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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 May 2015.

Colony stimulating factor 2

GM-CSF, granulocyte-macrophage colony stimulating factor
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CsF, CAN, Interleukin-6, IL-4, IL-10
Papers on GM-CSF
Specific Contributions of CSF-1 and GM-CSF to the Dynamics of the Mononuclear Phagocyte System.
New
Hamilton et al., Melbourne, Australia. In J Immunol, 27 Jun 2015
UNASSIGNED: M-CSF (or CSF-1) and GM-CSF can regulate the development and function of the mononuclear phagocyte system (MPS).
Natural products with therapeutic potential in melanoma metastasis.
New
Prieto et al., London, United Kingdom. In Nat Prod Rep, 27 Jun 2015
Consequently, downstream transcription factors namely NF-kB, AP-1, ATF-2, CREB, and HIF were inactivated leading to diminished production of MMPs, IL-1, IL-6, COX-2, VEGF and GM-CSF.
Characterization and Implementation of a Diverse SIVsm Envelope Panel in the Assessment of Neutralizing Antibody Breadth Elicited in Rhesus Macaques by Multi-Modal Vaccines Expressing the SIVmac239 Envelope.
New
Derdeyn et al., Philadelphia, United States. In J Virol, 27 Jun 2015
To assess the utility of this panel, we characterized the neutralizing activity elicited by four SIVmac239 envelope-expressing DNA/MVA and protein-based vaccination regimens that included the immunomodulatory adjuvants GM-CSF, Toll-like receptor (TLR) ligands, and CD40 ligand.
Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma.
New
Impact
Coffin et al., Chapel Hill, United States. In J Clin Oncol, 26 Jun 2015
PURPOSE: Talimogene laherparepvec (T-VEC) is a herpes simplex virus type 1-derived oncolytic immunotherapy designed to selectively replicate within tumors and produce granulocyte macrophage colony-stimulating factor (GM-CSF) to enhance systemic antitumor immune responses.
Differential Activation of Airway Eosinophils Induces IL-13 Mediated Allergic Th2 Pulmonary Responses in Mice.
New
Lee et al., Scottsdale, United States. In Allergy, 23 Jun 2015
METHODS: Wild type or cytokine deficient (IL-13(-/-) or IL-4(-/-) ) eosinophils treated with cytokines (GM-CSF, IL-4, IL-33) were adoptively transferred into eosinophil-deficient recipient mice subjected to allergen provocation using established models of respiratory inflammation.
The βc receptor family - Structural insights and their functional implications.
Review
New
Parker et al., Australia. In Cytokine, 14 Jun 2015
UNASSIGNED: Granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3) and IL-5 are members of a small family of cytokines that share a beta receptor subunit (βc).
Novel therapeutic targets in rheumatoid arthritis.
Review
New
van den Berg et al., Nijmegen, Netherlands. In Trends Pharmacol Sci, 30 Apr 2015
Here, we discuss two pathways that are regarded as interesting novel therapeutic targets in the field of rheumatology: the Janus kinase (JAK) pathway and the T helper-17 (Th17) pathway [including interleukin (IL)-17, IL-21, IL-22, and granulocyte-macrophage colony-stimulating factor (GM-CSF)].
Treatment with granulocyte colony-stimulating factor in patients with repetitive implantation failures and/or recurrent spontaneous abortions.
Review
New
Würfel, München, Germany. In J Reprod Immunol, Mar 2015
UNASSIGNED: Granulocyte colony-stimulating factor (G-CSF) belongs to the family of colony-stimulating factors (CSF).
CD47 Promotes Protective Innate and Adaptive Immunity in a Mouse Model of Disseminated Candidiasis.
New
Roberts et al., Bethesda, United States. In Plos One, Dec 2014
G-CSF, GM-CSF, and the inflammasome component NLRP3 were more highly expressed in infected cd47-/- kidneys than in infected wild-type controls.
Beyond the age of cellular discovery.
New
Impact
Irish, Nashville, United States. In Nat Immunol, Dec 2014
The combination of machine-learning tools and mass-cytometry measurements of more than 30 protein markers per cell comprehensively maps cell identity in the heterogeneous myeloid cell system and reveals the global effect of deletion of the gene encoding the receptor for the growth factor GM-CSF.
Biological mechanisms underlying the ultraviolet radiation-induced formation of skin wrinkling and sagging II: over-expression of neprilysin plays an essential role.
Review
New
Ishida et al., Kasugai, Japan. In Int J Mol Sci, Dec 2014
We have also characterized epithelial-mesenchymal paracrine cytokine interactions between UVB-exposed-keratinocytes and dermal fibroblasts and found that interleukin-1α and granulocyte macrophage colony stimulatory factor (GM-CSF) are intrinsic cytokines secreted by UVB-exposed keratinocytes that stimulate the expression of neprilysin by fibroblasts.
Inflammatory cytokines: potential biomarkers of immunologic dysfunction in autism spectrum disorders.
Review
New
Zhong et al., China. In Mediators Inflamm, Dec 2014
However, the expression of some cytokines, such as IL-1, IL-2, transforming growth factor-β (TGF-β), and granulocyte-macrophage colony-stimulating factor (GM-CSF), is controversial, and different studies have found various results in different tissues.
Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity.
New
Impact
Krummel et al., San Francisco, United States. In Cancer Cell, Dec 2014
These are uniquely dependent on IRF8, Zbtb46, and Batf3 transcription factors and are generated by GM-CSF and FLT3L cytokines.
Ipilimumab plus sargramostim vs ipilimumab alone for treatment of metastatic melanoma: a randomized clinical trial.
New
Impact
Kirkwood et al., Nashville, United States. In Jama, Dec 2014
CTLA-4 blockade and granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting tumor vaccine combinations demonstrate therapeutic synergy in preclinical models.
The oncoprotein and transcriptional regulator Bcl-3 governs plasticity and pathogenicity of autoimmune T cells.
New
Impact
Siebenlist et al., Bethesda, United States. In Immunity, Nov 2014
The protection against disease correlated with a decrease in Th1 cells that produced the cytokines IFN-γ and GM-CSF and an increase in Th17 cells.
Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27.
GeneRIF
Fitzgerald et al., Ireland. In J Immunol, 2012
IL-27 is a key negative regulator of GM-CSF expression by T cells, which likely regulates inflammation in health and disease.
Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis.
GeneRIF
Peters-Golden et al., Ann Arbor, United States. In J Immunol, 2012
GM-CSF is a critical mediator of leukotriene B4 (LTB4)-enhanced PU.1 and dectin-1 expression required for fungi-protective host responses.
GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells.
Impact
GeneRIF
Merad et al., New York City, United States. In Immunity, 2012
Csf-2 is important in vaccine-induced CD8(+) T cell immunity through the regulation of nonlymphoid tissue DC homeostasis rather than control of inflammatory DCs in vivo.
Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer.
Impact
GeneRIF
Vonderheide et al., Philadelphia, United States. In Cancer Cell, 2012
Data suggest that tumor-derived GM-CSF is an important regulator of inflammation and immune suppression within the tumor microenvironment.
Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia.
Impact
GeneRIF
Bar-Sagi et al., New York City, United States. In Cancer Cell, 2012
Data show that an oncogenic Kras-dependent upregulation of GM-CSF in mouse pancreatic ductal epithelial cells (PDECs).
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