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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 11 Dec 2014.

Colony stimulating factor 2

GM-CSF, granulocyte-macrophage colony stimulating factor
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CsF, CAN, Interleukin-6, IL-4, IL-10
Papers on GM-CSF
Ebola Virus Infection Induces Irregular Dendritic Cell Gene Expression.
New
Williams et al., Silver Spring, United States. In Viral Immunol, 10 Jan 2015
Monocytes from human donors were cultured in GM-CSF and IL-4 and were infected with Ebola virus Kikwit variant for up to 48 h.
Enhanced Th1-biased immune efficacy of porcine circovirus type 2 Cap-protein-based subunit vaccine when coadministered with recombinant porcine IL-2 or GM-CSF in mice.
New
Liu et al., Harbin, China. In Appl Microbiol Biotechnol, 09 Jan 2015
Interleukin 2 (IL-2) and granulocyte-macrophage colony-stimulating factor (GM-CSF), used as immune adjuvants, have been shown to enhance the immunogenicity of certain antigens or vaccines in various experimental models.
High-dimensional analysis of the murine myeloid cell system.
New
Impact
Newell et al., Singapore, Singapore. In Nat Immunol, 31 Dec 2014
Using mice that cannot sense granulocyte macrophage-colony stimulating factor GM-CSF (Csf2rb(-/-)), which have discrete alterations in myeloid development, we confirmed differences in barrier tissue dendritic cells, lung macrophages and eosinophils.
A Defective Oxidative Burst and Impaired Antigen Presentation are Hallmarks of Human Visceral Leishmaniasis.
New
Chatterjee et al., Calcutta, India. In J Clin Immunol, 25 Dec 2014
METHODS: In monocytes, the redox status, antigen presenting capacity, expression of Toll-like receptors (TLRs), co-stimulatory molecules (CD80/86) and generation of intracellular cytokines (IL-8, IL-1β, IL-10 and LAP-TGF-β1) was measured by flow cytometry, levels of circulating cytokines (IL-1β, IL-6, TNF-α, IL-8, IL-4, IL-13, IL-10 and GM-CSF) by ELISA and arginase activity by spectrophotometry.
Systematic review: New serological markers (anti-glycan, anti-GP2, anti-GM-CSF Ab) in the prediction of IBD patient outcomes.
Review
New
Paul et al., Saint-Étienne, France. In Autoimmun Rev, 13 Dec 2014
However, many recent data suggest the potential role of new serological markers (anti-glycan (ACCA, ALCA, AMCA, anti-L and anti-C), anti-GP2 and anti-GM-CSF Ab).
Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity.
New
Impact
Krummel et al., San Francisco, United States. In Cancer Cell, 10 Dec 2014
These are uniquely dependent on IRF8, Zbtb46, and Batf3 transcription factors and are generated by GM-CSF and FLT3L cytokines.
Ipilimumab plus sargramostim vs ipilimumab alone for treatment of metastatic melanoma: a randomized clinical trial.
New
Impact
Kirkwood et al., Nashville, United States. In Jama, 05 Dec 2014
CTLA-4 blockade and granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting tumor vaccine combinations demonstrate therapeutic synergy in preclinical models.
Asthma Phenotypes: Nonallergic (Intrinsic) Asthma.
Review
New
Peters, Winston-Salem, United States. In J Allergy Clin Immunol Pract, 30 Nov 2014
Although many of the immunopathologic features of nonallergic asthma are similar to those observed with allergic asthma, some differences have been described, including a higher expression of RANTES in mucosa and bronchoalveolar lavage fluid, as well as a higher GM-CSF receptor alpha expression.
Pulmonary macrophage transplantation therapy.
