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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Glypican 4

glypican-4, GPC4, K-glypican
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: GPC3, CAN, GPC, Insulin, glypican-1
Papers on glypican-4
Cell Adhesion Molecules and Stem Cell-Niche-Interactions in the Limbal Stem Cell Niche.
New
Schlötzer-Schrehardt et al., Erlangen, Germany. In Stem Cells, Jan 2016
In addition to the LEPC-associated heparan sulfate proteoglycans syndecan-2, glypican-3, and glypican-4, the IgCAM members ICAM-1 and VCAM-1 were found to be variably expressed on LEPCs and associated niche cells and to be dynamically regulated in response to chemokines such as interferon-γ to enhance interactions with immune cells.
Cell surface heparan sulfate proteoglycans as novel markers of human neural stem cell fate determination.
New
Haupt et al., Brisbane, Australia. In Stem Cell Res, Jan 2016
Furthermore, neuronal differentiation of the cells upregulated SDC4, GPC1, GPC2, GPC3 and GPC6 expression with increased GPC4 expression observed under astrocyte culture conditions.
Association of serum glypican-4 levels with cardiovascular risk predictors in women with polycystic ovary syndrome - a pilot study.
New
Milewicz et al., Wrocław, Poland. In Gynecol Endocrinol, Dec 2015
OBJECTIVE: Glypican-4 (Gpc4) is an adipokine which interacts with the insulin receptor and affects insulin sensitivity in proteoglycans.
A role of glypican4 and wnt5b in chondrocyte stacking underlying craniofacial cartilage morphogenesis.
New
Topczewski et al., Chicago, United States. In Mech Dev, Nov 2015
Here we demonstrate that while vang-like 2 (vangl2), wnt11 and scribbled (scrib) mutants have severe craniofacial morphogenesis defects they do not display the chondrocyte stacking and intercalation problems seen in glypican 4 (gpc4) and wnt5b mutants.
Expression of developmental genes in brown fat cells grown in vitro is linked with lipid accumulation.
New
Grover et al., Karnāl, India. In In Vitro Cell Dev Biol Anim, Nov 2015
En1, Nr2f1, Gpc4, Sfrp2, Shox2, Tbx15 and Thbd are among the genes involved in development process of an organism in a number of tissues, in particular adipose tissue.
Quantitative proteomics provides new insights into chicken eggshell matrix protein functions during the primary events of mineralisation and the active calcification phase.
New
Gautron et al., France. In J Proteomics, Sep 2015
We confirmed the important role of lysozyme, ovotransferrin, ovocleidin-17 and ovocleidin-116 for shell calcification process, characterised major calcium binding proteins (EDIL3, ALB, MFGE8, NUCB2), and described novel proteoglycans core proteins (GPC4, HAPLN3).
Glypican4 promotes cardiac specification and differentiation by attenuating canonical Wnt and Bmp signaling.
New
Bakkers et al., Utrecht, Netherlands. In Development, Jun 2015
To understand better the role of glypicans during heart development, we studied the zebrafish knypek mutant, which is deficient for Gpc4.
PTPσ functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission.
New
Ko et al., Seoul, South Korea. In Proc Natl Acad Sci U S A, Mar 2015
Here, we identify glypican 4 (GPC-4) as a ligand for PTPσ.
Glypican-4 is increased in human subjects with impaired glucose tolerance and decreased in patients with newly diagnosed type 2 diabetes.
Yang et al., Chongqing, China. In Acta Diabetol, 2014
CONTEXT: Glypican-4 (GPC-4) has been identified as a novel adipokine capable of enhancing insulin signaling.
The changes of serum glypican4 in obese patients with different glucose metabolism status.
Gong et al., Beijing, China. In J Clin Endocrinol Metab, 2014
CONTEXT AND OBJECTIVE: Glypican 4 (Gpc4) was identified as a novel adipokine capable of intensifying insulin signaling and regulating adipocyte differentiation.
Glypican 4 may be involved in the adipose tissue redistribution in high-fat feeding C57BL/6J mice with peroxisome proliferators-activated receptor γ agonist rosiglitazone treatment.
Yang et al., Shenyang, China. In Exp Ther Med, 2014
Glypican 4 (Gpc4) may be involved in the regulation of obesity and body fat distribution.
Phenotypic spectrum of Simpson-Golabi-Behmel syndrome in a series of 42 cases with a mutation in GPC3 and review of the literature.
Review
Toutain et al., Tours, France. In Am J Med Genet C Semin Med Genet, 2013
In the family reported by Golabi and Rosen, a duplication of GPC4 was recently identified, suggesting that GPC4 could be the second gene for SGBS but no point mutations within GPC4 have yet been reported.
Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors.
Impact
GeneRIF
Barres et al., Stanford, United States. In Nature, 2012
data identify glypicans as a family of novel astrocyte-derived molecules that are necessary and sufficient to promote glutamate receptor clustering and receptivity and to induce the formation of postsynaptically functioning CNS synapses
Craniofacial skeletal defects of adult zebrafish Glypican 4 (knypek) mutants.
GeneRIF
Topczewski et al., Chicago, United States. In Dev Dyn, 2009
These findings implicate Gpc4 in the regulation of zebrafish cartilage and bone morphogenesis.
Simpson-Golabi-Behmel Syndrome Type 1
Review
Lopez et al., Seattle, United States. In Unknown Journal, 2007
GPC3 and GPC4 are the only two genes in which mutations are known to cause SGBS1.
Expression pattern of glypican-4 suggests multiple roles during mouse development.
GeneRIF
Greene et al., London, United Kingdom. In Dev Dyn, 2005
complex pattern of glypican-4 mRNA localization at embryonic days 7-10.5, including sites in the anterior forebrain neuroepithelium, branchial arches, optic and otic vesicles, limb buds and somites
The glypican family of heparan sulfate proteoglycans: major cell-surface proteoglycans of the developing nervous system.
Review
Ivins et al., Irvine, United States. In Perspect Dev Neurobiol, 1995
The glypican family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans comprises four vertebrate members, glypican, cerebroglycan, OCI-5, and K-glypican, and the Drosophila protein, daily.
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