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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Oct 2014.

Colony stimulating factor 2

GM-CSF, granulocyte-macrophage colony stimulating factor
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CsF, CAN, Interleukin-6, IL-4, IL-10
Papers on GM-CSF
Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages.
New
Impact
Kopf et al., Zürich, Switzerland. In Nat Immunol, 30 Nov 2014
Expression of PPAR-γ in fetal lung monocytes was dependent on the cytokine GM-CSF.
Suitable in vitro Eimeria arloingi macromeront formation in host endothelial cells and modulation of adhesion molecule, cytokine and chemokine gene transcription.
New
Hermosilla et al., Évora, Portugal. In Parasitol Res, 23 Nov 2014
BUVEC activation due to invasion was also shown by increased chemokine (CXCL8, CCL2, CCL5), cytokine (GM-CSF) and COX-2 gene transcription.
Calcium Restores the Macrophage Response to Non-typeable Haemophilus influenzae in COPD.
New
Sethi et al., Buffalo, United States. In Am J Respir Cell Mol Biol, 22 Nov 2014
Methods: Monocytes were purified from whole blood from healthy control (n=20) and patients with moderate to severe COPD (n=35), and cultured in suspension with GM-CSF to generate monocyte-derived macrophages (MDM).
Absence of IFN-γ Increases Brain Pathology in Experimental Autoimmune Encephalomyelitis-Susceptible DRB1*0301.DQ8 HLA Transgenic Mice through Secretion of Proinflammatory Cytokine IL-17 and Induction of Pathogenic Monocytes/Microglia into the Central Nervous System.
New
David et al., Rochester, United States. In J Immunol, 22 Nov 2014
Atypical EAE in DRB1*0301.DQ8.IFN-γ(-/-) mice was associated with increased encephalitogenicity of CD4 T cells and their ability to produce greater levels of IL-17 and GM-CSF compared with DRB1*0301.DQ8 mice.
Intra-arterial bone marrow mononuclear cell (BM-MNC) transplantation correlates with GM-CSF, PDGF-BB and MMP-2 serum levels in stroke patients: Results from a clinical trial.
New
Gonzalez et al., In Cell Transplant, 20 Nov 2014
Eight cases and nine controls were included and the serum levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), platelet-derived growth factor-BB (PDGF-BB), beta nerve growth factor (b-NGF), and matrix metalloproteinases 2 (MMP-2) and 9 (MMP-9) were measured before and 4, 8 and 90 days after transplantation.
High-dimensional analysis of the murine myeloid cell system.
New
Impact
Newell et al., Singapore, Singapore. In Nat Immunol, 12 Nov 2014
Using mice that cannot sense granulocyte macrophage-colony stimulating factor GM-CSF (Csf2rb(-/-)), which have discrete alterations in myeloid development, we confirmed differences in barrier tissue dendritic cells, lung macrophages and eosinophils.
Secondary pulmonary alveolar proteinosis in hematologic malignancies.
Review
New
Erban et al., Weston, United States. In Hematol Oncol Stem Cell Ther, 06 Nov 2014
Idiopathic PAP occurs as a result of auto-antibodies directed against granulocyte-macrophage colony stimulating factor (GM-CSF) impeding the surfactant clearing function of alveolar macrophages leading to progressive respiratory failure.
Pulmonary macrophage transplantation therapy.
New
Impact
Trapnell et al., Cincinnati, United States. In Nature, 01 Nov 2014
Here, using granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor-β-deficient (Csf2rb(-/-)) mice that develop a myeloid cell disorder identical to hereditary pulmonary alveolar proteinosis (hPAP) in children with CSF2RA or CSF2RB mutations, we show that pulmonary macrophage transplantation (PMT) of either wild-type or Csf2rb-gene-corrected macrophages without myeloablation was safe and well-tolerated and that one administration corrected the lung disease, secondary systemic manifestations and normalized disease-related biomarkers, and prevented disease-specific mortality.
Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation.
New
Impact
Quintana et al., Boston, United States. In Nat Med, 31 Oct 2014
In addition, LacCer in astrocytes controls the recruitment and activation of microglia and CNS-infiltrating monocytes in a non-cell autonomous manner by regulating production of the chemokine CCL2 and granulocyte-macrophage colony-stimulating factor (GM-CSF), respectively.
Colony-stimulating factors for the treatment of the hematopoietic component of the acute radiation syndrome (H-ARS): A review.
Review
New
Seed et al., Bethesda, United States. In Cytokine, 09 Oct 2014
Although no drugs or products have yet been specifically approved by the United States Food and Drug Administration (US FDA) to treat the effects of acute radiation syndrome (ARS), granulocyte colony-stimulating factor (G-CSF), granulocyte macrophage colony-stimulating factor (GM-CSF), and pegylated G-CSF have been used off label for treating radiation accident victims.
Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense.
New
Impact
Penninger et al., Vienna, Austria. In Nat Genet, 30 Sep 2014
Treatment with granulocyte/macrophage colony-stimulating factor (GM-CSF) protected mutant mice from increased weight loss and accelerated mortality after Candida albicans challenge.
Targeting Th17 cells in autoimmune diseases.
Review
New
Yamagata et al., Cambridge, United States. In Trends Pharmacol Sci, 14 Sep 2014
Given that Th17 cells express IL-17 together with many other proinflammatory cytokines [IL-17F, IL-22, IL-26, and granulocyte-macrophage colony-stimulating factor (GM-CSF)], targeting the Th17 cell lineage may be superior to blocking a single effector cytokine.
Regulation of spontaneous eosinophil apoptosis-a neglected area of importance.
Review
New
Kankaanranta et al., Tampere, Finland. In J Cell Death, Dec 2013
Eosinophils are inflammatory cells that require an external survival-prolonging stimulus such as granulocyte macrophage-colony-stimulating factor (GM-CSF), interleukin (IL)-5, or IL-3 for survival.
Role of alveolar macrophages in chronic obstructive pulmonary disease.
Review
New
Bozinovski et al., Melbourne, Australia. In Front Immunol, Dec 2013
This distinct microenvironment coordinates the maturation of long-lived AMs, which originate from fetal blood monocytes and self-renew through mechanisms dependent on GM-CSF and CSF-1 signaling.
Fc Gamma Receptor IIb on GM-CSF Macrophages Controls Immune Complex Mediated Inhibition of Inflammatory Signals.
New
Radstake et al., Utrecht, Netherlands. In Plos One, Dec 2013
BACKGROUND: In rheumatoid arthritis (RA) macrophages play a major role in amplifying synovial inflammation.
Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27.
GeneRIF
Fitzgerald et al., Ireland. In J Immunol, 2012
IL-27 is a key negative regulator of GM-CSF expression by T cells, which likely regulates inflammation in health and disease.
Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis.
GeneRIF
Peters-Golden et al., Ann Arbor, United States. In J Immunol, 2012
GM-CSF is a critical mediator of leukotriene B4 (LTB4)-enhanced PU.1 and dectin-1 expression required for fungi-protective host responses.
GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells.
Impact
GeneRIF
Merad et al., New York City, United States. In Immunity, 2012
Csf-2 is important in vaccine-induced CD8(+) T cell immunity through the regulation of nonlymphoid tissue DC homeostasis rather than control of inflammatory DCs in vivo.
Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer.
Impact
GeneRIF
Vonderheide et al., Philadelphia, United States. In Cancer Cell, 2012
Data suggest that tumor-derived GM-CSF is an important regulator of inflammation and immune suppression within the tumor microenvironment.
Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia.
Impact
GeneRIF
Bar-Sagi et al., New York City, United States. In Cancer Cell, 2012
Data show that an oncogenic Kras-dependent upregulation of GM-CSF in mouse pancreatic ductal epithelial cells (PDECs).
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