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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 28 Aug 2015.

Colony stimulating factor 2

GM-CSF, granulocyte-macrophage colony stimulating factor
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CsF, CAN, Interleukin-6, IL-10, IL-4
Papers on GM-CSF
Combination of GM-CSF With Fludarabine-Containing Regimens in Chronic Lymphocytic Leukemia and Indolent Non-Hodgkin Lymphoma.
New
Flowers et al., Atlanta, United States. In Clin Lymphoma Myeloma Leuk, 30 Sep 2015
BACKGROUND: Granulocyte-monocyte colony stimulating factor (GM-CSF) is a hematopoietic cytokine with immunomodulatory activity that has preclinical evidence for enhancement of antitumor immunity when administered in combination with chemotherapy.
Coadministration of cruzipain and GM-CSF DNAs, a new immunotherapeutic vaccine against Trypanosoma cruzi infection.
New
Malchiodi et al., Buenos Aires, Argentina. In Hum Vaccin Immunother, 27 Sep 2015
The coadministration of a plasmid encoding GM-CSF improved vaccine performance, indicating that the stimulation of innate immune cells is needed in the event of an ongoing infection.
Chronic activation of innate immunity correlates with poor prognosis in cancer patients treated with oncolytic adenovirus.
New
Hemminki et al., Helsinki, Finland. In Mol Ther, 27 Sep 2015
GM-CSF signaling (p<0.001) and leukocyte extravasation signaling (p<0.001), in patients surviving a shorter time than their controls.
Therapeutic efficacy of PD-L1 blockade in a breast cancer model is enhanced by cellular vaccines expressing B7-1 and glycolipid-anchored IL-12.
New
Selvaraj et al., Atlanta, United States. In Hum Vaccin Immunother, 26 Sep 2015
We demonstrate that tumorigenicity is completely abrogated when adjuvanted with immune stimulatory molecules (ISMs) B7-1 and a cell-surface anchored (GPI) form of IL-12 or GM-CSF.
Immune responses of pigs immunized with a recombinant porcine reproductive and respiratory syndrome virus expressing porcine GM-CSF.
New
Zhou et al., China. In Vet Immunol Immunopathol, 14 Sep 2015
Granulocyte macrophage colony-stimulating factor (GM-CSF), an efficacious adjuvant, has been shown to enhance the immunogenicity of various vaccines.
The βc receptor family - Structural insights and their functional implications.
Review
New
Parker et al., Australia. In Cytokine, 31 Aug 2015
Granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3) and IL-5 are members of a small family of cytokines that share a beta receptor subunit (βc).
Stop Press: Eosinophils Drafted to Join the Th17 Team.
New
Impact
Foster et al., Newcastle, Australia. In Immunity, 21 Aug 2015
(2015) identify a new GM-CSF-dependent role for eosinophils in the pathogenesis of IL-23-Th17 cell-induced colitis.
Granulocyte Macrophage Colony-Stimulating Factor-Activated Eosinophils Promote Interleukin-23 Driven Chronic Colitis.
New
Impact
Powrie et al., Oxford, United Kingdom. In Immunity, 21 Aug 2015
Most commonly associated with Th2 cell-mediated diseases, we describe a role for eosinophils as crucial effectors of the interleukin-23 (IL-23)-granulocyte macrophage colony-stimulating factor (GM-CSF) axis in colitis.
GM-CSF: An immune modulatory cytokine that can suppress autoimmunity.
Review
New
Prabhakar et al., Chicago, United States. In Cytokine, 22 Jul 2015
UNASSIGNED: GM-CSF was originally identified as a colony stimulating factor (CSF) because of its ability to induce granulocyte and macrophage populations from precursor cells.
A Death Notice for In-Vitro-Generated GM-CSF Dendritic Cells?
New
Impact
Malissen et al., Gent, Belgium. In Immunity, 16 Jul 2015
Mouse bone marrow cells cultured with GM-CSF are often used to generate dendritic cells (DCs); in this issue of Immunity, Helft et al. (2015) show that this classical method produces heterogeneous populations of myeloid cells that are only distantly related to macrophages and DCs found in vivo.
GM-CSF Mouse Bone Marrow Cultures Comprise a Heterogeneous Population of CD11c(+)MHCII(+) Macrophages and Dendritic Cells.
New
Impact
Reis E Sousa et al., London, United Kingdom. In Immunity, 16 Jul 2015
A widely used protocol involves the culture of murine bone marrow (BM) cells with granulocyte-macrophage colony-stimulating factor (GM-CSF) to generate BM-derived DCs (BMDCs).
Innate Response Activator B cells: origins and functions.
Review
New
Swirski et al., Boston, United States. In Int Immunol, Jun 2015
UNASSIGNED: Innate response activator (IRA) B cells are a subset of B-1a derived B cells that produce the growth factors GM-CSF and IL-3.
Treatment with granulocyte colony-stimulating factor in patients with repetitive implantation failures and/or recurrent spontaneous abortions.
Review
New
Würfel, München, Germany. In J Reprod Immunol, Apr 2015
Granulocyte colony-stimulating factor (G-CSF) belongs to the family of colony-stimulating factors (CSF).
Genome-wide transcription profiling in neutrophils in acute respiratory distress syndrome.
New
Impact
Chilvers et al., Cambridge, United Kingdom. In Lancet, Mar 2015
METHODS: GeneChip Affymetrix oligonucleotide arrays were used to assess global transcriptional profiles in highly pure PMNs from ventilated patients fulfilling the Berlin ARDS definition (n=10), in freshly isolated PMNs from age-matched and sex-matched healthy volunteers (n=10), and in healthy volunteer PMNs exposed in vitro to recombinant human granulocyte-macrophage colony stimulating factor (rhGM-CSF) (1 ng/mL for 6 h).
Biological mechanisms underlying the ultraviolet radiation-induced formation of skin wrinkling and sagging II: over-expression of neprilysin plays an essential role.
Review
New
Ishida et al., Kasugai, Japan. In Int J Mol Sci, Dec 2014
We have also characterized epithelial-mesenchymal paracrine cytokine interactions between UVB-exposed-keratinocytes and dermal fibroblasts and found that interleukin-1α and granulocyte macrophage colony stimulatory factor (GM-CSF) are intrinsic cytokines secreted by UVB-exposed keratinocytes that stimulate the expression of neprilysin by fibroblasts.
Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27.
GeneRIF
Fitzgerald et al., Ireland. In J Immunol, 2012
IL-27 is a key negative regulator of GM-CSF expression by T cells, which likely regulates inflammation in health and disease.
Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis.
GeneRIF
Peters-Golden et al., Ann Arbor, United States. In J Immunol, 2012
GM-CSF is a critical mediator of leukotriene B4 (LTB4)-enhanced PU.1 and dectin-1 expression required for fungi-protective host responses.
GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells.
Impact
GeneRIF
Merad et al., New York City, United States. In Immunity, 2012
Csf-2 is important in vaccine-induced CD8(+) T cell immunity through the regulation of nonlymphoid tissue DC homeostasis rather than control of inflammatory DCs in vivo.
Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer.
Impact
GeneRIF
Vonderheide et al., Philadelphia, United States. In Cancer Cell, 2012
Data suggest that tumor-derived GM-CSF is an important regulator of inflammation and immune suppression within the tumor microenvironment.
Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia.
Impact
GeneRIF
Bar-Sagi et al., New York City, United States. In Cancer Cell, 2012
Data show that an oncogenic Kras-dependent upregulation of GM-CSF in mouse pancreatic ductal epithelial cells (PDECs).
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