GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 29 Mar 2014.
Colony stimulating factor 2
GM-CSF, granulocyte-macrophage colony stimulating factor
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008] (from
NCBI)
Top mentioned proteins:
CsF, Interleukin-6, CAN, IL-4, IL-10
Papers on
GM-CSF
Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells.
New
Impact
Barcelona, Spain. In Nat Immunol, 30 Apr 2014
Splenic ILCs further helped MZ B cells and their plasma-cell progeny by coopting neutrophils through release of the cytokine GM-CSF.
Microbiota-Dependent Crosstalk Between Macrophages and ILC3 Promotes Intestinal Homeostasis.
New
Impact
New York City, United States. In Science, 28 Apr 2014
Here, we show that deficient granulocyte-macrophage colony-stimulating factor (GM-CSF) production altered mononuclear phagocyte effector functions and led to reduced regulatory T cell (Treg) numbers and impaired oral tolerance.
Interleukin-17A modulates circulating tumor cells in tumor draining vein of colorectal cancers and affects metastases.
New
In Clin Cancer Res, 27 Apr 2014
Additionally, following invasion of orthotopically implanted tumors in our mouse model; we found that CTCs exhibited an increase-then-decrease pattern, accompanied by corresponding changes in serum IL-17A levels and opposing changes in serum GM-CSF levels.
Inflammatory biomarkers in serum in subjects with and without work related neck/shoulder complaints.
New
In Bmc Musculoskelet Disord, 26 Apr 2014
Serum levels of IL-1alpha, IL-1beta, IL-6, IL-8, IL-10, IL-12, MCP-1, MIP-1alpha, MIP-1beta, TNF-alpha, GM-CSF, CTGF and CRP were analysed.
Periodic fever, aphthous stomatitis, pharyngitis and cervical adenopathy syndrome is associated with activation of GM-CSF and burst-like expression of IL-8 in peripheral blood.
New
Beersheba, Israel. In Mod Rheumatol, 26 Apr 2014
Peripheral blood concentrations of IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IFN-γ, GM-CSF, TNF-α were measured using Luminex technology.
From the regulatory functions of B cells to the identification of cytokine-producing plasma cell subsets.
Review
New
Berlin, Germany. In Curr Opin Immunol, 13 Apr 2014
Remarkably, recent studies identified plasma blasts/plasma cells as the main types of activated B cells producing the cytokines interleukin (IL)-10, IL-35, tumor necrosis factor (TNF)-α, IL-17, and GM-CSF in various contexts in mice.
GM-CSF Induces Cyclin D1 Expression and Proliferation of Endothelial Progenitor Cells via PI3K and MAPK Signaling.
New
Shanghai, China. In Cell Physiol Biochem, 07 Apr 2014
Here, we investigated the mechanisms underlying the effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) on the acceleration of EPC proliferation and colony formation.
The new normal: immunomodulatory agents against sepsis immune suppression.
Review
New
Providence, United States. In Trends Mol Med, 02 Mar 2014
Recent studies from animal sepsis models and patient samples suggest that cytokines such as interleukin-7 (IL-7), IL-15, granulocyte macrophage colony-stimulating factor (GM-CSF), as well as co-inhibitory molecule blockade, such as anti-programmed cell death receptor-1 (anti-PD-1) and anti-B and T lymphocyte attenuator (anti-BTLA), may have utility in alleviating the clinical morbidity associated with sustained sepsis.
IL-17 regulates systemic fungal immunity by controlling the functional competence of NK cells.
New
Impact
Zürich, Switzerland. In Immunity, 16 Feb 2014
NK cells promoted antifungal immunity by secreting GM-CSF, necessary for the fungicidal activity of neutrophils.
Autoimmune pulmonary alveolar proteinosis: Clinical course and diagnostic criteria.
Review
New
Tel Aviv-Yafo, Israel. In Autoimmun Rev, 11 Feb 2014
Autoimmune PAP, a rare, antibody-mediated disease, that compromises 90% of cases of PAP, is causes by IgG autoantibodies that block GM-CSF effect, a crucial step for macrophage maturation.
Effect of progenitor cell mobilization with granulocyte-macrophage colony-stimulating factor in patients with peripheral artery disease: a randomized clinical trial.
New
Impact
Atlanta, United States. In Jama, Jan 2014
OBJECTIVE: To investigate whether therapy with granulocyte-macrophage colony-stimulating factor (GM-CSF) improves exercise capacity in patients with intermittent claudication.
Asthma: the importance of dysregulated barrier immunity.
Review
New
Gent, Belgium. In Eur J Immunol, Dec 2013
Barrier epithelial cells are being ever more implicated in disease pathogenesis than previously thought, as these cells have in recent years been shown to sense exposure to allergens via pattern recognition receptors and to activate conventional and inflammatory-type DCs and other innate immune cells through the secretion of thymic stromal lymphopoietin, granulocyte-macrophage colony stimulating factor, IL-1, IL-33, and IL-25.
Mavrilimumab: an evidence based review of its potential in the treatment of rheumatoid arthritis.
Review
New
Roma, Italy. In Core Evid, Dec 2013
Recent evidence has shown that granulocyte-macrophage colony-stimulating factor (GM-CSF) is involved in the pathogenesis of RA.
Engineering HSV-1 Vectors for Gene Therapy.
New
Pittsburgh, United States. In Methods Mol Biol, Dec 2013
In fact, T-VEC (talimogene laherparepvec, formerly known as OncoVex GM-CSF) displayed efficacy in a recent Phase III trial when compared to standard GM-CSF treatment alone (Andtbacka et al.
Granulocyte macrophage-colony stimulating factor induced Zn sequestration enhances macrophage superoxide and limits intracellular pathogen survival.
New
Impact
Cincinnati, United States. In Immunity, Nov 2013
The pleiotropic cytokine granulocyte macrophage-colony stimulating factor (GM-CSF) enhances antimicrobial defenses against intracellular pathogens such as Histoplasma capsulatum, but its mode of action remains elusive.
Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27.
GeneRIF
Ireland. In J Immunol, 2012
IL-27 is a key negative regulator of GM-CSF expression by T cells, which likely regulates inflammation in health and disease.
Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis.
GeneRIF
Ann Arbor, United States. In J Immunol, 2012
GM-CSF is a critical mediator of leukotriene B4 (LTB4)-enhanced PU.1 and dectin-1 expression required for fungi-protective host responses.
GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells.
Impact
GeneRIF
New York City, United States. In Immunity, 2012
Csf-2 is important in vaccine-induced CD8(+) T cell immunity through the regulation of nonlymphoid tissue DC homeostasis rather than control of inflammatory DCs in vivo.
Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer.
Impact
GeneRIF
Philadelphia, United States. In Cancer Cell, 2012
Data suggest that tumor-derived GM-CSF is an important regulator of inflammation and immune suppression within the tumor microenvironment.
Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia.
Impact
GeneRIF
New York City, United States. In Cancer Cell, 2012
Data show that an oncogenic Kras-dependent upregulation of GM-CSF in mouse pancreatic ductal epithelial cells (PDECs).
