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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 06 Jul 2015.

Colony stimulating factor 2

GM-CSF, granulocyte-macrophage colony stimulating factor
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CsF, CAN, Interleukin-6, IL-10, IL-4
Papers on GM-CSF
The βc receptor family - Structural insights and their functional implications.
Review
New
Parker et al., Australia. In Cytokine, 31 Aug 2015
Granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3) and IL-5 are members of a small family of cytokines that share a beta receptor subunit (βc).
Glycoprotein from street rabies virus BD06 induces early and robust immune responses when expressed from a non-replicative adenovirus recombinant.
New
Hu et al., Changchun, China. In Arch Virol, 05 Aug 2015
Moreover, the expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) was significantly higher in mice immunized with nrAd5-BD06-G, which might also contribute to the increased protection.
Dual silencing of Bcl-2 and Survivin by HSV-1 vector shows better antitumor efficacy in higher PKR phosphorylation tumor cells in vitro and in vivo.
New
Li et al., Beijing, China. In Cancer Gene Ther, 03 Aug 2015
Herein, RNAi of oncogenes Bcl-2 and Survivin was combined with oncolytic HSV-1 (ICP34.5-/ICP6-/ICP47-/CMV-GM-CSF)
Repeated intratumoral administration of ONCOS-102 leads to systemic antitumor CD8(+) T-cell response and robust cellular and transcriptional immune activation at tumor site in a patient with ovarian cancer.
New
Pesonen et al., Helsinki, Finland. In Oncoimmunology, 31 Jul 2015
She was treated in a Phase I study with a granulocyte-macrophage colony stimulating factor (GMCSF)-expressing oncolytic adenovirus, Ad5/3-D24-GMCSF (ONCOS-102).
GM-CSF: An immune modulatory cytokine that can suppress autoimmunity.
Review
New
Prabhakar et al., Chicago, United States. In Cytokine, 22 Jul 2015
UNASSIGNED: GM-CSF was originally identified as a colony stimulating factor (CSF) because of its ability to induce granulocyte and macrophage populations from precursor cells.
GM-CSF Mouse Bone Marrow Cultures Comprise a Heterogeneous Population of CD11c(+)MHCII(+) Macrophages and Dendritic Cells.
New
Impact
Reis E Sousa et al., London, United Kingdom. In Immunity, 16 Jul 2015
A widely used protocol involves the culture of murine bone marrow (BM) cells with granulocyte-macrophage colony-stimulating factor (GM-CSF) to generate BM-derived DCs (BMDCs).
A Death Notice for In-Vitro-Generated GM-CSF Dendritic Cells?
New
Impact
Malissen et al., Gent, Belgium. In Immunity, 16 Jul 2015
Mouse bone marrow cells cultured with GM-CSF are often used to generate dendritic cells (DCs); in this issue of Immunity, Helft et al.
Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma.
New
Impact
Coffin et al., Chapel Hill, United States. In J Clin Oncol, 26 Jun 2015
PURPOSE: Talimogene laherparepvec (T-VEC) is a herpes simplex virus type 1-derived oncolytic immunotherapy designed to selectively replicate within tumors and produce granulocyte macrophage colony-stimulating factor (GM-CSF) to enhance systemic antitumor immune responses.
Innate Response Activator B cells: origins and functions.
Review
New
Swirski et al., Boston, United States. In Int Immunol, 08 Jun 2015
UNASSIGNED: Innate response activator (IRA) B cells are a subset of B-1a derived B cells that produce the growth factors GM-CSF and IL-3.
A GMCSF and IL7 fusion cytokine leads to functional thymic-dependent T-cell regeneration in age-associated immune deficiency.
New
Galipeau et al., Atlanta, United States. In Clin Transl Immunology, May 2015
Our previous work has demonstrated that γc cytokines fused with granulocyte-macrophage colony stimulating factor (GMCSF) at the N-terminus acquire unheralded biological properties.
Treatment with granulocyte colony-stimulating factor in patients with repetitive implantation failures and/or recurrent spontaneous abortions.
Review
New
Würfel, München, Germany. In J Reprod Immunol, Apr 2015
Granulocyte colony-stimulating factor (G-CSF) belongs to the family of colony-stimulating factors (CSF).
Biological mechanisms underlying the ultraviolet radiation-induced formation of skin wrinkling and sagging II: over-expression of neprilysin plays an essential role.
Review
New
Ishida et al., Kasugai, Japan. In Int J Mol Sci, Dec 2014
We have also characterized epithelial-mesenchymal paracrine cytokine interactions between UVB-exposed-keratinocytes and dermal fibroblasts and found that interleukin-1α and granulocyte macrophage colony stimulatory factor (GM-CSF) are intrinsic cytokines secreted by UVB-exposed keratinocytes that stimulate the expression of neprilysin by fibroblasts.
Beyond the age of cellular discovery.
New
Impact
Irish, Nashville, United States. In Nat Immunol, Dec 2014
The combination of machine-learning tools and mass-cytometry measurements of more than 30 protein markers per cell comprehensively maps cell identity in the heterogeneous myeloid cell system and reveals the global effect of deletion of the gene encoding the receptor for the growth factor GM-CSF.
Safety and immunologic correlates of Melanoma GVAX, a GM-CSF secreting allogeneic melanoma cell vaccine administered in the adjuvant setting.
New
Topalian et al., Baltimore, United States. In J Transl Med, Dec 2014
This first-in-human study investigated the safety, tolerability and immunologic correlates of Melanoma GVAX, a lethally irradiated granulocyte-macrophage colony stimulating factor (GM-CSF)-secreting allogeneic whole-cell melanoma vaccine, administered in the adjuvant setting.
Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity.
New
Impact
Krummel et al., San Francisco, United States. In Cancer Cell, Dec 2014
These are uniquely dependent on IRF8, Zbtb46, and Batf3 transcription factors and are generated by GM-CSF and FLT3L cytokines.
Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27.
GeneRIF
Fitzgerald et al., Ireland. In J Immunol, 2012
IL-27 is a key negative regulator of GM-CSF expression by T cells, which likely regulates inflammation in health and disease.
Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis.
GeneRIF
Peters-Golden et al., Ann Arbor, United States. In J Immunol, 2012
GM-CSF is a critical mediator of leukotriene B4 (LTB4)-enhanced PU.1 and dectin-1 expression required for fungi-protective host responses.
GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells.
Impact
GeneRIF
Merad et al., New York City, United States. In Immunity, 2012
Csf-2 is important in vaccine-induced CD8(+) T cell immunity through the regulation of nonlymphoid tissue DC homeostasis rather than control of inflammatory DCs in vivo.
Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer.
Impact
GeneRIF
Vonderheide et al., Philadelphia, United States. In Cancer Cell, 2012
Data suggest that tumor-derived GM-CSF is an important regulator of inflammation and immune suppression within the tumor microenvironment.
Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia.
Impact
GeneRIF
Bar-Sagi et al., New York City, United States. In Cancer Cell, 2012
Data show that an oncogenic Kras-dependent upregulation of GM-CSF in mouse pancreatic ductal epithelial cells (PDECs).
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