MCAM(+) CD8 T lymphocytes mediate CNS inflammation.
Montréal, Canada. In Ann Neurol, 13 May 2015
We further demonstrate that MCAM(+) CD8(+) T lymphocytes express more IL-17, IFN-γ, GM-CSF and TNF than MCAM(neg) lymphocytes, and exhibit an enhanced killing capacity towards oligodendrocytes.
Pulmonary alveolar proteinosis: time to shift?
Athens, Greece. In Expert Rev Respir Med, 12 May 2015
Hereditary PAP is caused by mutations involving the GM-CSF signaling, particularly in genes for the GM-CSF receptor and sometimes by GATA2 mutations.
Novel therapeutic targets in rheumatoid arthritis.
Nijmegen, Netherlands. In Trends Pharmacol Sci, 27 Mar 2015
Here, we discuss two pathways that are regarded as interesting novel therapeutic targets in the field of rheumatology: the Janus kinase (JAK) pathway and the T helper-17 (Th17) pathway [including interleukin (IL)-17, IL-21, IL-22, and granulocyte-macrophage colony-stimulating factor (GM-CSF)].
Beyond the age of cellular discovery.
Nashville, United States. In Nat Immunol, Dec 2014
The combination of machine-learning tools and mass-cytometry measurements of more than 30 protein markers per cell comprehensively maps cell identity in the heterogeneous myeloid cell system and reveals the global effect of deletion of the gene encoding the receptor for the growth factor GM-CSF.
High-dimensional analysis of the murine myeloid cell system.
Singapore, Singapore. In Nat Immunol, Dec 2014
Using mice that cannot sense granulocyte macrophage-colony stimulating factor GM-CSF (Csf2rb(-/-)), which have discrete alterations in myeloid development, we confirmed differences in barrier tissue dendritic cells, lung macrophages and eosinophils.