GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Colony stimulating factor 2
GM-CSF, granulocyte-macrophage colony stimulating factor
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008] (from
NCBI)
Papers on
GM-CSF
Airways exposure to Staphylococcal enterotoxin A (SEA) potentiates allergen-induced bone marrow eosinophilia and trafficking to peripheral blood and airways.
New
In Am J Physiol Lung Cell Mol Physiol, 08 Apr 2013
Measurement of IL-5, eotaxin and GM-CSF levels, flow cytometry for CCR3+, VLA4+ and CCR3+VLA4+, as well as adhesion assays to VCAM-1 were performed in BM.
Immune response and survival of refractory cancer patients who received TGF-β2 antisense/GM-CSF gene modified autologous tumor cell (TAG) vaccine.
New
Dallas, United States. In Gene Ther, 07 Apr 2013
TAG vaccine is a novel 'triad vaccine' that involves transfection of autologous tumor with a dual plasmid, TGFβ2 antisense gene and GM-CSF gene.
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.
New
Impact
New Haven, United States. In Nature, 06 Apr 2013
The TH17 cells generated under high-salt conditions display a highly pathogenic and stable phenotype characterized by the upregulation of the pro-inflammatory cytokines GM-CSF, TNF-α and IL-2.
Histamine receptor 2 modifies dendritic cell responses to microbial ligands.
New
Zürich, Switzerland. In J Allergy Clin Immunol, 01 Apr 2013
Lactobacillus rhamnosus, which secretes histamine, significantly suppressed Peyer patch IL-2, IL-4, IL-5, IL-12, TNF-α, and GM-CSF secretion in wild-type but not H2R-deficient animals.
The Cytokines IL-21 and GM-CSF Have Opposing Regulatory Roles in the Apoptosis of Conventional Dendritic Cells.
New
Impact
Bethesda, United States. In Immunity, 26 Mar 2013
Here we show that IL-21 induced apoptosis of conventional dendritic cells (cDCs) via STAT3 and Bim, and this was inhibited by granulocyte-macrophage colony-stimulating factor (GM-CSF).
Protease-activated receptor-2 induces proinflammatory cytokine and chemokine gene expression in canine keratinocytes.
New
Tokyo, Japan. In Vet Immunol Immunopathol, 13 Mar 2013
Stimulation of CPEK cells with trypsin induced significant upregulation of the mRNA expression levels of tumor necrosis factor alpha (TNF-α, P<0.05), granulocyte-macrophage colony-stimulating factor (GM-CSF, P<0.01), thymus and activation regulated chemokine (TARC/CCL17, P<0.01), and interleukin 8 (IL-8/CXCL8, P<0.01).
Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer.
New
Impact
Pusan, South Korea. In Nat Med, 10 Mar 2013
JX-594 replication and granulocyte-macrophage colony-stimulating factor (GM-CSF) expression preceded the induction of anticancer immunity.
Dysregulated hematopoietic stem and progenitor cell activity promotes interleukin-23-driven chronic intestinal inflammation.
New
Impact
Oxford, United Kingdom. In Immunity, Jan 2013
Extramedullary hematopoiesis was also evident, and granulocyte macrophage-colony stimulating factor (GM-CSF) blockade reduced the accumulation of splenic and colonic GMPs, resulting in amelioration of colitis.
Mavrilimumab, a human monoclonal GM-CSF receptor-α antibody for the management of rheumatoid arthritis: a novel approach to therapy.
Review
New
Liverpool, United Kingdom. In Expert Opin Biol Ther, Dec 2012
INTRODUCTION: Mavrilimumab , formerly known as CAM-3001, a GM-CSF receptor-α antibody, is the first human monoclonal antibody to be used in Phase II studies (2011) to modulate the innate immunity pathway targeting GM-CSF signaling in moderate rheumatoid arthritis (RA).
Dipeptidylpeptidase 4 negatively regulates colony-stimulating factor activity and stress hematopoiesis.
