic Kras-dependent upregulation of GM-CSF in mouse pancreatic ductal epithelial cells (PDECs).
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