GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 27 Nov 2013.
Colony stimulating factor 2
GM-CSF, granulocyte-macrophage colony stimulating factor
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008] (from
NCBI)
Papers on
GM-CSF
Granulocyte-macrophage colony-stimulating factor: not just another haematopoietic growth factor.
New
Mexico City, Mexico. In Med Oncol, 31 Jan 2014
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is often used to treat leucopenia.
Distinct cytokine patterns in semen influence local HIV shedding and HIV target cell activation.
New
Cape Town, South Africa. In J Infect Dis, 23 Dec 2013
Semen contained higher concentrations of pro-inflammatory (MCP-1, IL-8, IL-6, Fractalkine, MIP-1β, GM-CSF) and adaptive cytokines (IL-7 and IL-15) and higher frequencies of activated T cells, compared to blood.
Oncolytic viral therapy with a combination of HF10, a herpes simplex virus type 1 variant, and granulocyte-macrophage colony-stimulating factor for murine ovarian cancer.
New
Nagoya, Japan. In Int J Cancer, 21 Dec 2013
Granulocyte-macrophage colony-stimulating factor (GM-CSF) plays an important role in the maturation of specialized antigen-presenting cells.
Molecular changes in bone marrow, tumor and serum after conductive ablation of murine 4T1 breast carcinoma.
New
Little Rock, United States. In Int J Oncol, 21 Dec 2013
Of 16 serum chemokines, IFNγ and GM-CSF levels were lower with treatment.
Effect of Progenitor Cell Mobilization With Granulocyte-Macrophage Colony-Stimulating Factor in Patients With Peripheral Artery Disease: A Randomized Clinical Trial.
New
Impact
Georgia. In Jama, 18 Dec 2013
OBJECTIVE To investigate whether therapy with granulocyte-macrophage colony-stimulating factor (GM-CSF) improves exercise capacity in patients with intermittent claudication.
An element of life: competition for zinc in host-pathogen interaction.
New
Impact
Aachen, Germany. In Immunity, 17 Nov 2013
(2013) demonstrate that stimulation of macrophages with GM-CSF deprives intracellular Histoplasma capsulatum of zinc, improving pathogen clearance.
Granulocyte macrophage-colony stimulating factor induced zn sequestration enhances macrophage superoxide and limits intracellular pathogen survival.
New
Impact
Cincinnati, United States. In Immunity, 17 Nov 2013
The pleiotropic cytokine granulocyte macrophage-colony stimulating factor (GM-CSF) enhances antimicrobial defenses against intracellular pathogens such as Histoplasma capsulatum, but its mode of action remains elusive.
CSF-1R inhibition alters macrophage polarization and blocks glioma progression.
New
Impact
New York City, United States. In Nat Med, 31 Oct 2013
Macrophages depend on colony stimulating factor-1 (CSF-1) for differentiation and survival.
Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes.
New
Impact
New York City, United States. In Immunity, May 2013
Similarly, we found that after depletion of lung macrophages, the majority of repopulation occurred by stochastic cellular proliferation in situ in a macrophage colony-stimulating factor (M-Csf)- and granulocyte macrophage (GM)-CSF-dependent manner but independently of interleukin-4.
Th17 cell development: from the cradle to the grave.
Review
New
Palo Alto, United States. In Immunol Rev, Mar 2013
Interleukin-23 (IL-23) is one of the key cytokines that shapes the development and function of Th17 cells with characteristic expression of retinoic acid receptor-related orphan receptor γ-t (RORγt), IL-17, IL-22, and granulocyte macrophage colony-stimulating factor (GM-CSF).
Erythropoietin: multiple targets, actions, and modifying influences for biological and clinical consideration.
Review
New
Indianapolis, United States. In J Exp Med, Mar 2013
EPO signals via two receptors, one comprising EPO receptor (EPOR) homodimers and the other a heterodimer of EPOR and CD131-the common β chain component of the GM-CSF, interleukin (IL)-3, and IL-5 receptors.
Functional defect in regulatory T cells in myasthenia gravis.
Review
New
Chicago, United States. In Ann N Y Acad Sci, Dec 2012
In vitro administration of granulocyte macrophage-colony-stimulating factor (GM-CSF) enhanced the suppressive function of T(reg) cells and upregulated FOXP3 expression.
Colony stimulating factors (including erythropoietin, granulocyte colony stimulating factor and analogues) for stroke.
Review
New
Nottingham, United Kingdom. In Cochrane Database Syst Rev, Dec 2012
CSFs included stem cell factor (SCF), erythropoietin (EPO), granulocyte colony stimulating factor (G-CSF), granulocyte-macrophage colony stimulating factor (GM-CSF), macrophage-colony stimulating factor (M-CSF, CSF-1), thrombopoietin (TPO), or analogues of these.
Oral Administration of Soluble β-Glucan Preparation from the Cauliflower Mushroom, Sparassis crispa (Higher Basidiomycetes) Modulated Cytokine Production in Mice.
New
Hachiōji, Japan. In Int J Med Mushrooms, Dec 2012
The level of induction of IFN-γ and GM-CSF by SCG was significantly increased in SCHWE-treated mice.
Co-expression of HIV-1 virus-like particles and granulocyte-macrophage colony stimulating factor by GEO-D03 DNA vaccine.
Review
New
Smyrna, United States. In Hum Vaccin Immunother, Dec 2012
Here, we report on GEO-D03, a DNA vaccine that co-expresses non-infectious HIV-1 virus-like particles (VLPs) and the human cytokine, granulocyte-macrophage colony-stimulating factor (GM-CSF).
GM-CSF-independent CD1a expression in epidermal Langerhans cells: evidence from human CD1A genome-transgenic mice.
GeneRIF
In J Invest Dermatol, 2012
GM-CSF independent signaling directed toward the CD1a genome is important in Langerhans cell biology.
Role of stem cell factor and granulocyte colony-stimulating factor in remodeling during liver regeneration.
GeneRIF
Temple, United States. In Hepatology, 2012
Expression of SCF+GM-CSF after hepatectomy can contribute to biliary remodeling (e.g., post-transplantation) by functional deregulation of the activity of key signaling intermediates involved in cell expansion and multipotent differentiation.
GM-CSF-induced regulatory T cells selectively inhibit anti-acetylcholine receptor-specific immune responses in experimental myasthenia gravis.
GeneRIF
Chicago, United States. In J Neuroimmunol, 2012
GM-CSF mobilizes tolerogenic dendritic cell precursors upon capture of acetylcholine receptor (AChR), suppressing the anti-AChR immune response through induction/expansion of AChR-specific regulatory T cells.
Local delivery of GM-CSF protects mice from lethal pneumococcal pneumonia.
GeneRIF
Hannover, Germany. In J Immunol, 2011
Recombinant mouse GM-CSF in the lung rescues mice from lethal pneumococcal pneumonia via adenoviral-mediated gene transfer of GM-CSF either 14 or even 28 days before infection.
GM-CSF modulates pulmonary resistance to influenza A infection.
GeneRIF
Tyler, United States. In Antiviral Res, 2011
In conclusion, GM-CSF enhances early host resistance to influenza.