New
Impact
Indianapolis, United States. In Nat Med, Dec 2012
In the course of experiments showing that inhibition of DPP4 enhances SDF-1-mediated progenitor cell survival, ex vivo cytokine expansion and replating frequency, we unexpectedly found that DPP4 has a more general role in regulating colony-stimulating factor (CSF) activity.
The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling.
Review
New
Australia. In Immunol Rev, Nov 2012
Granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 are members of a discrete family of cytokines that regulates the growth, differentiation, migration and effector function activities of many hematopoietic cells and immunocytes.
Basophil modulation by cytokine instruction.
Review
New
Erlangen, Germany. In Eur J Immunol, Oct 2012
IL-3, GM-CSF, and thymic stromal lymphopoietin activate the STAT5 pathway that promotes proliferation, activation, and cytokine secretion but also induces a negative feedback loop via Pim-1 and SOCS proteins.
The evolving role of immunotherapy in prostate cancer.
Review
New
Amsterdam, Netherlands. In Ann Oncol, Sep 2012
PROSTVAC(®)-VF, a poxvirus-based vaccine engineered to present prostate-specific antigen (PSA) and three immune costimulatory molecules, and GVAX, a vaccine consisting of two prostate cancer cell lines (LnCAP and PC3) and genetically modified to secrete granulocyte-macrophage colony-stimulating factor (GM-CSF), both showed promising results in phase II studies, although GVAX failed to meet its primary end point of overall survival when compared with docetaxel in a phase III study.
GM-CSF-independent CD1a expression in epidermal Langerhans cells: evidence from human CD1A genome-transgenic mice.
GeneRIF
In J Invest Dermatol, 2012
GM-CSF independent signaling directed toward the CD1a genome is important in Langerhans cell biology.
Role of stem cell factor and granulocyte colony-stimulating factor in remodeling during liver regeneration.
GeneRIF
Temple, United States. In Hepatology, 2012
Expression of SCF+GM-CSF after hepatectomy can contribute to biliary remodeling (e.g., post-transplantation) by functional deregulation of the activity of key signaling intermediates involved in cell expansion and multipotent differentiation.
GM-CSF-induced regulatory T cells selectively inhibit anti-acetylcholine receptor-specific immune responses in experimental myasthenia gravis.
GeneRIF
Chicago, United States. In J Neuroimmunol, 2012
GM-CSF mobilizes tolerogenic dendritic cell precursors upon capture of acetylcholine receptor (AChR), suppressing the anti-AChR immune response through induction/expansion of AChR-specific regulatory T cells.
Myeloid-derived suppressor cells adhere to physiologic STAT3- vs STAT5-dependent hematopoietic programming, establishing diverse tumor-mediated mechanisms of immunologic escape.
Review
Scottsdale, United States. In Immunol Invest, 2011
The presence or absence of GM-CSF is likely the major determinant in each compartment, given that GM-CSF's capacity to preempt STAT3-dependent with dominant STAT5-dependent hematopoietic programming confers sunitinib resistance and redirects differentiation from the n-MDSC lineage to the more versatile monocytoid (m-MDSC) lineage.
Local delivery of GM-CSF protects mice from lethal pneumococcal pneumonia.
GeneRIF
Hannover, Germany. In J Immunol, 2011
Recombinant mouse GM-CSF in the lung rescues mice from lethal pneumococcal pneumonia via adenoviral-mediated gene transfer of GM-CSF either 14 or even 28 days before infection.
GM-CSF modulates pulmonary resistance to influenza A infection.
GeneRIF
Tyler, United States. In Antiviral Res, 2011
In conclusion, GM-CSF enhances early host resistance to influenza.
Effects of nicotine on an in vitro reconstituted model oral mucosa in terms of cytokine production.
Karāchi, Pakistan. In J Ayub Med Coll Abbottabad, 2011
RESULTS: In this study there was evidence that after 5 minutes treatment on un-inflamed mucosa with nicotine at 10 mm concentration GM-CSF release decreased, and also after 24 hours treatment with nicotine at 10mM concentration GM-CSF release increased.
