GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 24 Feb 2014.
Colony stimulating factor 2
GM-CSF, granulocyte-macrophage colony stimulating factor
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008] (from
NCBI)
Papers on
GM-CSF
Histologic findings in skin biopsy of a JMML rash: a case report and review of literature.
New
United States. In Pediatr Dev Pathol, 20 Mar 2014
These findings along with absence of a BCR-ABL1 fusion gene and a hemoglobin F level of 3.4% were consistent with the diagnosis of JMML, which was confirmed by subsequent positive GM-CSF hypersensitivity and NRAS mutation studies.
PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML.
New
Indianapolis, United States. In Blood, 19 Mar 2014
Using genetic models, we demonstrate that inactivation of phosphatidylinositol-3-kinase (PI3K) catalytic subunit, p110δ, but not PI3K p110α, corrects gain-of-function (GOF) Shp2-induced GM-CSF hypersensitivity, Akt and Erk hyperactivation, and skewed hematopoietic progenitor distribution.
The new normal: immunomodulatory agents against sepsis immune suppression.
Review
New
Providence, United States. In Trends Mol Med, 02 Mar 2014
Recent studies from animal sepsis models and patient samples suggest that cytokines such as interleukin-7 (IL-7), IL-15, granulocyte macrophage colony-stimulating factor (GM-CSF), as well as co-inhibitory molecule blockade, such as anti-programmed cell death receptor-1 (anti-PD-1) and anti-B and T lymphocyte attenuator (anti-BTLA), may have utility in alleviating the clinical morbidity associated with sustained sepsis.
Fms-like tyrosine kinase 3 ligand-dependent dendritic cells in autoimmune inflammation.
Review
New
Amsterdam, Netherlands. In Autoimmun Rev, 28 Feb 2014
Initial in vitro studies of cytokines in DC development revealed distinct and important roles for the receptor tyrosine kinases, granulocyte-macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF, also called CSF1) and fms-like tyrosine kinase 3 ligand (Flt3L) in the generation of DCs.
IL-17 Regulates Systemic Fungal Immunity by Controlling the Functional Competence of NK Cells.
New
Impact
Zürich, Switzerland. In Immunity, 16 Feb 2014
NK cells promoted antifungal immunity by secreting GM-CSF, necessary for the fungicidal activity of neutrophils.
Autoimmune pulmonary alveolar proteinosis: Clinical course and diagnostic criteria.
Review
New
Tel Aviv-Yafo, Israel. In Autoimmun Rev, 11 Feb 2014
Autoimmune PAP, a rare, antibody-mediated disease, that compromises 90% of cases of PAP, is causes by IgG autoantibodies that block GM-CSF effect, a crucial step for macrophage maturation.
Effect of progenitor cell mobilization with granulocyte-macrophage colony-stimulating factor in patients with peripheral artery disease: a randomized clinical trial.
New
Impact
Georgia. In Jama, 25 Jan 2014
OBJECTIVE: To investigate whether therapy with granulocyte-macrophage colony-stimulating factor (GM-CSF) improves exercise capacity in patients with intermittent claudication.
Evaluation of Pre-Treatment Serum Levels of IL-7 and GM-CSF in Colorectal Cancer Patients.
New
Shīrāz, Iran. In Int J Mol Cell Med, Dec 2013
GM-CSF and IL-7 are reported to increase in different cancers and we aimed to investigate the pre-treatment serum levels of GM-CSF and IL-7 in Iranian patients with colorectal cancer.
A GM-CSF/IL-33 Pathway Facilitates Allergic Airway Responses to Sub-Threshold House Dust Mite Exposure.
New
Hamilton, Canada. In Plos One, Dec 2013
These findings suggest that exposures to environmental agents associated with GM-CSF production, including airway infections and pollutants, may decrease the threshold of allergen responsiveness and, hence, increase the susceptibility to develop allergic asthma through a GM-CSF/IL-33/OX40L pathway.
GM-CSF as a therapeutic target in inflammatory diseases.
Review
New
Melbourne, Australia. In Mol Immunol, Dec 2013
GM-CSF is a well-known haemopoietic growth factor that is used in the clinic to correct neutropaenia, usually as a result of chemotherapy.
Antitumor cell-complex vaccines employing genetically modified tumor cells and fibroblasts.
New
Valencia, Spain. In Toxins (basel), Dec 2013
The present study evaluates the immune response mediated by vaccination with cell complexes composed of irradiated B16 tumor cells and mouse fibroblasts genetically modified to produce GM-CSF.
Granulocyte macrophage-colony stimulating factor induced Zn sequestration enhances macrophage superoxide and limits intracellular pathogen survival.
New
Impact
Cincinnati, United States. In Immunity, Nov 2013
The pleiotropic cytokine granulocyte macrophage-colony stimulating factor (GM-CSF) enhances antimicrobial defenses against intracellular pathogens such as Histoplasma capsulatum, but its mode of action remains elusive.
An element of life: competition for zinc in host-pathogen interaction.
New
Impact
Aachen, Germany. In Immunity, Nov 2013
(2013) demonstrate that stimulation of macrophages with GM-CSF deprives intracellular Histoplasma capsulatum of zinc, improving pathogen clearance.
CSF-1R inhibition alters macrophage polarization and blocks glioma progression.
New
Impact
New York City, United States. In Nat Med, Oct 2013
Macrophages depend on colony stimulating factor-1 (CSF-1) for differentiation and survival.
Colony stimulating factors (including erythropoietin, granulocyte colony stimulating factor and analogues) for stroke.
Review
Nottingham, United Kingdom. In Cochrane Database Syst Rev, 2012
CSFs included stem cell factor (SCF), erythropoietin (EPO), granulocyte colony stimulating factor (G-CSF), granulocyte-macrophage colony stimulating factor (GM-CSF), macrophage-colony stimulating factor (M-CSF, CSF-1), thrombopoietin (TPO), or analogues of these.
GM-CSF-independent CD1a expression in epidermal Langerhans cells: evidence from human CD1A genome-transgenic mice.
GeneRIF
In J Invest Dermatol, 2012
GM-CSF independent signaling directed toward the CD1a genome is important in Langerhans cell biology.
Role of stem cell factor and granulocyte colony-stimulating factor in remodeling during liver regeneration.
GeneRIF
Temple, United States. In Hepatology, 2012
Expression of SCF+GM-CSF after hepatectomy can contribute to biliary remodeling (e.g., post-transplantation) by functional deregulation of the activity of key signaling intermediates involved in cell expansion and multipotent differentiation.
GM-CSF-induced regulatory T cells selectively inhibit anti-acetylcholine receptor-specific immune responses in experimental myasthenia gravis.
GeneRIF
Chicago, United States. In J Neuroimmunol, 2012
GM-CSF mobilizes tolerogenic dendritic cell precursors upon capture of acetylcholine receptor (AChR), suppressing the anti-AChR immune response through induction/expansion of AChR-specific regulatory T cells.
Local delivery of GM-CSF protects mice from lethal pneumococcal pneumonia.
GeneRIF
Hannover, Germany. In J Immunol, 2011
Recombinant mouse GM-CSF in the lung rescues mice from lethal pneumococcal pneumonia via adenoviral-mediated gene transfer of GM-CSF either 14 or even 28 days before infection.
GM-CSF modulates pulmonary resistance to influenza A infection.
GeneRIF
Tyler, United States. In Antiviral Res, 2011
In conclusion, GM-CSF enhances early host resistance to influenza.