New
Impact
Trapnell et al., Cincinnati, United States. In Nature, 23 Nov 2014
Here, using granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor-β-deficient (Csf2rb(-/-)) mice that develop a myeloid cell disorder identical to hereditary pulmonary alveolar proteinosis (hPAP) in children with CSF2RA or CSF2RB mutations, we show that pulmonary macrophage transplantation (PMT) of either wild-type or Csf2rb-gene-corrected macrophages without myeloablation was safe and well-tolerated and that one administration corrected the lung disease, secondary systemic manifestations and normalized disease-related biomarkers, and prevented disease-specific mortality.
The oncoprotein and transcriptional regulator bcl-3 governs plasticity and pathogenicity of autoimmune T cells.
New
Impact
Siebenlist et al., Bethesda, United States. In Immunity, 16 Nov 2014
The protection against disease correlated with a decrease in Th1 cells that produced the cytokines IFN-γ and GM-CSF and an increase in Th17 cells.
Secondary pulmonary alveolar proteinosis in hematologic malignancies.
Review
New
Erban et al., Weston, United States. In Hematol Oncol Stem Cell Ther, 06 Nov 2014
Idiopathic PAP occurs as a result of auto-antibodies directed against granulocyte-macrophage colony stimulating factor (GM-CSF) impeding the surfactant clearing function of alveolar macrophages leading to progressive respiratory failure.
IL-1β and TNFα promote monocyte viability through the induction of GM-CSF expression by rheumatoid arthritis synovial fibroblasts.
New
Le Goff et al., Nantes, France. In Mediators Inflamm, Dec 2013
GM-CSF but not M-CSF nor IL34 blocking antibodies was able to significantly decrease monocyte viability by 30% when added to the conditioned media from IL-1β and TNFα stimulated SF (P < 0.001).
Role of alveolar macrophages in chronic obstructive pulmonary disease.
Review
New
Bozinovski et al., Melbourne, Australia. In Front Immunol, Dec 2013
This distinct microenvironment coordinates the maturation of long-lived AMs, which originate from fetal blood monocytes and self-renew through mechanisms dependent on GM-CSF and CSF-1 signaling.
Myeloid Colony-Stimulating Factors as Regulators of Macrophage Polarization.
Review
New
Datta et al., Cleveland, United States. In Front Immunol, Dec 2013
Macrophage populations in different tissue locations exist in distinct phenotypic states across this M1/M2 spectrum and the development and abundance of individual subsets result from the local and systemic action of myeloid colony-stimulating factors (CSFs) including M-CSF and GM-CSF.
Response of Differentiated Human Airway Epithelia to Alcohol Exposure and Klebsiella Pneumoniae Challenge.
New
Wang et al., New Orleans, United States. In Med Sci (basel), Aug 2013
Apical bacterial challenge significantly elevated the basolateral secretion of inflammatory cytokines including IL-2, IL-4, IL-6, IL-8, IFN-γ, GM-CSF, and TNF-α.
Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27.
GeneRIF
Fitzgerald et al., Ireland. In J Immunol, 2012
IL-27 is a key negative regulator of GM-CSF expression by T cells, which likely regulates inflammation in health and disease.
Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis.
GeneRIF
Peters-Golden et al., Ann Arbor, United States. In J Immunol, 2012
GM-CSF is a critical mediator of leukotriene B4 (LTB4)-enhanced PU.1 and dectin-1 expression required for fungi-protective host responses.
GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells.
Impact
GeneRIF
Merad et al., New York City, United States. In Immunity, 2012
Csf-2 is important in vaccine-induced CD8(+) T cell immunity through the regulation of nonlymphoid tissue DC homeostasis rather than control of inflammatory DCs in vivo.
Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer.
Impact
GeneRIF
Vonderheide et al., Philadelphia, United States. In Cancer Cell, 2012
Data suggest that tumor-derived GM-CSF is an important regulator of inflammation and immune suppression within the tumor microenvironment.
Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia.
Impact
GeneRIF
Bar-Sagi et al., New York City, United States. In Cancer Cell, 2012
Data show that an oncogenic Kras-dependent upregulation of GM-CSF in mouse pancreatic ductal epithelial cells (PDECs).
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